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- Tsang, Kwong Y.; Fantini, Massimo; Fernando, Romaine I.; Palena, Claudia; David, Justin M.; Hodge, James W.; Gabitzsch, Elizabeth S.; Jones, Frank R.; Schlom, Jeffrey
- Vaccine 2017 v.35 no.19 pp. 2605-2611
- alleles; T-lymphocytes; neoplasm cells; epitopes; public health; uterine cervical neoplasms; Food and Drug Administration; antibodies; head; patients; coat proteins; Human papillomavirus type 16; humans; cytotoxicity; squamous cell carcinoma; neck; clinical trials; algorithms; etiology; vaccines; virus-like particles; agonists
- ... Human papillomavirus (HPV) is associated with the etiology of cervical carcinoma, head and neck squamous cell carcinoma, and several other cancer types. Vaccines directed against HPV virus-like particles and coat proteins have been extremely successful in the prevention of cervical cancer through the activation of host HPV-specific antibody responses; however, HPV-associated cancers remain a major ...
- PubMed Central:
- Hendin, Hilary E.; Pillet, Stéphane; Lara, Amanda N.; Wu, Cheng-Ying; Charland, Nathalie; Landry, Nathalie; Ward, Brian J.
- Vaccine 2017 v.35 no.19 pp. 2592-2599
- B-lymphocytes; adults; antibodies; avian influenza; birds; confocal microscopy; flow cytometry; hemagglutinins; humans; immune response; inactivated vaccines; innate immunity; interleukin-1beta; interleukin-6; interleukin-8; monocytes; pandemic; tumor necrosis factor-alpha; virus-like particle vaccines; viruses
- ... The recent emergence of avian influenza strains has fuelled concern about pandemic preparedness since vaccines targeting these viruses are often poorly immunogenic. Weak antibody responses to vaccines have been seen across multiple platforms including plant-made VLPs. To better understand these differences, we compared the in vitro responses of human immune cells exposed to plant-made virus-like p ...