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1. Rabies post-exposure prophylaxis: A systematic review on abridged vaccination schedules and the effect of changing administration routes during a single course

Author:
Kessels, Joss; Tarantola, Arnaud; Salahuddin, Naseem; Blumberg, Lucille; Knopf, Lea
Source:
Vaccine 2019 v.37 pp. A107
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; World Health Organization; at-risk population; disease control; immunogenicity; immunoglobulins; infants; patient compliance; people; pregnancy; protocols; rabies; systematic review; vaccination; vaccines; washing; zoonoses;     Show all 17 Subjects
Abstract:
... Rabies is a fatal zoonotic disease preventable through timely and adequate post-exposure prophylaxis (PEP) to potentially exposed persons i.e. wound washing and antisepsis, a series of intradermal (ID) or intramuscular (IM) rabies vaccinations, and rabies immunoglobulin in WHO category III exposures. The 2010 WHO position on rabies vaccines recommended PEP schedules requiring up to 5 clinic visits ...
DOI:
10.1016/j.vaccine.2019.01.041

2. Parainfluenza virus 5 (PIV5) amplifying virus-like particles expressing respiratory syncytial virus (RSV) antigens protect mice against RSV infection

Author:
Huertas-Díaz, María Cristina; Phan, Shannon; Elson, Andrew; Nuñez, Ivette; Wei, Huiling; Sakamoto, Kaori; He, Biao
Source:
Vaccine 2019 v.37 no.22 pp. 2925-2934
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; transcription factors; elderly; Mammalian orthorubulavirus 5; antigens; morbidity; vaccines; virus-like particles; pneumonia; transcription (genetics); mice; bronchiolitis; children; animal models; Respiratory syncytial virus; genes; immune response; RNA; mortality;     Show all 19 Subjects
Abstract:
... Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and pneumonia in children under one year of age. In addition to causing severe respiratory diseases in children, it is also a major cause of morbidity and mortality among the elderly and immunocompromised individuals. RSV is the most common cause of lower respiratory tract infections, yet there are currently no licensed vaccin ...
DOI:
10.1016/j.vaccine.2019.04.042

3. Cost of herpes zoster and herpes zoster-related complications among immunocompromised individuals

Author:
Meyers, Juliana L.; Candrilli, Sean D.; Rausch, Debora A.; Yan, Songkai; Patterson, Brandon J.; Levin, Myron J.
Source:
Vaccine 2018 v.36 no.45 pp. 6810-6818
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; case-control studies; Human alphaherpesvirus 3; health care costs; eyes; immunosuppression; vaccines; comorbidity; health insurance; United States;     Show all 10 Subjects
Abstract:
... Herpes zoster (HZ) is a painful dermatomal rash caused by reactivation of latent varicella-zoster virus. The incidence of HZ is increased for immunocompromised (IC) individuals. The objective of this study is to assess the healthcare costs incurred by IC individuals who develop HZ with or without associated complications. We conducted a retrospective case-control study across the US over a 5-year ...
DOI:
10.1016/j.vaccine.2018.08.080

4. Serum albumin nanoparticles vaccine provides protection against a lethal Pseudomonas aeruginosa challenge

Author:
Maria de Souza Morais, Stella; Ferreira Rodigues, Naiara; Ingrid Oliveira da Silva, Natalia; Aparecido Salvador, Ezequiel; Rodrigues Franco, Isabella; Augusto Pires de Souza, Gabriel; Henrique Cruvinel da Silva, Pedro; Gustavo Nogueira de Almeida, Luiz; Prado Rocha, Raissa; Carolina Toledo da Cunha Pereira, Anna; Portela Ferreira, Gustavo; Veras Quelemes, Patrick; Pereira de Araújo, Matheus; Fornias Sperandio, Felipe; Júnia de Souza Santos, Lorena; Assis Martins Filho, Olindo; Cosme Cotta Malaquias, Luiz; Felipe Leomil Coelho, Luiz
Source:
Vaccine 2018 v.36 no.43 pp. 6408-6415
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; Pseudomonas aeruginosa; animal models; antigens; bacteria; bovine serum albumin; cystic fibrosis; cytokines; histopathology; immunization; laboratory animals; lungs; mice; microbial load; nanoparticles; nose; pathogens; patients; phosphates; secondary infection; survival rate; vaccines; virulence;     Show all 23 Subjects
Abstract:
... Pseudomonas aeruginosa is an opportunistic pathogen that causes severe infections in immunocompromised individuals and in patients with cystic fibrosis. A range of vaccines to prevent infections caused by P. aeruginosa has already been tested, yet no vaccine against this pathogen is currently available. The goal of this study was to evaluate the potential of bovine serum albumin nanoparticles (BSA ...
DOI:
10.1016/j.vaccine.2018.08.070

