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You searched for: Journal Vaccine Remove constraint Journal: Vaccine Publication Year 2017 Remove constraint Publication Year: 2017 Source 2017 v.35 no.19 Remove constraint Source: 2017 v.35 no.19
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1. Assessment of sex-specific differences in adverse events following immunization reporting in Ontario, 2012–15

Author:
Harris, Tara; Nair, Jyotsna; Fediurek, Jill; Deeks, Shelley L.
Source:
Vaccine 2017 v.35 no.19 pp. 2600-2604
ISSN:
0264-410X
Subject:
adults; anaphylaxis; anesthesia; children; females; immunization; males; monitoring; risk; vaccines; Ontario
Abstract:
... We assessed sex-specific trends within passive vaccine safety surveillance in Ontario, Canada. AEFIs reported following vaccines administered between 2012 and 2015 were included. There were 2466 AEFI reports; 66.2% were female. Annualized reporting rates were 5.9 and 3.1 per 100,000 population, for females and males respectively. The female:male reporting rate ratio (RRR) was 1.9. Sex-specific dif ...
DOI:
10.1016/j.vaccine.2017.03.035

2. Comparison of the nine polymorphic membrane proteins of Chlamydia trachomatis for their ability to induce protective immune responses in mice against a C. muridarum challenge

Author:
Pal, Sukumar; Favaroni, Alison; Tifrea, Delia F.; Hanisch, Philipp T.; Luczak, Sören E.T.; Hegemann, Johannes H.; de la Maza, Luis M.
Source:
Vaccine 2017 v.35 no.19 pp. 2543-2549
ISSN:
0264-410X
Subject:
Chlamydia trachomatis; adjuvants; animal models; antigens; body weight changes; cross immunity; immune response; lungs; membrane proteins; mice; serotypes; vaccination; vaccines
Abstract:
... To test vaccines, formulated with novel antigens, to protect mice against Chlamydia infections.To determine the ability of polymorphic membrane proteins (Pmps) to induce cross-species protective immune responses, recombinant fragments from all nine C. trachomatis serovar E Pmps were used to vaccinate BALB/c mice utilizing CpG-1826 and Montanide ISA 720 as adjuvants. C. muridarum recombinant MOMP a ...
DOI:
10.1016/j.vaccine.2017.03.070
PubMed:
28385608
PubMed Central:
PMC5464790

3. Efficacy of a novel, protein-based pneumococcal vaccine against nasopharyngeal carriage of Streptococcus pneumoniae in infants: A phase 2, randomized, controlled, observer-blind study

Author:
Odutola, Aderonke; Ota, Martin O.C.; Antonio, Martin; Ogundare, Ezra O.; Saidu, Yauba; Foster-Nyarko, Ebenezer; Owiafe, Patrick K.; Ceesay, Fatima; Worwui, Archibald; Idoko, Olubukola T.; Owolabi, Olumuyiwa; Bojang, Abdoulie; Jarju, Sheikh; Drammeh, Isatou; Kampmann, Beate; Greenwood, Brian M.; Alderson, Mark; Traskine, Magali; Devos, Nathalie; Schoonbroodt, Sonia; Swinnen, Kristien; Verlant, Vincent; Dobbelaere, Kurt; Borys, Dorota
Source:
Vaccine 2017 v.35 no.19 pp. 2531-2542
ISSN:
0264-410X
Subject:
Streptococcus pneumoniae; children; histidine; immune response; infants; microbial load; polysaccharides; proteins; sequence analysis; vaccines
Abstract:
... Conserved pneumococcal proteins are potential candidates for inclusion in vaccines against pneumococcal diseases. In the first part of a two-part study, an investigational vaccine (PHiD-CV/dPly/PhtD-30) containing 10 pneumococcal serotype-specific polysaccharide conjugates (10VT) combined with pneumolysin toxoid and pneumococcal histidine triad protein D (30μg each) was well tolerated by Gambian c ...
DOI:
10.1016/j.vaccine.2017.03.071

