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Veterinary immunology and immunopathology
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2002
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- Author:
- Baldwin, C.L.; Sathiyaseelan, T.; Naiman, B.; White, A.M.; Brown, R.; Blumerman, S.; Rogers, A.; Black, S.J.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 251-259
- ISSN:
- 0165-2427
- Subject:
- CD4-positive T-lymphocytes; cattle; cell division; concanavalin A; flow cytometry; interferon-gamma; interleukin-12; monoclonal antibodies; monocytes; vaccines
- Abstract:
- ... Bovine peripheral blood γδ T cells have been evaluated for effector function (IFN-γ production) and clonal expansion in a variety of systems including following activation by mitogens, IL-12, and stimulation, through the T cell receptor (TCR) with anti-CD3 monoclonal antibody (mAb), a cell-bound molecule and a soluble antigenic extract. To evaluate cell division, carboxyfluorescein succinimidyl es ...
- DOI:
- 10.1016/S0165-2427(02)00091-0
- https://doi.org/10.1016/S0165-2427(02)00091-0
- Author:
- Zemann, B.; Griot-Wenk, M.; Marti, E.; Mayer, P.; Eder, C.; Nefzger, M.; Schneider, H.; Weck, A. de; Liehl, E.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 373-378
- ISSN:
- 0165-2427
- Subject:
- Beagle; antibodies; blood serum; compliance; detection limit; dogs; eosinophilia; hypersensitivity; immunoglobulin E; lungs; models; ovalbumin
- Abstract:
- ... Allergen-specific serum IgE may be insensitive as a marker for IgE-mediated reactions at the mucosal level. Five of six atopic beagle dogs developed high ovalbumin (OVA)-specific serum IgE levels after sensitization. This study aimed to show that these dogs still express allergen-specific IgE at the pulmonary and ocular mucosal levels and in the skin even when corresponding serum IgE was below the ...
- DOI:
- 10.1016/S0165-2427(02)00071-5
- https://doi.org/10.1016/S0165-2427(02)00071-5
- Author:
- Madsen, Sally A.; Weber, Patty S.D.; Burton, Jeanne L.
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 159-175
- ISSN:
- 0165-2427
- Subject:
- DNA-binding proteins; Northern blotting; animal health; blood serum; complementary DNA; cytochrome b; dairy cows; estradiol; gene expression; gene expression regulation; genes; immune response; mastitis; messenger RNA; metabolism; neutrophils; nucleic acid hybridization; nucleotide sequences; parturition; progesterone; radioimmunoassays; reverse transcriptase polymerase chain reaction; screening; sequence homology; steroid hormones; tricarboxylic acid cycle
- Abstract:
- ... The periparturient dairy cow undergoes a plethora of physiological changes, including changes in the immune system that lead to profound effects on animal health. Of the immune cells affected at parturition, the neutrophil has been of particular interest due to its primary role in innate immune defense against mastitis. Immune functions of bovine neutrophils are known to be depressed around partur ...
- DOI:
- 10.1016/S0165-2427(02)00020-X
- https://doi.org/10.1016/S0165-2427(02)00020-X
- Author:
- Collen, T.; Carr, V.; Parsons, K.; Charleston, B.; Morrison, W.I.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 235-238
- ISSN:
- 0165-2427
- Subject:
- epitopes; recombinant antigens; alleles; synthetic peptides; Hepatitis C virus; cattle; cell-mediated immunity; Bovine viral diarrhea virus 1; CD4-positive T-lymphocytes; homozygosity; glycoproteins; CD8-positive T-lymphocytes
- Abstract:
- ... Cell-mediated immunity and CD4+ cells in particular are important for the resolution of acute infection with non-cytopathic bovine viral diarrhoea virus (BVDV). CD4+ T cells were shown to recognise virus-infected and non-infectious-protein-pulsed APCs, whereas CD8+ T cells recognised only virus-infected APCs. T cell recognition was strain cross-reactive and MHC-restricted. Using native and recombi ...
- DOI:
- 10.1016/S0165-2427(02)00088-0
- https://doi.org/10.1016/S0165-2427(02)00088-0
- Author:
- Corbeil, L.B.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 169-175
- ISSN:
- 0165-2427
- Subject:
- antibodies; antigens; autoimmune diseases; cattle; pathogens
- Abstract:
- ... Antibodies are critical in protection against extracellular microbial pathogens. Although antibodies also play a role in transplant/tumor rejection and in autoimmune disease, this paper focuses on defense against bovine infections. Effector mechanisms of different bovine isotypes, subisotypes and allotypes are discussed. The importance of antigen specificity is also stressed. ...
- DOI:
- 10.1016/S0165-2427(02)00048-X
- https://doi.org/10.1016/S0165-2427(02)00048-X
- Author:
- Schijns, Virgil E.J.C.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 195-198
- ISSN:
- 0165-2427
- Subject:
- T-lymphocytes; antibodies; antigens; cytokines; immune response; lymph nodes; microorganisms; pathogens; vaccination; vaccine adjuvants; vaccine development; vaccines; virulence
- Abstract:
- ... The immune system evolved to free the host from invading noxious pathogens. Vaccines are inoculated as a prophylactic measure in order to program the immune system for accelerated recognition and elimination of specific pathogens. During vaccination the immune system is exposed to attenuated or inactivated microorganisms, or their fragments. The immune response to these structures, in contrast to ...
- DOI:
- 10.1016/S0165-2427(02)00072-7
- https://doi.org/10.1016/S0165-2427(02)00072-7
- Author:
- Šinkora, Marek; Šinkorova, Jana; Butler, John E.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 341-346
- ISSN:
- 0165-2427
- Subject:
- B-lymphocytes; bone marrow; flow cytometry; liver; ontogeny; phenotype; pregnancy; swine; yolk sac
- Abstract:
- ... Hematopoietic activity of the swine has been documented in three phases during fetal ontogeny. The hematopoietic system develops first in the yolk sac, then in fetal liver and finally in the bone marrow. Using flow cytometry (FCM) and molecular biological techniques we show that B-cell lymphogenesis and the appearance of B cells follows a pattern. First, VDJ rearrangement occurs at the 20th day of ...
- DOI:
- 10.1016/S0165-2427(02)00062-4
- https://doi.org/10.1016/S0165-2427(02)00062-4
- Author:
- Ratcliffe, Michael J.H.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 337-340
- ISSN:
- 0165-2427
- Subject:
- B-lymphocytes; bone marrow; bursa of Fabricius; chickens; embryogenesis; ileum; immunoglobulins; rodents; sheep; skeletal development
- Abstract:
- ... B lymphocyte development can occur in a variety of anatomical sites. While typically considered to be a process that occurs in the bone marrow throughout life, it is becoming clear that gut associates sites of B cell development are critically important in many species of veterinary importance. Among these sites, the bursa of Fabricius in chickens and the ileal Peyer’s patches of sheep are among t ...
- DOI:
- 10.1016/S0165-2427(02)00061-2
- https://doi.org/10.1016/S0165-2427(02)00061-2
- Author:
- Coussens, Paul M.; Nobis, William
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 229-244
- ISSN:
- 0165-2427
- Subject:
- infectious diseases; concanavalin A; complementary DNA; humans; microarray technology; cattle; bioinformatics; expressed sequence tags; reverse transcriptase polymerase chain reaction; gene expression; mice; pets; immune response; mononuclear leukocytes; RNA
- Abstract:
- ... The advent of technologies such as real-time reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA microarrays herald a new era in the study of biological systems. In immunobiology, these advances have begun to impact studies of infectious diseases, inflammatory processes, and immune cell function. However, a lack of genetic reagents for domestic and companion animals has precluded wid ...
- DOI:
- 10.1016/S0165-2427(02)00005-3
- https://doi.org/10.1016/S0165-2427(02)00005-3
- Author:
- Appleyard, G.D.; Furesz, S.E.; Wilkie, B.N.
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 221-228
- ISSN:
- 0165-2427
- Subject:
- Actinobacillus pleuropneumoniae; B-lymphocytes; CD4-positive T-lymphocytes; aerosols; antibodies; antigens; immunization; immunoglobulin M; phenotype; primary contact; secondary contact; swine
- Abstract:
- ... Actinobacillus pleuropneumoniae bacterins do not induce protection in pigs while infection with low doses of the CM5 strain of A. pleuropneumoniae given by aerosol induces complete protection. To evaluate possible correlates of protection in blood lymphocyte subset phenotypes, pigs were treated with a commercial bacterin given intramuscularly, low dose (10(5) cfu/ml) aerosol infection with CM5 or ...
- DOI:
- 10.1016/S0165-2427(02)00002-8
- https://doi.org/10.1016/S0165-2427(02)00002-8
- Author:
- DeMaula, Christopher D.; Leutenegger, Christian M.; Jutila, Mark A.; MacLachlan, N. James
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 147-157
- ISSN:
- 0165-2427
- Subject:
- Bluetongue virus; apoptosis; blood coagulation; bluetongue; cattle; endothelial cells; genes; inducible nitric oxide synthase; interleukin-1; interleukin-6; interleukin-8; messenger RNA; pathogenesis; prostaglandin synthase; quantitative polymerase chain reaction; sheep
- Abstract:
- ... Bluetongue is an insect-transmitted viral disease of sheep and some species of wild ruminants. Infection of lung microvascular endothelial cells (ECs) is central to the pathogenesis of bluetongue virus (BTV) infection of ruminants, but it is uncertain as to why cattle are resistant to BTV-induced microvascular injury and bluetongue disease. Thus, in order to better understand the pathogenesis of B ...
- DOI:
- 10.1016/S0165-2427(02)00012-0
- https://doi.org/10.1016/S0165-2427(02)00012-0
- Author:
- Li, Fang; Zhang, Xiaobei; Mizzi, Chris; Gordon, John R.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 65-77
- ISSN:
- 0165-2427
- Subject:
- CXCR1 receptor; CXCR2 receptor; antagonists; bacterial pneumonia; cattle; chemoattractants; chemotaxis; endotoxins; inflammation; interleukin-8; mastitis; neutrophils; pasteurellosis
- Abstract:
- ... The ELR+ CXC chemokines are critical for protective neutrophil responses to most bacterial infections, but nevertheless can contribute importantly to the pathogenic effects of many inflammatory responses. We recently engineered a series of high affinity CXCL8/IL-8 antagonists, one of which, CXCL8(3–73)K11R/G31P, binds very strongly to neutrophils via the CXCR1 and CXCR2. Herein we show in competit ...
- DOI:
- 10.1016/S0165-2427(02)00223-4
- https://doi.org/10.1016/S0165-2427(02)00223-4
- Author:
- Lamont, S.J.; Kaiser, M.G.; Liu, W.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 423-428
- ISSN:
- 0165-2427
- Subject:
- Salmonella Enteritidis; alleles; animal production; antibodies; backcrossing; chickens; chicks; disease resistance; esophagus; exposure pathways; food safety; gene interaction; heterozygosity; inbred lines; microsatellite repeats; mucosal immunity; salmonellosis; sires; spleen; vaccines; zoonoses; Iowa
- Abstract:
- ... Salmonellosis is a zoonotic disease that is problematic for both animal production and food safety. A novel genetic cross, named the Iowa Salmonella response resource population (ISRRP), was established to elucidate the genetic control of resistance to Salmonella enteritidis (SE) colonization in young chicks, to characterize unique resistance alleles, and to estimate gene interaction effects. Outb ...
- DOI:
- 10.1016/S0165-2427(02)00064-8
- https://doi.org/10.1016/S0165-2427(02)00064-8
- Author:
- Sedgmen, Bradley J.; Lofthouse, Shari A.; Scheerlinck, Jean-Pierre Y.; Meeusen, Els N.T.
