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- Ogaugwu, Christian E.; Agbo, Stanley O.; Adekoya, Modinat A.
- Trends in biotechnology 2019 v.37 no.3 pp. 234-237
- gene editing; medicine; public health; society; Sub-Saharan Africa
- ... Clustered regularly interspaced short palindromic repeats (CRISPR) technology has enabled genetic engineering feats previously considered impracticable, offering great hopes for solutions to problems facing society. We consider it timely to highlight how CRISPR can benefit public health, medicine, and agriculture in sub-Saharan Africa (SSA) and offer recommendations for successful implementation. ...
- Rui, Yuan; Wilson, David R.; Green, Jordan J.
- Trends in biotechnology 2019 v.37 no.3 pp. 281-293
- DNA-binding proteins; biotechnology; cell nucleus; gene editing; gene expression; genes; nucleases; patient care; translation (genetics)
- ... Genome-editing technologies such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENS), and the clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein system have revolutionized biological research. Each biotechnology consists of a DNA-binding protein that can be programmed to recognize and initiate double-strand breaks (DSBs) for s ...