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- Author:
- Harris, Tara; Nair, Jyotsna; Fediurek, Jill; Deeks, Shelley L.
- Source:
- Vaccine 2017 v.35 no.19 pp. 2600-2604
- ISSN:
- 0264-410X
- Subject:
- adults; anaphylaxis; anesthesia; children; females; immunization; males; monitoring; risk; vaccines; Ontario
- Abstract:
- ... We assessed sex-specific trends within passive vaccine safety surveillance in Ontario, Canada. AEFIs reported following vaccines administered between 2012 and 2015 were included. There were 2466 AEFI reports; 66.2% were female. Annualized reporting rates were 5.9 and 3.1 per 100,000 population, for females and males respectively. The female:male reporting rate ratio (RRR) was 1.9. Sex-specific dif ...
- DOI:
- 10.1016/j.vaccine.2017.03.035
-
https://dx.doi.org/10.1016/j.vaccine.2017.03.035
- Author:
- Pal, Sukumar; Favaroni, Alison; Tifrea, Delia F.; Hanisch, Philipp T.; Luczak, Sören E.T.; Hegemann, Johannes H.; de la Maza, Luis M.
- Source:
- Vaccine 2017 v.35 no.19 pp. 2543-2549
- ISSN:
- 0264-410X
- Subject:
- Chlamydia trachomatis; adjuvants; animal models; antigens; body weight changes; cross immunity; immune response; lungs; membrane proteins; mice; serotypes; vaccination; vaccines
- Abstract:
- ... To test vaccines, formulated with novel antigens, to protect mice against Chlamydia infections.To determine the ability of polymorphic membrane proteins (Pmps) to induce cross-species protective immune responses, recombinant fragments from all nine C. trachomatis serovar E Pmps were used to vaccinate BALB/c mice utilizing CpG-1826 and Montanide ISA 720 as adjuvants. C. muridarum recombinant MOMP a ...
- DOI:
- 10.1016/j.vaccine.2017.03.070
- PubMed:
- 28385608
- PubMed Central:
- PMC5464790
-
https://dx.doi.org/10.1016/j.vaccine.2017.03.070
- Author:
- Odutola, Aderonke; Ota, Martin O.C.; Antonio, Martin; Ogundare, Ezra O.; Saidu, Yauba; Foster-Nyarko, Ebenezer; Owiafe, Patrick K.; Ceesay, Fatima; Worwui, Archibald; Idoko, Olubukola T.; Owolabi, Olumuyiwa; Bojang, Abdoulie; Jarju, Sheikh; Drammeh, Isatou; Kampmann, Beate; Greenwood, Brian M.; Alderson, Mark; Traskine, Magali; Devos, Nathalie; Schoonbroodt, Sonia; Swinnen, Kristien; Verlant, Vincent; Dobbelaere, Kurt; Borys, Dorota
- Source:
- Vaccine 2017 v.35 no.19 pp. 2531-2542
- ISSN:
- 0264-410X
- Subject:
- Streptococcus pneumoniae; children; histidine; immune response; infants; microbial load; polysaccharides; proteins; sequence analysis; vaccines
- Abstract:
- ... Conserved pneumococcal proteins are potential candidates for inclusion in vaccines against pneumococcal diseases. In the first part of a two-part study, an investigational vaccine (PHiD-CV/dPly/PhtD-30) containing 10 pneumococcal serotype-specific polysaccharide conjugates (10VT) combined with pneumolysin toxoid and pneumococcal histidine triad protein D (30μg each) was well tolerated by Gambian c ...
- DOI:
- 10.1016/j.vaccine.2017.03.071
-
https://dx.doi.org/10.1016/j.vaccine.2017.03.071
- Author:
- Roberts, Lydia M.; Wehrly, Tara D.; Crane, Deborah D.; Bosio, Catharine M.