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 215-220
- ISSN:
- 0165-2427
- Subject:
- interleukin-2; interleukin-4; interleukin-8; messenger RNA; mucosa; phenotype; plasma cells; reverse transcriptase polymerase chain reaction; sheep; transforming growth factor beta; vaccines
- Abstract:
- ... Immunohistological characterisation of ovine rectal tissue has revealed the presence of lymphoid follicles, predominantly in the submucosa, that closely resemble those found in intestinal Peyer’s patches (PPs). Distinct T (CD4+, CD8+, γδ-TCR+) and B (CD21+, CD45R+) lymphocyte staining patterns were observed within and around follicles of the rectal mucosa. In addition, IgA+ and IgE+ cells were als ...
- DOI:
- 10.1016/S0165-2427(02)00011-9
- https://doi.org/10.1016/S0165-2427(02)00011-9
- Author:
- Salguero, F.J.; Ruiz-Villamor, E.; Bautista, M.J.; Sánchez-Cordón, P.J.; Carrasco, L.; Gómez-Villamandos, J.C.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 11-22
- ISSN:
- 0165-2427
- Subject:
- African swine fever; apoptosis; blood serum; immunohistochemistry; interleukin-1beta; lymph nodes; lymphocytes; macrophages; pathogenesis; piglets; space and time; spleen; tumor necrosis factor-alpha; virulence; viruses
- Abstract:
- ... To gain further insight into the pathogenesis of African swine fever (ASF), the cytokine expression by macrophages in spleen and lymph nodes were examined. Twenty-one piglets were inoculated with the highly virulent isolate Spain-70 of ASF virus and killed in groups at 1–7 post-inoculation days (pid). An increase in the immunohistochemical detection of proinflammatory monokines in spleen and renal ...
- DOI:
- 10.1016/S0165-2427(02)00225-8
- https://doi.org/10.1016/S0165-2427(02)00225-8
- Author:
- Salles, M.W.S.; Perez-Casal, J.; Willson, P.; Middleton, D.M.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.1-2 pp. 51-63
- ISSN:
- 0165-2427
- Subject:
- Streptococcus suis; T-lymphocytes; arthritis; epithelial cells; epithelium; innate immunity; macrophages; major histocompatibility complex; meningitis; monoclonal antibodies; neutrophils; pathogenesis; pathogens; septicemia; swine; tonsils; vaccination
- Abstract:
- ... The tonsils are portal of entry and a site of multiplication and persistence for a variety of pathogens, including Streptococcus suis (S. suis), which is a common cause of meningitis, septicemia and arthritis in pigs. Understanding the early changes that occur in the first barrier of the tonsil, i.e. the crypt epithelium, in response to S. suis infection is critical in clarifying the pathogenesis ...
- DOI:
- 10.1016/S0165-2427(02)00040-5
- https://doi.org/10.1016/S0165-2427(02)00040-5
- Author:
- Van Diemen, P.M.; Kreukniet, M.B.; Galina, L.; Bumstead, N.; Wallis, T.S.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.3-4 pp. 183-196
- ISSN:
- 0165-2427
- Subject:
- Salmonella enterica; antibodies; boars; breeding; genes; liver; lymphocytes; neutrophils; piglets; progeny; salmonellosis; spleen; survival rate
- Abstract:
- ... The degree of resistance to Salmonella choleraesuis infection in a reference family purposely bred to map resistance genes was assessed. Aspects of the innate and specific immune system were studied to find a parameter that might predict the resistance of pigs to salmonellosis. The family was bred from commercial full-sister pairs of F1-gilts and four boars. One boar (G398) was identified as breed ...
- DOI:
- 10.1016/S0165-2427(02)00165-4
- https://doi.org/10.1016/S0165-2427(02)00165-4
- Author:
- Rawson, Renee R.; Belov, Katherine; Gidley-Baird, A. Angus; Cooper, Desmond W.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.1-2 pp. 89-95
- ISSN:
- 0165-2427
- Subject:
- Macropus eugenii; Macropus giganteus; Phascolarctos cinereus; Trichosurus vulpecula; Western blotting; antiserum; blood serum; cross reaction; enzyme-linked immunosorbent assay; immunoglobulin A; immunoglobulin G; mucosal immunity; possums; recombinant proteins
- Abstract:
- ... One of the limiting factors in understanding immune responses in marsupials is the scarcity of marsupial specific immunological reagents. This paper describes the characterisation of an antiserum raised against a recombinant protein of the constant region of the heavy chain of IgA (Cα) of the common brushtail possum (Trichosurus vulpecula). The availability of a marsupial specific anti-IgA provide ...
- DOI:
- 10.1016/S0165-2427(02)00126-5
- https://doi.org/10.1016/S0165-2427(02)00126-5
- Author:
- Bautista, Elida M.; Gregg, Douglas; Golde, William T.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.3-4 pp. 131-148
- ISSN:
- 0165-2427
- Subject:
- antigens; dendritic cells; endocytosis; explants; functional properties; immune response; lymphocytes; macrophages; models; monocytes; polystyrenes; swine
- Abstract:
- ... A low-density cell population was isolated from skin explants of pigs and characterized as a highly enriched dendritic cell (DC) population based on phenotypical and functional properties. The skin-derived DCs were identified by their characteristic ultrastructural properties as well as by consistent co-expression of the CD1 and SWC3a antigens that clearly differentiate them from other porcine leu ...
- DOI:
- 10.1016/S0165-2427(02)00152-6
- https://doi.org/10.1016/S0165-2427(02)00152-6
- Author:
- Bautista, E.M.; Gregg, D.; Golde, W.T.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.3-4 pp. 131-148
- Subject:
- antigens; dendritic cells; cell culture; explants; major histocompatibility complex; immune response; swine
- Abstract:
- ... A low-density cell population was isolated from skin explants of pigs and characterized as a highly enriched dendritic cell (DC) population based on phenotypical and functional properties. The skin-derived DCs were identified by their characteristic ultrastructural properties as well as by consistent co-expression of the CD1 and SWC3a antigens that clearly differentiate them from other porcine leu ...
- Handle:
- 10113/40922
- Author:
- Dorn, A.D.; Waters, W.R.; Byers, V.M.; Pesch, B.A.; Wannemuehler, M.J.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.1-2 pp. 1-10
- ISSN:
- 0165-2427
- Subject:
- Phytolacca americana; antigens; cell membranes; concanavalin A; flow cytometry; fluorescence; lymphocyte proliferation; lymphocytes; phytohemagglutinin; swine
- Abstract:
- ... Stimulation of lymphocyte proliferation using mitogens or specific antigens is a method that is used frequently to assess immune responsiveness. While useful, lymphocyte blastogenesis, or [3H]-thymidine incorporation, provides little information regarding the response of specific subsets to the stimulant. Here, we report that the fluorescent cell membrane probe, PKH2, is a useful tool for measurin ...
- DOI:
- 10.1016/S0165-2427(02)00022-3
- https://doi.org/10.1016/S0165-2427(02)00022-3
- Author:
- Gangur, Venu; Birmingham, Neil P.; Thanesvorakul, Sirinart
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 127-136
- ISSN:
- 0165-2427
- Subject:
- antagonists; anti-inflammatory agents; arthritis; cattle; chemokine CCL2; chemokine CXCL10; chemokine receptors; dogs; encephalitis; endotoxemia; goats; horses; humans; interleukin-8; luteolysis; mastitis; mice; monocytes; neutrophils; pathogens; pathophysiology; sheep; viruses
- Abstract:
- ... Chemokines belong to a large family of structurally related proteins that play a pivotal role in immune system development and deployment. While a large number of chemokines (∼50) and their receptors (∼20) have been identified from humans or mice, only a few are known in domestic veterinary species. Recent data implicate CXCL8 (old name, IL-8), CXCL10 (old name, IP-10) (both CXC chemokines) and CC ...
- DOI:
- 10.1016/S0165-2427(02)00018-1
- https://doi.org/10.1016/S0165-2427(02)00018-1
- Author:
- Zawitkowski, Madelyn; Russ, Graeme; Krishnan, Ravi
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.1-2 pp. 37-45
- ISSN:
- 0165-2427
- Subject:
- Chinese hamsters; T-lymphocytes; animal ovaries; antigens; bioactive properties; cattle; complementary DNA; cysteine; dendritic cells; drainage; fibroblasts; glycosylation; green fluorescent protein; humans; messenger RNA; mice; monoclonal antibodies; precipitin tests; reverse transcriptase polymerase chain reaction; sheep; transfection
- Abstract:
- ... The CD40 molecule is a member of the tumour necrosis factor receptor (TNFR)-like supergene family and plays a major role as a co-stimulatory molecule in the activation of T cells in response to antigens presented by dendritic cells. In this study, reverse transcription–PCR cloning was used to derive the sequence encoding ovine CD40. The ovine CD40 sequence demonstrated a similarity of 97, 76 and 6 ...
- DOI:
- 10.1016/S0165-2427(02)00182-4
- https://doi.org/10.1016/S0165-2427(02)00182-4
- Author:
- Ahn, J.S.; Hamilton, M.J.; Davis, W.C.; Park, Y.H.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.1-2 pp. 43-48
- ISSN:
- 0165-2427
- Subject:
- amino acid sequences; antigens; casein; cattle; complementary DNA; humans; lectins; lymphocytes; mice; nucleotide sequences; phosphorylation; sequence analysis
- Abstract:
- ... CD69 is rapidly inducible on various hematopoietic cells upon stimulation and is detectable as an early activation antigen. Although CD69 is well characterized in human and mouse, no information is available on bovine CD69. We report here that, bovine CD69 was cloned from a cDNA expression library prepared from activated peripheral blood lymphocytes. The full-length cDNA contained an 80 bp 5′ untr ...
- DOI:
- 10.1016/S0165-2427(02)00125-3
- https://doi.org/10.1016/S0165-2427(02)00125-3
- Author:
- Wonderling, Ramani; Powell, Tim; Baldwin, Susan; Morales,Tony; Snyder, Scott; Keiser, Kathy; Hunter, Shirley; Best, Elaine; McDermott, Martin J.; Milhausen, Michael
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.1-2 pp. 13-27
- ISSN:
- 0165-2427
- Subject:
- sequence analysis; interferon-alpha; antiviral properties; Komagataella pastoris; complementary DNA; cats; cell culture; glycosylation; humans; recombinant proteins; yeasts; Western blotting; amino acid sequences; amino acids; clones; genes; viruses; immune response
- Abstract:
- ... Type I interferons (IFN) are important mediators of the host defense against viral infections in mammals. In humans multiple subtypes of IFN-α exist, most of which possess antiviral activity. Little is known about the type I IFN genes in cats and the role they may play in feline immunological responses to viruses. We have isolated cDNAs encoding five feline IFN-α (feIFN) subtypes that share from 9 ...
- DOI:
- 10.1016/S0165-2427(02)00188-5
- https://doi.org/10.1016/S0165-2427(02)00188-5
- Author:
- Howard, C.J.; Hope, J.C.; Stephens, S.A.; Gliddon, D.R.; Brooke, G.P.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 123-130
- ISSN:
- 0165-2427
- Subject:
- CD8-positive T-lymphocytes; antigen presentation; cattle; chemokines; crosslinking; dendritic cells; enzyme activity; humans; immune response; interleukin-10; interleukin-12; interleukin-1alpha; long term effects; lymph; models; rodents; secretion; tumor necrosis factor-alpha; tyrosine
- Abstract:
- ... As a consequence of the central role of dendritic cells (DC) in stimulating primary immune responses any bias in the response introduced by the DC has the potential for having a long-term effect on immunity. Examination and analysis of ruminant afferent lymph dendritic cells derived by cannulation allows studies on the properties of ex vivo DC that is not possible in humans and rodents and informa ...
