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You searched for: Journal Trends in analytical chemistry Remove constraint Journal: Trends in analytical chemistry Publication Year 2019 Remove constraint Publication Year: 2019 Source 2019 v.117 Remove constraint Source: 2019 v.117
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1. Acoustofluidic methods in cell analysis

Author:
Xie, Yuliang; Bachman, Hunter; Huang, Tony Jun
Source:
Trends in analytical chemistry 2019 v.117 pp. 280-290
ISSN:
0165-9936
Subject:
cellular microenvironment; image analysis; medicine; microfluidic technology; neoplasm cells; phenotype; sounds
Abstract:
... Cellular analysis is a central concept for both biology and medicine. Over the past two decades, acoustofluidic technologies, which marry acoustic waves with microfluidics, have significantly contributed to the development of innovative approaches for cellular analysis. Acoustofluidic technologies enable precise manipulations of cells and the fluids that confine them, and these capabilities have b ...
DOI:
10.1016/j.trac.2019.06.034

2. Advances in capillary electrophoresis-mass spectrometry for cell analysis

Author:
Zhou, Wei; Zhang, Baofang; Liu, Yikun; Wang, Chenlu; Sun, Wenqi; Li, Wen; Chen, Zilin
Source:
Trends in analytical chemistry 2019 v.117 pp. 316-330
ISSN:
0165-9936
Subject:
capillary zone electrophoresis; electrochromatography; isoelectric focusing; mass spectrometry; metabolism; micellar electrokinetic capillary chromatography; pH; solid phase extraction
Abstract:
... Mass spectrometry has become a powerful tool in the field of bioanalysis. The combination of capillary electrophoresis with mass spectrometry (CE-MS) offers fast and high-resolution separation, sensitive and selective detection with small sample volumes, which is suitable for cell analysis. Here, we review the recent technical development of CE, MS and hyphenated strategies as well as their potent ...
DOI:
10.1016/j.trac.2019.05.011

3. Analysis of cellular biomolecules and behaviors using microfluidic chip and fluorescence method

Author:
Li, Nan; Zhang, Weifei; Li, Yuxuan; Lin, Jin-Ming
Source:
Trends in analytical chemistry 2019 v.117 pp. 200-214
ISSN:
0165-9936
Subject:
biochemical compounds; fluorescence; fluorescent labeling; hydrophobicity; models; organ-on-a-chip
Abstract:
... Cells, as the fundamental structural elements and functional units of life, are necessary to be explored the variation of components and behaviors in the physiological and pathological processes. Benefited from the development of microfluidic culture and fluorescence labeling techniques, chips coupled with fluorescent tools have become a powerful platform for cell analysis. Thus, in this review, w ...
DOI:
10.1016/j.trac.2019.05.029

4. Analysis of circulating non-coding RNAs in a non-invasive and cost-effective manner

Author:
Wang, Yu-Min; Trinh, Michael Patrick; Zheng, Yongzan; Guo, Kaizhu; Jimenez, Luis A.; Zhong, Wenwan
Source:
Trends in analytical chemistry 2019 v.117 pp. 242-262
ISSN:
0165-9936
Subject:
biomarkers; body fluids; circulatory system; cost effectiveness; diagnostic techniques; gene expression regulation; neoplasms; non-coding RNA; point-of-care systems; prognosis
Abstract:
... Non-coding RNAs (ncRNAs) participate in regulation of gene expression, and are highly relevant to pathological development. They are found to be stably present in diverse body fluids, including those in the circulatory system, which can be sampled non-invasively for clinical tests. Thus, circulating ncRNAs have great potential to be disease biomarkers. However, tremendous efforts are desired to di ...
DOI:
10.1016/j.trac.2019.07.001
PubMed:
32292220
PubMed Central:
PMC7156030

5. Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis

Author:
Leung, Chung-Hang; Wu, Ke-Jia; Li, Guodong; Wu, Chun; Ko, Chung-Nga; Ma, Dik-Lung
Source:
Trends in analytical chemistry 2019 v.117 pp. 78-83
ISSN:
0165-9936
Subject:
biomarkers; blood flow; functional properties; microfluidic technology; neoplasm cells; neoplasms
Abstract:
... Circulating tumor cells (CTCs) are an important biomarker for various types of cancers. As CTCs are extremely rare in the bloodstream, the accurate analysis and efficient separation of CTCs is a challenging task. In order to develop new diagnostic approaches for cancer research, understanding the functional characteristics of biomolecules at the single-molecule level in individual cancer cells is ...
DOI:
10.1016/j.trac.2019.06.003

