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Trends in parasitology
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Publication year rev
7978-2022
Remove constraint Publication year rev: 7978-2022
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2022 v.38 no.1
Remove constraint Source: 2022 v.38 no.1
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- Author:
- Samuel Cota Teixeira; Marcelo Santos da Silva; Antoniel Augusto Severo Gomes; Nilmar Silvio Moretti; Daiana Silva Lopes; Eloisa Amália Vieira Ferro; Veridiana de Melo Rodrigues
- Source:
- Trends in parasitology 2022 v.38 no.1 pp. 80-94
- ISSN:
- 1471-4922
- Subject:
- Plasmodium; Toxoplasma; Trypanosomatidae; antiparasitic agents; drug design; drug resistance; helminths; parasitology; phospholipases; snake venoms; snakes
- Abstract:
- ... Parasitic diseases affect millions of individuals worldwide, mainly in low-income regions. There is no cure for most of these diseases, and the treatment relies on drugs that have side effects and lead to drug resistance, emphasizing the urgency to find new treatments. Snake venom has been gaining prominence as a rich source of molecules with antiparasitic potentials, such as phospholipases A₂ (PL ...
- DOI:
- 10.1016/j.pt.2021.07.004
- https://doi.org/10.1016/j.pt.2021.07.004
- Author:
- Bryan E. Abuchery; Jennifer A. Black; Marcelo S. da Silva
- Source:
- Trends in parasitology 2022 v.38 no.1 pp. 4-6
- ISSN:
- 1471-4922
- Subject:
- Trypanosomatidae; gene expression; parasites; parasitology; transcriptomics
- Abstract:
- ... Dixenic parasites often encounter environmental extremes during the transition from vector to host. Preadapted transmission stages overcome these challenges to promote parasites' survival and ensure life cycle progression. Recently, Vigneron et al. and Briggs et al. used single-cell transcriptomics to investigate developmental stage specific gene expression patterns during parasite differentiation ...
- DOI:
- 10.1016/j.pt.2021.10.006
- https://doi.org/10.1016/j.pt.2021.10.006
- Author:
- William R. Heath; Lauren E. Holz; Daniel Fernandez-Ruiz
- Source:
- Trends in parasitology 2022 v.38 no.1 pp. 7-8
- ISSN:
- 1471-4922
- Subject:
- immunity; liver; malaria; memory; parasitology
- Abstract:
- ... Malaria parasites replicate within the liver shortly after infection. This stage can be controlled by CD8 T cells, but which subsets undertake this function is unclear. Lefebvre et al. now elegantly show that effector memory T (TEM) cells are avid participants, working as a dynamic duo with liver tissue-resident memory T (TRM) cells to combat infection. ...
- DOI:
- 10.1016/j.pt.2021.11.002
- https://doi.org/10.1016/j.pt.2021.11.002
- Author:
- Sara Silva Pereira; Andrew P. Jackson; Luísa M. Figueiredo
- Source:
- Trends in parasitology 2022 v.38 no.1 pp. 23-36
- ISSN:
- 1471-4922
- Subject:
- Trypanosoma; antigenic variation; evolution; genes; immune evasion; nucleotide sequences; parasites; parasitology; sequence diversity; variant surface glycoproteins; virulence
- Abstract:
- ... An intriguing and remarkable feature of African trypanosomes is their antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamental to both immune evasion and disease epidemiology within host populations. Recent studies have revealed that the VSG repertoire has a complex evolutionary history. Sequence diversity, genomic organization, and expression patterns ...
- DOI:
- 10.1016/j.pt.2021.07.012
- https://doi.org/10.1016/j.pt.2021.07.012
- Author:
- James A. Watson; Nicholas J. White; Arjen M. Dondorp
- Source:
- Trends in parasitology 2022 v.38 no.1 pp. 11-14
- ISSN:
- 1471-4922
- Subject:
- Plasmodium falciparum; abnormal hemoglobin; alleles; childhood; falciparum malaria; mortality; parasitology; Sub-Saharan Africa
- Abstract:
- ... Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we estimate that the malaria-attributable childhood mortality in the pretreatment era was between 15% and 24%. ...