- DOI:
- 10.1016/S0165-2427(02)00043-0
- https://doi.org/10.1016/S0165-2427(02)00043-0
- Author:
- Santos-Gomes, Gabriela M; Rosa, Ricardo; Leandro, Clara; Cortes, Sofia; Romao, Pedro; Silveira, Henrique
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.1-2 pp. 21-30
- ISSN:
- 0165-2427
- Subject:
- Beagle; Leishmania infantum; amastigotes; antibodies; blood serum; bone marrow; concanavalin A; cultured cells; disease control; disease severity; dogs; humoral immunity; interferon-gamma; interleukin-10; interleukin-12; interleukin-2; interleukin-6; lymph nodes; messenger RNA; mononuclear leukocytes; parasites
- Abstract:
- ... In this study, the cytokines, interferon-gamma (IFN-γ), interleukin-2 (IL-2), IL-12 p40, IL-6 and IL-10, expressed by peripheral blood mononuclear cells of 13 beagle dogs inoculated with Leishmania infantum amastigotes, were analysed during a period of up to 23 months. The course of infection was monitored through clinical and parasitological examinations, haematological alterations and serum anti ...
- DOI:
- 10.1016/S0165-2427(02)00134-4
- https://doi.org/10.1016/S0165-2427(02)00134-4
- Author:
- Markowski-Grimsrud, Carrie J.; Schat, Karel, A.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.3-4 pp. 133-144
- ISSN:
- 0165-2427
- Subject:
- Mardivirus; T-lymphocytes; antigens; cell-mediated immunity; chickens; cytotoxicity; epithelium; feathers; glycoproteins; major histocompatibility complex; reticuloendotheliosis; splenocytes; viral proteins
- Abstract:
- ... Cell-mediated immune responses are important for protective immunity to Marek’s disease (MD), especially because MD herpesvirus (MDV) infection is strictly cell-associated in chickens with the exception of the feather follicle epithelium. A system previously developed using reticuloendotheliosis (REV)-transformed cell lines stably expressing individual MDV genes allows the determination of relevan ...
- DOI:
- 10.1016/S0165-2427(02)00229-5
- https://doi.org/10.1016/S0165-2427(02)00229-5
- Author:
- Oshop, G.L.; Elankumaran, S.; Heckert, R.A.
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.1-2 pp. 1-12
- ISSN:
- 0165-2427
- Subject:
- DNA; birds; maternal immunity; poultry; poultry industry; recombinant vaccines; vaccination
- Abstract:
- ... Inoculation of naked DNA represents a novel approach to vaccine and immune therapeutic development. DNA vaccines or genetic immunization offers several advantages over the conventional vaccines for specific immune activation. Although a large number of vaccines have been made and are being used in the poultry industry, there have been no major advances in vaccine technology for this animal industr ...
- DOI:
- 10.1016/S0165-2427(02)00189-7
- https://doi.org/10.1016/S0165-2427(02)00189-7
- Author:
- Johansson, E.; Wallgren, P.; Fuxler, L.; Domeika, K.; Lefevre, F.; Fossum, C.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.1-2 pp. 29-40
- ISSN:
- 0165-2427
- Subject:
- blood serum; granulocyte-macrophage colony-stimulating factor; immune response; interferon-alpha; interferon-gamma; interleukin-6; macrophage colony-stimulating factor; models; plasmids; recombinant vaccines; swine; vaccination
- Abstract:
- ... The cytokine inducing capacity of the vaccine vector pcDNA3, a methylated form of the plasmid, and pcDNA3 encoding porcine interleukin (IL)-6 or granulocyte/macrophage colony-stimulating factor (GM-CSF) was studied in pigs, using a model with tissue chambers implanted subcutaneously. The production of interferon (IFN)-α, IFN-γ, IL-6 and GM-CSF was studied at local (tissue chamber fluid (TCF)) and ...
- DOI:
- 10.1016/S0165-2427(02)00024-7
- https://doi.org/10.1016/S0165-2427(02)00024-7
- Author:
- Bengtsson, Otti; Daggfeldt, Annika; Andersson, Jan; Grönvik, Kjell-Olov
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 331-336
- ISSN:
- 0165-2427
- Subject:
- antibodies; blood serum; females; heterozygosity; homozygosity; immune response; immunization; immunoglobulin A; immunoglobulin G; males; mice; progeny
- Abstract:
- ... Antibody responses to kappa (κ)-light (L) chain are absent in normal (Cκ+/+) animals because of tolerance due to the abundance of κ-L chains expressed on more than 95% of all B cells and serum Ig. When heterozygous κ-sufficient (Cκ+/−) females are bred with homozygous κ-deficient (Cκ−/−) males, half of their offspring will become κ-deficient but have received κ-L chain containing maternal Ig, main ...
- DOI:
- 10.1016/S0165-2427(02)00060-0
- https://doi.org/10.1016/S0165-2427(02)00060-0
- Author:
- Southey, A.; Costello, E.; Gormley, E.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.1-2 pp. 73-78
- ISSN:
- 0165-2427
- Subject:
- Meles meles; Mycobacterium bovis; badgers; cattle; herds; humans; immune response; interleukin-2; lymphocyte proliferation; lymphocytes; tuberculin; tuberculosis; wildlife; Ireland
- Abstract:
- ... The Eurasian badger (Meles meles) is considered to be an important wildlife reservoir for Mycobacterium bovis infection of cattle in Ireland and in GB. However, rapid diagnosis of tuberculosis in live badgers has been constrained through a lack of suitable immuno-diagnostic reagents for detection of M. bovis-infected animals. To date, there have been no reports of cytokine activity in badgers that ...
- DOI:
- 10.1016/S0165-2427(02)00129-0
- https://doi.org/10.1016/S0165-2427(02)00129-0
- Author:
- Min, Wongi; Lillehoj, Hyun S.; Li, Guangxing; Sohn, Eun J.; Miyamoto, Tadashi
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.1-2 pp. 49-56
- ISSN:
- 0165-2427
- Subject:
- T-lymphocytes; Western blotting; cell growth; chickens; enzyme-linked immunosorbent assay; genes; interleukin-15; interleukin-2; monoclonal antibodies; polypeptides
- Abstract:
- ... The chicken IL-15 gene was recently cloned and shown to encode a polypeptide with T cell growth factor activity similar to IL-2. To further characterize the chemical and biological properties of chicken IL-15, we generated a panel of monoclonal antibodies against bacterially expressed protein and characterized their binding specificities. All antibodies were reactive by ELISA with recombinant IL-1 ...
- DOI:
- 10.1016/S0165-2427(02)00123-X
- https://doi.org/10.1016/S0165-2427(02)00123-X
- Author:
- Mwangi, Simon Musyoka; Stabel, Thomas J.; Kehrli, Marcus E. Jr.
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 251-254
- ISSN:
- 0165-2427
- Subject:
- Salmonella enterica; affinity chromatography; antibodies; cell culture; culture media; cytotoxicity; fibrosarcoma; immunoglobulin G; in vitro studies; inflammation; insects; mice; salmonellosis; sepsis (infection); swine; tumor necrosis factor-alpha
- Abstract:
- ... Tumor necrosis factor-α (TNF-α) is a key mediator of inflammatory responses and gram-negative bacterial sepsis, but the role that it plays during Salmonella enterica species bacterial infections in swine has not yet been elucidated. To facilitate studies on the role of TNF-α on the pathology associated with Salmonella infections in pigs, recombinant soluble porcine TNF receptor type I (rspTNF-RI) ...
- DOI:
- 10.1016/S0165-2427(02)00034-X
- https://doi.org/10.1016/S0165-2427(02)00034-X
- Author:
- Waritani, Takaki; Okuno, Yoko; Ashida, Yoshinori; Hisasue, Masaharu; Tsuchiya, Ryo; Kobayashi, Kosaku; Yamada, Takatsugu
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.1-2 pp. 41-49
- ISSN:
- 0165-2427
- Subject:
- blood serum; correlation; dogs; enzyme-linked immunosorbent assay; immunoaffinity chromatography; monoclonal antibodies; pancreatitis; radioimmunoassays; variance; veterinary clinics
- Abstract:
- ... The radioimmunoassay (RIA) for trypsin-like immunoreactivity (TLI) is one of the most sensitive and specific tests for detecting exocrine pancreatic insufficiency (EPI). An abnormally low serum TLI concentration (<2.5 ng/ml) indicates end-stage EPI. Although RIA methods can be used to detect canine serum TLI, these procedures are beyond the capabilities of most veterinary clinics and general labor ...
- DOI:
- 10.1016/S0165-2427(02)00120-4
- https://doi.org/10.1016/S0165-2427(02)00120-4
- Author:
- Skjolaas, K.A.; Minton, J.E.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 451-458
- ISSN:
- 0165-2427
- Subject:
- T-lymphocytes; blood serum; concanavalin A; cortisol; dexamethasone; interferon-gamma; interleukin-10; interleukin-2; macrophage migration inhibitory factors; messenger RNA; mineralocorticoid receptors; phenotype; splenocytes; swine; synthetic glucocorticoids
- Abstract:
- ... Glucocorticoids are reported to bias the production of cytokines from a type 1 to a type 2 phenotype. However, this dogma has been advanced largely from studies utilizing potent glucocorticoid analogs, particularly dexamethasone (DEX). Although studies utilizing DEX certainly have clinical and pharmacological relevance, DEX is probably not the best glucocorticoid for studies designed to evaluate t ...
- DOI:
- 10.1016/S0165-2427(02)00073-9
- https://doi.org/10.1016/S0165-2427(02)00073-9
- Author:
- Sinkora, J.; Rehakova, Z.; Sinkora, M.; Cukrowska, B.; Tlaskalova-Hogenova, H.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 301-306
- ISSN:
- 0165-2427
- Subject:
- T-lymphocytes; antibodies; bacteria; bone marrow; early development; flow cytometry; germ-free animals; immunoglobulin A; immunoglobulin G; liver; miniature swine; phenotype; piglets; pregnancy; thymocytes; viruses; yolk sac
- Abstract:
- ... Prenatal and early postnatal immune system development has been studied in minipigs. First leukocytes were observed in the yolk sac and fetal liver (FL) on the 17th day of gestation, the majority of them being SWC3+. The colonization of the thymus (TH) with leukocytes was observed 21 days later. Two waves of fetal TH colonization with pro-T cells were deduced from the frequency of thymocyte subset ...
- DOI:
- 10.1016/S0165-2427(02)00056-9
- https://doi.org/10.1016/S0165-2427(02)00056-9
- Author:
- Chen, D.; Colditz, I.G.; Glenn, G.M.; Tsonis, C.G.
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 177-182
- ISSN:
- 0165-2427
- Subject:
- alum; antibodies; antigens; blood serum; cats; cholera toxin; dogs; humans; immune response; immunization; immunoglobulin A; immunoglobulin G; intramuscular injection; mice; sheep; tetanus
- Abstract:
- ... Direct application of antigens to skin together with an adjuvant, a procedure called transcutaneous immunization (TCI), can induce systemic immune responses in mice, humans, cats and dogs. In previous studies we found that cholera toxin (CT) applied topically on unbroken skin induces systemic antibody and lymphocyte proliferative responses in sheep. The current study examined whether concurrent ad ...