6. Aptamer-based microfluidics for isolation, release and analysis of circulating tumor cells

Author:
Wu, Lingling; Zhu, Lin; Huang, Mengjiao; Song, Jia; Zhang, Huimin; Song, Yanling; Wang, Wei; Yang, Chaoyong
Source:
Trends in analytical chemistry 2019 v.117 pp. 69-77
ISSN:
0165-9936
Subject:
automation; ligands; microfluidic technology; neoplasm cells; oligonucleotides; organ-on-a-chip; selection methods
Abstract:
... The analysis of circulating tumor cells (CTCs) holds great significance for cancer diagnosis, prognosis, and personalized therapy. However, the rarity, vulnerability and heterogeneity of CTCs bring daunting technical challenges to their isolation, release and analysis. Recent exciting advances in microfluidics have greatly promoted CTC isolation and analysis due to its merits of precise control of ...
DOI:
10.1016/j.trac.2019.05.003

7. Cell-based drug screening on microfluidics

Author:
Zhai, Jiao; Yi, Shuhong; Jia, Yanwei; Mak, Pui-In; Martins, Rui P.
Source:
Trends in analytical chemistry 2019 v.117 pp. 231-241
ISSN:
0165-9936
Subject:
droplets; drugs; microfluidic technology; paper; screening
Abstract:
... With the inherent merits of a low reagent consumption, the small amount of sample needed and easy integration, a wide variety of microfluidic platforms (continuous-flow, droplet, digital and paper) have been developed to address the challenges (e.g. throughput, single-cell isolation, cost and flexibility) of cell-based drug screening. This review essentially summarises the pros and cons of the pla ...
DOI:
10.1016/j.trac.2019.05.018

8. Confined Nanopipette-A new microfluidic approach for single cell analysis

Author:
Lu, Si-Min; Long, Yi-Tao
Source:
Trends in analytical chemistry 2019 v.117 pp. 39-46
ISSN:
0165-9936
Subject:
analytical methods; chemical species; electrochemistry; monitoring
Abstract:
... Monitoring the dynamic behaviour of a single cell in a natural environment is vital in biological studies and contributes to the understanding of the relationship between the function of single cells and the pathology. The advent of specially designed and sensitive chemical or biological analytical methods that enable the application in single cell analysis is urgently demanded. Confined nanopipet ...
DOI:
10.1016/j.trac.2019.05.050

9. Current progress in long-term and continuous cell metabolite detection using microfluidics

Author:
Shi, Jiaming; Tong, Lei; Tong, Wenqiang; Chen, Huaying; Lan, Minbo; Sun, Xiaoxi; Zhu, Yonggang
Source:
Trends in analytical chemistry 2019 v.117 pp. 263-279
ISSN:
0165-9936
Subject:
cell culture; cellular microenvironment; chemical reactions; dissolved oxygen; environmental factors; glucose; lactic acid; metabolism; metabolites; microfluidic technology; oxygen; pH; pyruvic acid; reactive oxygen species
Abstract:
... Cellular metabolism involves complex sequences of controlled biochemical reactions and many chemical compounds or metabolites. The quantification of these metabolites will provide information on the dynamic cellular metabolism and the effect of environmental conditions. There have been extensive studies in this field since the last few decades, including the recent developments in microfluidic-bas ...
DOI:
10.1016/j.trac.2019.05.028

10. Current techniques and future advance of microfluidic devices for circulating tumor cells

Author:
Cheng, Shi-Bo; Chen, Miao-Miao; Wang, Yi-Ke; Sun, Zi-Han; Xie, Min; Huang, Wei-Hua
Source:
Trends in analytical chemistry 2019 v.117 pp. 116-127
ISSN:
0165-9936
Subject:
blood; genotype; metastasis; neoplasm cells; neoplasm progression; neoplasms; organ-on-a-chip; phenotype
Abstract:
... Circulating tumor cells (CTCs), escaped from solid tumor to peripheral blood, are responsible for tumor metastasis and closely relevant to cancer progression. As one of the targets of “liquid biopsy”, CTCs play an important role in noninvasive tumor diagnosis. In the past decades, various microfluidic devices have been developed to efficiently isolate and accurately numerate CTCs. However, simply ...
DOI:
10.1016/j.trac.2019.06.018

