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Veterinary immunology and immunopathology
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1. Adjuvanted rush immunotherapy using CpG oligodeoxynucleotides in experimental feline allergic asthma
- Author:
- Reinero, Carol R.; Cohn, Leah A.; Delgado, Cherlene; Spinka, Christine M.; Schooley, Elizabeth K.; DeClue, Amy E.
- Source:
- Veterinary immunology and immunopathology 2008 v.121 no.3-4 pp. 241-250
- ISSN:
- 0165-2427
- Subject:
- protective effect; etiology; gene overexpression; Cynodon dactylon; cats; immunotherapy; immunomodulators; allergens; disease control; drug adjuvants; disease severity; eosinophils; asthma; cat diseases; immune response; DNA-binding domains; synergism; synergists
- Abstract:
- ... Allergic asthma is driven by relative overexpression of Th2 cell-derived cytokines in response to aeroallergens. In independent studies, both allergen-specific rush immunotherapy (RIT) and CpG oligodeoxynucleotides (ODN) showed promise in blunting eosinophilic inflammation in a model of feline allergic asthma. We hypothesized that RIT using allergen and CpG ODN would work synergistically to dampen ...
- DOI:
- 10.1016/j.vetimm.2007.09.013
- https://doi.org/10.1016/j.vetimm.2007.09.013
- Author:
- Soboll, G.; Hussey, S.B.; Whalley, J.M.; Allen, G.P.; Koen, M.T.; Santucci, N.; Fraser, D.G.; Macklin, M.D.; Swain, W.F.; Lunn, D.P.
- Source:
- Veterinary immunology and immunopathology 2006 v.111 no.1-2 pp. 81-95
- ISSN:
- 0165-2427
- Subject:
- vertebrate viruses; Equid alphaherpesvirus 1; glycoproteins; viral diseases of animals and humans; lymphocyte proliferation; antibodies; viremia; new products; disease control; plasmids; viral proteins; immune response; vaccination; cytotoxic T-lymphocytes; horse diseases; subunit vaccines; horses; disease incidence
- Abstract:
- ... Equine herpesvirus-1 (EHV-1) is the cause of serious disease with high economic impact on the horse industry, as outbreaks of EHV-1 disease occur every year despite the frequent use of vaccines. Cytotoxic T-lymphocytes (CTLs) are important for protection from primary and reactivating latent EHV-1 infection. DNA vaccination is a powerful technique for stimulating CTLs, and the aim of this study was ...
- DOI:
- 10.1016/j.vetimm.2006.01.011
- https://doi.org/10.1016/j.vetimm.2006.01.011
- Author:
- Kumudika de Silva; Sally Browne; Douglas J. Begg; Richard J. Whittington; David Emery
- Source:
- Veterinary immunology and immunopathology 2013 v.156 no.1-2 pp. 82-90
- ISSN:
- 0165-2427
- Subject:
- Mycobacterium avium subsp. paratuberculosis; T-lymphocytes; antigens; apoptosis; cell-mediated immunity; disease control; disease course; early diagnosis; longitudinal studies; lymph; macrophages; models; paratuberculosis; sheep
- Abstract:
- ... Ovine Johne's disease (OJD) is a degenerative wasting condition of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). Similar to other pathogenic mycobacterial infections it is a slow-progressing chronic disease and subclinically infected individuals can spread the disease while appearing healthy. MAP infects macrophages and the host responds by mounting a cell-mediated immune ...
- DOI:
- 10.1016/j.vetimm.2013.08.001
- PubMed:
- 24054092
- https://doi.org/10.1016/j.vetimm.2013.08.001
- Author:
- Rupa, Prithy; Schmied, Julie; Lai, Serene; Wilkie, Bruce N.
- Source:
- Veterinary immunology and immunopathology 2009 v.132 no.1 pp. 78-83
- ISSN:
- 0165-2427
- Subject:
- swine; swine diseases; Escherichia coli; food allergies; interferons; hygiene; etiology; immunotherapy; trypsin inhibitors; egg albumen; intramuscular injection; cholera toxin; neonates; antibodies; blood serum; disease control
- Abstract:
- ... Food allergy is epidemic and prompts investigation to reduce allergic predisposition. It was hypothesized that heat-killed Escherichia coli injected intramuscularly (im) with or without interferon gamma (IFN-γ), reduces neonatal susceptibility to experimental egg allergy. Two litters of Yorkshire pigs were assigned to three intramuscular treatment groups (four/group): control (PBS), heat-killed E. ...
- DOI:
- 10.1016/j.vetimm.2009.09.019
- https://doi.org/10.1016/j.vetimm.2009.09.019
- Author:
- Li, Xiao-Yu; Jin, Li-Ji; Uzonna, Jude E.; Li, Shu-Ying; Liu, Jun-Jun; Li, Hua-Qiang; Lu, Ya-Nan; Zhen, Yu-Hong; Xu, Yong-Ping
- Source:
- Veterinary immunology and immunopathology 2009 v.129 no.1-2 pp. 132-136
- ISSN:
- 0165-2427
- Subject:
- immunotherapy; alginates; microencapsulation; oral administration; protective effect; diarrhea; gastrointestinal system; swine diseases; bioavailability; antibodies; gastrointestinal transit; human diseases; chitosan; disease control; egg yolk; enterotoxigenic Escherichia coli; weight loss; Escherichia infections; pharmacokinetics; swine; bacterial enteritis; immunoglobulin Y
- Abstract:
- ... In our previous study, the applicability of chitosan-alginate microcapsules for oral delivery of egg yolk immunoglobulin (IgY) was established in a simulated gastrointestinal tract environment. The objective of the present study was to evaluate the protective efficacy of microencapsulated IgY against K88+ ETEC (enterotoxigenic Escherichia coli)-induced diarrhea in 40-day-old pigs. Groups of pigs o ...
- DOI:
- 10.1016/j.vetimm.2008.12.016
- PubMed:
- 19150135
- https://doi.org/10.1016/j.vetimm.2008.12.016
- Author:
- Sveinung Eskeland; Snorre Stuen; Ulrike G. Munderloh; Anthony Barbet; Liliana Crosby; Kari Lybeck; Peter Wilhelmsson; Per-Eric Lindgren; Shokouh Makvandi-Nejad; Stig Tollefsen; Erik G. Granquist
- Source:
- Veterinary immunology and immunopathology 2021 v.231 pp. 110165
- ISSN:
- 0165-2427
- Subject:
- Anaplasma phagocytophilum; acaricides; animal welfare; bacteremia; bacteria; cell lines; disease control; genetic transformation; humoral immunity; immunogenicity; immunopathology; nucleotide sequences; tick-borne diseases; ticks; vaccines; virulence; virulent strains; Norway
- Abstract:
- ... In Norway, the tick-transmitted bacterium Anaplasma phagocytophilum is estimated to cause tick-borne fever (TBF) in 300 000 lambs on pastures each year, resulting in economic and animal welfare consequences. Today, prophylactic measures mainly involve the use of acaricides, but a vaccine has been requested by farmers and veterinarians for decades. Several attempts have been made to produce a vacci ...
