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- O'Rourke, K.I.; Knowles, D.P.; Baszler, T.V.; Parish, S.M.
- United States Department of Agriculture patents 2000 no.6,165,784
- human diseases; animal diseases; prion diseases; central nervous system diseases; protein composition; disease detection; monoclonal antibodies; disease transmission; diagnostic techniques; patents; USDA; United States
- ... Methods to detect prion or PrP-Sc protein as an indication of transmissible spongiform encephalopathies (TSEs), including preclinical detection of infected live animals, and postmortem detection methods, are described. In one aspect, the invention is directed to a non-invasive diagnostic assay using third eyelid-associated lymphoid tissue. In another aspect, the invention is directed to monoclonal ...