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1. Cancer‐testis antigens in canine histiocytic sarcoma and other malignancies

Author:
Nemec, Paige S.; Kapatos, Alexander; Holmes, Jennifer C.; Stowe, Devorah M.; Hess, Paul R.
Source:
Veterinary and comparative oncology 2019 v.17 no.3 pp. 317-328
ISSN:
1476-5810
Subject:
CD8-positive T-lymphocytes; RNA; T-cell lymphoma; alleles; autoimmunity; biopsy; brain; dogs; epigenetics; epitopes; gametogenesis; gene overexpression; humans; immunotherapy; kidneys; mass spectrometry; peptides; proteins; reverse transcriptase polymerase chain reaction; risk; sarcoma; tissues
Abstract:
... Cancer‐testis antigens (CTAs) are a category of self proteins aberrantly expressed in diverse malignancies, mostly solid tumours, due to epigenetic de‐repression. Normally expressed only in fetal or gametogenic tissues, CTAs are tantalizing immunotherapy targets, since autoimmunity risks appear minimal. Few prevalent CTAs have been identified in human hematologic cancers, and just two in their vet ...
DOI:
10.1111/vco.12475

2. Cytology and the cell block method in diagnostic characterization of canine lymphadenopathy and in the immunophenotyping of nodal lymphoma

Author:
Heinrich, Daniel A.; Avery, Anne C.; Henson, Michael S.; Overmann, Jed A.; Rendahl, Aaron K.; Walz, Jillian Z.; Seelig, Davis M.
Source:
Veterinary and comparative oncology 2019 v.17 no.3 pp. 365-375
ISSN:
1476-5810
Subject:
B-cell lymphoma; T-cell lymphoma; antigens; biopsy; cell biology; disease diagnosis; dogs; flow cytometry; immunohistochemistry; immunophenotyping; lymph nodes; metastasis; patients; staining
Abstract:
... Minimally invasive techniques used to evaluate canine peripheral lymphadenopathy (PLN), including fine needle aspiration biopsy with cytological evaluation (FNAB‐C) and flow cytometry (FC), have benefits and limitations. The cell block (CB) method is an alternate processing technique in which fine needle aspirate biopsy samples are concentrated, fixed, and embedded in paraffin for routine histolog ...
DOI:
10.1111/vco.12484

3. Evaluation of information presented within soft tissue sarcoma histopathology reports in the United States: 2012‐2015

Author:
Livaccari, A. M.; Selmic, L. E.; Reagan, J. K.; Driskell, E. A.; Cray, M. T.; Lamoureux, L. M.; Garrett, L. D.
Source:
Veterinary and comparative oncology 2018 v.16 no.4 pp. 424-430
ISSN:
1476-5810
Subject:
animal pathology; biopsy; dogs; drug therapy; guidelines; histology; histopathology; patient care; patients; resection; retrospective studies; sarcoma; tissues; United States
Abstract:
... Despite the existence of the American College of Veterinary Pathology guidelines for tumour biopsy specimens, anecdotally the authors' have seen inconsistency of reporting of information on the pathology report for canine soft tissue sarcomas (STSs). If crucial aspects are not reported this can result in slower or impeded patient care. This retrospective study evaluated 255 STS histopathology repo ...
DOI:
10.1111/vco.12397

4. Diagnostic accuracy of pre‐treatment biopsy for grading cutaneous mast cell tumours in dogs

Author:
Shaw, T.; Kudnig, S. T.; Firestone, S. M.
Source:
Veterinary and comparative oncology 2018 v.16 no.2 pp. 214-219
ISSN:
1476-5810
Subject:
biopsy; dogs; education; histopathology; mast cells; metastasis; planning; skin neoplasms
Abstract:
... Mast cell tumours (MCTs) are common tumours of the canine skin, and are estimated to represent up to 20% of all skin tumours in dogs. Tumour grade has a major impact on the incidence of local recurrence and metastatic potential. In addition to helping the clinician with surgical planning, knowledge of the tumour grade also assists in proper prognostication and client education. For pre‐treatment b ...
DOI:
10.1111/vco.12346

5. Metastasis‐associated microRNA expression in canine uveal melanoma

Author:
Starkey, M. P.; Compston‐Garnett, L.; Malho, P.; Dunn, K.; Dubielzig, R.
Source:
Veterinary and comparative oncology 2018 v.16 no.1 pp. 81-89
ISSN:
1476-5810
Subject:
biopsy; dogs; gene expression regulation; humans; melanoma; metastasis; microRNA; microarray technology; prediction; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcription (genetics)
Abstract:
... BACKGROUND: Uveal melanoma (UM) is the most common primary intraocular tumour in dogs. There is no effective means of predicting whether a tumour will metastasize. microRNA (miRNA) metastasis signatures have been identified for several human cancers, including UM. AIMS: In this study we investigated whether metastasizing and non‐metastasizing canine UMs can be distinguished by miRNA expression lev ...
DOI:
10.1111/vco.12315