4. Expansion and retention of pulmonary CD4+ T cells after prime boost vaccination correlates with improved longevity and strength of immunity against tularemia

Author:
Roberts, Lydia M.; Wehrly, Tara D.; Crane, Deborah D.; Bosio, Catharine M.
Source:
Vaccine 2017 v.35 no.19 pp. 2575-2581
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; Francisella tularensis; bacteria; breathing; epitopes; immunity; live vaccines; longevity; pathogens; secondary immunization; tularemia; vaccination; virulence; United States
Abstract:
... Francisella tularensis subsp. tularensis strain SchuS4 (Ftt) is a highly virulent intracellular bacterium. Inhalation of 10 or fewer organisms results in an acute and potentially lethal disease called pneumonic tularemia. Ftt infections occur naturally in the U.S. and Ftt was developed as a bioweapon. Thus, there is a need for vaccines that protect against this deadly pathogen. Although a live vac ...
DOI:
10.1016/j.vaccine.2017.03.064

5. Identification and characterization of enhancer agonist human cytotoxic T-cell epitopes of the human papillomavirus type 16 (HPV16) E6/E7

Author:
Tsang, Kwong Y.; Fantini, Massimo; Fernando, Romaine I.; Palena, Claudia; David, Justin M.; Hodge, James W.; Gabitzsch, Elizabeth S.; Jones, Frank R.; Schlom, Jeffrey
Source:
Vaccine 2017 v.35 no.19 pp. 2605-2611
ISSN:
0264-410X
Subject:
alleles; T-lymphocytes; neoplasm cells; epitopes; public health; uterine cervical neoplasms; Food and Drug Administration; antibodies; head; patients; coat proteins; Human papillomavirus type 16; humans; cytotoxicity; squamous cell carcinoma; neck; clinical trials; algorithms; etiology; vaccines; virus-like particles; agonists
Abstract:
... Human papillomavirus (HPV) is associated with the etiology of cervical carcinoma, head and neck squamous cell carcinoma, and several other cancer types. Vaccines directed against HPV virus-like particles and coat proteins have been extremely successful in the prevention of cervical cancer through the activation of host HPV-specific antibody responses; however, HPV-associated cancers remain a major ...
DOI:
10.1016/j.vaccine.2017.03.025
PubMed:
28389098
PubMed Central:
PMC5444324

6. Influenza vaccination responses: Evaluating impact of repeat vaccination among health care workers

Author:
Leung, Vivian K.Y.; Carolan, Louise A.; Worth, Leon J.; Harper, Susan A.; Peck, Heidi; Tilmanis, Danielle; Laurie, Karen L.; Slavin, Monica A.; Sullivan, Sheena G.
Source:
Vaccine 2017 v.35 no.19 pp. 2558-2568
ISSN:
0264-410X
Subject:
antibodies; geometry; health care workers; hemagglutination; influenza; influenza vaccination; influenza vaccines; issues and policy; seroprevalence
Abstract:
... To compare the antibody response to influenza between health care workers (HCWs) who have received multiple vaccinations (high vaccination group) and those who have received fewer vaccinations (low vaccination group).Prospective serosurvey.Tertiary referral hospital.Healthcare workers.Healthcare workers were vaccinated with the 2015 southern hemisphere trivalent influenza vaccine. Influenza antibo ...
DOI:
10.1016/j.vaccine.2017.03.063

7. Investigation of phosphorylated adjuvants co-encapsulated with a model cancer peptide antigen for the treatment of colorectal cancer and liver metastasis

Author:
Goodwin, Tyler J.; Huang, Leaf
Source:
Vaccine 2017 v.35 no.19 pp. 2550-2557
ISSN:
0264-410X
Subject:
CD8-positive T-lymphocytes; adjuvants; antigens; calcium phosphates; cecum; chemical elements; colorectal neoplasms; encapsulation; immunotherapy; ligands; lipids; liver; metastasis; models; nanoparticles; nucleotides; peptides; population growth; suppressor cells; vaccines
Abstract:
... The lipid calcium phosphate nanoparticle is a versatile platform capable of encapsulating a wide range of phosphorylated molecules from single nucleotides to pDNA. The use of this platform has shown great success as an immunotherapeutic vaccine carrier, capable of delivering co-encapsulated phosphorylated adjuvants and peptides. Three potent vaccine formulations were investigated for anti-cancer e ...
DOI:
10.1016/j.vaccine.2017.03.067
PubMed:
28385609
PubMed Central:
PMC5448460

