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- San Millan, Alvaro
- Trends in microbiology 2018 v.26 no.12 pp. 978-985
- antibiotic resistance; antibiotic resistance genes; bacteria; clones; evolution; mortality; mutation; patients; plasmids; risk
- ... Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance genes among bacteria is driven by bacterial plasmids, promoting the evolution of resistance. Crucially, particular associations exist between resistance plasmids and bacterial clones that become especially ...
- Tanner, Jennifer R.; Kingsley, Robert A.
- Trends in microbiology 2018 v.26 no.12 pp. 986-998
- Salmonella; animal husbandry; anti-infective agents; evolution; gastroenteritis; genetic variation; host range; hosts; pathovars; typhoid fever
- ... Within-host evolution has resulted in thousands of variants of Salmonella that exhibit remarkable diversity in host range and disease outcome, from broad host range to exquisite host restriction, causing gastroenteritis to disseminated disease such as typhoid fever. Within-host evolution is a continuing process driven by genomic variation that occurs during each infection, potentiating adaptation ...
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