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You searched for: Journal Vaccine Remove constraint Journal: Vaccine Publication Year 2014 Remove constraint Publication Year: 2014 Source 2014 v.32 no.40 Remove constraint Source: 2014 v.32 no.40
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1. A national reference for inactivated polio vaccine derived from Sabin strains in Japan

Author:
Shirato, Haruko; Someya, Yuichi; Ochiai, Masaki; Horiuchi, Yoshinobu; Takahashi, Motohide; Takeda, Naokazu; Wakabayashi, Kengo; Ouchi, Yasumitsu; Ota, Yoshihiro; Tano, Yoshio; Abe, Shinobu; Yamazaki, Shudo; Wakita, Takaji
Source:
Vaccine 2014 v.32 no.40 pp. 5163-5169
ISSN:
0264-410X
Subject:
World Health Organization; immune response; immunization; infectious diseases; quality control; rats; serotypes; vaccines; Japan
Abstract:
... As one aspect of its campaign to eradicate poliomyelitis, the World Health Organization (WHO) has encouraged development of the inactivated polio vaccine (IPV) derived from the Sabin strains (sIPV) as an option for an affordable polio vaccine, especially in low-income countries. The Japan Poliomyelitis Research Institute (JPRI) inactivated three serotypes of the Sabin strains and made sIPV prepara ...
DOI:
10.1016/j.vaccine.2014.07.065

2. Antibody and memory CD4+ T-cell responses after meningococcal disease

Author:
Cruz, Aline C.; Figueredo, Bruna S.; Souza, Simone L.; Rebelo, Maria Cristina; Carvalho, Aldrin G.A.; Milagres, Lucimar G.
Source:
Vaccine 2014 v.32 no.40 pp. 5145-5148
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; Neisseria meningitidis; adolescents; adults; antibodies; memory; meningitis; outer membrane proteins; patients; serotypes; vaccination; vaccines; Brazil
Abstract:
... Currently, Neisseria meningitidis serogroup C (MenC) is the major cause of bacterial meningitis in Brazil, affecting mainly teenagers and adults due to the lack of routine public vaccination of these age groups. The goal of this study was to investigate the bactericidal antibody response and the development of CD4+ T cell memory during the convalescent phase of patients infected with N. menigitidi ...
DOI:
10.1016/j.vaccine.2014.07.072

3. Apoptosis of antigen-specific CTLs contributes to low immune response in gut-associated lymphoid tissue post vaccination

Author:
Shimada, Masaru; Yoshizaki, Shinji; Ichino, Motohide; Klinman, Dennis M.; Okuda, Kenji
Source:
Vaccine 2014 v.32 no.40 pp. 5198-5205
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; HIV infections; Human immunodeficiency virus; Peyer's patches; apoptosis; genes; immune response; liver; lymph nodes; mice; spleen; vaccination; vaccines
Abstract:
... The gut-associated lymphoid tissue (GALT) represents a major reservoir of HIV in infected individuals. Vaccines can induce strong systemic immune responses but these have less impact on CD4 T cells activity and numbers in GALT. In this study, we vaccinated mice with an adenovirus vector that expressed the envelope gene from HIV and observed immune responses in the peripheral blood, spleen, liver, ...
DOI:
10.1016/j.vaccine.2014.07.046

4. A randomized, phase 1/2 trial of the safety, tolerability, and immunogenicity of bivalent rLP2086 meningococcal B vaccine in healthy infants

Author:
Martinon-Torres, Federico; Gimenez-Sanchez, Francisco; Bernaola-Iturbe, Enrique; Diez-Domingo, Javier; Jiang, Qin; Perez, John L.
Source:
Vaccine 2014 v.32 no.40 pp. 5206-5211
ISSN:
0264-410X
Subject:
Neisseria meningitidis; childhood; data collection; fever; immune response; infants; lipoproteins; recombinant vaccines; serotypes
Abstract:
... Neisseria meningitidis serogroup B (MnB) is a major cause of invasive meningococcal disease in infants. A conserved, surface-exposed lipoprotein, LP2086 (a factor H-binding protein [fHBP]), is a promising MnB vaccine target. A bivalent, recombinant vaccine targeting the fHBP (rLP2086) of MnB was developed.This phase 1/2 clinical study was designed to assess the immunogenicity, safety, and tolerabi ...
DOI:
10.1016/j.vaccine.2014.07.049

