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- Turoverov, Konstantin K.; Kuznetsova, Irina M.; Fonin, Alexander V.; Darling, April L.; Zaslavsky, Boris Y.; Uversky, Vladimir N.
- Trends in biochemical sciences 2019 v.44 no.8 pp. 716-728
- evolution; models; organelles; proteins; separation
- ... At the turn of this century, cardinal changes took place in the perceptions of the structure and function of proteins, as well as in the organizational principles of membrane-less organelles. As a result, the model of the organization of living matter is changing to one described by highly dynamic biological soft matter positioned at the edge of chaos. Intrinsically disordered proteins (IDPs) and ...
- Thirumalai, D.; Samanta, Himadri S.; Maity, Hiranmay; Reddy, Govardhan
- Trends in biochemical sciences 2019 v.44 no.8 pp. 675-687
- energy transfer; evolution; prediction; protein folding; proteins; small-angle X-ray scattering
- ... Theory and simulations predicted that the sizes of the unfolded states of globular proteins should decrease as the denaturant concentration is reduced from a high to a low value. However, small angle X-ray scattering (SAXS) data were used to assert the opposite, while interpretation of single molecule Förster resonance energy transfer experiments (FRET) supported the theoretical predictions. The d ...