- DOI:
- 10.1016/j.vetimm.2020.110165
- https://doi.org/10.1016/j.vetimm.2020.110165
- Author:
- Petra Bizikova; Gregg A. Dean; Takashi Hashimoto; Thierry Olivry
- Source:
- Veterinary immunology and immunopathology 2012 v.149 no.3-4 pp. 197-207
- ISSN:
- 0165-2427
- Subject:
- antigens; autoimmune diseases; disease control; disease severity; dog diseases; dogs; fluorescent antibody technique; humans; immunoglobulin G; pyoderma
- Abstract:
- ... Pemphigus foliaceus (PF) is the most common antibody-mediated autoimmune skin disease of dogs. Desmoglein-1 (DSG1), the major human PF antigen, represents only a minor autoantigen in canine PF (cPF). A recent immunomapping study proposed desmocollin-1 (DSC1) as a relevant candidate autoantigen for cPF. To investigate this hypothesis, 85 cPF sera were screened for the presence of anti-DSC1 IgG usin ...
- DOI:
- 10.1016/j.vetimm.2012.06.025
- PubMed:
- 22884397
- https://doi.org/10.1016/j.vetimm.2012.06.025
- Author:
- Michele Drigo; Enrico Giacomini; Massimiliano Lazzaro; Daniela Pasotto; Dania Bilato; Jessica Ruggeri; Maria Beatrice Boniotti; Giovani Loris Alborali; Massimo Amadori
- Source:
- Veterinary immunology and immunopathology 2018 v.200 pp. 32-39
- ISSN:
- 0165-2427
- Subject:
- Porcine reproductive and respiratory syndrome virus; acclimation; antibodies; blood sampling; blood serum; cell-mediated immunity; disease control; early development; environmental factors; excretion; farms; gilts; herds; immune response; immunoglobulin A; immunoglobulin G; interferon-gamma; livestock and meat industry; maternal immunity; models; pathogenicity; phenotype; piglets; porcine reproductive and respiratory syndrome; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signs and symptoms (animals and humans); suckling; swine breeds; viremia; viruses
- Abstract:
- ... Porcine Reproductive and Respiratory Syndrome (PRRS) is an elusive model of host/virus relationship in which disease is determined by virus pathogenicity, pig breed susceptibility and phenotype, microbial infectious pressure and environmental conditions. Successful disease control in PRRS-endemic Countries corresponds to “stability”, i.e. a condition with no clinical signs of PRRS in the breeding- ...
- DOI:
- 10.1016/j.vetimm.2018.04.007
- https://doi.org/10.1016/j.vetimm.2018.04.007
- Author:
- Michel, A.L.; Simões, M.
- Source:
- Veterinary immunology and immunopathology 2009 v.127 no.1-2 pp. 186-189
- ISSN:
- 0165-2427
- Subject:
- diagnostic techniques; Syncerus caffer; immunoassays; product evaluation; antibody detection; wildlife diseases; rapid methods; disease control; bovine tuberculosis; analytical kits; field experimentation; wild animals; Mycobacterium bovis; conservation areas; disease diagnosis; South Africa
- Abstract:
- ... Panels of sera from African buffalo with confirmed bovine tuberculosis and from known uninfected controls were used to evaluate the performance of two commercial rapid chromatographic immunoassays (A and B) for the detection of antibodies to Mycobacterium bovis. The sensitivity was 33% and 23%, respectively, while the specificity was determined at 90% and 94%, respectively. Overall the performance ...
- DOI:
- 10.1016/j.vetimm.2008.09.025
- PubMed:
- 19007999
- https://doi.org/10.1016/j.vetimm.2008.09.025
- Author:
- Melkebeek, V.; Verdonck, F.; Goddeeris, B.M.; Cox, E.
- Source:
- Veterinary immunology and immunopathology 2007 v.116 no.3-4 pp. 199-214
- ISSN:
- 0165-2427
- Subject:
- dermal exposure; enteropathogenic Escherichia coli; vaccination; oral administration; protective effect; immunoglobulin G; swine diseases; drug evaluation; enterotoxins; fimbriae; mucosal immunity; disease control; calcitriol; vaccine development; Escherichia infections; swine; bacterial colonization; antibody formation; vaccines; vaccine adjuvants
- Abstract:
- ... We previously showed that an intradermal (i.d.) FaeG DNA prime (2x)-oral F4 protein boost immunization induces a systemic response and weakly primes a mucosal IgG response in pigs, especially when plasmid vectors encoding the A and B subunit of the E. coli thermo-labile enterotoxin (LT) are added to the DNA vaccine. In the present study, we evaluated whether addition of 1α,25-dihydroxyvitamin D3 ( ...
- DOI:
- 10.1016/j.vetimm.2007.01.021
- https://doi.org/10.1016/j.vetimm.2007.01.021
- Author:
- J. Bouvet; C. Cariou; A. Poulard; F. Oberli; L. Cupillard; P.M. Guigal
- Source:
- Veterinary immunology and immunopathology 2018 v.205 pp. 93-96
- ISSN:
- 0165-2427
- Subject:
- Adenoviridae; Protoparvovirus; antibodies; canine distemper; disease control; dogs; leptospirosis; rabies; seroconversion; vaccination; vaccines; viruses
- Abstract:
- ... In many cicumstances, veterinarians are requiring to be able to administer rabies vaccine in dogs at the same time as vaccinating against canine distemper, adenovirus, parvovirus, parainfluenza virus and leptospirosis. The aim of this study was to assess the compatibility between a multivalent vaccine and a rabies vaccine when injected at two separate sites. Lack of interference was assessed by co ...
- DOI:
- 10.1016/j.vetimm.2018.11.001
- https://doi.org/10.1016/j.vetimm.2018.11.001
- Author:
- Javier Robalino; Ryan B. Carnegie; Nuala O‘Leary; Severine A. Ouvry-Patat; Enrique de la Vega; Sarah Prior; Paul S. Gross; Craig L. Browdy; Robert W. Chapman; Kevin L. Schey; Gregory Warr
- Source:
- Veterinary immunology and immunopathology 2009 v.128 no.1-3 pp. 110-118
- ISSN:
- 0165-2427
- Subject:
- Litopenaeus vannamei; RNA; disease control; ecosystems; expressed sequence tags; gene expression regulation; genomics; immune response; immune system; mass spectrometry; microarray technology; proteomics; sequence analysis; shellfish diseases; shrimp; shrimp culture; suppression subtractive hybridization
- Abstract:
- ... The need for better control of infectious diseases in shrimp aquaculture and the ecological importance of crustacea in marine ecosystems have prompted interest in the study of crustacean immune systems, particularly those of shrimp. As shrimp and other crustacea are poorly understood from the immunological point of view, functional genomic and proteomic approaches have been applied as a means of q ...
- DOI:
- 10.1016/j.vetimm.2008.10.329
- PubMed:
- 19070907
- https://doi.org/10.1016/j.vetimm.2008.10.329
- Author:
- Santos-Gomes, Gabriela M; Rosa, Ricardo; Leandro, Clara; Cortes, Sofia; Romao, Pedro; Silveira, Henrique
- Source:
- Veterinary immunology and immunopathology 2002 v.88 no.1-2 pp. 21-30
- ISSN:
- 0165-2427
- Subject:
- Beagle; Leishmania infantum; amastigotes; antibodies; blood serum; bone marrow; concanavalin A; cultured cells; disease control; disease severity; dogs; humoral immunity; interferon-gamma; interleukin-10; interleukin-12; interleukin-2; interleukin-6; lymph nodes; messenger RNA; mononuclear leukocytes; parasites
- Abstract:
- ... In this study, the cytokines, interferon-gamma (IFN-γ), interleukin-2 (IL-2), IL-12 p40, IL-6 and IL-10, expressed by peripheral blood mononuclear cells of 13 beagle dogs inoculated with Leishmania infantum amastigotes, were analysed during a period of up to 23 months. The course of infection was monitored through clinical and parasitological examinations, haematological alterations and serum anti ...
