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1. A protective chimeric antibody to tick-borne encephalitis virus

Author:
Baykov, Ivan K.; Matveev, Andrey L.; Stronin, Oleg V.; Ryzhikov, Alexander B.; Matveev, Leonid E.; Kasakin, Marat F.; Richter, Vladimir A.; Tikunova, Nina V.
Source:
Vaccine 2014 v.32 no.29 pp. 3589-3594
ISSN:
0264-410X
Subject:
Tick-borne encephalitis virus; biosensors; chimerism; disease control; glycoproteins; hybridomas; immunoglobulins; in vivo studies; inhibitory concentration 50; lethal dose 50; mice; monoclonal antibodies; neutralization; neutralization tests; vaccines
Abstract:
... The efficiency of several mouse monoclonal antibodies (mAbs) specific to the tick-borne encephalitis virus (TBEV) glycoprotein E in post-exposure prophylaxis was assessed, and mAb14D5 was shown to be the most active of all those studied. It was proven that the hybridoma cell line 14D5 produced one immunoglobulin H chain and two L chains. They were used to construct chimeric antibodies ch14D5a and ...
DOI:
10.1016/j.vaccine.2014.05.012

2. Booster immune response in children 6–7 years of age, randomly assigned to four groups with two MMR vaccines applied by aerosol or by injection

Author:
Díaz-Ortega, José-Luis; Bennett, John V.; Castañeda-Desales, Deyanira; Quintanilla, Doris-Ma. Arellano; Martínez, David; Castro, Jorge Fernández de
Source:
Vaccine 2014 v.32 no.29 pp. 3680-3686
ISSN:
0264-410X
Subject:
Mexicans; aerosols; antibodies; blood serum; children; clinical trials; elementary schools; enzyme-linked immunosorbent assay; immune response; immunization; seroprevalence; vaccines; India
Abstract:
... Aerosol immunization may be a useful tool to reach and sustain the elimination of measles, rubella, and congenital rubella syndrome. We compared booster seroresponses to aerosolized or injected MMR vaccines containing different strains of measles (Attenuvax or Edmonston–Zagreb) and mumps (Jeryl–Lynn or Leningrad–Zagreb).To assess the safety and immunogenicity of two MMR: Vaccines administered by a ...
DOI:
10.1016/j.vaccine.2014.04.031

3. Cluster randomized trial of a toolkit and early vaccine delivery to improve childhood influenza vaccination rates in primary care

Author:
Zimmerman, Richard K.; Nowalk, Mary Patricia; Lin, Chyongchiou Jeng; Hannibal, Kristin; Moehling, Krissy K.; Huang, Hsin-Hui; Matambanadzo, Annamore; Troy, Judith; Allred, Norma J.; Gallik, Greg; Reis, Evelyn C.
Source:
Vaccine 2014 v.32 no.29 pp. 3656-3663
ISSN:
0264-410X
Subject:
childhood; children; confidence interval; influenza; insurance; models; odds ratio; regression analysis; surveys; vaccination; vaccines
Abstract:
... To increase childhood influenza vaccination rates using a toolkit and early vaccine delivery in a randomized cluster trial.Twenty primary care practices treating children (range for n=536–8183) were randomly assigned to Intervention and Control arms to test the effectiveness of an evidence-based practice improvement toolkit (4 Pillars Toolkit) and early vaccine supplies for use among disadvantaged ...
DOI:
10.1016/j.vaccine.2014.04.057
PubMed:
24793941
PubMed Central:
PMC4070849

4. Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation

Author:
Wibowo, Nani; Chuan, Yap P.; Seth, Arjun; Cordoba, Yoann; Lua, Linda H.L.; Middelberg, Anton P.J.
Source:
Vaccine 2014 v.32 no.29 pp. 3664-3669
ISSN:
0264-410X
Subject:
antigens; immune response; medicine; nanoparticles; silica; vaccination; vaccine development; vaccines
Abstract:
... Nanotechnology promises a revolution in medicine including through new vaccine approaches. The use of nanoparticles in vaccination has, to date, focused on attaching antigen directly to or within nanoparticle structures to enhance antigen uptake by immune cells. Here we question whether antigen incorporation with the nanoparticle is actually necessary to boost vaccine effectiveness. We show that t ...
DOI:
10.1016/j.vaccine.2014.04.043