5. Clinical features and outcomes of Bacille Calmette-Guérin (BCG)-induced diseases following neonatal BCG Tokyo-172 strain immunization

Author:
Rermruay, Rattanachai; Rungmaitree, Supattra; Chatpornvorarux, Sunsanee; Brukesawan, Chantapat; Wittawatmongkol, Orasri; Lapphra, Keswadee; Phongsamart, Wanatpreeya; Kongstan, Nantaka; Khumcha, Benjawan; Chokephaibulkit, Kulkanya
Source:
Vaccine 2018 v.36 no.28 pp. 4046-4053
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; Mycobacterium tuberculosis; adverse effects; children; excision; immunosuppression; issues and policy; lymphadenitis; males; medical records; monitoring; neonates; pathogens; patients; vaccination; vaccines; virulence;     Show all 17 Subjects
Abstract:
... Bacille Calmette-Guérin (BCG) vaccination at birth may cause mild and benign local adverse effects (AE). More serious AE are rarely reported.To describe clinical features and outcomes of BCG (Tokyo-172 strain)-induce diseases (BCG-ID) that required medical attention at a tertiary care center in Bangkok, Thailand.We retrospectively reviewed medical records from January 2007 to December 2016 that we ...
DOI:
10.1016/j.vaccine.2018.05.098

6. Vaccination in immunocompromised host: Recommendations of Italian Primary Immunodeficiency Network Centers (IPINET)

Author:
Martire, Baldassarre; Azzari, Chiara; Badolato, Raffaele; Canessa, Clementina; Cirillo, Emilia; Gallo, Vera; Graziani, Simona; Lorenzini, Tiziana; Milito, Cinzia; Panza, Raffaella; Moschese, Viviana
Source:
Vaccine 2018 v.36 no.24 pp. 3541-3554
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; guidelines; health services; immunosuppression; infectious diseases; morbidity; mortality; patients; people; risk; vaccination; vaccines; Italy;     Show all 13 Subjects
Abstract:
... Infectious complications are a major cause of morbidity and mortality in patients with primary or secondary immunodeficiency. Prevention of infectious diseases by vaccines is among the most effective healthcare measures mainly for these subjects. However immunocompromised people vary in their degree of immunosuppression and susceptibility to infection and, therefore, represent a heterogeneous popu ...
DOI:
10.1016/j.vaccine.2018.01.061

7. The respiratory syncytial virus fusion protein formulated with a polymer-based adjuvant induces multiple signaling pathways in macrophages

Author:
Sarkar, Indranil; Garg, Ravendra; van Drunen Littel-van den Hurk, Sylvia
Source:
Vaccine 2018 v.36 no.17 pp. 2326-2336
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; adaptive immunity; adjuvants; calcium-calmodulin-dependent protein kinase; cell lines; chemokines; elderly; gene expression; gene expression regulation; immunization; infants; innate immunity; interferon-beta; lambs; macrophages; mice; mitogen-activated protein kinase; phosphatidylinositol 3-kinase; receptors; respiratory tract diseases; signal transduction; tissues; transcription factor NF-kappa B; vaccines; viral fusion proteins; viruses;     Show all 26 Subjects
Abstract:
... Respiratory syncytial virus (RSV) causes acute respiratory tract infections in infants, the elderly and immunocompromised individuals. No licensed vaccine is available against RSV. We previously reported that intranasal immunization of rodents and lambs with a RSV vaccine candidate (ΔF/TriAdj) induces protective immunity with a good safety profile. ΔF/TriAdj promoted innate immune responses in res ...
DOI:
10.1016/j.vaccine.2018.03.016

8. The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells

Author:
Westcott, Marlena M.; Clemens, Elene A.; Holbrook, Beth C.; King, S. Bruce; Alexander-Miller, Martha A.
Source:
Vaccine 2018 v.36 no.9 pp. 1174-1182
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; Cercopithecus aethiops; Orthomyxoviridae; Toll-like receptors; agonists; at-risk population; crosslinking; dendritic cells; elderly; humans; immunogenicity; immunostimulants; inactivated vaccines; infants; influenza; influenza vaccines; live vaccines; lungs; macrophages; mice; monocytes; virion;     Show all 22 Subjects
Abstract:
... Inactivated influenza vaccines are not approved for use in infants less than 6 months of age due to poor immunogenicity in that population. While the live attenuated influenza vaccine has the potential to be more immunogenic, it is not an option for infants and other vulnerable populations, including the elderly and immunocompromised individuals due to safety concerns. In an effort to improve the ...
DOI:
10.1016/j.vaccine.2018.01.035