- DOI:
- 10.1016/S0165-2427(02)00134-4
- https://doi.org/10.1016/S0165-2427(02)00134-4
- Author:
- Ju, Ying; Hao, Huai-Jie; Xiong, Guo-Hua; Geng, Hong-Ran; Zheng, Yu-Ling; Wang, Jing; Cao, Yuanyin; Yang, Yin-Hui; Cai, Xue-Hui; Jiang, Yong-Qiang
- Source:
- Veterinary immunology and immunopathology 2010 v.133 no.2-4 pp. 207-211
- ISSN:
- 0165-2427
- Subject:
- colloidal properties; gold; assays; rapid methods; Streptococcus suis; serotypes; product development; antigen detection; antibodies; disease control; diagnostic techniques
- Abstract:
- ... To develop colloidal gold immunochromatographic strips for the direct detection of the Streptococcus suis serotype 2 antigen, colloidal gold was prepared by reduction of a gold salt with sodium citrate and coupled with polyclonal antibody against S. suis serotype 2. The optimal concentrations of the capture antibody and the coating antibody were determined to be 22μg/mL and 2.0mg/mL, respectively, ...
- DOI:
- 10.1016/j.vetimm.2009.08.010
- PubMed:
- 19733402
- https://doi.org/10.1016/j.vetimm.2009.08.010
- Author:
- Laetitia Delgado; Ramón A. Juste; María Muñoz; Silvia Morales; Julio Benavides; M. Carmen Ferreras; J. Francisco García Marín; Valentín Pérez
- Source:
- Veterinary immunology and immunopathology 2012 v.145 no.1-2 pp. 23-31
- ISSN:
- 0165-2427
- Subject:
- Mycobacterium avium; animal age; disease control; ewes; humoral immunity; immune response; lambs; paratuberculosis; polymerase chain reaction; skin tests
- Abstract:
- ... The peripheral immune response, and its relationship with the outcome of the infection according to the age of the animal, has been investigated in young lambs and adult ewes experimentally infected with two different doses of Mycobacterium avium subspecies paratuberculosis (Map). Sixteen 1.5-month-old lambs out of 24 and 23 adult ewes out of 30 were orally challenged with an ovine Map field isola ...
- DOI:
- 10.1016/j.vetimm.2011.10.005
- PubMed:
- 22070826
- https://doi.org/10.1016/j.vetimm.2011.10.005
- Author:
- U. Castillo-Velázquez; R. Gomez-Flores; R. Tamez-Guerra; P. Tamez-Guerra; C. Rodríguez-Padilla
- Source:
- Veterinary immunology and immunopathology 2013 v.154 no.1-2 pp. 8-16
- ISSN:
- 0165-2427
- Subject:
- Mycobacterium tuberculosis; avirulent strains; cattle; macrophages; disease control; gene expression; bovine tuberculosis; immune response; Mycobacterium bovis; blood
- Abstract:
- ... It is known that macrophages from naturally resistant animals possess a strong immune response against bovine tuberculosis to control mycobacterial infections. In the present study, the macrophage phagocytic activity, intracellular bacterial survival, and cytokine gene expression induced by classical and alternative activators against Mycobacterium bovis in naturally resistant or susceptible bovin ...
- DOI:
- 10.1016/j.vetimm.2013.04.010
- PubMed:
- 23707003
- https://doi.org/10.1016/j.vetimm.2013.04.010
- Author:
- E. Stuyven; E. Cox; S. Vancaeneghem; S. Arnouts; P. Deprez; B.M. Goddeeris
- Source:
- Veterinary immunology and immunopathology 2009 v.128 no.1-3 pp. 60-66
- ISSN:
- 0165-2427
- Subject:
- in vivo studies; immunoglobulin M; diarrhea; swine feeding; glucans; weaning; disease control; Saccharomyces cerevisiae; immunoglobulin A; enterotoxigenic Escherichia coli; ingredients; oral administration; Athelia rolfsii; piglets; excretion; protective effect
- Abstract:
- ... The effect of orally administered β-glucans in protecting pigs against an ETEC infection after weaning was analysed in this study. Three β-glucans that differed in origin (Saccharomyces cerevisiae (MCG (Macrogard) and G2) or Sclerotium rolfsii (G3)) and/or extraction procedure were tested. Pigs fed for 2 weeks after weaning with these glucans were less susceptible to an F4⁺ ETEC infection in compa ...
- DOI:
- 10.1016/j.vetimm.2008.10.311
- https://doi.org/10.1016/j.vetimm.2008.10.311
- Author:
- C. Vega; M. Bok; P. Chacana; L. Saif; F. Fernandez; V. Parreño
- Source:
- Veterinary immunology and immunopathology 2011 v.142 no.3-4 pp. 156-169
- ISSN:
- 0165-2427
- Subject:
- Rotavirus; antibodies; birds; chicken eggs; colostrum; dairy calves; diarrhea; diet; disease control; duodenum; egg yolk; enzyme-linked immunosorbent assay; feces; immune response; immunoglobulin Y; intestinal mucosa; milk; neonates; neutralization tests; oral administration; passive immunity
- Abstract:
- ... Bovine rotavirus (BRV) is an important cause of diarrhea in newborn calves. Local passive immunity is the most efficient protective strategy to control the disease. IgY technology (the use of chicken egg yolk immunoglobulins) is an economic and practical alternative to prevent BRV diarrhea in dairy calves. The aim of this study was to evaluate the protection and immunomodulation induced by the ora ...
- DOI:
- 10.1016/j.vetimm.2011.05.003
- PubMed:
- 21652087
- PubMed Central:
- PMC3155943
- https://doi.org/10.1016/j.vetimm.2011.05.003
- Author:
- Fumuso, Elida; Giguère, Steeve; Wade, José; Rogan, Dragan; Videla-Dorna, Ignacio; Bowden, Raúl A.
- Source:
- Veterinary immunology and immunopathology 2003 v.96 no.1-2 pp. 31-41
- ISSN:
- 0165-2427
- Subject:
- Mycobacterium phlei; artificial insemination; biopsy; diestrus; disease control; endometritis; endometrium; estrus; gene expression; herds; immunomodulation; immunomodulators; interleukin-1beta; interleukin-6; mares; messenger RNA; ovulation; quantitative polymerase chain reaction; semen; tumor necrosis factor-alpha
- Abstract:
- ... Endometrial mRNA expression of the pro-inflammatory cytokines interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α) was assessed in mares resistant (RM) or susceptible (SM) to persistent post-breeding endometritis (PPBE). Eight RM and eight SM, were selected based on reproductive records and functional tests out of a herd of 2000 light cross-type mares. Three experi ...
- DOI:
- 10.1016/S0165-2427(03)00137-5
- https://doi.org/10.1016/S0165-2427(03)00137-5
- Author:
- Chong Liu; Sheila J. Cook; Jodi K. Craigo; Frank R. Cook; Charles J. Issel; Ronald C. Montelaro; David W. Horohov
- Source:
- Veterinary immunology and immunopathology 2014 v.161 no.3-4 pp. 161-169
- ISSN:
- 0165-2427
- Subject:
- HIV infections; Human immunodeficiency virus; T-lymphocytes; biopsy; carrier state; cell-mediated immunity; disease control; epitopes; horses; immune response; mutation; peptides; quantitative polymerase chain reaction; viruses
- Abstract:
- ... Unlike other lentiviruses, EIAV replication can be controlled in most infected horses leading to an inapparent carrier state free of overt clinical signs which lasts for many years. While the resolution of the initial infection is correlated with the appearance of virus specific cellular immune responses, the precise immune mechanisms responsible for control of the infection are not yet identified ...
