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- Sandhu, Brindar K.; McBride, Shonna M.
- Trends in microbiology 2018 v.26 no.12 pp. 1049-1050
- Clostridium difficile; actin; bacteria; bile acids; cell death; colon; death; diarrhea; health care costs; pathogens; people; polymerization; spores; sporulation; toxins; United States
- ... [Display omitted]Clostridioides difficile is a spore-forming, anaerobic, intestinal pathogen that causes severe diarrhea that can lead to death. In 2011, C. difficile infected ∼500000 people in the USA and killed ∼29000 people. C. difficile infection (CDI) is the most common healthcare-related infection in the USA, leading to increased healthcare costs of $4.8 billion. This pathogen transmits via ...
- PubMed Central:
- San Millan, Alvaro
- Trends in microbiology 2018 v.26 no.12 pp. 978-985
- antibiotic resistance; antibiotic resistance genes; bacteria; clones; evolution; mortality; mutation; patients; plasmids; risk
- ... Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance genes among bacteria is driven by bacterial plasmids, promoting the evolution of resistance. Crucially, particular associations exist between resistance plasmids and bacterial clones that become especially ...