9. Herpes zoster vaccine live: A 10 year review of post-marketing safety experience

Author:
Willis, English D.; Woodward, Meredith; Brown, Elizabeth; Popmihajlov, Zoran; Saddier, Patricia; Annunziato, Paula W.; Halsey, Neal A.; Gershon, Anne A.
Source:
Vaccine 2017 v.35 no.52 pp. 7231-7239
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; Human alphaherpesvirus 3; immunosuppression; injection site; vaccines; polymerase chain reaction; health care workers; vaccination; pathogenesis; clinical trials; databases;     Show all 11 Subjects
Abstract:
... Zoster vaccine is a single dose live, attenuated vaccine (ZVL) indicated for individuals ≥50 years-old for the prevention of herpes zoster (HZ). Safety data from clinical trials and post-licensure studies provided reassurance that ZVL is generally safe and well tolerated. The objective of this review was to provide worldwide post-marketing safety information following 10 years of use and >34 milli ...
DOI:
10.1016/j.vaccine.2017.11.013
PubMed:
29174682
PubMed Central:
PMC5739308

10. Natural acquired group B Streptococcus capsular polysaccharide and surface protein antibodies in HIV-infected and HIV-uninfected children

Author:
Dzanibe, Sonwabile; Adrian, Peter V.; Kimaro Mlacha, Sheila Z.; Madhi, Shabir A.
Source:
Vaccine 2016 v.34 no.44 pp. 5217-5224
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; HIV infections; Human immunodeficiency virus; Streptococcus agalactiae; adhesins; antibodies; children; fibrinogen; immunoassays; immunoglobulin G; infants; lipoproteins; lymphocyte count; people; polysaccharides; serotypes; surface antigens; surface proteins; vaccines;     Show all 19 Subjects
Abstract:
... Group B Streptococcus (GBS) is a major cause of invasive disease in young infants and also in older immunocompromised individuals, including HIV-infected persons. We compared naturally acquired antibody titres to GBS polysaccharide and surface protein antigens in HIV-uninfected and HIV-infected children aged 4–7 years.A multiplex Luminex immunoassay was used to measure IgG concentrations against G ...
DOI:
10.1016/j.vaccine.2016.09.015

11. Improved safety of a replication-competent poxvirus-based HIV vaccine with the introduction of the HSV-TK/GCV suicide gene system

Author:
Zhang, Qicheng; Liu, Zheng; Hou, Jue; Wang, Shuhui; Liu, Chang; Wei, Min; Liu, Ying; Shao, Yiming
Source:
Vaccine 2016 v.34 no.30 pp. 3447-3453
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; rabbits; risk; suicide genes; antiviral agents; Human immunodeficiency virus 1; antigens; Human alphaherpesvirus 1; humoral immunity; vaccines; mice; children; thymidine kinase; viruses; Vaccinia virus; immune response;     Show all 16 Subjects
Abstract:
... Replication-competent vaccinia viruses (VACVs) show prolonged antigen expression time and greater stimulation of immune responses than their replication-incompetent counterparts. However, there is the potential risk of serious post-vaccination complications, especially for children and immunocompromised individuals, leading to safety concerns about the reintroduction of VACV as a vaccine vector. I ...
DOI:
10.1016/j.vaccine.2016.05.012

12. Quantifying the risk of pandemic influenza virus evolution by mutation and re-assortment

Author:
Reperant, Leslie A.; Grenfell, Bryan T.; Osterhaus, Albert D.M.E.
Source:
Vaccine 2015 v.33 no.49 pp. 6955-6966
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; Influenza A virus; evolution; genotype; health care workers; humans; influenza; mixed infection; mutants; mutation; pandemic; probabilistic models; risk; uncertainty; vaccination; vaccines; viral load;     Show all 17 Subjects
Abstract:
... Large outbreaks of zoonotic influenza A virus (IAV) infections may presage an influenza pandemic. However, the likelihood that an airborne-transmissible variant evolves upon zoonotic infection or co-infection with zoonotic and seasonal IAVs remains poorly understood, as does the relative importance of accumulating mutations versus re-assortment in this process. Using discrete-time probabilistic mo ...
DOI:
10.1016/j.vaccine.2015.10.056