- Source:
- Vaccine 2017 v.35 no.19 pp. 2575-2581
- ISSN:
- 0264-410X
- Subject:
- CD4-positive T-lymphocytes; Francisella tularensis; bacteria; breathing; epitopes; immunity; live vaccines; longevity; pathogens; secondary immunization; tularemia; vaccination; virulence; United States
- Abstract:
- ... Francisella tularensis subsp. tularensis strain SchuS4 (Ftt) is a highly virulent intracellular bacterium. Inhalation of 10 or fewer organisms results in an acute and potentially lethal disease called pneumonic tularemia. Ftt infections occur naturally in the U.S. and Ftt was developed as a bioweapon. Thus, there is a need for vaccines that protect against this deadly pathogen. Although a live vac ...
- DOI:
- 10.1016/j.vaccine.2017.03.064
-
https://dx.doi.org/10.1016/j.vaccine.2017.03.064
- Author:
- Tsang, Kwong Y.; Fantini, Massimo; Fernando, Romaine I.; Palena, Claudia; David, Justin M.; Hodge, James W.; Gabitzsch, Elizabeth S.; Jones, Frank R.; Schlom, Jeffrey
- Source:
- Vaccine 2017 v.35 no.19 pp. 2605-2611
- ISSN:
- 0264-410X
- Subject:
- alleles; T-lymphocytes; neoplasm cells; epitopes; public health; uterine cervical neoplasms; Food and Drug Administration; antibodies; head; patients; coat proteins; Human papillomavirus type 16; humans; cytotoxicity; squamous cell carcinoma; neck; clinical trials; algorithms; etiology; vaccines; virus-like particles; agonists
- Abstract:
- ... Human papillomavirus (HPV) is associated with the etiology of cervical carcinoma, head and neck squamous cell carcinoma, and several other cancer types. Vaccines directed against HPV virus-like particles and coat proteins have been extremely successful in the prevention of cervical cancer through the activation of host HPV-specific antibody responses; however, HPV-associated cancers remain a major ...
- DOI:
- 10.1016/j.vaccine.2017.03.025
- PubMed:
- 28389098
- PubMed Central:
- PMC5444324
-
https://dx.doi.org/10.1016/j.vaccine.2017.03.025
- Author:
- Leung, Vivian K.Y.; Carolan, Louise A.; Worth, Leon J.; Harper, Susan A.; Peck, Heidi; Tilmanis, Danielle; Laurie, Karen L.; Slavin, Monica A.; Sullivan, Sheena G.
- Source:
- Vaccine 2017 v.35 no.19 pp. 2558-2568
- ISSN:
- 0264-410X
- Subject:
- antibodies; geometry; health care workers; hemagglutination; influenza; influenza vaccination; influenza vaccines; issues and policy; seroprevalence
- Abstract:
- ... To compare the antibody response to influenza between health care workers (HCWs) who have received multiple vaccinations (high vaccination group) and those who have received fewer vaccinations (low vaccination group).Prospective serosurvey.Tertiary referral hospital.Healthcare workers.Healthcare workers were vaccinated with the 2015 southern hemisphere trivalent influenza vaccine. Influenza antibo ...
- DOI:
- 10.1016/j.vaccine.2017.03.063
-
https://dx.doi.org/10.1016/j.vaccine.2017.03.063
- Author:
- Goodwin, Tyler J.; Huang, Leaf
- Source:
- Vaccine 2017 v.35 no.19 pp. 2550-2557
- ISSN:
- 0264-410X
- Subject:
- CD8-positive T-lymphocytes; adjuvants; antigens; calcium phosphates; cecum; chemical elements; colorectal neoplasms; encapsulation; immunotherapy; ligands; lipids; liver; metastasis; models; nanoparticles; nucleotides; peptides; population growth; suppressor cells; vaccines
- Abstract:
- ... The lipid calcium phosphate nanoparticle is a versatile platform capable of encapsulating a wide range of phosphorylated molecules from single nucleotides to pDNA. The use of this platform has shown great success as an immunotherapeutic vaccine carrier, capable of delivering co-encapsulated phosphorylated adjuvants and peptides. Three potent vaccine formulations were investigated for anti-cancer e ...
