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Trends in biotechnology
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Publication year rev
7978-2022
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2022 v.40 no.5
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- Author:
- Ana Tinoco; Madalena Martins; Artur Cavaco-Paulo; Artur Ribeiro
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 591-605
- ISSN:
- 0167-7799
- Subject:
- biotechnology; color; cosmetics; industry; odors; peptides
- Abstract:
- ... Cosmetics procedures and products combined with environmental insults and daily routines induce irreversible changes in hair. As result of damage, the hair loses some of its properties like strength, elasticity, and smoothness. Recent studies revealed the positive effects of protein-based cosmetics in providing protection to hair. Additionally, these cosmetic products have also shown a great abili ...
- DOI:
- 10.1016/j.tibtech.2021.09.010
- https://doi.org/10.1016/j.tibtech.2021.09.010
- Author:
- Kartik Aiyer; Lucinda E. Doyle
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 564-575
- ISSN:
- 0167-7799
- Subject:
- biotechnology; electrodes; electron transfer; momentum
- Abstract:
- ... Recently several non-traditional electroactive microorganisms have been discovered. These can be considered weak electricigens; microorganisms that typically rely on soluble electron acceptors and donors in their lifecycle but are also capable of extracellular electron transfer (EET), resulting in either a low, unreliable, or otherwise unexpected current. These unanticipated electroactive microorg ...
- DOI:
- 10.1016/j.tibtech.2021.10.002
- https://doi.org/10.1016/j.tibtech.2021.10.002
- Author:
- Ricardo Oliveira; Eva Pinho; Ana Luísa Sousa; Jeffrey J. DeStefano; Nuno Filipe Azevedo; Carina Almeida
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 549-563
- ISSN:
- 0167-7799
- Subject:
- bioinformatics; biotechnology; nucleic acids; oligonucleotides; systematic evolution of ligands by exponential enrichment
- Abstract:
- ... Aptamers are structural single-stranded oligonucleotides generated in vitro to bind to a specific target molecule. Aptamers’ versatility can be enhanced with nucleic acid mimics (NAMs) during or after a selection process, also known as systematic evolution of ligands by exponential enrichment (SELEX). We address advantages and limitations of the technologies used to generate NAM aptamers, especial ...
- DOI:
- 10.1016/j.tibtech.2021.09.011
- https://doi.org/10.1016/j.tibtech.2021.09.011
- Author:
- Lukas A. Rettenbacher; Klaudia Arauzo-Aguilera; Luisa Buscajoni; Angel Castillo-Corujo; Borja Ferrero-Bordera; Aliki Kostopoulou; Rafael Moran-Torres; David Núñez-Nepomuceno; Ayşegül Öktem; Arianna Palma; Beatrice Pisent; Martina Puricelli; Tobias Schilling; Aatir A. Tungekar; Jonathan Walgraeve; David Humphreys; Tobias von der Haar; Brigitte Gasser; Diethard Mattanovich; Lloyd Ruddock; Jan Maarten van Dijl; SECRETERS - European Union’s Horizon 2020 Programme
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 576-590
- ISSN:
- 0167-7799
- Subject:
- biopharmaceuticals; biotechnology; mammals; markets; post-translational modification; secretion; therapeutics
- Abstract:
- ... The biopharmaceutical market is growing faster than ever, with two production systems competing for market dominance: mammalian cells and microorganisms. In recent years, based on the rise of antibody-based therapies, new biotherapeutic approvals have favored mammalian hosts. However, not only has extensive research elevated our understanding of microbes to new levels, but emerging therapeutic mol ...
- DOI:
- 10.1016/j.tibtech.2021.10.003
- https://doi.org/10.1016/j.tibtech.2021.10.003
- Author:
- Kenneth S. Ogueri; Sheri L. Shamblin
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 606-619
- ISSN:
- 0167-7799
- Subject:
- biotechnology; drug delivery systems; mechanics
- Abstract:
- ... In recent years, oral osmotic tablets have sparked a therapeutic paradigm for controlled-release dosage forms due to their intrinsic insensitivity to physiological and physicochemical factors. Despite these benefits, the design of an optimal osmotic technology is precluded by various challenges. These limitations include manufacturing complexity, the lack of understanding of the functional mechani ...