13. Naturally occurring bactericidal antibodies specific for Haemophilus influenzae Lipooligosaccharide are present in healthy adult individuals

Author:
Choi, Joshua; Nix, Eli B.; Gaultier, Gabrielle N.; Cox, Andrew D.; McCready, William; Ulanova, Marina
Source:
Vaccine 2015 v.33 no.16 pp. 1941-1947
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; Haemophilus influenzae; adults; antibacterial properties; antibodies; antigens; blood serum; complement; immune evasion; immune response; immunoglobulin G; immunoglobulin M; lipooligosaccharides; otitis media; pathogens; respiratory tract diseases; vaccines; virulence;     Show all 18 Subjects
Abstract:
... Nontypeable Haemophilus influenzae (NTHi), a typical mucosal pathogen largely responsible for respiratory infections and pediatric otitis media, has been increasingly recognized as a significant cause of invasive disease, especially in immunocompromised individuals. Lipooligosaccharide (LOS) is a conserved molecule with an important role in H. influenzae virulence and immune evasion, and it may be ...
DOI:
10.1016/j.vaccine.2015.02.060

14. Cost-effectiveness of administering 13-valent pneumococcal conjugate vaccine in addition to 23-valent pneumococcal polysaccharide vaccine to adults with immunocompromising conditions

Author:
Cho, Bo-Hyun; Stoecker, Charles; Link-Gelles, Ruth; Moore, Matthew R.
Source:
Vaccine 2013 v.31 no.50 pp. 6011-6021
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; HIV infections; adults; cost effectiveness; disease incidence; kidney diseases; observational studies; organ transplantation; pneumonia; probabilistic models; quality-adjusted life year; randomized clinical trials; risk; vaccination; vaccines; United States;     Show all 16 Subjects
Abstract:
... In June, 2012 a single dose of 13-valent pneumococcal conjugate vaccine (PCV13) was added to the recommendation for immunocompromised adults who were previously recommended to receive only 23-valent pneumococcal polysaccharide vaccine (PPSV23). PCV13 may be more effective, though it covers fewer disease-causing strains.We examined the incremental cost-effectiveness of adding one dose of PCV13 to t ...
DOI:
10.1016/j.vaccine.2013.10.024

15. Safety and tolerability of a live oral Salmonella typhimurium vaccine candidate in SIV-infected nonhuman primates

Author:
Ault, Alida; Tennant, Sharon M.; Gorres, J. Patrick; Eckhaus, Michael; Sandler, Netanya G.; Roque, Annelys; Livio, Sofie; Bao, Saran; Foulds, Kathryn E.; Kao, Shing-Fen; Roederer, Mario; Schmidlein, Patrick; Boyd, Mary Adetinuke; Pasetti, Marcela F.; Douek, Daniel C.; Estes, Jacob D.; Nabel, Gary J.; Levine, Myron M.; Rao, Srinivas S.
Source:
Vaccine 2013 v.31 no.49 pp. 5879-5888
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; Macaca mulatta; Salmonella Typhimurium; Simian immunodeficiency virus; digestive tract; disease incidence; elderly; gastroenteritis; histopathology; hosts; infants; macrophages; models; mortality; multiple drug resistance; neutrophils; permeability; serotypes; vaccination; vaccines; Sub-Saharan Africa;     Show all 21 Subjects
Abstract:
... Nontyphoidal Salmonella (NTS) serovars are a common cause of acute food-borne gastroenteritis worldwide and can cause invasive systemic disease in young infants, the elderly, and immunocompromised hosts, accompanied by high case fatality. Vaccination against invasive NTS disease is warranted where the disease incidence and mortality are high and multidrug resistance is prevalent, as in sub-Saharan ...
DOI:
10.1016/j.vaccine.2013.09.041

16. Modified Vaccinia virus Ankara: Innate immune activation and induction of cellular signalling

Author:
Price, Philip J.R.; Torres-Domínguez, Lino E.; Brandmüller, Christine; Sutter, Gerd; Lehmann, Michael H.
Source:
Vaccine 2013 v.31 no.39 pp. 4231-4234
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; Vaccinia virus; antigens; engineering; genes; immune response; influenza; innate immunity; malaria; mammals; tuberculosis; vaccine development; vaccines; virulence; virus replication;     Show all 15 Subjects
Abstract:
... Attenuated poxviruses are currently under development as vaccine vectors against a number of diseases including, influenza, HIV, malaria and tuberculosis. Modified Vaccinia virus Ankara (MVA) is an attenuated, replication deficient vaccinia virus (VACV) strain which, similar to replication competent VACV, is highly immunogenic. The lack of productive viral replication further improves the safety p ...
DOI:
10.1016/j.vaccine.2013.03.017