5. Development and preclinical testing of HNVAC, a cell culture-based H1N1 pandemic influenza vaccine from India

Author:
Hegde, Nagendra R.; Kumar, Deepak; Rao, P. Panduranga; Kumari, P. Krishna; Kaushik, Yashpal; Ravikrishnan, R.; Prasad, Sai D.; Ella, Krishna M.
Source:
Vaccine 2014 v.32 no.29 pp. 3636-3643
ISSN:
0264-410X
Subject:
DNA; adults; aluminum hydroxide; antigens; bioprocessing; developing countries; dogs; eggs; electron microscopy; epithelium; females; guinea pigs; hemagglutination; in vitro studies; in vivo studies; influenza; karyotyping; laboratory animals; mice; neonates; neoplasms; neutralization; pandemic; rabbits; rats; reverse transcriptase polymerase chain reaction; sialidase; toxicity testing; vaccines; viruses; India
Abstract:
... Several limitations of the use of embryonated eggs and the threat of pandemics have highlighted the need for other platforms for the production of influenza vaccines. We report the indigenous development and pre-clinical testing of an MDCK-based H1N1 pandemic influenza vaccine HNVAC from India. The cell bank and virus seed were characterized extensively. The cells were characterized by PCR, electr ...
DOI:
10.1016/j.vaccine.2014.04.072

6. Effectiveness of typhoid vaccination in US travelers

Author:
Mahon, Barbara E.; Newton, Anna E.; Mintz, Eric D.
Source:
Vaccine 2014 v.32 no.29 pp. 3577-3579
ISSN:
0264-410X
Subject:
Salmonella; confidence interval; fever; paratyphoid; patients; people; travel; typhoid fever; vaccination; vaccines; South Asia; United States
Abstract:
... Typhoid vaccination is recommended in the United States before travel to countries where typhoid fever is endemic, though little information is available on its effectiveness in travelers.We estimated typhoid vaccination effectiveness (VE) by comparing vaccination status in cases of typhoid fever and paratyphoid fever (Salmonella Paratyphi A infection, against which typhoid vaccine offers no prote ...
DOI:
10.1016/j.vaccine.2014.04.055
PubMed:
24837780
PubMed Central:
PMC4604742

7. Effects of varying antigens and adjuvant systems on the immunogenicity and safety of investigational tetravalent human oncogenic papillomavirus vaccines: Results from two randomized trials

Author:
Van Damme, Pierre; Leroux-Roels, Geert; Simon, Philippe; Foidart, Jean-Michel; Donders, Gilbert; Hoppenbrouwers, Karel; Levin, Myron; Tibaldi, Fabian; Poncelet, Sylviane; Moris, Philippe; Dessy, Francis; Giannini, Sandra L.; Descamps, Dominique; Dubin, Gary
Source:
Vaccine 2014 v.32 no.29 pp. 3694-3705
ISSN:
0264-410X
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; Papillomaviridae; adjuvants; antibodies; antigens; genotype; humans; immune response; uterine cervical neoplasms; vaccines
Abstract:
... A prophylactic human papillomavirus (HPV) vaccine targeting oncogenic HPV types in addition to HPV-16 and -18 may broaden protection against cervical cancer. Two Phase I/II, randomized, controlled studies were conducted to compare the immunogenicity and safety of investigational tetravalent HPV L1 virus-like particle (VLP) vaccines, containing VLPs from two additional oncogenic genotypes, with the ...
DOI:
10.1016/j.vaccine.2014.03.040

8. European enhanced surveillance of invasive pneumococcal disease in 2010: Data from 26 European countries in the post-heptavalent conjugate vaccine era

Author:
Torné, Adoración Navarro; Dias, Joana Gomes; Quinten, Chantal; Hruba, Frantiska; Busana, Marta Cecilia; Lopalco, Pier Luigi; Gauci, Andrew J. Amato; Pastore-Celentano, Lucia
Source:
Vaccine 2014 v.32 no.29 pp. 3644-3650
ISSN:
0264-410X
Subject:
European Union; Streptococcus pneumoniae; antibiotic resistance; aspartate transaminase; cefotaxime; children; erythromycin; infectious diseases; issues and policy; minimum inhibitory concentration; monitoring; penicillins; serotypes; vaccines; Europe
Abstract:
... Streptococcus pneumoniae is a leading cause of severe infectious diseases worldwide. This paper presents the results from the first European invasive pneumococcal disease (IPD) enhanced surveillance where additional and valuable data were reported and analysed. Following its authorisation in Europe in 2001 for use in children aged between two months and five years, the heptavalent pneumococcal con ...
DOI:
10.1016/j.vaccine.2014.04.066

