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- Dias Junior, Antonio Gregorio; Sampaio, Natalia G.; Rehwinkel, Jan
- Trends in microbiology 2019 v.27 no.1 pp. 75-85
- Picornaviridae; RNA; genes; immunity; interferons; mutation; neoplasm cells; proteins; viruses
- ... Induction of interferons during viral infection is mediated by cellular proteins that recognise viral nucleic acids. MDA5 is one such sensor of virus presence and is activated by RNA. MDA5 is required for immunity against several classes of viruses, including picornaviruses. Recent work showed that mutations in the IFIH1 gene, encoding MDA5, lead to interferon-driven autoinflammatory diseases. Tog ...