5. A role for impaired regulatory T cell function in adverse responses to aluminum adjuvant-containing vaccines in genetically susceptible individuals

Author:
Terhune, Todd D.; Deth, Richard C.
Source:
Vaccine 2014 v.32 no.40 pp. 5149-5155
ISSN:
0264-410X
Subject:
T-lymphocytes; adjuvants; adverse effects; aluminum; animal models; immune response; interleukin-4; interleukin-6; vaccination; vaccines
Abstract:
... Regulatory T cells play a critical role in the immune response to vaccination, but there is only a limited understanding of the response of regulatory T cells to aluminum adjuvants and the vaccines that contain them. Available studies in animal models show that although induced T regulatory cells may be induced concomitantly with effector T cells following aluminum-adjuvanted vaccination, they are ...
DOI:
10.1016/j.vaccine.2014.07.052

6. Enhanced immune responses of foot-and-mouth disease vaccine using new oil/gel adjuvant mixtures in pigs and goats

Author:
Park, Min-Eun; Lee, Seo-Yong; Kim, Rae-Hyung; Ko, Mi-Kyeong; Lee, Kwang-Nyeong; Kim, Su-Mi; Kim, Byoung-Kwan; Lee, Jong-Soo; Kim, Byounghan; Park, Jong-Hyeon
Source:
Vaccine 2014 v.32 no.40 pp. 5221-5227
ISSN:
0264-410X
Subject:
adjuvants; aluminum hydroxide; cattle; dairy goats; foot-and-mouth disease; gels; immune response; neutralizing antibodies; oils; swine; vaccines
Abstract:
... The immunity and protective capability produced by vaccines can vary remarkably according to the kinds of adjuvants being used. In the case of foot-and-mouth disease (FMD) vaccines in pigs, only oil-adjuvant vaccines have been used, and these tend to show lower immunity in pigs than in cattle. New adjuvants for these vaccines are therefore needed. We made different experimental FMD vaccines using ...
DOI:
10.1016/j.vaccine.2014.07.040

7. Enhancement of vaccine efficacy by expression of a TLR5 ligand in the defined live attenuated Francisella tularensis subsp. novicida strain U112ΔiglB::fljB

Author:
Cunningham, Aimee L.; Dang, Kim Minh; Yu, Jieh-Juen; Guentzel, M. Neal; Heidner, Hans W.; Klose, Karl E.; Arulanandam, Bernard P.
Source:
Vaccine 2014 v.32 no.40 pp. 5234-5240
ISSN:
0264-410X
Subject:
Francisella tularensis subsp. novicida; Salmonella Typhimurium; Toll-like receptor 5; agonists; animal models; cytosol; flagellin; humans; immunity; immunoglobulin G; lymphocytes; macrophages; mice; oral vaccination; rats; splenocytes; tularemia; tumor necrosis factor-alpha; vaccines; virulence
Abstract:
... Oral vaccination with the defined live attenuated Francisella novicida vaccine strain U112ΔiglB has been demonstrated to induce protective immunity against pulmonary challenge with the highly human virulent Francisella tularensis strain SCHU S4. However, this vaccination regimen requires a booster dose in mice and Exhibits 50% protective efficacy in the Fischer 344 rat model. To enhance the effica ...
DOI:
10.1016/j.vaccine.2014.07.038
PubMed:
25050972
PubMed Central:
PMC4140432

8. Fc receptor-targeting of immunogen as a strategy for enhanced antigen loading, vaccination, and protection using intranasally administered antigen-pulsed dendritic cells

Author:
Pham, Giang H.; Iglesias, Bibiana V.; Gosselin, Edmund J.
Source:
Vaccine 2014 v.32 no.40 pp. 5212-5220
ISSN:
0264-410X
Subject:
Francisella tularensis; T-lymphocytes; antigen presentation; antigen-antibody complex; antigens; dendritic cells; humans; intranasal administration; live vaccines; models; monoclonal antibodies; neoplasms; receptors; tularemia; vaccination
Abstract:
... Dendritic cells (DCs) play a critical role in the generation of adaptive immunity via the efficient capture, processing, and presentation of antigen (Ag) to naïve T cells. Administration of Ag-pulsed DCs is also an effective strategy for enhancing immunity to tumors and infectious disease organisms. Studies have also demonstrated that targeting Ags to Fcγ receptors (FcγR) on Ag presenting cells ca ...
DOI:
10.1016/j.vaccine.2014.07.050
PubMed:
25068496
PubMed Central:
PMC4144271

9. Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice

Author:
Solans, Luis; Uranga, Santiago; Aguilo, Nacho; Arnal, Carmen; Gomez, Ana Belen; Monzon, Marta; Badiola, Juan Jose; Gicquel, Brigitte; Martin, Carlos
Source:
Vaccine 2014 v.32 no.40 pp. 5192-5197
ISSN:
0264-410X
Subject:
at-risk population; Human immunodeficiency virus; HIV infections; live vaccines; Mycobacterium bovis BCG; virulence; mice; tuberculosis; animal models; genes; genetic engineering; mutants; Mycobacterium tuberculosis; severe combined immunodeficiency
Abstract:
... Safety of individuals at risk of immune suppression is an important concern for live vaccines. The new-generation tuberculosis vaccine candidate MTBVAC, a genetically engineered doubly attenuated Mycobacterium tuberculosis mutant with deletions in phoP and fadD26 virulence genes has demonstrated comparable safety in different relevant animal models and superior protection in mice as compared to th ...
DOI:
10.1016/j.vaccine.2014.07.047

10. Immunogenicity and safety of a single dose of a CRM-conjugated meningococcal ACWY vaccine in children and adolescents aged 2–18 years in Taiwan: Results of an open label study

Author:
Huang, Li-Min; Chiu, Nan-Chang; Yeh, Shu-Jen; Bhusal, Chiranjiwi; Arora, Ashwani Kumar
Source:
Vaccine 2014 v.32 no.40 pp. 5177-5184
ISSN:
0264-410X
Subject:
European Union; Neisseria meningitidis; adolescents; antibacterial properties; blood serum; children; immune response; people; serotypes; vaccination; vaccines; Italy; Taiwan; United States
Abstract:
... MenACWY-CRM (Menveo®, Novartis Vaccines, Siena, Italy) is a quadrivalent meningococcal conjugate vaccine developed to help prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W, and Y. It is approved within the European Union in persons >2 years of age and in persons from 2 months to 55 years of age in the United States, among other countries. Little is known a ...
DOI:
10.1016/j.vaccine.2014.07.063

11. Influenza A virus hemagglutinin protein subunit vaccine elicits vaccine-associated enhanced respiratory disease in pigs

Author:
Rajão, Daniela S.; Loving, Crystal L.; Gauger, Phillip C.; Kitikoon, Pravina; Vincent, Amy L.
Source:
Vaccine 2014 v.32 no.40 pp. 5170-5176
ISSN:
0264-410X
Subject:
Influenza A virus; hemagglutinins; immune response; lungs; neutralizing antibodies; pandemic; protein subunits; respiratory tract diseases; subunit vaccines; swine; vaccination; viral shedding; viruses
Abstract:
... Vaccine-associated enhanced respiratory disease (VAERD) can occur when pigs are challenged with heterologous virus in the presence of non-neutralizing but cross-reactive antibodies elicited by whole inactivated virus (WIV) vaccine. The aim of this study was to compare the effects of heterologous δ1-H1N2 influenza A virus (IAV) challenge of pigs after vaccination with 2009 pandemic H1N1 virus (H1N1 ...
DOI:
10.1016/j.vaccine.2014.07.059
CHORUS:
10.1016/j.vaccine.2014.07.059

12. Modelling the epidemiological impact of rotavirus vaccination in Germany – A Bayesian approach

Author:
Weidemann, Felix; Dehnert, Manuel; Koch, Judith; Wichmann, Ole; Höhle, Michael
Source:
Vaccine 2014 v.32 no.40 pp. 5250-5257
ISSN:
0264-410X
Subject:
Bayesian theory; Markov chain; Rotavirus; children; decision making; dynamic models; gastroenteritis; infants; infectious diseases; people; prediction; surveys; uncertainty; vaccination; vaccines; Germany
Abstract:
... Rotavirus (RV) infection is the primary cause of severe gastroenteritis in children aged <5 years in Germany and worldwide. In 2013 the German Standing Committee on Vaccination (STIKO) developed a national recommendation for routine RV-immunization of infants. To support informed decision-making we predicted the epidemiological impact of routine RV-vaccination in Germany using statistical modellin ...
DOI:
10.1016/j.vaccine.2014.06.090

