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- Schaffer, David V., et al. Show all 2 Author
- Trends in biotechnology 2010 v.28 no.3 pp. 117-124
- engineering; population; stem cells
- ... The stem cell niche is an anatomical site that contains a reservoir of multipotent stem cells (SCs) that can maintain normal tissue, or replenish injured or aged cell populations, in response to mechanisms that regulate whether they should remain quiescent, undergo self-renewal, or differentiate. The choice among these hallmark SC behaviors is governed by intricate soluble and “solid phase” signal ...
- Schaffer, David V., et al. Show all 4 Authors
- Trends in biotechnology 2011 v.29 no.10 pp. 517-525
- chromatin; drug resistance; epigenetics; eukaryotic cells; gene expression; genes; phenotypic variation; population; transcription (genetics); virulence
- ... Gene expression noise is a significant source of phenotypic heterogeneity in otherwise identical populations of cells. Phenotypic heterogeneity can cause reversible drug resistance in diseased cells, and thus a better understanding of its origins might improve treatment strategies. In eukaryotes, data strongly suggest that intrinsic noise arises from transcriptional bursts caused by slow, random t ...