17. Cost-effectiveness of pneumococcal conjugate vaccination in immunocompromised adults

Author:
Smith, Kenneth J.; Nowalk, Mary Patricia; Raymund, Mahlon; Zimmerman, Richard K.
Source:
Vaccine 2013 v.31 no.37 pp. 3950-3956
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; HIV infections; adults; childhood; cost effectiveness; herds; immunity; longevity; models; patients; people; pneumonia; quality-adjusted life year; vaccination; vaccines;     Show all 15 Subjects
Abstract:
... Pneumococcal disease is a significant problem in immunocompromised persons, particularly in HIV-infected individuals. The CDC recently updated pneumococcal vaccination recommendations for immunocompromised adults, adding the 13-valent pneumococcal conjugate vaccine (PCV13) to the previously recommended 23-valent pneumococcal polysaccharide vaccine (PPSV23). This analysis estimates the cost-effecti ...
DOI:
10.1016/j.vaccine.2013.06.037
PubMed:
23806240
PubMed Central:
PMC3742552

18. Cell-mediated immune responses to a varicella-zoster virus glycoprotein E vaccine using both a TLR agonist and QS21 in mice

Author:
Dendouga, Najoua; Fochesato, Michel; Lockman, Laurence; Mossman, Sally; Giannini, Sandra L.
Source:
Vaccine 2012 v.30 no.20 pp. 3126-3135
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; risk; Human alphaherpesvirus 3; antigens; interferon-gamma; lipid A; vaccines; cell-mediated immunity; interleukin-2; mice; animal models; aluminum; immune response; CD4-positive T-lymphocytes; immunostimulants; agonists; glycoproteins;     Show all 17 Subjects
Abstract:
... Lack of adequate cell-mediated immunity (CMI) to varicella-zoster virus (VZV) has been associated with higher risks of developing herpes zoster (HZ) and associated post-herpetic neuralgia (PHN), and is of particular concern for older and immunocompromised individuals. Thus, the development of an effective HZ vaccine with a clinically acceptable safety profile that is capable of addressing decrease ...
DOI:
10.1016/j.vaccine.2012.01.088

19. Biosafety aspects of modified vaccinia virus Ankara (MVA)-based vectors used for gene therapy or vaccination

Author:
Verheust, Céline; Goossens, Martine; Pauwels, Katia; Breyer, Didier
Source:
Vaccine 2012 v.30 no.16 pp. 2623-2632
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; Vaccinia virus; biosafety; environmental health; gene therapy; genes; genetically modified organisms; human health; humans; infectious diseases; neoplasms; recombinant vaccines; risk; vaccination; vaccine development;     Show all 15 Subjects
Abstract:
... The modified vaccinia virus Ankara (MVA) strain is a highly attenuated strain of vaccinia virus that has been demonstrated to be safe for humans. MVA is widely considered as the vaccinia virus strain of choice for clinical investigation because of its high safety profile. It also represents an excellent candidate for use as vector system in recombinant vaccine development for gene delivery or vacc ...
DOI:
10.1016/j.vaccine.2012.02.016

20. Antibody against Haemophilus influenzae protein D in patients with chronic conditions causing secondary immunodeficiency

Author:
Hawdon, N.; Biman, B.; McCready, W.; Brigden, M.; Malik, S.; Vergidis, D.; Kisselgoff, O.; Ulanova, M.
Source:
Vaccine 2012 v.30 no.7 pp. 1235-1238
ISSN:
0264-410X
Subject:
immunocompromised population,   etc   ; etiology; immunoglobulin G; Haemophilus influenzae; blood serum; antigens; renal failure; immunosuppression; vaccines; otitis media; pathogenesis; immunization; diabetes; patients; adult development; adults; protective effect;     Show all 17 Subjects
Abstract:
... Prevalence of non-typeable Haemophilus influenzae (NTHi) in the etiology of invasive infections in immunocompromised individuals is increasing. Serum IgG antibody levels to H. influenzae protein D (PD) were significantly lower in adults suffering from chronic conditions causing secondary immunodeficiency (COPD, cancer, chronic renal failure, and diabetes) compared to age-matched healthy controls. ...
DOI:
10.1016/j.vaccine.2011.12.113