- DOI:
- 10.1016/S0165-2427(02)00037-5
- https://doi.org/10.1016/S0165-2427(02)00037-5
- Author:
- Hsiao, Ya-Wen; Liao, Kuang-Wen; Hung, Shao-Wen; Chu, Rea-Min
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.1-2 pp. 19-27
- ISSN:
- 0165-2427
- Subject:
- coculture; developmental stages; dogs; flow cytometry; heat treatment; histopathology; immune response; immunoblotting; immunocytochemistry; lymphocytes; major histocompatibility complex; mixed breeds; monitoring; neoplasm cells; remission; transmissible venereal tumors
- Abstract:
- ... Canine transmissible venereal tumor (CTVT) can be allo-transplanted across major histocompatibility complex barriers. The expression of MHC molecules is usually low in the progression (P) stage and then greatly increases during tumor regression (R). We investigated the effects of tumor infiltrating lymphocytes (TIL) on the expression of MHC molecules of CTVT cells. Isolated, viable CTVT cells were ...
- DOI:
- 10.1016/S0165-2427(02)00026-0
- https://doi.org/10.1016/S0165-2427(02)00026-0
- Author:
- Moiré, Nathalie; Roy, Olivier; Gardey, Laure
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 459-466
- ISSN:
- 0165-2427
- Subject:
- Holstein; antibiotics; calves; dexamethasone; immune response; lymphocytes; monocytes; nonsteroidal anti-inflammatory agents; pneumonic pasteurellosis
- Abstract:
- ... Experimental pneumonic pasteurellosis was used in 30 Holstein calves to compare the effects on the immune response of different treatments: antibiotics alone or antibiotics in combination with either steroidal (SAID) or non-steroidal anti-inflammatory drugs (NSAID). Clinical parameters and the effect of treatments on the mitogen-induced proliferation of peripheral mononuclear blood cells (PMBCs) a ...
- DOI:
- 10.1016/S0165-2427(02)00074-0
- https://doi.org/10.1016/S0165-2427(02)00074-0
- Author:
- Ortuño, Jesús; Esteban, M. Angeles; Meseguer, J.
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.1-2 pp. 29-36
- ISSN:
- 0165-2427
- Subject:
- Sparus aurata; anesthesia; aquaculture; blood glucose; blood serum; complement; cortisol; fish; immune system; phagocytosis; sedatives; stress response
- Abstract:
- ... Phenoxyethanol is routinely used in seabream aquaculture to minimise fish stress response despite the secondary negative effects which have been observed. In this study, two different doses (60 and 200 μl/l) of phenoxyethanol, sedative and narcotic, were tested for their ability to reduce the stress caused in gilthead seabream (Sparus aurata L.) by crowding. Blood glucose and serum cortisol concen ...
- DOI:
- 10.1016/S0165-2427(02)00183-6
- https://doi.org/10.1016/S0165-2427(02)00183-6
- Author:
- Tuchscherer, M.; Kanitz, E.; Otten, W.; Tuchscherer, A.
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 195-203
- ISSN:
- 0165-2427
- Subject:
- B-lymphocytes; Phytolacca americana; T-lymphocytes; blood serum; concanavalin A; corticotropin; cytotoxicity; disease resistance; humoral immunity; immune response; immunoglobulin G; lymphocyte proliferation; morbidity; mortality; ontogeny; piglets; pregnancy; progeny; sows; suckling
- Abstract:
- ... In the present study, we investigated the effects of a daily 5 min restraint stress of pregnant sows in the last five gestational weeks on the development and reactivity of the immune system of the offspring. Maternal stress resulted in significant decreased serum immunoglobulin G (IgG) concentrations in suckling piglets at 1 and 3 days of age. Furthermore, the stress treatment of the sows had an ...
- DOI:
- 10.1016/S0165-2427(02)00035-1
- https://doi.org/10.1016/S0165-2427(02)00035-1
- Author:
- De Rose, Robert; Tennent, Jan; McWaters, Peter; Chaplin, Paul J.; Wood, Paul R.; Kimpton, Wayne; Cahill, Ross; Scheerlinck, Jean-Pierre Y.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 55-63
- ISSN:
- 0165-2427
- Subject:
- Corynebacterium pseudotuberculosis; antibodies; antigens; genes; immune response; immunoglobulin G; intramuscular injection; laboratory animals; phospholipase D; plasmids; recombinant vaccines; sheep; vaccination
- Abstract:
- ... DNA vaccination, delivered through various routes, has been used extensively in laboratory animals. Few studies have focused on veterinary species and while results obtained in laboratory animals can often be extrapolated to veterinary species this is not always the case. In this study we have compared the effect of the route of immunisation with DNA on the induction of immune responses and protec ...
- DOI:
- 10.1016/S0165-2427(02)00221-0
- https://doi.org/10.1016/S0165-2427(02)00221-0
- Author:
- Ridyard, Alison E.; Nuttall, Timothy J.; Else, Rod W.; Simpson, James W.; Miller, Hugh R.P.
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 205-214
- ISSN:
- 0165-2427
- Subject:
- colitis; colon; diarrhea; dogs; gene expression; histopathology; interferon-gamma; interleukin-10; interleukin-2; interleukin-4; interleukin-6; lymphocytes; messenger RNA; mucosa; transforming growth factor beta; tumor necrosis factor-alpha
- Abstract:
- ... The objective of this study was to evaluate the expression of the immunoregulatory and pro-inflammatory cytokines interleukin (IL)-2, IL-4, IL-6, IL-12p35, IL-12p40, interferon-gamma (IFN-γ), and tumour necrosis factor-alpha (TNF-α), and the expression of the predominantly immunosuppressive cytokines transforming growth factor-beta (TGF-β) and IL-10 in canine idiopathic lymphocytic–plasmacytic col ...
- DOI:
- 10.1016/S0165-2427(02)00039-9
- https://doi.org/10.1016/S0165-2427(02)00039-9
- Author:
- Guarga, Jose Luis; Moreno, Javier; Lucientes, Javier; Gracia, Maria Jesus; Peribanez, Miguel Angel; Castillo, Juan Antonio
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.1-2 pp. 13-20
- ISSN:
- 0165-2427
- Subject:
- Leishmania infantum; Phlebotomus perniciosus; T-lymphocytes; antibodies; antigens; disease transmission; dog diseases; dogs; females; flow cytometry; fluorescent antibody technique; humoral immunity; phytohemagglutinin; therapeutics; visceral leishmaniasis
- Abstract:
- ... The efficacy of specific immunochemotherapy against Leishmania infantum infection in dog was studied. The effects on transmission of the disease, as well as the cellular and humoral immune response were examined. The treated animals showed a significant reduction in the infection rates that were detected in Phlebotomus perniciosus females fed on the dog. The humoral immune response, assayed with a ...
- DOI:
- 10.1016/S0165-2427(02)00128-9
- https://doi.org/10.1016/S0165-2427(02)00128-9
- Author:
- Yamamoto, Akira; Iwata, Akira; Saitoh, Toshiki; Tuchiya, Kotaro; Kanai, Tomoko; Tsujimoto, Hajime; Hasegawa, Atsuhiko; Ishihama, Akira; Ueda, Susumu
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.3-4 pp. 169-177
- ISSN:
- 0165-2427
- Subject:
- Escherichia coli; adverse effects; antibody formation; cats; cell proliferation; granulocyte colony-stimulating factor; histidine; inclusion bodies; lymphocytes; monocytes; neutrophils; washing
- Abstract:
- ... Feline granulocyte colony-stimulating factor (G-CSF) with an N-terminal histidine hexamer tag was expressed as inclusion bodies in E. coli. The G-CSF solubilized in 6 M guanidine solution was absorbed onto a Ni-NTA column and, after washing with decreasing concentrations of guanidine, eluted with imidazole in a soluble and apparently pure form. The activity of the recombinant feline G-CSF was 3×10 ...
- DOI:
- 10.1016/S0165-2427(02)00259-3
- https://doi.org/10.1016/S0165-2427(02)00259-3
- Author:
- Maeda, Sadatoshi; Okayama, Taro; Omori, Keitaro; Masuda, Kenichi; Sakaguchi, Masahiro; Ohno, Koichi; Tsujimoto, Hajime
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.3-4 pp. 145-154
- ISSN:
- 0165-2427
- Subject:
- CCR4 receptor; amino acid sequences; amino acids; atopic dermatitis; chemokine CCL17; complementary DNA; dogs; guinea pigs; heart; humans; lymph nodes; messenger RNA; mice; nucleotides; open reading frames; skin lesions; small intestine; spleen; tissues
- Abstract:
- ... CC chemokine receptor 4 (CCR4) is a G protein-coupled seven transmembrane receptor that is selectively expressed on Th2 cells and plays an important role in the trafficking of Th2 cells into inflammatory sites. In this study, a full-length canine CCR4 cDNA was cloned and characterized in order to examine the potential role of CCR4 in allergic responses that produce skin lesions in canine atopic de ...
- DOI:
- 10.1016/S0165-2427(02)00232-5
- https://doi.org/10.1016/S0165-2427(02)00232-5
- Author:
- Mikami, O.; Muneta, Y.; Mori, Y.; Yokomizo, Y.; Nakajima, Y.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.3-4 pp. 203-207
- ISSN:
- 0165-2427
- Subject:
- adults; foreign bodies; gene expression; interleukin-18; interleukin-1beta; interleukin-6; lymph nodes; messenger RNA; piglets; reverse transcriptase polymerase chain reaction; spleen; tonsils; tumor necrosis factor-alpha
- Abstract:
- ... Inflammatory cytokine mRNA expression in the lymphatic organs of neonatal, 1-month-old and adult pigs was compared. The mRNA expression of interleukin (IL)-1β, IL-6, IL-18 and tumor necrosis factor (TNF)-α in the spleen, thymus, tonsil and popliteal and mesenteric lymph nodes was investigated by semi-quantitative RT-PCR. Stronger IL-1β mRNA expression was observed in the 1-day-old and 1-month-old ...
- DOI:
- 10.1016/S0165-2427(02)00260-X
- https://doi.org/10.1016/S0165-2427(02)00260-X
- Author:
- Uhl, E.W.; Heaton-Jones, T.G.; Pu, R.; Yamamoto, J.K.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.3-4 pp. 113-132
- ISSN:
- 0165-2427
- Subject:
- Feline immunodeficiency virus; Human immunodeficiency virus; USDA; Western blotting; acquired immunodeficiency syndrome; cats; cross reaction; diagnostic techniques; human diseases; humans; industry; medicine; models; vaccine development; vaccines; veterinary medicine
- Abstract:
- ... Feline immunodeficiency virus (FIV) is a natural infection of domestic cats that results in acquired immunodeficiency syndrome resembling human immunodeficiency virus (HIV) infection in humans. The worldwide prevalence of FIV infection in domestic cats has been reported to range from 1 to 28%. Hence, an effective FIV vaccine will have an important impact on veterinary medicine in addition to being ...
- DOI:
- 10.1016/S0165-2427(02)00227-1
- PubMed:
- 12459160
- PubMed Central:
- PMC7119750
- https://doi.org/10.1016/S0165-2427(02)00227-1
- Author:
- Nielsen, K.; Widdison, J.; Balachandran, A.; Stevenson, D.; Algire, J.