11. Digital microfluidics for cell manipulation

Author:
Pang, Long; Ding, Jing; Liu, Xi-Xian; Fan, Shih-Kang
Source:
Trends in analytical chemistry 2019 v.117 pp. 291-299
ISSN:
0165-9936
Subject:
cell culture; droplets; electric field; microfluidic technology
Abstract:
... A droplet-based technique to handle liquids called digital microfluidics (DMF) has attracted attention for cell manipulation (e.g., cell culture, cell sorting and single-cell analysis). With DMF, one manipulates droplets, of size ranging from picolitre to microlitre, on a planar surface by means of an electric field. DMF hence becomes an appealing platform to use for eventual integration into stan ...
DOI:
10.1016/j.trac.2019.06.008

12. Engineering microfluidic chip for circulating tumor cells: From enrichment, release to single cell analysis

Author:
Yu, Xu; Wu, Na; Chen, Feng; Wei, Jing; Zhao, Yongxi
Source:
Trends in analytical chemistry 2019 v.117 pp. 27-38
ISSN:
0165-9936
Subject:
drug resistance; engineering; genomics; monitoring; neoplasm cells; neoplasms; organ-on-a-chip; proteomics; therapeutics
Abstract:
... Circulating tumor cells (CTCs) contain relatively complete clinical information of the original tumors that could be used for cancer diagnosis, therapy monitoring and drug resistance evaluation. The microfluidic chip is a promising tool for the low abundance of CTC enrichment, controllable release and downstream analysis. It will help to unlock the innate powers of the CTCs for establishment of bi ...
DOI:
10.1016/j.trac.2019.03.027

13. Mechanical characterization of single cells based on microfluidic techniques

Author:
Huang, Jianyong; Lin, Feng; Xiong, Chunyang
Source:
Trends in analytical chemistry 2019 v.117 pp. 47-57
ISSN:
0165-9936
Subject:
extracellular matrix; hydrogels; mechanical properties; mechanotransduction; microfluidic technology
Abstract:
... Interactions between cells and their microenvironment trigger a series of complex mechanotransduction signals that regulate cell behavior. Mechanical characterization of cell interactions with extracellular matrix (ECM)/substrate is a prerequisite for quantitative investigations of the mechanisms of mechanotransduction. Here, we present recent progress in the quantification of traction forces gene ...
DOI:
10.1016/j.trac.2019.07.015

14. Microfluidic analysis of circulating tumor cells and tumor-derived extracellular vesicles

Author:
Tian, Fei; Liu, Chao; Lin, Ling; Chen, Qinghua; Sun, Jiashu
Source:
Trends in analytical chemistry 2019 v.117 pp. 128-145
ISSN:
0165-9936
Subject:
biopsy; monitoring; neoplasm cells; neoplasms; point-of-care testing; prediction; prognosis
Abstract:
... Liquid biopsy of circulating tumor cells (CTCs) and tumor-derived extracellular vesicles (EVs) holds immense promise in early detection of cancer, monitoring efficacy of therapy, and predicting prognosis. Microfluidic techniques provide new tools for isolation and detection of CTCs and EVs, by offering a multitude of advantages in terms of high-level of integration, multiplex analysis, small sampl ...
DOI:
10.1016/j.trac.2019.05.013

15. Microfluidic analysis of heterotypic cellular interactions: A review of techniques and applications

Author:
Sakthivel, Kabilan; O'Brien, Allen; Kim, Keekyoung; Hoorfar, Mina
Source:
Trends in analytical chemistry 2019 v.117 pp. 166-185
ISSN:
0165-9936
Subject:
cell communication; coculture; disease models; droplets; drugs; engineering; guidelines; screening
Abstract:
... Analyzing heterotypic cellular communications is essential to understand various physiological and pathological mechanisms. Although static, 2-dimensional in vitro cell monoculture models allow a high degree of experimental control, they poorly approximate in vivo conditions due to the lack of heterotypic cellular interactions. Co-culture systems permit such interactions and recently, microfluidic ...
DOI:
10.1016/j.trac.2019.03.026