- DOI:
- 10.1016/j.vetimm.2014.08.001
- PubMed:
- 25176006
- PubMed Central:
- PMC4337894
- https://doi.org/10.1016/j.vetimm.2014.08.001
- Author:
- Christine L. Wimer; Armando Damiani; Nikolaus Osterrieder; Bettina Wagner
- Source:
- Veterinary immunology and immunopathology 2011 v.140 no.3-4 pp. 266-274
- ISSN:
- 0165-2427
- Subject:
- immunity; Equid alphaherpesvirus 1; humans; polymerase chain reaction; models; disease control; gene expression; encephalopathy; mice; pathogenicity; viruses; mononuclear leukocytes; herpes simplex; chemokines; horses; chemotaxis
- Abstract:
- ... Equine herpesvirus type 1 (EHV-1) is highly prevalent in horses and causes rhinopneumonitis, abortion, and encephalopathy. Studies on the related human herpes simplex virus and of murine models of EHV-1 suggest that chemokines play important roles in coordinating of innate and adaptive immune responses, and thus effective control of herpesvirus infection and prevention of severe clinical disease. ...
- DOI:
- 10.1016/j.vetimm.2011.01.009
- PubMed:
- 21349590
- https://doi.org/10.1016/j.vetimm.2011.01.009
- Author:
- Hans-Joachim Baetza
- Source:
- Veterinary immunology and immunopathology 2014 v.158 no.1-2 pp. 116-119
- ISSN:
- 0165-2427
- Subject:
- animal health; bluetongue; cattle; consumer protection; disease control; disease outbreaks; disease transmission; field experimentation; goats; insects; polymerase chain reaction; prototypes; serotypes; sheep; vaccination; vaccines; Belgium; Germany; Netherlands
- Abstract:
- ... Bluetongue disease first broke out in Germany on 21 August 2006, almost simultaneously with the first outbreaks in Belgium and The Netherlands. More extensive tests showed that the serotype was serotype 8. Due to westerly winds the disease spread rapidly towards the East, with the result that in the year 2008 large parts of Germany were affected. The traditional methods of animal disease control w ...
- DOI:
- 10.1016/j.vetimm.2013.09.001
- https://doi.org/10.1016/j.vetimm.2013.09.001
- Author:
- Arathi Dharmaratnam; Arun Sudhagar; Sundar Raj Nithianantham; Sweta Das; Thangaraj Raja Swaminathan
- Source:
- Veterinary immunology and immunopathology 2021 v.237 pp. 110270
- ISSN:
- 0165-2427
- Subject:
- Carassius auratus; algorithms; disease control; gene expression; goldfish; heart; immunology; immunopathology; intestines; kidneys; liver; muscles; pathogens; peptide elongation factors; quantitative polymerase chain reaction; ribosomal RNA; spleen; world wide web
- Abstract:
- ... The accuracy of quantitative real time PCR (RTqPCR) can be attained only when a suitable reference gene is used. The gene expression for a particular gene may vary within different cells at different conditions. Hence, the suitability and stability of various potential reference genes have to be determined for expression studies. In this study, we have examined the potential of four different refe ...
- DOI:
- 10.1016/j.vetimm.2021.110270
- https://doi.org/10.1016/j.vetimm.2021.110270
- Author:
- Giovanni Curina; Roberto Nardini; Sara Corneli; Nicoletta D’Avino; Michele Tentellini; Claudia Montagnoli; Giulio Severi; Katia Forti; Beatrice Paternesi; Mauro Coletti; Monica Cagiola
- Source:
- Veterinary immunology and immunopathology 2018 v.198 pp. 44-53
- ISSN:
- 0165-2427
- Subject:
- B-lymphocytes; Brucella melitensis; CD4-positive T-lymphocytes; agglutination; bioreactors; blood serum; brucellosis; cost effectiveness; cytotoxic T-lymphocytes; dendritic cells; developing countries; disease control; farms; females; flow cytometry; goats; herds; liquids; live vaccines; macrophages; major histocompatibility complex; mice; natural killer cells; serodiagnosis; sheep; vaccination
- Abstract:
- ... The Brucella melitensis REV1 vaccine is the most widely employed vaccine for prophylaxis against brucellosis in sheep and goats. The objective of vaccination is disease control in herds or preventing infection in farms. In this study, we produced REV1 vaccine with a protocol, based on the use of liquid medium in a bioreactor, that resulted efficient, safe, relatively fast, and cost-effective. The ...
- DOI:
- 10.1016/j.vetimm.2018.02.010
- https://doi.org/10.1016/j.vetimm.2018.02.010
- Author:
- Karel Novák
- Source:
- Veterinary immunology and immunopathology 2014 v.157 no.1-2 pp. 1-11
- ISSN:
- 0165-2427
- Subject:
- germplasm; immunity; mastitis; haplotypes; cattle; farms; breeding; health status; disease control; mutation; breeds; genes; genetic variation; receptors; pathogens; prediction
- Abstract:
- ... The exploitation of the genetic factors affecting the health status of farm animals represents an alternative approach to controlling the diseases caused by microbial pathogens. The determination of innate immunity based on the genotype of the germplasm cells is a constraint for specificity but becomes an advantage in breeding schemes. The structural deviations among Toll-like receptors (TLRs), as ...
- DOI:
- 10.1016/j.vetimm.2013.10.016
- https://doi.org/10.1016/j.vetimm.2013.10.016
26. Genes controlling vaccine responses and disease resistance to respiratory viral pathogens in cattle
- Author:
- Elizabeth J. Glass; Rebecca Baxter; Richard J. Leach; Oliver C. Jann
- Source:
- Veterinary immunology and immunopathology 2012 v.148 no.1-2 pp. 90-99
- ISSN:
- 0165-2427
- Subject:
- T-lymphocytes; respiratory tract diseases; vaccination; receptors; quantitative trait loci; risk; phenotype; Bovine orthopneumovirus; viruses; genotype; disease resistance; foot-and-mouth disease; population structure; pathogens; humoral immunity; herds; hosts; cattle; disease control; major histocompatibility complex; single nucleotide polymorphism; vaccines; genetic disorders; bovine respiratory disease; genetic variation; pedigree
- Abstract:
- ... Farm animals remain at risk of endemic, exotic and newly emerging viruses. Vaccination is often promoted as the best possible solution, and yet for many pathogens, either there are no appropriate vaccines or those that are available are far from ideal. A complementary approach to disease control may be to identify genes and chromosomal regions that underlie genetic variation in disease resistance ...
- DOI:
- 10.1016/j.vetimm.2011.05.009
- PubMed:
- 21621277
- PubMed Central:
- PMC3413884
- https://doi.org/10.1016/j.vetimm.2011.05.009
- Author:
- Meredith A. Brown
- Source:
- Veterinary immunology and immunopathology 2011 v.143 no.3-4 pp. 265-268
- ISSN:
- 0165-2427
- Subject:
- proteins; avirulent strains; feline infectious peritonitis; cats; genetic background; Feline coronavirus; mutation; disease control; genetic disorders; viruses; genes; pathogenesis; virulence
- Abstract:
- ... Feline infectious peritonitis (FIP) is a fatal, immune-augmented, and progressive viral disease of cats associated with feline coronavirus (FCoV). Viral genetic determinants specifically associated with FIPV pathogenesis have not yet been discovered. Viral gene signatures in the spike, non-structural protein 3c, and membrane of the coronavirus genome have been shown to often correlate with disease ...