9. Evaluating the potential risks and benefits of infant rotavirus vaccination in England

Author:
Clark, Andy; Jit, Mark; Andrews, Nick; Atchison, Christina; Edmunds, W. John; Sanderson, Colin
Source:
Vaccine 2014 v.32 no.29 pp. 3604-3610
ISSN:
0264-410X
Subject:
children; death; gastroenteritis; infants; risk; risk-benefit analysis; vaccination; vaccines; Australia; England; United States
Abstract:
... Rotarix®, a vaccine for the prevention of gastroenteritis in young children, was introduced in England in July 2013. At around this time, an elevated risk of intussusception (a cause of bowel obstruction) was reported among infants vaccinated in Australia and the USA. A risk-benefit analysis compared potential vaccine-related risks (additional intussusception admissions and deaths) with estimated ...
DOI:
10.1016/j.vaccine.2014.04.082

10. Heat-killed yeast protects diabetic ketoacidotic-steroid treated mice from pulmonary mucormycosis

Author:
Luo, Guanpingsheng; Gebremariam, Teclegiorgis; Clemons, Karl V.; Stevens, David A.; Ibrahim, Ashraf S.
Source:
Vaccine 2014 v.32 no.29 pp. 3573-3576
ISSN:
0264-410X
Subject:
Rhizopus oryzae; Saccharomyces cerevisiae; antibodies; aspergillosis; candidiasis; coccidioidomycosis; cryptococcosis; diabetes; immune response; lungs; mice; quantitative polymerase chain reaction; steroids; vaccination; vaccines; yeasts
Abstract:
... Previous studies have shown that vaccination with heat-killed yeast, Saccharomyces cerevisiae (HKY), protects mice against systemic candidiasis, aspergillosis, cryptococcosis or coccidioidomycosis. Here we sought to define the potential use of HKY as a vaccine to protect mice from mucormycosis. Mice were vaccinated with different regimens of HKY prior to induction of diabetes. Diabetic ketoacidoti ...
DOI:
10.1016/j.vaccine.2014.04.086
PubMed:
24814556
PubMed Central:
PMC4074171

11. IFN-?, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection

Author:
Roberts, Lydia M.; Davies, John S.; Sempowski, Gregory D.; Frelinger, Jeffrey A.
Source:
Vaccine 2014 v.32 no.29 pp. 3595-3603
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; Francisella tularensis; bacteria; immune response; interleukin-17; live vaccines; lungs; memory; mice; monoclonal antibodies; respiratory tract diseases; spleen; staining; weight loss
Abstract:
... IL-17 and IFN-? production by Th17 and Th1 cells, respectively, is critical for survival during primary respiratory infection with the pathogenic bacterium, Francisella tularensis Live Vaccine Strain (LVS). The importance, however, of these T cell subsets and their soluble mediators is not well understood during a secondary or memory response. We measured the number of CD4+ T cells producing IFN-? ...
DOI:
10.1016/j.vaccine.2014.05.013
PubMed:
24837506
PubMed Central:
PMC4075325

12. Immune response to hepatitis B vaccine with high antigen content in non-responders after standard primary vaccination in Chinese adults

Author:
Pan, Hong-Xing; Zeng, Ying; Song, Xue-Fang; Zhang, Yi-Ju; Xu, Ke; Liang, Zheng-Lun; Zhu, Feng-Cai
Source:
Vaccine 2014 v.32 no.29 pp. 3706-3712
ISSN:
0264-410X
Subject:
adults; adverse effects; antibodies; antigens; blood sampling; clinical trials; hepatitis B; immune response; injection site; seroconversion; vaccination; vaccines; China
Abstract:
... Alternative schedules are needed to provide greater immunogenicity in adults who fail to respond to the standard hepatitis B (HB) vaccine regimen.To evaluate the immunogenicity and safety of high antigen content HB vaccine formulations administered to non-responders after routine primary vaccination.This was a phase III, double-blind, controlled clinical trial in China. We enrolled healthy partici ...
DOI:
10.1016/j.vaccine.2014.02.094