- DOI:
- 10.1016/j.vaccine.2017.03.067
- PubMed:
- 28385609
- PubMed Central:
- PMC5448460
-
https://dx.doi.org/10.1016/j.vaccine.2017.03.067
- Author:
- Hendin, Hilary E.; Pillet, Stéphane; Lara, Amanda N.; Wu, Cheng-Ying; Charland, Nathalie; Landry, Nathalie; Ward, Brian J.
- Source:
- Vaccine 2017 v.35 no.19 pp. 2592-2599
- ISSN:
- 0264-410X
- Subject:
- B-lymphocytes; adults; antibodies; avian influenza; birds; confocal microscopy; flow cytometry; hemagglutinins; humans; immune response; inactivated vaccines; innate immunity; interleukin-1beta; interleukin-6; interleukin-8; monocytes; pandemic; tumor necrosis factor-alpha; virus-like particle vaccines; viruses
- Abstract:
- ... The recent emergence of avian influenza strains has fuelled concern about pandemic preparedness since vaccines targeting these viruses are often poorly immunogenic. Weak antibody responses to vaccines have been seen across multiple platforms including plant-made VLPs. To better understand these differences, we compared the in vitro responses of human immune cells exposed to plant-made virus-like p ...
- DOI:
- 10.1016/j.vaccine.2017.03.058
-
https://dx.doi.org/10.1016/j.vaccine.2017.03.058
- Author:
- Tang, Xian; Guo, Jia; Cheng, Lin; Sun, Caijun; Liu, Li; Zuo, Teng; Wang, Hui; Chen, Ling; Zhang, Linqi; Chen, Zhiwei
- Source:
- Vaccine 2017 v.35 no.19 pp. 2582-2591
- ISSN:
- 0264-410X
- Subject:
- B-lymphocytes; Human immunodeficiency virus; Simian immunodeficiency virus; antibodies; antigens; antiserum; cytotoxicity; enzyme-linked immunosorbent assay; glycosylation; humoral immunity; immune response; laboratory animals; neutralization; vaccines; yeasts
- Abstract:
- ... An effective HIV vaccine remains elusive, and immunogens capable of eliciting protective host humoral immunity have not yet been identified. Although HIV/SIV infections result in the abundant production of CD4-induced (CD4i) antibodies (Abs), these Abs are not protective due to steric restrictions following gp120 binding to CD4 on target cells. Here we report that both DNA- and vaccinia-based vacc ...
- DOI:
- 10.1016/j.vaccine.2017.03.062
-
https://dx.doi.org/10.1016/j.vaccine.2017.03.062
- Author:
- Peiffer-Smadja, Nathan; Ouedraogo, Ramatou; D'Ortenzio, Eric; Cissé, Papa Ndiaga; Zeggani, Zahra; Beavogui, Abdoul Habib; Faye, Sylvain Landry; Le Marcis, Frédéric; Yazdanpanah, Yazdan; Nguyen, Vinh-Kim
- Source:
- Vaccine 2017 v.35 no.19 pp. 2569-2574
- ISSN:
- 0264-410X
- Subject:
- Muslims; blood; blood sampling; clinical trials; cross-sectional studies; fasting; health services; questionnaires; scientists; vaccination; Guinea
- Abstract:
- ... There are few data on the acceptability of vaccination or blood sampling during Ramadan fasting month in Muslim countries. This could impact vaccination campaigns, clinical trials or healthcare during Ramadan.Using a semi-structured questionnaire, we conducted a cross-sectional study on 201 practising Muslims and 10 religious leaders in Conakry, Guinea in the wake of the recent epidemic Ebola epid ...
- DOI:
- 10.1016/j.vaccine.2017.03.068
-
https://dx.doi.org/10.1016/j.vaccine.2017.03.068