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.3-4 pp. 197-205
- ISSN:
- 0165-2427
- Subject:
- Acinetobacter calcoaceticus; antibodies; antigens; blood serum; brain; cattle; elks; feeds; lipopolysaccharides; myelin basic protein; prion diseases; sheep; soil microorganisms
- Abstract:
- ... Acinetobacter calcoaceticus, a soil microbe, contains molecular sequences which resemble those found in neurofilaments of the brain tissue. It was hypothesized that if cattle ingest large amounts of feedstuff containing A. calcoaceticus, they may develop an autoimmune reaction, with consequences of pathological changes associated with transmissible spongiform encephalopathies (TSEs). The hypothesi ...
- DOI:
- 10.1016/S0165-2427(02)00209-X
- https://doi.org/10.1016/S0165-2427(02)00209-X
51. Functional expression of a bovine major histocompatibility complex class I gene in transgenic mice
- Author:
- Russell, George C.; Oliver, Robert A.; Craigmile, Susan; Nene, Vish; Glass, Elizabeth J.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 417-421
- ISSN:
- 0165-2427
- Subject:
- DNA; RNA; T-lymphocytes; alleles; antigen presentation; antigens; cattle; cytotoxicity; genetically modified organisms; humans; immune response; major histocompatibility complex; mice; models; pathogens; peptides; spleen; transgenes; vaccines
- Abstract:
- ... Major histocompatibility complex (MHC) class I restricted cellular immune responses play an important role in immunity to intracellular pathogens. By binding antigenic peptides and presenting them to T cells, class I molecules impose significant selection on the targets of immune responses. Candidate vaccine antigens for cellular immune responses should therefore be analysed in the context of MHC ...
- DOI:
- 10.1016/S0165-2427(02)00095-8
- https://doi.org/10.1016/S0165-2427(02)00095-8
- Author:
- Whist, S.K.; Storset, A.; Larsen, H.J.S.
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 183-193
- ISSN:
- 0165-2427
- Subject:
- Anaplasma phagocytophilum; blood flow; intravenous injection; neutrophils; phagocytosis; sheep
- Abstract:
- ... Ehrlichia phagocytophila infection in sheep is characterized by persistent neutropaenia, indicative of decreased phagocytic capacity. This predisposes infected animals to other infections. A whole blood flow cytometrical method was used to document the degree and extent of reduced phagocytic and respiratory burst activity in phagocytes during an experimental infection with E. phagocytophila, and m ...
- DOI:
- 10.1016/S0165-2427(02)00038-7
- https://doi.org/10.1016/S0165-2427(02)00038-7
- Author:
- Detilleux, J.C.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.3-4 pp. 103-110
- ISSN:
- 0165-2427
- Subject:
- DNA; animal pathogens; bovine mastitis; breeding; dairy cows; genetic improvement; hosts; udders
- Abstract:
- ... Bovine mastitis remains the most costly disease in dairy cattle. Breeding for resistance to udder pathogens has been proposed as a complementary tool to therapeutic and prophylactic measures not totally effective against the disease. This paper reviews factors affecting cows’ susceptibility to pathogens at the animal, cellular/hormonal and DNA levels. Such factors will be useful in achieving genet ...
- DOI:
- 10.1016/S0165-2427(02)00138-1
- https://doi.org/10.1016/S0165-2427(02)00138-1
- Author:
- Conrad, M.L.; Pettman, R.; Whitehead, J.; McKinnel, L.; Davis, S.K.; Koop, B.F.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 439-441
- ISSN:
- 0165-2427
- Subject:
- T-lymphocytes; cattle; evolution; genes; genomic libraries; humans; loci; mice; sequence analysis
- Abstract:
- ... The T cell, which plays an integral role in the coordination of the immune system, has a heterodimer receptor (TCR) that can exist in one of the two forms: alpha/beta or gamma/delta. Cells displaying the gamma/delta TCR comprise less than 5% of T cell populations in humans and mice. In the bovine system, however, gamma/delta populations can reach as high as 60%. Differences in T cell populations m ...
- DOI:
- 10.1016/S0165-2427(02)00093-4
- https://doi.org/10.1016/S0165-2427(02)00093-4
- Author:
- Skjolaas, K.A.; Grieger, D.M.; Hill, C.M.; Minton, J.E.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.1-2 pp. 79-87
- ISSN:
- 0165-2427
- Subject:
- concanavalin A; cortisol; cultured cells; dexamethasone; gene expression; interleukin-10; interleukin-2; messenger RNA; phenotype; splenocytes; swine; synthetic glucocorticoids
- Abstract:
- ... Glucocorticoids are reported to bias cytokines to a Th2 phenotype. However, this dogma has been advanced largely from studies utilizing potent glucocorticoid analogs. The current study was conducted to revisit the issue of glucocorticoid modulation of Th1/Th2 cytokine production and evaluate migration inhibitory factor (MIF) mRNA expression in cultured pig splenocytes treated with physiologically ...
- DOI:
- 10.1016/S0165-2427(02)00122-8
- https://doi.org/10.1016/S0165-2427(02)00122-8
- Author:
- Qin, Q.W.; Ototake, M.; Nagoya, H.; Nakanishi, T.
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.1-2 pp. 83-89
- ISSN:
- 0165-2427
- Subject:
- Cyprinidae; Oncorhynchus; T-lymphocytes; allografting; anorexia; diploidy; feces; flow cytometry; graft versus host reactions; hemorrhage; kidney cells; kidneys; liver; salmon; spleen; splenocytes; triploidy; water temperature
- Abstract:
- ... The graft-versus-host reaction (GVHR) was demonstrated in a salmonid model system of clonal diploid and triploid amago salmon. Triploid operculum grafts on clonal diploid evoked an acute rejection within 12 days. Grafts exchanged among triploid amago salmon exhibited prolonged survival for 18 days. In contrast, diploid grafts on triploid, and allografts among clonal diploid amago salmon were accep ...
- DOI:
- 10.1016/S0165-2427(02)00187-3
- https://doi.org/10.1016/S0165-2427(02)00187-3
- Author:
- Kodama, Hitoshi; Tijiwa, Kiyohiko; Moritomo, Tadaaki; Nakanishi, Teruyuki
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 101-105
- ISSN:
- 0165-2427
- Subject:
- Aeromonas hydrophila; Cyprinus carpio; Escherichia coli; bacteria; bacterial infections; basophils; carp; eosinophils; kidneys; neutrophils
- Abstract:
- ... The objective of the study was to investigate the dynamics of changes in number of granulocytes in bacterial infections of carp (Cyprinus carpio). Carp were inoculated with non-pathogenic or pathogenic bacteria and changes in type I (neutrophils) and type II granulocyte (basophils/eosinophils) counts in kidney, circulating blood and peritoneal cavity were assessed. After the injection of non-patho ...
- DOI:
- 10.1016/S0165-2427(02)00230-1
- https://doi.org/10.1016/S0165-2427(02)00230-1
- Author:
- Parmentier, Henk K.; Baelmans, Rudy; Nieuwland, Mike G.B.; Dorny, Pierre; Demey, Fred
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 91-100
- ISSN:
- 0165-2427
- Subject:
- antibodies; blood serum; chickens; complement; erythrocytes; hemolysis; immunization; immunoglobulin G; sheep
- Abstract:
- ... Antibody responses, serum complement haemolytic activity, and complement component C3 and Factor B consumption were studied in chickens divergently selected for high and low antibody responses to sheep red blood cells, and in a randombred control line. Significantly higher total and IgG antibody responses to SRBC were found after intramuscular immunisation in the high antibody responder (H) line v ...
- DOI:
- 10.1016/S0165-2427(02)00231-3
- https://doi.org/10.1016/S0165-2427(02)00231-3
- Author:
- Krakowka, Steven; Eaton, K.A.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.3-4 pp. 173-182
- ISSN:
- 0165-2427
- Subject:
- Helicobacter; antibodies; bile; biopsy; blood serum; enzyme-linked immunosorbent assay; humoral immunity; ileum; immunoglobulin A; immunoglobulin G; immunoglobulin M; inflammation; lymph nodes; mucosal immunity; normal values; piglets; plasma cells; spleen; stomach
- Abstract:
- ... Short term tissue biopsy cultures and paired, sera, bile and gastric and intestinal contents from Helicobacter pylori-infected gnotobiotic piglets were tested for the synthesis of H. pylori-specific immunoglobulin (Ig) isotype production by antigen-specific ELISA from post-infection days (PIDs) 2–28. Serum antibody levels in all three Ig isotypes were elevated from baseline values by PID 14, serum ...
- DOI:
- 10.1016/S0165-2427(02)00164-2
- https://doi.org/10.1016/S0165-2427(02)00164-2
60. High level expression and purification of bioactive bovine interleukin-18 using a baculovirus system
- Author:
- Nagata, Tomoshi; Ishikawa, Satoko; Shimokawa, Eiko; Kamikawa, Makiyo; Kikuma, Reiko; Muneta, Yoshihiro; Yokomizo, Yuichi; Nakamura, Masayuki; Takehara, Kazuaki
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.1-2 pp. 65-72
- ISSN:
- 0165-2427
- Subject:
- Baculoviridae; antibodies; bioactive properties; cattle; genes; histidine; humans; immunoblotting; insect viruses; interferon-gamma; interleukin-18; interleukin-1beta; polypeptides; synergism; viruses
- Abstract:
- ... Bioactive recombinant bovine interleukin-18 (rboIL-18) was expressed using a baculovirus system. Normally, IL-18 is translated as a precursor form of a 24 kDa polypeptide and processed by IL-1β converting enzyme (ICE) to a mature bioactive form of 18 kDa protein. Hence, to express active form IL-18, we constructed two recombinant baculoviruses containing boIL-18 and human ICE (hICE) genes, respect ...
- DOI:
- 10.1016/S0165-2427(02)00127-7
- https://doi.org/10.1016/S0165-2427(02)00127-7
- Author:
- Johansson, M.; Berg, M.; Berg, A.L.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 23-33
- ISSN:
- 0165-2427
- Subject:
- Borna disease virus; antibodies; blood serum; cats; cerebrospinal fluid; enzyme-linked immunosorbent assay; humoral immunity
- Abstract:
- ... In order to investigate the peripheral and intracerebral humoral immune response against Borna disease virus (BDV) in cats, serum and cerebrospinal fluid (CSF) samples from experimentally and naturally BDV-infected cats were analysed in two different test systems (indirect enzyme-linked immunosorbent assay and indirect immunofluorescent test). The experimentally infected cats developed high antibo ...
- DOI:
- 10.1016/S0165-2427(02)00226-X
- https://doi.org/10.1016/S0165-2427(02)00226-X
- Author:
- Walravens, K.; Marché, S.; Rosseels, V.; Wellemans, V.; Boelaert, F.; Huygen, K.; Godfroid, J.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 401-406
- ISSN:
- 0165-2427
- Subject:
- Mycobacterium avium subsp. paratuberculosis; Mycobacterium bovis; Mycobacterium phlei; bacterial antigens; birds; calves; cell-mediated immunity; diagnostic techniques; interferon-gamma; oral administration; paratuberculosis; tuberculosis; Belgium
- Abstract:
- ... In countries where cattle tuberculosis caused by Mycobacterium bovis (Mbov) and paratuberculosis caused by Mycobacterium avium subsp. paratuberculosis (Mptb) are present, testing strategies for the Mbov eradication have to discriminate between these two infections. Present indirect tests are based on the analysis of the specific cellular immune response (DTH, IFN-γ) against crude mycobacterial ant ...
- DOI:
- 10.1016/S0165-2427(02)00092-2
- https://doi.org/10.1016/S0165-2427(02)00092-2
- Author:
- Goff, W.L.; Johnson, W.C.; Parish, S.M.; Barrington, G.M.; Elsasser, T.H.; Davis, W.C.; Valdez, R.A.