- DOI:
- 10.1016/j.vetimm.2011.06.021
- PubMed:
- 21719115
- https://doi.org/10.1016/j.vetimm.2011.06.021
- Author:
- Simojoki, Heli; Hyvönen, Paula; Orro, Toomas; Pyörälä, Satu
- Source:
- Veterinary immunology and immunopathology 2010 v.136 no.3-4 pp. 265-271
- ISSN:
- 0165-2427
- Subject:
- chemical concentration; transgenes; humans; Staphylococcus chromogenes; cattle; recombinant proteins; transgenic animals; disease control; disease severity; signs and symptoms (animals and humans); lactoferrin; milk; disease resistance; immune response; bovine mastitis; disease course; protective effect
- Abstract:
- ... Six transgenic cows producing recombinant human lactoferrin (rhLf) in their milk and five normal cows at the same lactation stage were experimentally infected with Staphylococcus chromogenes to study the effect of a high concentration of lactoferrin in milk. Coagulase-negative staphylococci such as S. chromogenes have become very common as agents causing mild or subclinical mastitis. All transgeni ...
- DOI:
- 10.1016/j.vetimm.2010.03.017
- https://doi.org/10.1016/j.vetimm.2010.03.017
- Author:
- Moreira, Nádia das Dores; Giunchetti, Rodolfo Cordeiro; Carneiro, Cláudia Martins; Vitoriano-Souza, Juliana; Roatt, Bruno Mendes; Malaquias, Luiz Cosme Cotta; Corrêa-Oliveira, Rodrigo; Reis, Alexandre Barbosa
- Source:
- Veterinary immunology and immunopathology 2009 v.128 no.4 pp. 418-424
- ISSN:
- 0165-2427
- Subject:
- hamsters; visceral leishmaniasis; vaccination; protective effect; lymphocytes; saponins; dermis; nitric oxide synthase; antigens; histology; disease control; immune response; vaccine development; Leishmania braziliensis; nitric oxide; vaccines; physiological transport; inflammation; vaccine adjuvants; animal models
- Abstract:
- ... Vaccine candidates, including live and/or killed parasites, Leishmania-purified fractions, defined recombinant antigens and antigen-encoding DNA-plasmids have been proposed to use as vaccine anti-Leishmania. More recently, the hamsters have been used to pre-selection of antigens candidate to apply in further experiments using canine model. In this report we evaluated the kinetics of cell migration ...
- DOI:
- 10.1016/j.vetimm.2008.11.030
- PubMed:
- 19147234
- https://doi.org/10.1016/j.vetimm.2008.11.030
- Author:
- Pridgeon, Julia W.; Klesius, Phillip H.
- Source:
- Veterinary immunology and immunopathology 2010 v.138 no.1-2 pp. 25-33
- ISSN:
- 0165-2427
- Subject:
- Flavobacterium columnare; animal pathogenic bacteria; live vaccines; vaccination; fish diseases; bacterial infections; disease control; Ictalurus punctatus; catfish; fish fry; gene expression regulation; expressed sequence tags
- Abstract:
- ... Using PCR-select subtractive cDNA hybridization technique, 32 expressed sequence tags (ESTs) were isolated from 96 clones of a channel catfish (Ictalurus punctatus) fry subtractive library 10min post-vaccination with a modified live Flavobacterium columnare vaccine. The transcription levels of the 32 ESTs in response to F. columnare vaccination were then evaluated by quantitative PCR (QPCR). Of th ...
- Handle:
- 10113/45728
- DOI:
- 10.1016/j.vetimm.2010.06.011
- https://doi.org/10.1016/j.vetimm.2010.06.011
- Author:
- Federico Carlos Blanco; Fabiana Bigi; Marcelo Abel Soria
- Source:
- Veterinary immunology and immunopathology 2014 v.160 no.3-4 pp. 177-183
- ISSN:
- 0165-2427
- Subject:
- animal identification; biomarkers; bovine tuberculosis; cattle; developing countries; diagnostic techniques; discriminant analysis; disease control; disease course; herds; interferon-gamma; interleukin-10; interleukin-17; interleukin-2; tuberculin; zoonoses
- Abstract:
- ... Bovine tuberculosis (bTB) remains an important animal and zoonotic disease in many countries. The diagnosis of bTB is based on tuberculin skin test and IFN-γ release assays (IGRA). Positive animals are separated from the herd and sacrificed. The cost of this procedure is difficult to afford for developing countries with high prevalence of bTB; therefore, the improvement of diagnostic methods and t ...
- DOI:
- 10.1016/j.vetimm.2014.04.008
- https://doi.org/10.1016/j.vetimm.2014.04.008
- Author:
- Adam J. Karpala; John W. Lowenthal; Andrew G.D. Bean
- Source:
- Veterinary immunology and immunopathology 2012 v.148 no.1-2 pp. 100-109
- ISSN:
- 0165-2427
- Subject:
- avian influenza; chickens; control methods; disease control; disease outbreaks; good agricultural practices; hosts; immunity; mammals; poultry industry; public health; therapeutics
- Abstract:
- ... Zoonotic viruses, such as highly pathogenic avian influenza (HPAI), present a significant threat to both the poultry industry and public health. The present method of controlling avian influenza (AI) relies on good farming practice with limited use of vaccination in some countries. However, new ways to control disease outbreaks might be possible with additional knowledge of the natural host respon ...
- DOI:
- 10.1016/j.vetimm.2011.05.031
- PubMed:
- 21715024
- https://doi.org/10.1016/j.vetimm.2011.05.031
- Author:
- Alejandra G. Díaz; María Clausse; Fernando A. Paolicchi; María A. Fiorentino; Giselle Ghersi; Vanesa Zylberman; Fernando A. Goldbaum; Silvia M. Estein
- Source:
- Veterinary immunology and immunopathology 2013 v.154 no.1-2 pp. 36-41
- ISSN:
- 0165-2427
- Subject:
- Brucella melitensis biovar Ovis; antibacterial properties; antibodies; antigens; antiserum; brucellosis; culling (animals); disease control; evolution; humans; immune response; immunologic techniques; rams; serodiagnosis; vaccination; vaccines; virulence
- Abstract:
- ... Brucella ovis is the etiologic agent of ovine brucellosis. The control measures for this disease are periodical diagnosis by serological tests and/or bacteriological culture and culling of positive animals. Vaccination with Brucella melitensis Rev 1 is recommended when prevalence is high. This attenuated strain vaccine gives protection against B. ovis but it has important disadvantages associated ...