6. Clinical prognostic factors in canine histiocytic sarcoma

Author:
Dervisis, N. G.; Kiupel, M.; Qin, Q.; Cesario, L.
Source:
Veterinary and comparative oncology 2017 v.15 no.4 pp. 1171-1180
ISSN:
1476-5810
Subject:
Golden Retriever; Labrador Retriever; adrenal cortex hormones; biopsy; disease course; dogs; histopathology; immunohistochemistry; interviews; medical records; patients; sarcoma; veterinary clinics
Abstract:
... Canine histiocytic sarcoma (HS) is an aggressive neoplasia with variable clinical course and fatal outcome. The goals of this study were to evaluate a large cohort of canine patients with immunohistochemically confirmed HS and identify clinical prognostic factors. Biopsy submissions to the Michigan State University with tentative HS diagnoses were histologically and immunohistochemically confirmed ...
DOI:
10.1111/vco.12252

7. Intratumoural interleukin 12 gene therapy stimulates the immune system and decreases angiogenesis in dogs with spontaneous cancer

Author:
Cicchelero, L.; Denies, S.; Haers, H.; Vanderperren, K.; Stock, E.; Van Brantegem, L.; de Rooster, H.; Sanders, N. N.
Source:
Veterinary and comparative oncology 2017 v.15 no.4 pp. 1187-1205
ISSN:
1476-5810
Subject:
angiogenesis; antineoplastic activity; biopsy; blood flow; blood sampling; blood serum; blood volume; dogs; erythema; gene therapy; immunostimulants; interferon-gamma; interleukin-10; interleukin-12; leukocytes; metastasis; neoplasms; remission; ultrasonics; vascular endothelial growth factors
Abstract:
... Interleukin 12 (IL‐12) is a powerful immunostimulatory cytokine with a strong antitumoural activity. In this work, the immunological, anti‐angiogenic and clinical effects of three consecutive intratumoural IL‐12 electrogene therapy (EGT) treatments were evaluated in nine dogs with spontaneous cancer. In all the dogs, tumour biopsies and blood samples were taken prior, during and after the intratum ...
DOI:
10.1111/vco.12255

8. Pretreatment leukocyte ratios and concentrations as predictors of outcome in dogs with cutaneous mast cell tumours

Author:
Skor, O.; Fuchs‐Baumgartinger, A.; Tichy, A.; Kleiter, M.; Schwendenwein, I.
Source:
Veterinary and comparative oncology 2017 v.15 no.4 pp. 1333-1345
ISSN:
1476-5810
Subject:
biopsy; dogs; humans; mast cells; medical records; monocytes; neoplasms; neutrophils
Abstract:
... Leukocyte ratios correlate with outcome in several human cancers. Little is known about their prognostic significance in mast cell tumour (MCT). The aim of the study was to evaluate the prognostic significance of pretreatment leukocyte concentrations and their ratios in dogs with MCT for survival. Medical records of 92 dogs with MCT were retrospectively reviewed. Tumour diagnosis was made by tumou ...
DOI:
10.1111/vco.12274

9. Bilateral removal of the mandibular and medial retropharyngeal lymph nodes through a single ventral midline incision for staging of head and neck cancers in dogs: a description of surgical technique

Author:
Green, K.; Boston, S. E.
Source:
Veterinary and comparative oncology 2017 v.15 no.1 pp. 208-214
ISSN:
1476-5810
Subject:
biopsy; cell biology; dogs; head; head and neck neoplasms; histopathology; lymph nodes; neck; salivary glands
Abstract:
... Currently, there is no standard protocol for removal of regional lymph nodes for the staging of head and neck cancers in dogs. Palpation and fine needle aspiration of mandibular lymph nodes are most commonly performed for staging of head and neck cancers. Although cytology is commonly performed for staging of head and neck, cancers histopathology is required for definitive lymph node staging. When ...
DOI:
10.1111/vco.12154

10. Anti‐tumour activity of oncolytic Western Reserve vaccinia viruses in canine tumour cell lines, xenografts, and fresh tumour biopsies

Author:
Autio, K.; Knuuttila, A.; Kipar, A.; Ahonen, M.; Parviainen, S.; Diaconu, I.; Kanerva, A.; Hakonen, T.; Vähä‐Koskela, M.; Hemminki, A.
Source:
Veterinary and comparative oncology 2016 v.14 no.4 pp. 395-408
ISSN:
1476-5810
Subject:
Vaccinia virus; antineoplastic activity; biopsy; cell lines; cell viability; colorimetry; death; dogs; fluorescence; genetic markers; luciferase; mice; models; neoplasm cells; neoplasms; patients; tissues; viability assays
Abstract:
... Cancer is one of the most common reasons for death in dogs. One promising approach is oncolytic virotherapy. We assessed the oncolytic effect of genetically modified vaccinia viruses in canine cancer cells, in freshly excised tumour biopsies, and in mice harbouring canine tumour xenografts. Tumour transduction efficacy was assessed using virus expressing luciferase or fluorescent marker genes and ...
DOI:
10.1111/vco.12119

