Jump to Main Content
- Tsang, Kwong Y.; Fantini, Massimo; Fernando, Romaine I.; Palena, Claudia; David, Justin M.; Hodge, James W.; Gabitzsch, Elizabeth S.; Jones, Frank R.; Schlom, Jeffrey
- Vaccine 2017 v.35 no.19 pp. 2605-2611
- alleles; T-lymphocytes; neoplasm cells; epitopes; public health; uterine cervical neoplasms; Food and Drug Administration; antibodies; head; patients; coat proteins; Human papillomavirus type 16; humans; cytotoxicity; squamous cell carcinoma; neck; clinical trials; algorithms; etiology; vaccines; virus-like particles; agonists
- ... Human papillomavirus (HPV) is associated with the etiology of cervical carcinoma, head and neck squamous cell carcinoma, and several other cancer types. Vaccines directed against HPV virus-like particles and coat proteins have been extremely successful in the prevention of cervical cancer through the activation of host HPV-specific antibody responses; however, HPV-associated cancers remain a major ...
- PubMed Central:
- Tang, Xian; Guo, Jia; Cheng, Lin; Sun, Caijun; Liu, Li; Zuo, Teng; Wang, Hui; Chen, Ling; Zhang, Linqi; Chen, Zhiwei
- Vaccine 2017 v.35 no.19 pp. 2582-2591
- B-lymphocytes; Human immunodeficiency virus; Simian immunodeficiency virus; antibodies; antigens; antiserum; cytotoxicity; enzyme-linked immunosorbent assay; glycosylation; humoral immunity; immune response; laboratory animals; neutralization; vaccines; yeasts
- ... An effective HIV vaccine remains elusive, and immunogens capable of eliciting protective host humoral immunity have not yet been identified. Although HIV/SIV infections result in the abundant production of CD4-induced (CD4i) antibodies (Abs), these Abs are not protective due to steric restrictions following gp120 binding to CD4 on target cells. Here we report that both DNA- and vaccinia-based vacc ...