- DOI:
- 10.1016/j.vetimm.2013.04.003
- PubMed:
- 23643287
- https://doi.org/10.1016/j.vetimm.2013.04.003
- Author:
- Supatsak Subharat; Dairu Shu; D. Neil Wedlock; Marian Price-Carter; Geoffrey W. de Lisle; Dongwen Luo; Desmond M. Collins; Bryce M. Buddle
- Source:
- Veterinary immunology and immunopathology 2012 v.149 no.3-4 pp. 225-236
- ISSN:
- 0165-2427
- Subject:
- nitric oxide synthase; disease control; disease severity; feces; gene expression; immune response; interleukin-10; mononuclear leukocytes; calves; lymph nodes; Mycobacterium avium subsp. paratuberculosis; interferons; tissue culture
- Abstract:
- ... This study examined the immune responses related to the infection, progression and control of Mycobacterium avium subsp. paratuberculosis (MAP) infection in calves. Twenty calves were challenged orally with MAP and 11 non-challenged calves served as controls. Approximately half the calves from each group were sacrificed at either 7 or 15 months post-challenge (PC). The majority of the challenged c ...
- DOI:
- 10.1016/j.vetimm.2012.07.005
- PubMed:
- 22871577
- https://doi.org/10.1016/j.vetimm.2012.07.005
- Author:
- Yu-Xiong Lai; Bao-Lei Jin; Yu Xu; Li-jie Huang; Run-Qing Huang; Yong Zhang; Jimmy Kwang; Jian-Guo He; Jun-Feng Xie
- Source:
- Veterinary immunology and immunopathology 2014 v.157 no.1-2 pp. 87-96
- ISSN:
- 0165-2427
- Subject:
- Betanodavirus; Epinephelus coioides; Escherichia coli; bass; body weight; disease control; gene expression regulation; genes; humoral immunity; immune response; liver; marine fish; mortality; necrosis; neutralizing antibodies; polymerase chain reaction; spleen; vaccination; vaccines; virus-like particles; viruses
- Abstract:
- ... Betanodaviruses are the causative agents of viral nervous necrosis (VNN), a serious disease of cultured marine fish worldwide. Virus-like particles (VLPs) are one of the good novel vaccine candidates to control this disease. Until now, betanodavirus vaccine studies mainly focused on the humoral immune response and mortality after virus challenge. However, little is known about the activation of ge ...
- DOI:
- 10.1016/j.vetimm.2013.10.003
- https://doi.org/10.1016/j.vetimm.2013.10.003
- Author:
- Virginie Roupie; Sophie Viart; Baptiste Leroy; Marta Romano; Nicolas Trinchero; Marc Govaerts; Jean-Jacques Letesson; Ruddy Wattiez; Kris Huygen
- Source:
- Veterinary immunology and immunopathology 2012 v.145 no.1-2 pp. 74-85
- ISSN:
- 0165-2427
- Subject:
- DNA; Mycobacterium avium subsp. paratuberculosis; T-lymphocytes; antigens; disease control; enteritis; etiological agents; genome; immune response; livestock and meat industry; mice; recombinant vaccines; ruminants; screening; small intestine
- Abstract:
- ... Mycobacterium avium subsp. paratuberculosis (Map), the etiological agent of chronic enteritis of the small intestine in domestic and wild ruminants, causes substantial losses to livestock industry. Control of this disease is seriously hampered by the lack of adequate diagnostic tools and vaccines. Here we report on the immunogenicity of eight Map specific antigens, i.e. MAP1693c, Ag3, MAP2677c (id ...
- DOI:
- 10.1016/j.vetimm.2011.10.012
- PubMed:
- 22088673
- https://doi.org/10.1016/j.vetimm.2011.10.012
- Author:
- Donald P. King; Alison Burman; Sarah Gold; Andrew E. Shaw; Terry Jackson; Nigel P. Ferris
- Source:
- Veterinary immunology and immunopathology 2011 v.140 no.3-4 pp. 259-265
- ISSN:
- 0165-2427
- Subject:
- Foot-and-mouth disease virus; cell culture; complementary DNA; disease control; disease diagnosis; gene expression; integrins; messenger RNA; receptors; reverse transcription; swine; vaccines; viruses
- Abstract:
- ... The ability to propagate foot-and-mouth disease virus (FMDV) plays an important role in laboratory diagnosis and the production of vaccines to control the spread of the disease. Many established cell lines suffer from poor sensitivity for isolating virus from field samples. One possible factor that limits sensitivity to FMDV is the lack of expression of surface integrins, the primary class of cell ...
- DOI:
- 10.1016/j.vetimm.2011.01.008
- PubMed:
- 21329991
- https://doi.org/10.1016/j.vetimm.2011.01.008
- Author:
- McNeil, Heather J.; Shewen, Patricia E.; Lo, Reggie Y.C.; Conlon, Jennifer A.; Miller, Michael W.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 107-110
- ISSN:
- 0165-2427
- Subject:
- Mannheimia haemolytica serotype 1; Pasteurella trehalosi; Western blotting; disease control; fibrinogen; pneumonia; serotypes; virulence
- Abstract:
- ... Fibrinogen-binding proteins were found in the culture supernatants of Mannheimia haemolytica serotype 1 (ATCC 43270) and Pasteurella trehalosi serotype 10 (ECO-100). Sheep fibrinogen was biotinylated and shown to bind to proteins in the culture supernatants by modified western blot. Fibrinogen-binding proteins in the culture supernatant may be important virulence factors leading to the characteris ...
- DOI:
- 10.1016/S0165-2427(02)00222-2
- https://doi.org/10.1016/S0165-2427(02)00222-2
- Author:
- Farinacci, Maura; Colitti, Monica; Stefanon, Bruno
- Source:
- Veterinary immunology and immunopathology 2009 v.128 no.4 pp. 366-373
- ISSN:
- 0165-2427
- Subject:
- sheep; sheep diseases; infectious diseases; inflammation; disease control; drug therapy; immunostimulants; phytochemicals; plant extracts; Echinacea angustifolia; Butea monosperma; Curcuma longa; anti-inflammatory activity; gene expression; neutrophils; immune response; interleukin-8; apoptosis; superoxide anion
- Abstract:
- ... Impaired neutrophil function has been associated with increased infectious diseases in ruminants. Attachment of neutrophils to endothelium and superoxide production is critical features of their immune activity. Once the infection is cleared, programmed cell death ensures the rapid resolution of inflammation. To develop new natural therapeutics for ruminants, standard extracts of Echinacea angusti ...
- DOI:
- 10.1016/j.vetimm.2008.11.024
- PubMed:
- 19128841
- https://doi.org/10.1016/j.vetimm.2008.11.024
- Author:
- Sandra Sommer; Chas B. Pudrith; Christopher J. Colvin; Paul M. Coussens
- Source:
- Veterinary immunology and immunopathology 2009 v.128 no.1-3 pp. 44-52
- ISSN:
- 0165-2427
- Subject:
- Crohn disease; Mycobacterium avium; T-lymphocytes; cattle; chromosome mapping; disease control; enteritis; gene expression; genes; hosts; macrophage activation; macrophages; mitogen-activated protein kinase; paratuberculosis; receptors; small intestine; wasting syndrome
- Abstract:
- ... Mycobacterium avium subspecies paratuberculosis (MAP) is a facultative intracellular organism that resides in host macrophages. MAP causes a fatal wasting syndrome in ruminants, typified by granulomatous enteritis in the small intestine. MAP has also been suspected as a causative or exacerbating factor in some cases of human Crohn’s disease. In MAP infections, a cytotoxic and proinflammatory Th1-l ...