- DOI:
- 10.1016/j.tibtech.2021.10.001
- https://doi.org/10.1016/j.tibtech.2021.10.001
- Author:
- Vincent Courdavault; Nicolas Papon
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 529-531
- ISSN:
- 0167-7799
- Subject:
- Dictyostelium discoideum; biotechnology; drugs
- Abstract:
- ... Engineered bacteria and yeasts have progressively emerged in the past decade as convenient cell factories for supplying plant and fungal natural products (NPs). A new study by Reimer et al. provides compelling evidence that the amoeba Dictyostelium discoideum could be also engineered in favor of the production of plant drug precursors. ...
- DOI:
- 10.1016/j.tibtech.2022.02.002
- https://doi.org/10.1016/j.tibtech.2022.02.002
- Author:
- Marcel A. Heinrich; Marina Mangia; Jai Prakash
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 532-534
- ISSN:
- 0167-7799
- Subject:
- biocompatible materials; biotechnology; cartilage; endotoxins
- Abstract:
- ... Endotoxins are commonly present in both naturally derived and synthetic biomaterials. This Forum highlights the consequences of endotoxin contamination in biomaterials on different engineered tissues, such as bone, skin, or cartilage, and discusses the potential effects on novel 3D immunocompetent pathophysiological models. ...
- DOI:
- 10.1016/j.tibtech.2021.12.001
- https://doi.org/10.1016/j.tibtech.2021.12.001
- Author:
- Durga Madhab Mahapatra; Puranjan Mishra; Sveta Thakur; Lakhveer Singh
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 535-538
- ISSN:
- 0167-7799
- Subject:
- artificial intelligence; bioenergy; biotechnology; models
- Abstract:
- ... Bioelectrochemical systems (BESs) are highly evolved and sophisticated systems that produce bioenergy via exoelectrogenic microbes. Artificial intelligence (AI) helps to understand, relate, model, and predict both process parameters and microbial diversity, resulting in higher performance. This approach has revolutionized BESs through highly advanced computational algorithms that best suit the sys ...
- DOI:
- 10.1016/j.tibtech.2021.11.005
- https://doi.org/10.1016/j.tibtech.2021.11.005
- Author:
- Megumi Ishii; Tetsuya Ishii
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 525-528
- ISSN:
- 0167-7799
- Subject:
- DNA; biotechnology; genetically modified organisms
- Abstract:
- ... A genome-edited agricultural product that is proven to contain no exogenous DNA is not subject to genetically modified organism (GMO) regulations in some countries. However, whether such proof is definitive is often disputed. We discuss the approaches to substantially proving that a genome-edited organism is not GMO, while considering social aspects. ...
- DOI:
- 10.1016/j.tibtech.2021.11.001
- https://doi.org/10.1016/j.tibtech.2021.11.001
- Author:
- Ying Liu; Yuxin Huang; Ran Lu; Fengxue Xin; Guannan Liu
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 620-631
- ISSN:
- 0167-7799
- Subject:
- Saccharomyces cerevisiae; biosensors; biotechnology; cell fusion; industrialization; membrane fusion; metabolism; mitogen-activated protein kinase; signal transduction; synthetic biology; yeasts
- Abstract:
- ... Cell fusion is a fundamental biological process that is involved in the development of most eukaryotic organisms. During the fusion process in Saccharomyces cerevisiae, cells respond to pheromones to trigger the MAPK (mitogen-activated protein kinase) cascade to initiate mating, followed by polarization, cell-wall remodeling, membrane fusion, and karyogamy. We highlight the applications of the yea ...
- DOI:
- 10.1016/j.tibtech.2021.09.007
- https://doi.org/10.1016/j.tibtech.2021.09.007
- Author:
- Zhou Li; He Yang; Yifei Wang; Shan-Ho Chou; Jin He
- Source:
- Trends in biotechnology 2022 v.40 no.5 pp. 539-548
- ISSN:
- 0167-7799
- Subject:
- biotechnology; gene regulatory networks; genomics; synthetic biology; synthetic genes
- Abstract:
- ... Microbial cell factories are critical to achieving green biomanufacturing. A position effect occurs when a synthetic gene circuit is expressed from different positions in the chassis strain genome. Here, we propose the concept of the ‘spatial position effect,’ which uses technologies in 3D genomics to reveal the spatial structure characteristics of the 3D genome of the chassis. On this basis, we p ...
- DOI:
- 10.1016/j.tibtech.2021.09.001
- https://doi.org/10.1016/j.tibtech.2021.09.001