8. Plant-made virus-like particle vaccines bearing the hemagglutinin of either seasonal (H1) or avian (H5) influenza have distinct patterns of interaction with human immune cells in vitro

Author:
Hendin, Hilary E.; Pillet, Stéphane; Lara, Amanda N.; Wu, Cheng-Ying; Charland, Nathalie; Landry, Nathalie; Ward, Brian J.
Source:
Vaccine 2017 v.35 no.19 pp. 2592-2599
ISSN:
0264-410X
Subject:
B-lymphocytes; adults; antibodies; avian influenza; birds; confocal microscopy; flow cytometry; hemagglutinins; humans; immune response; inactivated vaccines; innate immunity; interleukin-1beta; interleukin-6; interleukin-8; monocytes; pandemic; tumor necrosis factor-alpha; virus-like particle vaccines; viruses
Abstract:
... The recent emergence of avian influenza strains has fuelled concern about pandemic preparedness since vaccines targeting these viruses are often poorly immunogenic. Weak antibody responses to vaccines have been seen across multiple platforms including plant-made VLPs. To better understand these differences, we compared the in vitro responses of human immune cells exposed to plant-made virus-like p ...
DOI:
10.1016/j.vaccine.2017.03.058

9. Single N277A substitution in C2 of simian immunodeficiency virus envelope influences vaccine-elicited CD4i neutralizing and anti-V2 antibody responses

Author:
Tang, Xian; Guo, Jia; Cheng, Lin; Sun, Caijun; Liu, Li; Zuo, Teng; Wang, Hui; Chen, Ling; Zhang, Linqi; Chen, Zhiwei
Source:
Vaccine 2017 v.35 no.19 pp. 2582-2591
ISSN:
0264-410X
Subject:
B-lymphocytes; Human immunodeficiency virus; Simian immunodeficiency virus; antibodies; antigens; antiserum; cytotoxicity; enzyme-linked immunosorbent assay; glycosylation; humoral immunity; immune response; laboratory animals; neutralization; vaccines; yeasts
Abstract:
... An effective HIV vaccine remains elusive, and immunogens capable of eliciting protective host humoral immunity have not yet been identified. Although HIV/SIV infections result in the abundant production of CD4-induced (CD4i) antibodies (Abs), these Abs are not protective due to steric restrictions following gp120 binding to CD4 on target cells. Here we report that both DNA- and vaccinia-based vacc ...
DOI:
10.1016/j.vaccine.2017.03.062

10. Vaccination and blood sampling acceptability during Ramadan fasting month: A cross-sectional study in Conakry, Guinea

Author:
Peiffer-Smadja, Nathan; Ouedraogo, Ramatou; D'Ortenzio, Eric; Cissé, Papa Ndiaga; Zeggani, Zahra; Beavogui, Abdoul Habib; Faye, Sylvain Landry; Le Marcis, Frédéric; Yazdanpanah, Yazdan; Nguyen, Vinh-Kim
Source:
Vaccine 2017 v.35 no.19 pp. 2569-2574
ISSN:
0264-410X
Subject:
Muslims; blood; blood sampling; clinical trials; cross-sectional studies; fasting; health services; questionnaires; scientists; vaccination; Guinea
Abstract:
... There are few data on the acceptability of vaccination or blood sampling during Ramadan fasting month in Muslim countries. This could impact vaccination campaigns, clinical trials or healthcare during Ramadan.Using a semi-structured questionnaire, we conducted a cross-sectional study on 201 practising Muslims and 10 religious leaders in Conakry, Guinea in the wake of the recent epidemic Ebola epid ...
DOI:
10.1016/j.vaccine.2017.03.068