11. The use of flow cytometry for immunophenotyping lymphoproliferative disorders in cats: a retrospective study of 19 cases

Author:
Guzera, M.; Cian, F.; Leo, C.; Winnicka, A.; Archer, J.
Source:
Veterinary and comparative oncology 2016 v.14 Suppl S1 pp. 40-51
ISSN:
1476-5810
Subject:
biopsy; cats; flow cytometry; humans; lymphoma; retrospective studies; veterinary medicine
Abstract:
... Flow cytometric immunophenotyping is a useful step in the diagnosis of lymphoproliferative malignancies in human and veterinary medicine. The purpose of this study was to assess the usefulness of this technique for the diagnosis of lymphoproliferative disorders in cats. Nineteen cats were retrospectively enrolled in this study and allocated into two groups. Group 1 consisted of 13 cats with lympho ...
DOI:
10.1111/vco.12098

12. Lymphangiosarcoma in 12 dogs: a case series (1998–2013)

Author:
Curran, K. M.; Halsey, C. H. C.; Worley, D. R.
Source:
Veterinary and comparative oncology 2016 v.14 no.2 pp. 181-190
ISSN:
1476-5810
Subject:
biopsy; cell biology; dogs; drug therapy; endothelium; histopathology; inflammation; neoplasms; prednisone
Abstract:
... Lymphangiosarcoma (LAS) is an uncommon malignant neoplasia arising from lymphatic endothelium; little information exists regarding therapy. Single institutional retrospective review for canine LAS histopathology diagnoses over a 15‐year period yielded 12 dogs. Ten dogs were presented for a mass and/or swelling at cervical, trunk or limb regions. Prior to diagnosis, 10 dogs received empiric wound t ...
DOI:
10.1111/vco.12087

13. Canine transmissible venereal tumour: a review

Author:
Ganguly, B.; Das, U.; Das, A. K.
Source:
Veterinary and comparative oncology 2016 v.14 no.1 pp. 1-12
ISSN:
1476-5810
Subject:
allografting; biopsy; contraception; dogs; intravenous injection; neoplasm cells; neoplasms; sulfates; vincristine
Abstract:
... Canine transmissible venereal tumour (CTVT) is a contagious venereal tumour of dogs, commonly observed in dogs that are in close contact with one another, or in stray and wild dogs that exhibit unrestrained sexual activity. CTVT represents a unique, naturally transmissible, contagious tumour, where the mutated tumour cell itself is the causative agent and perpetuates as a parasitic allograft in th ...
DOI:
10.1111/vco.12060

14. Detection of comorbidities and synchronous primary tumours via thoracic radiography and abdominal ultrasonography and their influence on treatment outcome in dogs with soft tissue sarcomas, primary brain tumours and intranasal tumours

Author:
Bigio Marcello, A.; Gieger, T. L.; Jiménez, D. A.; Granger, L. Abbigail
Source:
Veterinary and comparative oncology 2015 v.13 no.4 pp. 433-442
ISSN:
1476-5810
Subject:
biopsy; brain; cell biology; comorbidity; dogs; image analysis; metastasis; radiography; radiotherapy; sarcoma; ultrasonics; ultrasonography
Abstract:
... Canine soft tissue sarcomas (STS), primary brain tumours and intranasal tumours are commonly treated with radiotherapy (RT). Given the low metastatic potential of these tumours, recommendations regarding imaging tests as staging are variable among institutions. The purpose of our study was to describe thoracic radiographic and abdominal ultrasonographic findings in dogs with these neoplasms and to ...
DOI:
10.1111/vco.12063

15. Selection of suitable reference genes for normalization of genes of interest in canine soft tissue sarcomas using quantitative real‐time polymerase chain reaction

Author:
Zornhagen, K. W.; Kristensen, A. T.; Hansen, A. E.; Oxboel, J.; Kjær, A.
Source:
Veterinary and comparative oncology 2015 v.13 no.4 pp. 485-493
ISSN:
1476-5810
Subject:
algorithms; beta-glucuronidase; biopsy; dogs; gene expression; genes; proteasome endopeptidase complex; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; sarcoma
Abstract:
... Quantitative real‐time reverse transcription polymerase chain reaction (RT‐qPCR) is a sensitive technique for quantifying gene expression. Stably expressed reference genes are necessary for normalization of RT‐qPCR data. Only a few articles have been published on reference genes in canine tumours. The objective of this study was to demonstrate how to identify suitable reference genes for normaliza ...
DOI:
10.1111/vco.12108

