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You searched for: Journal Veterinary and comparative oncology Remove constraint Journal: Veterinary and comparative oncology Source 2011 v.9 no.2 Remove constraint Source: 2011 v.9 no.2
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1. Comparison of examination of thoracic radiographs and thoracic computed tomography in dogs with appendicular osteosarcoma

Author:
Eberle, N.; Fork, M.; von Babo, V.; Nolte, I.; Simon, D.
Source:
Veterinary and comparative oncology 2011 v.9 no.2 pp. 131-140
ISSN:
1476-5810
Subject:
image analysis; retrospective studies; radiography; dog diseases; osteosarcoma; dogs; thoracic cavity; lungs; computed tomography; thorax
Abstract:
... Appendicular osteosarcoma (OSA) is a highly metastatic tumour in dogs. The aim of the study was to compare thoracic radiographs with thoracic computed tomography (CT) in the staging of canine appendicular OSA. In all, 39 canine patients histologically diagnosed with OSA were reviewed in the retrospective study. All dogs underwent radiographic examination as well as CT examination of the thoracic c ...
DOI:
10.1111/j.1476-5829.2010.00241.x
PubMed:
21569198

2. COX-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy*†

Author:
Belshaw, Z.; Constantio-Casas, F.; Brearley, M.J.; Dunning, M.D.; Holmes, M.A.; Dobson, J.M.
Source:
Veterinary and comparative oncology 2011 v.9 no.2 pp. 141-148
ISSN:
1476-5810
Subject:
carcinoma; dogs; immunohistochemistry; nose; prognosis; prostaglandin synthase; radiotherapy
Abstract:
... The expression of cyclooxygenase isoform 2 (COX-2) in canine nasal carcinomas has been well documented. COX-2 expression has proven to be a prognostic factor in several human tumours. The aims of this study were to assess the correlation between immunohistochemical COX-2 expression and prognosis using rhinoscopic biopsies from 42 dogs with nasal carcinomas treated with hypofractionated radiotherap ...
DOI:
10.1111/j.1476-5829.2010.00243.x
PubMed:
21569199

3. Epidermal growth factor receptor as a therapeutic target in veterinary oncology

Author:
Bergkvist, G.T.; Yool, D.A.
Source:
Veterinary and comparative oncology 2011 v.9 no.2 pp. 81-94
ISSN:
1476-5810
Subject:
animal diseases; biomarkers; cell proliferation; epidermal growth factor; mammary neoplasms (animal); prognosis; receptors; therapeutics; veterinary medicine
Abstract:
... Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that stimulates cell proliferation and survival and becomes dysregulated in a range of solid tumours in man. It is recognized as a key oncogenic driver and has become a favoured therapeutic target and a prognostic and predictive marker of cancer in man. In animals, EGFR dysregulation is emerging as a potential factor in the deve ...
DOI:
10.1111/j.1476-5829.2010.00237.x
PubMed:
21569194

4. Expression of epidermal growth factor receptor (EGFR) and Ki67 in feline oral squamous cell carcinomas (FOSCC)

Author:
Bergkvist, G.T.; Argyle, D.J.; Morrison, L.; MacIntyre, N.; Hayes, A.; Yool, D.A.
Source:
Veterinary and comparative oncology 2011 v.9 no.2 pp. 106-117
ISSN:
1476-5810
Subject:
biomarkers; biopsy; cats; cell proliferation; correlation; epidermal growth factor receptors; immunohistochemistry; screening
Abstract:
... The aims of this study were to establish expression of epidermal growth factor receptor (EGFR) and Ki67 in 67 archived biopsy samples of feline oral squamous cell carcinomas (FOSCCs) and to establish if the expression of either markers was predictive of survival. Samples were immunohistochemically labelled for the two proteins and scored. Statistical analyses of data, including Kaplan-Meier surviv ...
DOI:
10.1111/j.1476-5829.2010.00239.x
PubMed:
21569196

5. Immunotherapy with autologous tumour antigen-coated microbeads (large multivalent immunogen), IL-2 and GM-CSF in dogs with spontaneous B-cell lymphoma

Author:
Henson, M.S.; Curtsinger, J.M.; Larson, V.S.; Klausner, J.S.; Modiano, J.F.; Mescher, M.F.; Miller, J.S.
Source:
Veterinary and comparative oncology 2011 v.9 no.2 pp. 95-105
ISSN:
1476-5810
Subject:
silica; lymphoma; drug therapy; hypersensitivity; antigens; humans; melanoma; dogs; cell-mediated immunity; carcinoma; immunotherapy; interleukin-2; excision; cell membranes; toxicity; colony-stimulating factors; cytotoxic T-lymphocytes; lymph nodes; B-lymphocytes
Abstract:
... Cytotoxic T-lymphocyte responses to subcellular antigens are enhanced when antigens are presented on cell-sized silica microbeads called large multivalent immunogens (LMIs). LMIs prepared with tumour cell membrane fragments have induced partial remissions in humans with melanoma and renal cell carcinoma. The purpose of this phase I study was to evaluate the safety of LMIs, prepared with autologous ...
DOI:
10.1111/j.1476-5829.2010.00234.x
PubMed:
21569195

6. Induction of VEGF by tepoxalin does not lead to increased tumour growth in a canine osteosarcoma xenograft

Author:
Sottnik, J.L.; Hansen, R.J.; Gustafson, D.L.; Dow, S.W.; Thamm, D.H.
Source:
Veterinary and comparative oncology 2011 v.9 no.2 pp. 118-130
ISSN:
1476-5810
Subject:
analgesics; angiogenesis; cell growth; dogs; in vitro studies; osteosarcoma; vascular endothelial growth factors
Abstract:
... The purpose of this study was to determine the impact of the non-steroidal anti-inflammatory drug tepoxalin on canine tumour cell growth and describe the changes associated with tepoxalin treatment. In vitro experiments were performed to assess tepoxalin-associated alterations in tumour cell growth. Clinically achievable tepoxalin concentrations did not significantly alter tumour cell growth in vi ...
DOI:
10.1111/j.1476-5829.2010.00240.x
PubMed:
21569197

7. 5-Lipoxygenase expression in benign and malignant canine prostate tissues

Author:
Goodman, L.A.; Jarrett, C.L.; Krunkosky, T.M.; Budsberg, S.C.; Northrup, N.C.; Saba, C.F.; LeRoy, B.E.
Source:
Veterinary and comparative oncology 2011 v.9 no.2 pp. 149-157
ISSN:
1476-5810
Subject:
phenotype; humans; immunohistochemistry; dogs; metastasis; prostatitis; prostatic neoplasms; gene expression regulation; apoptosis; hyperplasia
Abstract:
... 5-Lipoxygenase (5-LO) is overexpressed in human prostate carcinomas (PCs), and its inhibition decreases proliferation and induces apoptosis in prostate cancer cell lines. We hypothesized that 5-LO would be overexpressed in canine PC compared with benign prostate tissue and may be important in the pathogenesis of the disease. Immunoblot analysis of canine PC and benign prostatic hyperplasia (BPH) t ...
DOI:
10.1111/j.1476-5829.2010.00245.x
PubMed:
21569200