13. Protection promoted by pGP3 or pGP4 against Chlamydia muridarum is mediated by CD4+ cells in C57BL/6N mice

Author:
Mosolygó, Tímea; Szabó, Ágnes M.; Balogh, Emese P.; Faludi, Ildikó; Virók, Dezső P.; Endrész, Valéria; Samu, Alíz; Krenács, Tibor; Burián, Katalin
Source:
Vaccine 2014 v.32 no.40 pp. 5228-5233
ISSN:
0264-410X
Subject:
Chlamydia muridarum; Chlamydia trachomatis; animal models; antibodies; immune response; inflammation; interferon-gamma; lungs; mice; microbial load; neutralization; plasmids; protective effect; proteins; sexually transmitted diseases; splenocytes; vaccination; vaccines; virulence
Abstract:
... Urogenital tract infection with Chlamydia trachomatis is a leading cause of sexually transmitted infections. There is currently no commercially available vaccine against C. trachomatis. The highly conserved plasmid of chlamydiae has been considered to be a virulence factor and the plasmid proteins have important roles in the Chlamydia-specific immune response. This study was designed to evaluate t ...
DOI:
10.1016/j.vaccine.2014.07.039

14. Relative cost-effectiveness of a norovirus vaccine in the deployed military setting compared to a vaccine against Campylobacter sp., ETEC, and Shigella sp.

Author:
Tallant, Aaron; Porter, Chad K.; Putnam, Shannon D.; Tribble, David R.; Hooper, Tomoko I.; Riddle, Mark S.
Source:
Vaccine 2014 v.32 no.40 pp. 5156-5162
ISSN:
0264-410X
Subject:
Campylobacter; Norovirus; Shigella; cost effectiveness; diagnostic techniques; diarrhea; enterotoxigenic Escherichia coli; models; prioritization; vaccines
Abstract:
... Norovirus (NoV) has been identified as a significant cause of acute gastrointestinal illness among deployed military troops. We conducted a cost-effectiveness analysis for the use of a NoV vaccine in the military using a previously developed model that evaluated vaccines for ETEC, Campylobacter, and Shigella for prevention of non-outbreak associated travelers’ diarrhea. Under conservative assumpti ...
DOI:
10.1016/j.vaccine.2014.07.070

15. Serotype epidemiology of invasive pneumococcal disease in Swiss adults: A nationwide population-based study

Author:
Meichtry, Jurka; Born, Rita; Küffer, Marianne; Zwahlen, Marcel; Albrich, Werner C.; Brugger, Silvio D.; Mühlemann, Kathrin; Hilty, Markus
Source:
Vaccine 2014 v.32 no.40 pp. 5185-5191
ISSN:
0264-410X
Subject:
adults; childhood; comorbidity; epidemiology; infants; monitoring; patients; regression analysis; serotypes; vaccination; vaccines; Switzerland
Abstract:
... In Switzerland, the heptavalent (PCV7) and 13-valent pneumococcal conjugate vaccine (PCV13) were recommended for all infants aged <2 years in 2007 and 2011, respectively. Due to herd effects, a protective impact on the invasive pneumococcal disease (IPD) rates in adults had been expected.Within this study, data from the nationwide mandatory surveillance was analyzed for all adult patients ≥16 year ...
DOI:
10.1016/j.vaccine.2014.07.060

16. Vaccination against the M protein of Streptococcus pyogenes prevents death after influenza virus:S. pyogenes super-infection

Author:
Klonoski, Joshua M.; Hurtig, Heather R.; Juber, Brian A.; Schuneman, Margaret J.; Bickett, Thomas E.; Svendsen, Joshua M.; Burum, Brandon; Penfound, Thomas A.; Sereda, Grigoriy; Dale, James B.; Chaussee, Michael S.; Huber, Victor C.
Source:
Vaccine 2014 v.32 no.40 pp. 5241-5249
ISSN:
0264-410X
Subject:
Haemophilus influenzae; Influenza A virus; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes; antibodies; bacteria; bacterial infections; death; immunity; immunoglobulin G; influenza; macrophages; mice; models; pneumonia; sepsis (infection); superinfection; throat; vaccination; vaccines
Abstract:
... Influenza virus infections are associated with a significant number of illnesses and deaths on an annual basis. Many of the deaths are due to complications from secondary bacterial invaders, including Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Streptococcus pyogenes. The β-hemolytic bacteria S. pyogenes colonizes both skin and respiratory surfaces, and frequently ...
DOI:
10.1016/j.vaccine.2014.06.093
PubMed:
25077423
PubMed Central:
PMC4146501