- DOI:
- 10.1016/j.vetimm.2008.10.294
- PubMed:
- 19022505
- https://doi.org/10.1016/j.vetimm.2008.10.294
- Author:
- Entrican, Gary
- Source:
- Veterinary immunology and immunopathology 2002 v.87 no.3-4 pp. 485-490
- ISSN:
- 0165-2427
- Subject:
- disease control; gene expression; immunology; livestock; molecular biology; protein synthesis; proteins; ruminants; technology
- Abstract:
- ... There remains a great need for the development of reagents and techniques to study immune regulation in ruminants. These tools are fundamental to our understanding of the mechanisms of immune modulation and underpin the rational design of disease control strategies in livestock. Technological advances in molecular biology have resulted in the development of a new range of techniques to measure and ...
- DOI:
- 10.1016/S0165-2427(02)00082-X
- https://doi.org/10.1016/S0165-2427(02)00082-X
- Author:
- Shaw, Richard; Pfeffer, Alex; Bischof, Robert
- Source:
- Veterinary immunology and immunopathology 2009 v.132 no.1 pp. 31-40
- ISSN:
- 0165-2427
- Subject:
- sheep; sheep diseases; immunoglobulin E; parasitoses; immune response; disease control; vaccination; monoclonal antibodies
- Abstract:
- ... The importance of internal and external parasites in limiting productivity and compromising the welfare of sheep has provided the impetus for extensive research on ovine IgE with the objectives of better understanding protective immunological responses and developing novel methods of control; particularly vaccination. The molecular structures of ovine IgE and its high affinity receptor have been d ...
- DOI:
- 10.1016/j.vetimm.2009.09.012
- PubMed:
- 19836086
- https://doi.org/10.1016/j.vetimm.2009.09.012
- Author:
- R. Pérez-Caballero; M. Siles-Lucas; J. González-Miguel; F.J. Martínez-Moreno; A. Escamilla; J. Pérez; A. Martínez-Moreno; L. Buffoni
- Source:
- Veterinary immunology and immunopathology 2018 v.202 pp. 115-121
- ISSN:
- 0165-2427
- Subject:
- Fasciola hepatica; adjuvants; antibodies; disease control; fecal egg count; flukes; humoral immunity; immunogenicity; immunoglobulin G; recombinant proteins; recombinant vaccines; sheep
- Abstract:
- ... In this study, the immunogenicity and protective capacity of a new recombinant vaccine candidate, the rFh14-3-3z protein was analysed in sheep experimentally challenged with Fasciola hepatica, in terms of fluke burden, faecal egg counts, hepatic damage and humoral immune response. Three groups of 8 animals each were used for study, group 1 was immunised with the rFh14-3-3z in Montanide adjuvant, w ...
- DOI:
- 10.1016/j.vetimm.2018.07.006
- https://doi.org/10.1016/j.vetimm.2018.07.006
- Author:
- Rupa, Prithy; Schmied, Julie; Wilkie, Bruce N.
- Source:
- Veterinary immunology and immunopathology 2009 v.132 no.1 pp. 41-45
- ISSN:
- 0165-2427
- Subject:
- swine; swine diseases; anaphylaxis; ovalbumin; food allergies; allergens; monoclonal antibodies; polyclonal antibodies; pathogenesis; disease control
- Abstract:
- ... Anaphylaxis was reported in 1963 in pigs experimentally sensitized with ovalbumin and was subsequently associated indirectly with IgE-related antibodies by functional assays to confirm heat-labile passive cutaneous anaphylaxis (PCA), reverse passive anaphylaxis (RPA) and Prausnitz-Küstner (PK) reactions to this and other allergens. The immunoglobulin mediating immediate hypersensitivity could be c ...
- DOI:
- 10.1016/j.vetimm.2009.09.013
- PubMed:
- 19854520
- https://doi.org/10.1016/j.vetimm.2009.09.013
- Author:
- Bruce N. Wilkie; Prithy Rupa; Julie Schmied
- Source:
- Veterinary immunology and immunopathology 2012 v.148 no.1-2 pp. 110-115
- ISSN:
- 0165-2427
- Subject:
- Escherichia coli; Lactococcus lactis; bacteria; chronic diseases; disease control; environmental impact; food allergies; hygiene; immune response; models; phenotype; piglets; protective effect; receptors; remediation
- Abstract:
- ... The importance of environment in immune response is identified and the increase in prevalence of allergic, autoimmune and chronic inflammatory diseases reviewed. In particular, altered opportunity to acquire evolutionarily anticipated commensal microbiota is associated through the “hygiene hypothesis” with defective developmental and response signals to the innate and adaptive immune systems. Evid ...
- DOI:
- 10.1016/j.vetimm.2011.03.010
- PubMed:
- 21489640
- https://doi.org/10.1016/j.vetimm.2011.03.010
46. Prophylaxis of experimentally induced ovomucoid allergy in neonatal pigs using Lactococcus lactis
- Author:
- P. Rupa; J. Schmied; B.N. Wilkie
- Source:
- Veterinary immunology and immunopathology 2011 v.140 no.1-2 pp. 23-29
- ISSN:
- 0165-2427
- Subject:
- Lactococcus lactis; antibodies; blood cells; cholera toxin; disease control; egg albumen; hygiene; hypersensitivity; immune response; immunoglobulin E; immunoglobulin G; intraperitoneal injection; oral administration; ovomucin; piglets; probiotics; skin tests
- Abstract:
- ... Probiotic Lactococcus lactis (LL) is immunomodulatory and may prevent allergy by biasing from type-2 to a type-1 immune response. We hypothesized that newborn pigs pre-treated orally with LL are protected against allergy to ovomucoid (Ovm). Pigs were assigned to two treatment groups. Piglets were pretreated orally on days of age 1–7, 10, 12, 14, 21, 28 and 35 with LL (n=30) or medium (control, n=3 ...
- DOI:
- 10.1016/j.vetimm.2010.11.004
- PubMed:
- 21134696
- https://doi.org/10.1016/j.vetimm.2010.11.004
- Author:
- Leitner, G.; Krifucks, O.
- Source:
- Veterinary immunology and immunopathology 2007 v.119 no.3-4 pp. 198-203
- ISSN:
- 0165-2427
- Subject:
- mastitis; antibody formation; immunosuppression; sheep; vaccines; goats; disease control; sheep diseases; disease outbreaks; vaccine development; animal models; mice; vaccination; Pseudomonas aeruginosa; goat diseases; virulence; protective effect; Israel
- Abstract:
- ... Pseudomonas aeruginosa is most often associated with sporadic clinical mastitis. Outbreaks among more than 15 Israeli dairy sheep and goat herds presented clinical signs, including gangrenous infections. Characterization of the P. aeruginosa isolates revealed the presence of multiple environmental strains in the various farms, and it was hypothesized that the infected herds were temporarily immuno ...
- DOI:
- 10.1016/j.vetimm.2007.05.007
- https://doi.org/10.1016/j.vetimm.2007.05.007
- Author:
- Laval, F.; Paillot, R.; Bollard, S.; Fischer, L.; Audonnet, J.C.; Andreoni, C.; Juillard, V.
- Source:
- Veterinary immunology and immunopathology 2002 v.90 no.3-4 pp. 191-201
- ISSN:
- 0165-2427
- Subject:
- Suid alphaherpesvirus 1; infectious diseases; hypersensitivity; loci; quantitative analysis; interferon-gamma; dendritic cells; cell-mediated immunity; disease control; pathogens; major histocompatibility complex; plasmids; neoplasm cells; immunization; recombinant vaccines; CD8-positive T-lymphocytes; swine
- Abstract:
- ... It is now well established that antigen-specific CD8+ T cells play a major role in vaccine-induced immunity against intracellular pathogens and tumor cells. The detection of these immune cells in outbred animals has been hampered mainly by the need to generate individual autologous antigen-presenting cells (APCs) due to the high degree of polymorphism of the major histocompatibility complex (MHC) ...