- Source:
- Veterinary immunology and immunopathology 2002 v.84 no.3/4 pp. 237-251
- ISSN:
- 0165-2427
- Subject:
- cell differentiation; Babesia bovis; tumor necrosis factors; nitric oxide; monocytes; biosynthesis; cattle; developmental stages; macrophages; interleukin-10; interleukin-4; interferons
- Abstract:
- ... The requirement for IFN-gamma and/or TNF-alpha as co-stimulants with Babesia bovis merozoites for nitric oxide (NO) production was examined, as well as the regulatory role of IL-4 and IL-10. Purified B. bovis merozoites did not induce the production of NO in undifferentiated monocytes without addition of exogenous IFN-gamma and TNF-alpha unless the monocytes taken ex vivo were producing TNF-alpha ...
- Handle:
- 10113/40680
- DOI:
- 10.1016/S0165-2427(01)00413-5
- https://doi.org/10.1016/S0165-2427(01)00413-5
- Author:
- Naessens, J.; Teale, A.J.; Sileghem, M.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 187-194
- ISSN:
- 0165-2427
- Subject:
- African trypanosomiasis; B-lymphocytes; anemia; antibodies; breeds; calves; complement; cytokines; immune response; parasites; trypanotolerance; Western Africa
- Abstract:
- ... Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differences in antibody response, complement level and cytokine expression, but it is not known whether these di ...
- DOI:
- 10.1016/S0165-2427(02)00070-3
- https://doi.org/10.1016/S0165-2427(02)00070-3
- Author:
- Pedersen, L.G.; Castelruiz, Y.; Jacobsen, S.; Aasted, B.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.3-4 pp. 111-122
- ISSN:
- 0165-2427
- Subject:
- Western blotting; cattle; dogs; flow cytometry; goats; granulocyte-macrophage colony-stimulating factor; horses; humans; interferon-gamma; interleukin-2; interleukin-4; interleukin-6; interleukin-8; mink; monoclonal antibodies; mononuclear leukocytes; rabbits; sheep; swine; tumor necrosis factor-alpha
- Abstract:
- ... Eleven monoclonal antibodies specific for ovine, bovine and human cytokines were investigated by flow cytometry for cross-reactivities with cytokines produced by peripheral blood mononuclear cells (PBMCs) from sheep, cattle, goat, swine, horse, dog, mink, rabbit and human. Four antibodies specific for IL-4, IL-8, IFN-γ and TNF-α cross-reacted with cytokines from a majority of the species investiga ...
- DOI:
- 10.1016/S0165-2427(02)00139-3
- https://doi.org/10.1016/S0165-2427(02)00139-3
- Author:
- Mizukoshia, Fuminori; Maeda, Ken; Hamano, Masataka; Iwata, Hiroyuki; Matsumura, Tomio; Kondo, Takashi; Sugiura, Takeo
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.1-2 pp. 97-101
- ISSN:
- 0165-2427
- Subject:
- immunoglobulin G; antibodies; enzyme-linked immunosorbent assay; racehorses; Equid alphaherpesvirus 4; glycoproteins
- Abstract:
- ... In this study, IgG subclass responses against equine herpesvirus type 4 (EHV-4) were examined by enzyme-linked immunosorbent assay (ELISA) using a type-specific region of EHV-4 glycoprotein G (gG). ELISA using sera collected from horses experimentally infected with EHV-4 revealed that IgGa and IgGb antibodies were detected at high level, but IgGc and IgG(T) antibody responses were detected at low ...
- DOI:
- 10.1016/S0165-2427(02)00130-7
- https://doi.org/10.1016/S0165-2427(02)00130-7
- Author:
- Sinke, J.D.; Rutten, V.P.M.G.; Willemse, T.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 351-356
- ISSN:
- 0165-2427
- Subject:
- atopic dermatitis; dogs; humans; interleukin-12; patch test; pathogenesis; skin lesions
- Abstract:
- ... Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans and dogs with comparable clinical features. Comparative studies of immunological events in the pathogenesis of AD may contribute to understanding of the disease in dogs and to development and evaluation of immunomodulatory strategies of relevance to both species. Both allergen-specific as well as non-specific mechanisms contri ...
- DOI:
- 10.1016/S0165-2427(02)00066-1
- https://doi.org/10.1016/S0165-2427(02)00066-1
- Author:
- Pinard-van der Laan, M.H.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 199-205
- ISSN:
- 0165-2427
- Subject:
- alleles; antibodies; cell-mediated immunity; chickens; disease resistance; gene frequency; genetic markers; immune response; phagocytosis
- Abstract:
- ... As part of a comprehensive strategy to combat diseases, improving genetically resistance to diseases and therefore immune capacities of animals is more and more desirable. However, research is still needed to develop genetic tools that may be used. In this search, lines selected for various immune responses are used to study relevant immune markers. Chickens have been selected for six generations ...
- DOI:
- 10.1016/S0165-2427(02)00075-2
- https://doi.org/10.1016/S0165-2427(02)00075-2
- Author:
- Morein, Bror; Abusugra, Izzeldin; Blomqvist, Gunilla
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 207-213
- ISSN:
- 0165-2427
- Subject:
- Murine respirovirus; adjuvants; vaccination; neonates; adults; cytokines; herd health; ecosystem services; herds; mice; immune response; immune system; maternal immunity; progeny; seals; proteins; sheep; vaccines; progesterone; viral antigens; horses
- Abstract:
- ... Passively derived maternal immunity hampers active immunization of newborns. Further, an immature immune system contributes to a weak and Th2 polarized immunity. This state of immunity in early life sustains endemic infections in man and continuous reinfections in animal herds. The endemic infections of the young occur preferentially when the immune system is still functionally immature and when t ...
- DOI:
- 10.1016/S0165-2427(02)00078-8
- https://doi.org/10.1016/S0165-2427(02)00078-8
- Author:
- Patarroyo, J.H.; Portela, R.W.; Castro, R.O. De; Pimentel, J. Couto; Guzman, F.; Patarroyo, M.E.; Vargas, M.I.; Prates, A.A.; Mendes, M.A. Dias
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.3-4 pp. 163-172
- ISSN:
- 0165-2427
- Subject:
- Rhipicephalus microplus; Western blotting; antibodies; cattle; digestive system; females; glycoproteins; immune response; immunization; immunoglobulin G; oviposition; saponins; synthetic peptides; ticks
- Abstract:
- ... Three synthetic peptides (SBm4912, SBm7462 and SBm19733), derived from the Bm86 glycoprotein from Boophilus microplus gut, were constructed and used to immunize cattle from a tick-free area. The immunized animals received three subcutaneous doses of the peptides, with saponin as adjuvant, at 30-day intervals. The immune response was evaluated by IgG elicited against the peptides by the detection o ...
- DOI:
- 10.1016/S0165-2427(02)00154-X
- https://doi.org/10.1016/S0165-2427(02)00154-X
- Author:
- Koenen, Marjorie E.; Boonstra-Blom, Anneke G.; Jeurissen, Suzan H.M.
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.1-2 pp. 47-56
- ISSN:
- 0165-2427
- Subject:
- antibiotics; antibodies; antigens; blood serum; broiler chickens; dose response; enzyme-linked immunosorbent assay; hemocyanin; humoral immunity; immune response; immunization; immunoglobulin G; immunoglobulin M; intravenous injection; longevity; lymphocyte proliferation; vaccines
- Abstract:
- ... In commercial poultry husbandry, alternatives for the use of antibiotics and vaccines are under investigation, which preferably have to be applicable for both layer- and broiler-type chickens. There are indications that the defense mechanisms vary between layer- and broiler-type chickens. Therefore, the difference in immune response between layer- and broiler-type chickens of the same age was inve ...
- DOI:
- 10.1016/S0165-2427(02)00169-1
- https://doi.org/10.1016/S0165-2427(02)00169-1
- Author:
- Winter, P.; Colditz, I.G.
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.1-2 pp. 57-65
- ISSN:
- 0165-2427
- Subject:
- Staphylococcus epidermidis; bacteria; enzyme-linked immunosorbent assay; ewes; fever; immune response; interleukin-1beta; interleukin-6; interleukin-8; lactation; lymphocytes; mastitis; milk; neutrophils; udders
- Abstract:
- ... The responses of five lactating ewes to experimental mammary infection with Staphylococcusepidermidis were examined. Infection caused an intense but transient influx of neutrophils into milk, which peaked at 8 h and was accompanied by mild fever and mild leukopaenia in blood. No other signs of systemic infection were observed. Number of staphylococci in milk decreased logarithmically until 24 h, w ...
- DOI:
- 10.1016/S0165-2427(02)00184-8
- https://doi.org/10.1016/S0165-2427(02)00184-8
- Author:
- Hasvold, H.J.; Valheim, M.; Berntsen, G.; Storset, A.K.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 79-89
- ISSN:
- 0165-2427
- Subject:
- Mycobacterium avium subsp. paratuberculosis; T-lymphocytes; flow cytometry; immunity; interferon-gamma; interleukin-2; kids (goats); live vaccines; paratuberculosis; phenotype; vaccination
- Abstract:
- ... Live attenuated vaccines provide protection against intestinal lesions in goats infected with Mycobacterium avium subsp. paratuberculosis. To examine the role of different T lymphocyte subsets in the development of this protective immunity, CD4+, CD8+ and γδ T cell receptor (TCR)+ cells from peripheral blood of goat kids vaccinated with live attenuated strains of M. a. paratuberculosis were studie ...
- DOI:
- 10.1016/S0165-2427(02)00224-6
- https://doi.org/10.1016/S0165-2427(02)00224-6
- Author:
- Reeth, Kristien Van; Gucht, Steven Van; Pensaert, Maurice
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 161-168
- ISSN:
- 0165-2427
- Subject:
- Actinobacillus pleuropneumoniae; Coronavirinae; Escherichia coli; Influenza A virus; Mycoplasma hyopneumoniae; Porcine reproductive and respiratory syndrome virus; anti-inflammatory activity; food animals; in vivo studies; interferon-alpha; interleukin-1; interleukin-10; interleukin-6; mycoplasmosis; pleuropneumonia; rodents; swine; swine diseases; tumor necrosis factor-alpha
- Abstract:
- ... The early cytokines interferon-α (IFN-α), tumour necrosis factor-α (TNF-α), interleukin-1, -6 and -8 (IL-1, -6, -8) are produced during the most early stage of an infection. The activities of these cytokines have been studied extensively in vitro and in rodents, but in vivo studies on the role of these cytokines in infectious diseases of food animals are few. This review concentrates on in vivo st ...
- DOI:
- 10.1016/S0165-2427(02)00047-8
- PubMed:
- 12072230
- PubMed Central:
- PMC7119797
- https://doi.org/10.1016/S0165-2427(02)00047-8
- Author:
- Yagi, Yukio; Shiono, Hiroki; Shibahara, Tomoyuki; Chikayama, Yukio; Nakamura, Ichiro; Ohnuma, Aiko
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.3-4 pp. 115-125
- ISSN:
- 0165-2427
- Subject:
- DNA fragmentation; Escherichia coli; apoptosis; bovine mastitis; cattle; gel electrophoresis; intravenous injection; jugular vein; leukopenia; lipopolysaccharides; milk; neutrophils; receptors
- Abstract:
- ... A transient increase in apoptotic polymorphonuclear neutrophils (PMNs) as revealed by the terminal deoxynucleotidyl, transferase-mediated dUTP nick end labeling (TUNEL) technique in bovine jugular and milk vein blood was observed 4 h after intramammary infusion of Escherichia coli lipopolysaccharide (LPS) (jugular vein; before infusion 10.1%, 4 h 58.3%: milk vein; before infusion 13.2%, 4 h 76.6%) ...
