Jump to Main Content
- Foster, Timothy J.
- Trends in microbiology 2019 v.27 no.1 pp. 26-38
- antibiotic resistance; biosynthesis; cell walls; daptomycin; drugs; enzyme activity; genes; medicine; methicillin; methicillin-resistant Staphylococcus aureus; peptidoglycans; teichoic acids; vancomycin; virulence
- ... The use of β-lactam antibiotics to treat infections caused by Staphylococcus aureus has been severely compromised by the acquisition by horizontal gene transfer of a gene that encodes the β-lactam-insensitive penicillin-binding protein PBP2a. This allows methicillin-resistant S. aureus (MRSA) to proliferate in the presence of β-lactam antibiotics. Paradoxically the dependence on PBP2a for the esse ...
- Davis, Kimberly M.; Isberg, Ralph R.
- Trends in microbiology 2019 v.27 no.1 pp. 64-74
- Mycobacterium; Salmonella; Yersinia; antibiotic resistance; genes; metabolism; pathogenesis; proteins; virulence
- ... It has been known for decades that individual cells within pathogenic bacterial populations have reduced antibiotic susceptibility, which is linked to decreased metabolic rates. A similar phenomenon occurs with virulence-associated proteins, as reduced expression is associated with increased fitness of individual cells. Non-producers within the population can benefit from the virulence proteins pr ...