16. Diagnostic accuracy of pre‐treatment biopsy for grading soft tissue sarcomas in dogs

Author:
Perry, J. A.; Culp, W. T. N.; Dailey, D. D.; Eickhoff, J. C.; Kamstock, D. A.; Thamm, D. H.
Source:
Veterinary and comparative oncology 2014 v.12 no.2 pp. 106-113
ISSN:
1476-5810
Subject:
biopsy; dogs; metastasis; sarcoma
Abstract:
... Histologic grade is an important prognostic factor for both local recurrence and metastatic potential with canine soft tissue sarcoma (STS). Pre‐treatment biopsy with identification of tumour grade may aid in prognostication and determination of surgical margins necessary for local control. The purpose of this study was to evaluate the grading accuracy of various pre‐treatment biopsy techniques (w ...
DOI:
10.1111/j.1476-5829.2012.00333.x

17. Angiofibroma of the nasal cavity in 13 dogs

Author:
Burgess, K. E.; Green, E. M.; Wood, R. D.; Dubielzig, R. R.
Source:
Veterinary and comparative oncology 2011 v.9 no.4 pp. 304-309
ISSN:
1476-5810
Subject:
biopsy; dogs; histopathology; inflammation; nasal cavity; radiography
Abstract:
... This case series describes a rare entity, nasal angiofibroma, in 13 dogs that were presented to the University of Wisconsin, School of Veterinary Medicine from 1988 to 2000. All dogs in this case series presented with clinical signs and radiographic changes that were strongly suggestive of a locally invasive neoplasm. However, histopathology completed on transnostral core biopsy samples revealed b ...
DOI:
10.1111/j.1476-5829.2011.00278.x
PubMed:
22077412

18. Expression of epidermal growth factor receptor (EGFR) and Ki67 in feline oral squamous cell carcinomas (FOSCC)

Author:
Bergkvist, G.T.; Argyle, D.J.; Morrison, L.; MacIntyre, N.; Hayes, A.; Yool, D.A.
Source:
Veterinary and comparative oncology 2011 v.9 no.2 pp. 106-117
ISSN:
1476-5810
Subject:
biomarkers; biopsy; cats; cell proliferation; correlation; epidermal growth factor receptors; immunohistochemistry; screening
Abstract:
... The aims of this study were to establish expression of epidermal growth factor receptor (EGFR) and Ki67 in 67 archived biopsy samples of feline oral squamous cell carcinomas (FOSCCs) and to establish if the expression of either markers was predictive of survival. Samples were immunohistochemically labelled for the two proteins and scored. Statistical analyses of data, including Kaplan-Meier surviv ...
DOI:
10.1111/j.1476-5829.2010.00239.x
PubMed:
21569196

19. Using lymph node fine needle aspirates for gene expression profiling of canine lymphoma

Author:
Starkey, M.P.; Murphy, S.
Source:
Veterinary and comparative oncology 2010 v.8 no.1 pp. 56-71
ISSN:
1476-5810
Subject:
dogs; lymphoma; dog diseases; lymph nodes; gene expression; classification; phenotype; assays; biopsy; lymphocytes
Abstract:
... Conventional classification schemes for canine lymphomas do not discriminate between phenotypically indistinct tumours that may exhibit differences in behaviour. Transcriptional profiling has the potential to afford objective clinically relevant stratification of canine lymphomas, and its sensitivity means that prognostic assays could be performed on tumour needle aspirates collected without anaes ...
DOI:
10.1111/j.1476-5829.2009.00205.x
PubMed:
20230582

20. Telomerase activity and telomerase reverse transcriptase catalytic subunit expression in canine lymphoma: correlation with Ki67 immunoreactivity

Author:
Renwick, M.G.; Argyle, D.J.; Long, S.; Nixon, C.; Gault, E.A.; Nasir, L.
Source:
Veterinary and comparative oncology 2006 v.4 no.3 pp. 141-150
ISSN:
1476-5810
Subject:
carcinogenesis; messenger RNA; lymphoma; telomeres; immunohistochemistry; dog diseases; dogs; telomerase; biopsy; enzyme activity; lymph nodes
Abstract:
... Increased telomerase activity (TA) has been found in human and canine solid tumours, stem cells and somatic tissues with enhanced proliferative potential. The relationship between TA in normal and malignant lymphoid tissues remains unclear. The TA and the expression of canine telomerase reverse transcriptase catalytic subunit (dogTERT) messenger RNA (mRNA) were analyzed in malignant lymph nodes fr ...
DOI:
10.1111/j.1476-5829.2006.00103.x
PubMed:
19754811