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- Tang, Xian; Guo, Jia; Cheng, Lin; Sun, Caijun; Liu, Li; Zuo, Teng; Wang, Hui; Chen, Ling; Zhang, Linqi; Chen, Zhiwei
- Vaccine 2017 v.35 no.19 pp. 2582-2591
- B-lymphocytes; Human immunodeficiency virus; Simian immunodeficiency virus; antibodies; antigens; antiserum; cytotoxicity; enzyme-linked immunosorbent assay; glycosylation; humoral immunity; immune response; laboratory animals; neutralization; vaccines; yeasts
- ... An effective HIV vaccine remains elusive, and immunogens capable of eliciting protective host humoral immunity have not yet been identified. Although HIV/SIV infections result in the abundant production of CD4-induced (CD4i) antibodies (Abs), these Abs are not protective due to steric restrictions following gp120 binding to CD4 on target cells. Here we report that both DNA- and vaccinia-based vacc ...