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- Belshaw, Z.; Constantio-Casas, F.; Brearley, M.J.; Dunning, M.D.; Holmes, M.A.; Dobson, J.M.
- Veterinary and comparative oncology 2011 v.9 no.2 pp. 141-148
- carcinoma; dogs; immunohistochemistry; nose; prognosis; prostaglandin synthase; radiotherapy
- ... The expression of cyclooxygenase isoform 2 (COX-2) in canine nasal carcinomas has been well documented. COX-2 expression has proven to be a prognostic factor in several human tumours. The aims of this study were to assess the correlation between immunohistochemical COX-2 expression and prognosis using rhinoscopic biopsies from 42 dogs with nasal carcinomas treated with hypofractionated radiotherap ...
- Henson, M.S.; Curtsinger, J.M.; Larson, V.S.; Klausner, J.S.; Modiano, J.F.; Mescher, M.F.; Miller, J.S.
- Veterinary and comparative oncology 2011 v.9 no.2 pp. 95-105
- silica; lymphoma; drug therapy; hypersensitivity; antigens; humans; melanoma; dogs; cell-mediated immunity; carcinoma; immunotherapy; interleukin-2; excision; cell membranes; toxicity; colony-stimulating factors; cytotoxic T-lymphocytes; lymph nodes; B-lymphocytes
- ... Cytotoxic T-lymphocyte responses to subcellular antigens are enhanced when antigens are presented on cell-sized silica microbeads called large multivalent immunogens (LMIs). LMIs prepared with tumour cell membrane fragments have induced partial remissions in humans with melanoma and renal cell carcinoma. The purpose of this phase I study was to evaluate the safety of LMIs, prepared with autologous ...