13. Oral vaccination and protection of striped skunks (Mephitis mephitis) against rabies using ONRAB®

Author:
Brown, L.J.; Rosatte, R.C.; Fehlner-Gardiner, C.; Ellison, J.A.; Jackson, F.R.; Bachmann, P.; Taylor, J.S.; Franka, R.; Donovan, D.
Source:
Vaccine 2014 v.32 no.29 pp. 3675-3679
ISSN:
0264-410X
Subject:
geographical distribution; oral vaccination; Rabies lyssavirus; baits; Mephitis mephitis; blood sampling; antibodies; rabies; residential housing; skunks; mouth; serology; vaccines; enzyme-linked immunosorbent assay; cost effectiveness; domestic animals; wildlife; North America
Abstract:
... Skunks are one of the most important rabies vector species in North America due to their wide geographic distribution, high susceptibility to the rabies virus, and tendency to inhabit areas around human dwellings and domestic animals. Oral vaccination is a cost-effective, socially acceptable technique often used to control rabies in terrestrial wildlife; however, control of rabies in skunks has pr ...
DOI:
10.1016/j.vaccine.2014.04.029

14. Perceptions of personal belief vaccine exemption policy: A survey of Arizona vaccine providers

Author:
Haenchen, Steven D.; Jacobs, Elizabeth T.; Bratton, Kristin N.; Carman, Aubri S.; Oren, Eyal; Pottinger, Heidi L.; Regan, Jessica A.; Ernst, Kacey C.
Source:
Vaccine 2014 v.32 no.29 pp. 3630-3635
ISSN:
0264-410X
Subject:
Rotavirus B; attitudes and opinions; childhood; databases; hepatitis B; issues and policy; parent education; parents; patients; physicians; public health; school children; surveys; vaccination; vaccines; Arizona
Abstract:
... As exemptions to school-entry requirements rise, vaccination rates in Arizona school children are approaching levels that may threaten public health. Understanding the interactions physicians have with vaccine-hesitant parents, as well as the opinions physicians hold regarding vaccination, exemption, and exemption policies, are critical to our understanding of, and ability to affect, vaccination e ...
DOI:
10.1016/j.vaccine.2014.04.081

15. Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: Extending the potential of broadly cross-protecting epitopes

Author:
Wibowo, Nani; Hughes, Fiona K.; Fairmaid, Emily J.; Lua, Linda H.L.; Brown, Lorena E.; Middelberg, Anton P.J.
Source:
Vaccine 2014 v.32 no.29 pp. 3651-3655
ISSN:
0264-410X
Subject:
DNA; Escherichia coli; Influenza A virus; aluminum hydroxide; antibodies; cross immunity; epitopes; immunization; influenza; lungs; manufacturing; mice; pandemic; prediction; vaccines; viral load; viruses
Abstract:
... Influenza A viruses drift and shift, emerging as antigenically distinct strains that lead to epidemics and pandemics of varying severity. Even epitopes associated with broad cross-protection against different strains, such as the ectodomain of matrix protein 2 (M2e), mutate unpredictably. Vaccine protective efficacy is only ensured when the emerging virus lies within the vaccine's cross-protective ...
DOI:
10.1016/j.vaccine.2014.04.062

16. Protective humoral immune response induced by an inactivated porcine reproductive and respiratory syndrome virus expressing the hypo-glycosylated glycoprotein 5

Author:
Lee, Jung-Ah; Kwon, Byungjoon; Osorio, Fernando A.; Pattnaik, Asit K.; Lee, Nak-Hyung; Lee, Sang-Won; Park, Seung-Yong; Song, Chang-Seon; Choi, In-Soo; Lee, Joong-Bok
Source:
Vaccine 2014 v.32 no.29 pp. 3617-3622
ISSN:
0264-410X
Subject:
Porcine reproductive and respiratory syndrome virus; amino acid substitution; blood serum; financial economics; glycoproteins; glycosylation; histopathology; humoral immunity; immune response; inactivated vaccines; live vaccines; lungs; mutants; neutralization; neutralizing antibodies; porcine reproductive and respiratory syndrome; pork industry; site-directed mutagenesis; viremia; virulence; viruses
Abstract:
... Porcine reproductive and respiratory syndrome (PRRS) causes significant economic losses to the swine industry worldwide. Although inactivated and live vaccines are commercially available for the control of PRRS, both types of vaccine have not always proven successful in terms of generating a protective immune response, particularly in the case of inactivated vaccines. In this study, we tested whet ...
DOI:
10.1016/j.vaccine.2014.04.083
PubMed:
24814552
PubMed Central:
PMC4152009