- DOI:
- 10.1016/S0165-2427(02)00199-X
- https://doi.org/10.1016/S0165-2427(02)00199-X
- Author:
- Yuan, Lijuan; Saif, Linda J.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 147-160
- ISSN:
- 0165-2427
- Subject:
- B-lymphocytes; Escherichia coli; Rotavirus; adjuvants; adults; animal models; bone marrow; diarrhea; enterotoxins; heat; humans; ileum; immunoglobulin A; immunoglobulin G; mucosal immunity; mutants; neonates; neutralizing antibodies; oral administration; spleen; swine; vaccination; viral antigens; viral vaccines; virulence; viruses; young animals
- Abstract:
- ... Enteric viruses are a major cause of diarrhea in animals and humans. Among them, rotaviruses are one of the most important causes of diarrhea in young animals and human infants. A lack of understanding of mechanisms to induce intestinal immunity and the correlates of protective immunity in neonates has impaired development of safe and effective vaccines against enteric viruses. Studies of candidat ...
- Author:
- Mutwiri, G.; Bowersock, T.; Kidane, A.; Sanchez, M.; Gerdts, V.; Babiuk, L.A.; Griebel, P.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 269-276
- ISSN:
- 0165-2427
- Subject:
- T-lymphocytes; animal models; antibodies; antigens; biodegradability; humoral immunity; immunization; interferon-gamma; intestines; lambs; mucosal immunity; serum albumin; swine
- Abstract:
- ... Oral immunization is the most effective way of inducing immune responses in the intestinal tract. Biodegradable microspheres have been used extensively for the delivery of antigens to the Peyer’s patches (PPs) within the gut-associated lymphoid tissue (GALT). We evaluated various formulations of alginate microspheres for their capacity to induce mucosal immune responses in vivo. Multiple intestina ...
- DOI:
- 10.1016/S0165-2427(02)00052-1
- https://doi.org/10.1016/S0165-2427(02)00052-1
- Author:
- Murtaugh, Michael P.; Foss, Dennis L.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 109-121
- ISSN:
- 0165-2427
- Subject:
- antigen-presenting cells; antigens; bacteria; cell-mediated immunity; cholera toxin; cytokines; immune response; inflammation; macrophages; mucosal immunity; pathogens; small intestine; swine; vaccine adjuvants; vaccines; viruses
- Abstract:
- ... Immune responses are stimulated in response to threats against health. In animals, defense against infectious agents, particularly rapidly growing viruses and bacteria, requires an immediate response to limit growth and dissemination, and then stimulation of a more prolonged, specific immunity to prevent re-infection. The process by which animals meet the dual needs of an immediate response to dan ...
- DOI:
- 10.1016/S0165-2427(02)00042-9
- https://doi.org/10.1016/S0165-2427(02)00042-9
79. Inhibition of nitric oxide enhances ovine lentivirus replication in monocyte-derived macrophages
- Author:
- Keane, Kevin A.; Mason, Gary L.; DeMartini, James C.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.3-4 pp. 179-189
- ISSN:
- 0165-2427
- Subject:
- Ovine lentivirus; RNA-directed DNA polymerase; Visna maedi virus; blood serum; containers; inducible nitric oxide synthase; macrophages; mononuclear leukocytes; nitric oxide; polytetrafluoroethylene; sheep; viral antigens
- Abstract:
- ... Ovine lentivirus (OvLV) also known as maedi-visna virus, infects and replicates primarily in macrophages. This investigation examined the role of nitric oxide in the replication of OvLV in cultured macrophages. Peripheral blood mononuclear cells were collected from OvLV-free sheep and cultured in Teflon coated flasks at a high concentration of lamb serum. The cells were subsequently infected with ...
- DOI:
- 10.1016/S0165-2427(02)00245-3
- https://doi.org/10.1016/S0165-2427(02)00245-3
- Author:
- Massey, Emma J.; Sundstedt, Anette; Day, Michael J.; Corfield, Gaynor; Anderton, Stephen; Wraith, David C.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 357-372
- ISSN:
- 0165-2427
- Subject:
- epitopes; mechanism of action; genetically modified organisms; intranasal administration; T-lymphocytes; models; mice; sclerosis; encephalitis; interleukin-10; in vitro studies; autoimmune diseases
- Abstract:
- ... Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease commonly employed as a model for multiple sclerosis. Extensive studies have demonstrated that EAE may be prevented or ameliorated by the intranasal administration of soluble peptides representing encephalitogenic epitopes. There is increasing evidence that this peptide administration may function via the genera ...
- DOI:
- 10.1016/S0165-2427(02)00068-5
- https://doi.org/10.1016/S0165-2427(02)00068-5
- Author:
- Dil, N.; Qureshi, M.A.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.3-4 pp. 149-161
- ISSN:
- 0165-2427
- Subject:
- Toll-like receptor 4; antibodies; chickens; flow cytometry; gene expression; gene induction; inducible nitric oxide synthase; lipopolysaccharides; macrophages; nitrites; transcription factor NF-kappa B
- Abstract:
- ... Macrophages from Cornell K-strain chickens (B15B15) are hyper and from GB2 chickens (B6B6) are hypo-responders to LPS-mediated inducible NOS (iNOS) expression and activity. The molecular mechanism(s) responsible for this differential expression is not yet fully understood. We have previously reported that macrophages from K (iNOS hyper-responder) and GB2 (iNOS hypo-responder) chickens differ in co ...
- DOI:
- 10.1016/S0165-2427(02)00153-8
- https://doi.org/10.1016/S0165-2427(02)00153-8
- Author:
- Carrillo, Ana; Chamorro, Sonia; Rodrı́guez-Gago, Manuel; Álvarez, Belen; Molina, Marı́a Jesús; Rodrı́guez-Barbosa, José Ignacio; Sánchez, Alicia; Ramı́rez, Pablo; Muñoz, Antonio; Domı́nguez, Javier; Parrilla, Pascual; Yélamos, Jose
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.1-2 pp. 91-98
- ISSN:
- 0165-2427
- Subject:
- endothelium; endothelial cells; antigens; African swine fever; humans; cytotoxicity; genome; longevity; flow cytometry; plasmids; gene expression; low density lipoprotein; swine; immune response; in vitro studies; pathogenesis; hog cholera
- Abstract:
- ... Primary porcine endothelial cells have a limited life span in culture. After four to five passages, they tend to de-differentiate and eventually reach senescence. The aim of this work was to establish immortalized porcine aortic endothelial cell lines (AOCs) to facilitate in vitro studies of different pathological process involving the endothelium. Primary porcine aortic endothelial cells (PAECs) ...
- DOI:
- 10.1016/S0165-2427(02)00170-8
- https://doi.org/10.1016/S0165-2427(02)00170-8
- Author:
- Grone, A.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.1-2 pp. 1-12
- ISSN:
- 0165-2427
- Subject:
- T-lymphocytes; cytokine receptors; interleukin-10; interleukin-18; interleukin-2; interleukin-4; interleukin-7; keratinocytes; lymphoma; pathogenesis; tumor necrosis factor-alpha
- Abstract:
- ... The skin has long been recognized as a major producer of cytokines, but the keratinocyte as principal epidermal cell has received less attention as potential source and target of cytokines. Nevertheless, keratinocytes produce a plethora of cytokines including interleukin (IL)-1, -6, -7, -8, -10, -12, -15, -18, and -20, and tumor necrosis factor α (TNF). The production by keratinocytes of pro-infla ...
- DOI:
- 10.1016/S0165-2427(02)00136-8
- https://doi.org/10.1016/S0165-2427(02)00136-8
- Author:
- Harmelin, A.; Pinthus, J.H.; Friedmann-Morvinski, D.; Kaufman, K.; Brenner, O.
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 245-249
- ISSN:
- 0165-2427
- Subject:
- adults; dogs; mice; models; neoplasm cells; severe combined immunodeficiency; transmissible venereal tumors
- Abstract:
- ... Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells ...
- DOI:
- 10.1016/S0165-2427(02)00036-3
- https://doi.org/10.1016/S0165-2427(02)00036-3
- Author:
- Olivry, Thierry; Dunston, Stanley M.; Zhang, Guyiun; Ghohestani, Reza F.
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.3-4 pp. 123-129
- ISSN:
- 0165-2427
- Subject:
- autoantibodies; autoantigens; basement membrane; cats; collagen; dogs; epitopes; fluorescent antibody technique; gingiva; humans; immunoblotting; immunoglobulin A; immunoglobulin G; integrins; mucosa; patients
- Abstract:
- ... In human and canine patients with mucous membrane (cicatricial) pemphigoid (MMP), circulating autoantibodies have been shown to target multiple epidermal basement membrane antigenic epitopes. These autoantigens include collagen XVII in humans and dogs, as well as laminin-5, laminin-6 or integrin alpha-6/beta-4 in human beings. The purpose of this study was to determine if autoantibodies targeted l ...
- DOI:
- 10.1016/S0165-2427(02)00166-6
- https://doi.org/10.1016/S0165-2427(02)00166-6
- Author:
- Maeda, Sadatoshi; Fujiwara, Shunsuke; Keitaro, Omori; Kawano, Koji; Kurata, Keigo; Masuda, Kenichi; Ohno, Koichi; Tsujimoto, Hajime
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.1-2 pp. 79-87
- ISSN:
- 0165-2427
- Subject:
- atopic dermatitis; chemokine CCL17; dogs; gene expression; humans; interferon-gamma; interleukin-1beta; interleukin-4; messenger RNA; pathogenesis; tumor necrosis factor-alpha
- Abstract:
- ... In this study, we investigated the mRNA expression of a chemokine, thymus and activation-regulated chemokine (TARC), and cytokines including IL-1β, IL-4, IFN-γ and TNF-α in skin samples obtained from both dogs with atopic dermatitis (AD) and healthy dogs. TARC mRNA was found to be selectively expressed in lesional skin of the dogs with AD, but not in non-lesional skin of the dogs with AD or the no ...
- DOI:
- 10.1016/S0165-2427(02)00140-X
- https://doi.org/10.1016/S0165-2427(02)00140-X
- Author:
- Holgersson, Jan; Ehrnfelt, Cecilia; Hauzenberger, Elenor; Serrander, Lena
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 407-415
- ISSN:
- 0165-2427
- Subject:
- T-lymphocytes; antibodies; cell movement; chemokines; complement; endothelial cells; endothelium; humans; immunoglobulins; integrins; monocytes; neutrophils; swine
- Abstract:
- ... In cases where antibody- and complement-mediated hyperacute rejection (HAR) of vascularized organ xenografts has been prevented, acute vascular rejection (AVR) and acute T cell-mediated rejection (ACR) cause graft destruction. Infiltration of leukocytes (innate and graft-primed T cells) into the graft execute the latter two rejection modalities. The leukocyte extravasation process, which is a prer ...
- DOI:
- 10.1016/S0165-2427(02)00094-6
- https://doi.org/10.1016/S0165-2427(02)00094-6
- Author:
- Cuesta, A.; Esteban, M.A.; Meseguer, J.
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.3-4 pp. 169-174
- ISSN:
- 0165-2427
- Subject:
- Sparus aurata; cytotoxicity; diet; fish; kidneys; leukocytes; levamisole; neoplasm cells
- Abstract:
- ... Gilthead seabream (Sparus aurata L.) head–kidney (HK) leucocytes were incubated with 10(3) to 10(−4) ng levamisole/ml for 4, 24 or 48 h and then assayed for their natural cytotoxic activity against xenogeneic tumor cells. This activity was slightly increased after 24 h of incubation. In a second experiment, fish specimens were fed 0, 75, 150 or 300 mg levamisole/kg diet for 10 consecutive days. Th ...