16. Microfluidic chip and its application in autophagy detection

Author:
Wang, Xiaobo; Liu, Zixuan; Fan, Fangfang; Hou, Ya; Yang, Hailing; Meng, Xianli; Zhang, Yi; Ren, Fugang
Source:
Trends in analytical chemistry 2019 v.117 pp. 300-315
ISSN:
0165-9936
Subject:
automation; autophagy; biosensors; drugs; image analysis; mass spectrometry; metabolites; models; organ-on-a-chip; screening; technology
Abstract:
... Microfluidic chip (MC) has helped more researchers to perform labs on a chip, with the advantages of precise control, lower sample requirement and reagent consumption, economic efficiency and high throughput screening. Its combination with other technologies, such as biosensor technology, mass spectrometry, and automated imaging systems, has emerged as a novel platform for model construction of mu ...
DOI:
10.1016/j.trac.2019.05.043

17. Microfluidic models of physiological or pathological flow shear stress for cell biology, disease modeling and drug development

Author:
Chen, Huaying; Yu, Zhihang; Bai, Siwei; Lu, Huaxiu; Xu, Dong; Chen, Chang; Liu, Di; Zhu, Yonggang
Source:
Trends in analytical chemistry 2019 v.117 pp. 186-199
ISSN:
0165-9936
Subject:
cell biology; cell culture; drug development; exposure duration; humans; image analysis; microfluidic technology; microscopy; models; shear stress
Abstract:
... Shear stress of physiological flows in the human body plays a critical role in maintaining the structure and functions of single cells and multicellular organs. Recently, the wide-spreading microfluidic technologies have made significant contributions to the in-vitro recapitulation of complex biochemical and mechanical cues. Microfluidic approaches are of inherent advantages in modeling of flow sh ...
DOI:
10.1016/j.trac.2019.06.023

18. Microfluidics-based approaches for separation and analysis of circulating tumor cells

Author:
Yin, Jiaxiang; Deng, Jinqi; Du, Chang; Zhang, Wei; Jiang, Xingyu
Source:
Trends in analytical chemistry 2019 v.117 pp. 84-100
ISSN:
0165-9936
Subject:
biomarkers; circulatory system; diagnostic techniques; epithelium; metastasis; mortality; neoplasm cells; neoplasms
Abstract:
... Metastasis is the leading cause of epithelial cancer-associated mortality. The shedding of tumor cells into the circulatory system is a key step for metastasis. Circulating tumor cells (CTCs) are reliable biomarkers for cancer diagnostics and treatment. To obtain clinical information, accurate approaches for separating and analyzing CTCs are necessary. Microfluidic technologies have demonstrated t ...
DOI:
10.1016/j.trac.2019.07.018

19. Microfluidics towards single cell resolution protein analysis

Author:
Chen, Peng; Chen, Dongjuan; Li, Shunji; Ou, Xiaowen; Liu, Bi-Feng
Source:
Trends in analytical chemistry 2019 v.117 pp. 2-12
ISSN:
0165-9936
Subject:
capillary electrophoresis; droplets; flow cytometry; gel electrophoresis; mass spectrometry; microfluidic technology; proteins
Abstract:
... Single cell analysis has aroused great interest with its remarkable ability to investigate cell-to-cell heterogeneity in large populations. However, probing protein information at single cells resolution including quantity, interactions, and dynamics have been great challenges as a result of the small size of cells, the complexity and a large concentration range of the protein and the lack of geno ...
DOI:
10.1016/j.trac.2019.06.022

20. Micro/nanofluidic technologies for efficient isolation and detection of circulating tumor cells

Author:
Yue, Wan-Qing; Tan, Zheng; Li, Xiu-Ping; Liu, Fei-Fei; Wang, Chen
Source:
Trends in analytical chemistry 2019 v.117 pp. 101-115
ISSN:
0165-9936
Subject:
Raman spectroscopy; blood; cell culture; electrochemistry; fluorescence; neoplasm cells; neoplasms
Abstract:
... Sensitive detection of circulating tumor cells (CTCs) is of great importance for early cancer diagnosis. However, the number of CTCs is very rare in the peripheral blood. Therefore, there is an urgent demand to develop new methods to efficiently isolate and detect trace amount of CTCs. Among various methods and analytical platforms, micro/nanofluidic technologies have been demonstrated as a great ...
DOI:
10.1016/j.trac.2019.06.009