17. Serological response of foals to polyvalent and monovalent live-attenuated African horse sickness virus vaccines

Author:
Crafford, J.E.; Lourens, C.W.; Smit, T.K.; Gardner, I.A.; MacLachlan, N.J.; Guthrie, A.J.
Source:
Vaccine 2014 v.32 no.29 pp. 3611-3616
ISSN:
0264-410X
Subject:
African horse sickness; African horse sickness virus; disease occurrence; endemic diseases; foaling; foals; immune response; neutralizing antibodies; serotypes; vaccination; vaccines; viruses; South Africa
Abstract:
... African horse sickness (AHS) is typically a highly fatal disease in susceptible horses and vaccination is currently used to prevent the occurrence of disease in endemic areas. Similarly, vaccination has been central to the control of incursions of African horse sickness virus (AHSV) into previously unaffected areas and will likely play a significant role in any future incursions. Horses in the AHS ...
DOI:
10.1016/j.vaccine.2014.04.087

18. The effectiveness of seasonal trivalent inactivated influenza vaccine in preventing laboratory confirmed influenza hospitalisations in Auckland, New Zealand in 2012

Author:
Turner, Nikki; Pierse, Nevil; Bissielo, Ange; Huang, Q Sue; Baker, Michael G.; Widdowson, Marc-Alain; Kelly, Heath
Source:
Vaccine 2014 v.32 no.29 pp. 3687-3693
ISSN:
0264-410X
Subject:
confidence interval; cough; ethnic differences; fever; hospitals; influenza; monitoring; patients; vaccines; New Zealand
Abstract:
... Few studies report the effectiveness of trivalent inactivated influenza vaccine (TIV) in preventing hospitalisation for influenza-confirmed respiratory infections. Using a prospective surveillance platform, this study reports the first such estimate from a well-defined ethnically diverse population in New Zealand (NZ).A case test-negative design was used to estimate propensity adjusted vaccine eff ...
DOI:
10.1016/j.vaccine.2014.04.013
PubMed:
24768730
PubMed Central:
PMC4620982

19. The epidemiology of varicella cases among children in Beijing's Fengtai District from 2008 to 2012

Author:
Zhang, Xue; Yu, Yuncui; Zhang, Jie; Huang, Shengtian; Wang, Zhongzhan; Zhang, Jianjun; Yan, Yuxiang; Liu, Fen; Zhao, Jianzhong; He, Yan
Source:
Vaccine 2014 v.32 no.29 pp. 3569-3572
ISSN:
0264-410X
Subject:
children; epidemiology; infectious diseases; information systems; vaccination; vaccines; China
Abstract:
... In recent years, the number of breakthrough cases of varicella (onset >42 days after vaccination) increased each year, and varicella outbreaks continue to occur in Beijing. Data from the Immunization Information System and the Infectious Disease Reporting System demonstrated that in Beijing's Fengtai District, the varicella breakthrough rate increased from 0.7% in 2008 to 2.5% in 2012 and showed a ...
DOI:
10.1016/j.vaccine.2014.04.069

20. The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4+ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs

Author:
Commandeur, Susanna; van den Eeden, Susan J.F.; Dijkman, Karin; Clark, Simon O.; van Meijgaarden, Krista E.; Wilson, Louis; Franken, Kees L.M.C.; Williams, Ann; Christensen, Dennis; Ottenhoff, Tom H.M.; Geluk, Annemieke
Source:
Vaccine 2014 v.32 no.29 pp. 3580-3588
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; Human immunodeficiency virus; Mycobacterium bovis BCG; Mycobacterium tuberculosis; Toll-like receptor 2; Toll-like receptor 3; Toll-like receptor 4; Toll-like receptor 5; Toll-like receptor 7; Toll-like receptor 9; antibodies; drug resistance; epitopes; guinea pigs; humans; immune response; lungs; mice; mixed infection; transgenic animals; tuberculosis; vaccination; vaccines
Abstract:
... Tuberculosis (TB) remains a life-threatening infectious disease of global proportions with serious negative health and economic consequences. The lack of sufficient protection induced by Mycobacterium bovis BCG, the current vaccine for TB, as well as the impact of HIV co-infection and the emergence of drug resistant Mycobacterium tuberculosis (Mtb) strains all urge for improved vaccines against TB ...
DOI:
10.1016/j.vaccine.2014.05.005