- DOI:
- 10.1016/S0165-2427(02)00220-9
- https://doi.org/10.1016/S0165-2427(02)00220-9
- Author:
- Trebichavský, Ilja; Šplı́chal, Igor; Zahradnı́čková, Marie; Šplı́chalová, Alla; Mori, Yasuyuki
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.1-2 pp. 11-18
- ISSN:
- 0165-2427
- Subject:
- Gram-negative bacteria; amnion; amniotic fluid; epithelium; fetus; gene expression; interleukin-8; lipopolysaccharides; pregnancy; reverse transcriptase polymerase chain reaction; swine; transforming growth factor beta 1; tumor necrosis factor-alpha
- Abstract:
- ... Inflammatory mediators that are induced by gram-negative bacteria in the course of intrauterine infections threaten successful pregnancy. To compare the effect of two different routes of cytokine induction, bacterial lipopolysaccharide (LPS) was administered in vivo either into the cord vein or into the amniotic cavity of pig fetuses in the second half of gestation for 20 h and cytokines were dete ...
- DOI:
- 10.1016/S0165-2427(02)00025-9
- https://doi.org/10.1016/S0165-2427(02)00025-9
- Author:
- Mayer, Balázs; Zolnai, Anna; Frenyó, László V.; Jancsik, Veronika; Szentirmay, Zoltán; Hammarström, Lennart; Kacskovıcs, Imre
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 327-330
- ISSN:
- 0165-2427
- Subject:
- biopsy; colostrum; cytoplasm; epithelial cells; immunoglobulin G; immunohistochemistry; in situ hybridization; lambing; mammary glands; messenger RNA; neonates; sheep
- Abstract:
- ... Among the multiple functions, which have been identified for the neonatal Fc receptor (FcRn), we study its role in the IgG transport in the mammary gland during the colostrum formation. For this reason, we have obtained several mammary gland biopsies from a pregnant sheep around parturition. The presence of the FcRn heavy chain mRNA was detected exclusively in the acinar and ductal epithelial cell ...
- DOI:
- 10.1016/S0165-2427(02)00059-4
- https://doi.org/10.1016/S0165-2427(02)00059-4
- Author:
- McNeil, Heather J.; Shewen, Patricia E.; Lo, Reggie Y.C.; Conlon, Jennifer A.; Miller, Michael W.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 107-110
- ISSN:
- 0165-2427
- Subject:
- Mannheimia haemolytica serotype 1; Pasteurella trehalosi; Western blotting; disease control; fibrinogen; pneumonia; serotypes; virulence
- Abstract:
- ... Fibrinogen-binding proteins were found in the culture supernatants of Mannheimia haemolytica serotype 1 (ATCC 43270) and Pasteurella trehalosi serotype 10 (ECO-100). Sheep fibrinogen was biotinylated and shown to bind to proteins in the culture supernatants by modified western blot. Fibrinogen-binding proteins in the culture supernatant may be important virulence factors leading to the characteris ...
- DOI:
- 10.1016/S0165-2427(02)00222-2
- https://doi.org/10.1016/S0165-2427(02)00222-2
- Author:
- Taylor, Bernadette C.; Brotheridge, Rory M.; Jessup, David A.; Stott, Jeffrey L.
- Source:
- Veterinary immunology and immunopathology 2002 v.89 no.3-4 pp. 187-195
- ISSN:
- 0165-2427
- Subject:
- Enhydra lutris; Orcinus orca; adults; ammonium sulfate; antiserum; blood serum; captive animals; confidence interval; immunoelectrophoresis; immunoglobulin G; infectious diseases; marine mammals; monitoring; octanoic acid; pollution; polyclonal antibodies; pups; rabbits
- Abstract:
- ... Killer whales and sea otters maintained in captivity are the subjects of routine health monitoring programs, and interest in immunologic studies in sea otters has been rising recently in response to potential impacts from infectious disease and environmental pollution on the threatened southern sea otter population. Development of species-specific reagents for immunologic studies in these two mari ...
- DOI:
- 10.1016/S0165-2427(02)00208-8
- https://doi.org/10.1016/S0165-2427(02)00208-8
- Author:
- Vecchione, Anna; Catchpole, Brian; D’Mello, Felicity; Kanellos, Theo; Hamblin, Anne
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 215-221
- ISSN:
- 0165-2427
- Subject:
- bone marrow cells; complementary DNA; concanavalin A; dendritic cells; granulocyte-macrophage colony-stimulating factor; horses; immune response; immunomodulators; interleukin-3; interleukin-4; interleukin-7; mice; mononuclear leukocytes; nucleotide sequences; phenotype; polymerase chain reaction; rats; tumor necrosis factor-alpha; veterinary medicine
- Abstract:
- ... Dendritic cells (DCs) are antigen presenting cells that potently modulate immune responses with varying outcomes depending on the DC sub-population involved. To understand how DC sub-types arise, it is necessary to determine which factors influence their differentiation. At least three major sub-populations of DCs have been described in mice: CD4+/CD8− “myeloid” DCs, CD4−/CD8+ “lymphoid” DCs and L ...
- DOI:
- 10.1016/S0165-2427(02)00079-X
- https://doi.org/10.1016/S0165-2427(02)00079-X
- Author:
- Hopkins, J.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 245-249
- ISSN:
- 0165-2427
- Subject:
- cytokines; genes; humans; immunoassays; microarray technology; monoclonal antibodies; oligonucleotides; rodents; signal transduction
- Abstract:
- ... Research on ‘molecular immunology—gene regulation and signal transduction’ in veterinary species is relatively new. The reason for its novelty is that until recently there have been very few tools with which we can work. Over the last 10 years the veterinary immunology community has succeeded in generating panels of defined monoclonal antibodies (mAb) and cloned genes that has enabled such work to ...
- DOI:
- 10.1016/S0165-2427(02)00090-9
- https://doi.org/10.1016/S0165-2427(02)00090-9
- Author:
- Yokomizo, Y.; Watanabe, F.; Imada, Y.; Inumaru, S.; Yanaka, T.; Tsuji, T.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 291-300
- ISSN:
- 0165-2427
- Subject:
- Bordetella bronchiseptica; Brevibacillus brevis; Erysipelothrix rhusiopathiae; Escherichia coli O157; adhesins; adverse effects; antibodies; antigens; bacteria; calves; colostrum; cows; diarrhea; enterotoxins; genes; immunization; infectious diseases; intimin; mutants; nose; saliva; secretion; subunit vaccines; swine; toxicity; tripeptides; virulence; virulent strains
- Abstract:
- ... A gene encoding the mature Escherichia coli heat-labile enterotoxin (LT) lacking the nick site in the A subunit by deleting tripeptides was introduced in a vector pNH301 and expressed extracellularly as mutant molecule of holotoxin at high levels in Bacilus brevis HPD31-S5 of the host bacterium. The mucosal adjuvant activities of the produced mutant LT (mLT) preparation were studied in pigs and ca ...
- DOI:
- 10.1016/S0165-2427(02)00055-7
- https://doi.org/10.1016/S0165-2427(02)00055-7
- Author:
- Hannant, Duncan
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 265-267
- ISSN:
- 0165-2427
- Subject:
- B-lymphocytes; CD4-positive T-lymphocytes; adjuvants; animals; antigens; cytokines; digestive system; epithelial cells; half life; immunoglobulin A; mucosal immunity; pathogens; respiratory system; secretion
- Abstract:
- ... A large part of the immune system is dedicated to protection from infection at mucosal surfaces. The concept of the common mucosal immune system has been investigated in several veterinary species where traffic of mucosally activated lymphocytes from induction to effector sites has been demonstrated. The dominant isotype found in secretions of the upper respiratory tract and gut of normal healthy ...
- DOI:
- 10.1016/S0165-2427(02)00051-X
- https://doi.org/10.1016/S0165-2427(02)00051-X
- Author:
- Husband, Alan J.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 131-136
- ISSN:
- 0165-2427
- Subject:
- antibodies; cell proliferation; cytokines; digestive system; eyes; immunity; immunoglobulin A; livestock; rodents
- Abstract:
- ... The maintenance of IgA antibody responses at mucosal surfaces is the outcome of influences on IgA precursor cell dissemination from the mucosal inductive sites, such as the intestinal Peyer’s patches, their selective extravasation at mucosal effector sites and the retention and local proliferation of these cell populations under local influences. Examination of these local post-extravasational eff ...
- DOI:
- 10.1016/S0165-2427(02)00044-2
- https://doi.org/10.1016/S0165-2427(02)00044-2
- Author:
- Langelaar, M.; Koets, A.; Muller, K.; Eden, W. van; Noordhuizen, J.; Howard, C.; Hope, J.; Rutten, V.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 239-244
- ISSN:
- 0165-2427
- Subject:
- CD4-positive T-lymphocytes; Mycobacterium avium subsp. paratuberculosis; antibodies; antigen presentation; antigens; cattle; confocal microscopy; cytotoxicity; fluorescence; heat-shock protein 70; macrophages; monocytes; paratuberculosis
- Abstract:
- ... Paratuberculosis in cattle is a chronic intestinal disease in which a distinctive cellular reactivity of a Th1-type preceeds the phase in which antibody titers are easily detectable and the animal becomes clinically ill. During infection with Mycobacterium avium ssp. paratuberculosis (M.a.p), a decrease in CD4 T-helper cells has been observed in the clinical phase. Our ultimate aim is to elicit a ...
- DOI:
- 10.1016/S0165-2427(02)00089-2
- https://doi.org/10.1016/S0165-2427(02)00089-2
- Author:
- Engelsma, Marc Y.; Huising, Mark O.; Muiswinkel, Willem B. van; Flik, Gert; Kwang, Jimmy; Savelkoul, Huub F.J.; Verburg-van Kemenade, B.M. Lidy
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 467-479
- ISSN:
- 0165-2427
- Subject:
- B-lymphocytes; corticotropin; corticotropin-releasing hormone; cortisol; fish; granulocytes; homeostasis; innate immunity; interleukin-1; interleukin-6; neurosecretory system; receptors; sympathetic nervous system; tumor necrosis factor-alpha
- Abstract:
- ... Bi-directional communication between the hypothalamus–pituitary–adrenal (HPA)-axis and the sympathetic nervous system with the immune system is crucial to ensure homeostasis. Shared use of ligands and especially receptors forms a key component of this bi-directional interaction. Glucocorticoids (GC), the major end products of the HPA-axis differentially modulate immune function. Cytokines, especia ...
- DOI:
- 10.1016/S0165-2427(02)00077-6
- https://doi.org/10.1016/S0165-2427(02)00077-6
- Author:
- Soethout, Ernst C.; Müller, Kerstin E.; Rutten, Victor P.M.G.
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 277-285
- ISSN:
- 0165-2427
- Subject:
- adverse effects; anti-inflammatory activity; cell movement; endothelium; fibrin; inflammation; neutrophils; pneumonia; signal transduction
- Abstract:
- ... Lung inflammation is often associated with sustained neutrophil migration into the lung tissue, causing undesired side effects, i.e. substantial damage of lung tissue and fibrin deposition, which hamper complete recovery. The need for additional anti-inflammatory treatment strategies focused attention on the function of cellular adhesion molecules (CAMs) on the leukocyte membrane, which guide migr ...
- DOI:
- 10.1016/S0165-2427(02)00053-3
- https://doi.org/10.1016/S0165-2427(02)00053-3