- DOI:
- 10.1016/j.pt.2021.10.005
- https://doi.org/10.1016/j.pt.2021.10.005
- Author:
- Shengzhang Dong; Yuemei Dong; Maria L. Simões; George Dimopoulos
- Source:
- Trends in parasitology 2022 v.38 no.1 pp. 54-66
- ISSN:
- 1471-4922
- Subject:
- Culicidae; antiparasitic agents; gene expression; genes; malaria; microRNA; parasitology; transgenesis; vector control
- Abstract:
- ... Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-control methods, several novel mosquito vector-based control strategies have been proposed to supplement existing control strategies. Mosquito transgenesis and gene drive have emerged as promising tools for preventing the spread of malaria by either suppressing mosquito populations by self-destructing mosqu ...
- DOI:
- 10.1016/j.pt.2021.08.001
- https://doi.org/10.1016/j.pt.2021.08.001
- Author:
- Justin Komguep Nono; Severin Donald Kamdem; Fungai Musaigwa; Chukwudi A. Nnaji; Frank Brombacher
- Source:
- Trends in parasitology 2022 v.38 no.1 pp. 67-79
- ISSN:
- 1471-4922
- Subject:
- Schistosoma; helminths; immune response; parasitology; praziquantel; schistosomiasis; vaccines
- Abstract:
- ... Schistosomiasis is a debilitating helminthiasis which commonly establishes as a chronic infection in people from endemic areas. As a potent modulator of the host immune response, the Schistosoma parasite and its associated products can directly interfere with its host’s ability to mount adequate immune responses to unrelated antigens. As a result, increased attention is gathering on studies assess ...
- DOI:
- 10.1016/j.pt.2021.07.009
- https://doi.org/10.1016/j.pt.2021.07.009
- Author:
- Patrick E. Duffy
- Source:
- Trends in parasitology 2022 v.38 no.1 pp. 9-10
- ISSN:
- 1471-4922
- Subject:
- World Health Organization; antibodies; malaria; malaria vaccines; parasitology
- Abstract:
- ... Last month, the World Health Organization (WHO) recommended widespread use of RTS,S/AS01 vaccine to prevent malaria in young African children, noting its 30% reduction in deadly severe malaria. In a recent report, Das et al. describe antibody effector functions that may contribute to RTS,S efficacy and thereby guide vaccine improvements. ...
- DOI:
- 10.1016/j.pt.2021.11.006
- https://doi.org/10.1016/j.pt.2021.11.006
- Author:
- Dani Lucas-Barbosa; Matthew DeGennaro; Alexander Mathis; Niels O. Verhulst
- Source:
- Trends in parasitology 2022 v.38 no.1 pp. 15-22
- ISSN:
- 1471-4922
- Subject:
- dengue; malaria; parasitology; skin (animal); topical application; vector control
- Abstract:
- ... The skin microbiota plays an essential role in the protection against pathogens. It is our skin microbiota that makes us smell different from each other, rendering us more or less attractive to mosquitoes. Mosquitoes exploit skin bacterial odours to locate their hosts and are vectors of pathogens that can cause severe diseases such as malaria and dengue fever. A novel solution for long-lasting pro ...
- DOI:
- 10.1016/j.pt.2021.08.010
- https://doi.org/10.1016/j.pt.2021.08.010
- Author:
- Dayana C. Farhat; Mohamed-Ali Hakimi
- Source:
- Trends in parasitology 2022 v.38 no.1 pp. 37-53
- ISSN:
- 1471-4922
- Subject:
- Toxoplasma gondii; epigenetics; parasitology; sexual development
- Abstract:
- ... Toxoplasma gondii is considered to be one of the most successful parasitic pathogens. It owes this success to its flexibility in responding to signals emanating from the different environments it encounters during its multihost life cycle. The adaptability of this unicellular organism relies on highly coordinated and evolutionarily optimized developmental abilities that allow it to adopt the forms ...
- DOI:
- 10.1016/j.pt.2021.07.016
- https://doi.org/10.1016/j.pt.2021.07.016