- DOI:
- 10.1016/S0165-2427(02)00261-1
- https://doi.org/10.1016/S0165-2427(02)00261-1
- Author:
- Jiang, W.; Jiang, P.; Li, Y.; Tang, J.; Wang, X.; Ma, S.
- Source:
- Veterinary immunology and immunopathology 2006 v.113 no.1-2 pp. 169-180
- ISSN:
- 0165-2427
- Subject:
- vertebrate viruses; Porcine reproductive and respiratory syndrome virus; humoral immunity; antibodies; disease control; mice; viral proteins; animal models; recombinant vaccines; vaccination; immune response; lymphocyte proliferation; Adenoviridae
- Abstract:
- ... Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important contagious agents of swine in the world. PRRSV infection poses a challenge to current vaccination strategies. In this study, three replication-defective adenovirus recombinants were developed as potential vaccine against PRRSV in a mouse model. Three groups of BALB/c mice (24 mice per group) were inoculated su ...
- DOI:
- 10.1016/j.vetimm.2006.05.001
- https://doi.org/10.1016/j.vetimm.2006.05.001
- Author:
- Slater, J.D.; Lunn, D.P.; Horohov, D.W.; Antczak, D.F.; Babiuk, L.; Breathnach, C.; Chang, Y.W.; Davis-Poynter, N.; Edington, N.; Ellis, S.
- Source:
- Veterinary immunology and immunopathology 2006 v.111 no.1-2 pp. 3-13
- ISSN:
- 0165-2427
- Subject:
- foals; vertebrate viruses; Equid alphaherpesvirus 1; disease course; viral diseases of animals and humans; respiratory tract diseases; abortion (animals); vaccination; disease outbreaks; disease control; neonatal mortality; myeloencephalopathy; eye diseases; horse diseases; signs and symptoms (animals and humans); disease incidence
- Abstract:
- ... Amongst the infectious diseases that threaten equine health, herpesviral infections remain a world wide cause of serious morbidity and mortality. Equine herpesvirus-1 infection is the most important pathogen, causing an array of disorders including epidemic respiratory disease abortion, neonatal foal death, myeloencephalopathy and chorioretinopathy. Despite intense scientific investigation, extens ...
- DOI:
- 10.1016/j.vetimm.2006.01.004
- https://doi.org/10.1016/j.vetimm.2006.01.004
- Author:
- Mario Delgado-Ortega; Daniel Marc; Joëlle Dupont; Sascha Trapp; Mustapha Berri; François Meurens
- Source:
- Veterinary immunology and immunopathology 2013 v.151 no.1-2 pp. 1-19
- ISSN:
- 0165-2427
- Subject:
- disease control; endothelial cells; hosts; immune response; infectious diseases; mammals; pathogens; proteins
- Abstract:
- ... As for most biological processes, the immune response to microbial infections has to be tightly controlled to remain beneficial for the host. Inflammation is one of the major consequences of the host's immune response. For its orchestration, this process requires a fine-tuned interplay between interleukins, endothelial cells and various types of recruited immune cells. Suppressors of cytokine sign ...
- DOI:
- 10.1016/j.vetimm.2012.11.008
- PubMed:
- 23219158
- https://doi.org/10.1016/j.vetimm.2012.11.008
- Author:
- Kazuya Yamanouchi
- Source:
- Veterinary immunology and immunopathology 2012 v.148 no.1-2 pp. 12-15
- ISSN:
- 0165-2427
- Subject:
- Variola virus; disease control; rinderpest; vaccine development
- Abstract:
- ... The global eradication of rinderpest was declared in 2011. This is the second infectious disease to have been eradicated from the world after smallpox, for which eradication was declared in 1980. From a scientific aspect, smallpox eradication was achieved by improvements in the Jenner vaccine, originally developed in the 18th century. Developments in vaccine technology and virological techniques d ...
- DOI:
- 10.1016/j.vetimm.2012.06.006
- PubMed:
- 22748234
- https://doi.org/10.1016/j.vetimm.2012.06.006
- Author:
- Ramon A. Juste
- Source:
- Veterinary immunology and immunopathology 2012 v.148 no.1-2 pp. 190-196
- ISSN:
- 0165-2427
- Subject:
- disease control; disease course; disease models; medical sciences; paratuberculosis; sustainable agriculture; vaccination
- Abstract:
- ... Classical causality models for infectious diseases have fulfilled an important role in the progress of medical sciences, however, new forms of association where weakly pathogenic agents cause widespread infections that mostly do not progress to disease, but that if they do so, cause protracted clinical courses where the host resources are exhausted fit better with the slow infection concept propos ...
- DOI:
- 10.1016/j.vetimm.2012.05.017
- PubMed:
- 22698388
- https://doi.org/10.1016/j.vetimm.2012.05.017
- Author:
- Van Diemen, P.M.; Dziva, F.; Abu-Median, A.; Wallis, T.S.; Bosch, H. van den; Dougan, G.; Chanter, N.; Frankel, G.; Stevens, M.P.
- Source:
- Veterinary immunology and immunopathology 2007 v.116 no.1-2 pp. 47-58
- ISSN:
- 0165-2427
- Subject:
- intranasal administration; adhesins; vaccination; protective effect; cattle diseases; polypeptides; inactivated vaccines; intestines; subunit vaccines; intramuscular injection; humoral immunity; serotypes; cattle; bacterial adhesion; disease control; immune response; vaccine development; Escherichia infections; bacterial colonization; food pathogens; Escherichia coli O157; intimin
- Abstract:
- ... Enterohaemorrhagic Escherichia coli (EHEC) infections in humans are an important public health concern and are commonly acquired via contact with ruminant faeces. Cattle are a key control point however cross-protective vaccines for the control of EHEC in the bovine reservoir do not yet exist. The EHEC serogroups that are predominantly associated with human infection in Europe and North America are ...
- DOI:
- 10.1016/j.vetimm.2006.12.009
- PubMed:
- 17258324
- PubMed Central:
- PMC2656997
- https://doi.org/10.1016/j.vetimm.2006.12.009
- Author:
- Brandon L. Plattner; Elise Huffman; Douglas E. Jones; Jesse M. Hostetter
- Source:
- Veterinary immunology and immunopathology 2014 v.157 no.1-2 pp. 12-19
- ISSN:
- 0165-2427
- Subject:
- CD4-positive T-lymphocytes; Mycobacterium avium; antigens; calves; disease control; herds; immunity; immunologic techniques; industry; interferon-gamma; paratuberculosis; phenotype; vaccination
- Abstract:
- ... Johne's disease (JD) is a costly intestinal disease of ruminants caused by Mycobacterium avium subspecies paratuberculosis (Map), which is transmitted to perinatal calves by the fecal-oral route. Disease control efforts focus on identification and culling of infected cattle from herds; therefore failure to identify animals early is a major obstacle to reducing transmission. Development of host imm ...
- DOI:
- 10.1016/j.vetimm.2013.11.001
- https://doi.org/10.1016/j.vetimm.2013.11.001
- Author:
- Andrea Rossi; Amy Mónaco; Julio Guarnaschelli; Fernando Silveira; Andrés Iriarte; Arndt G. Benecke; José A. Chabalgoity
- Source:
- Veterinary immunology and immunopathology 2018 v.202 pp. 46-51
- ISSN:
- 0165-2427
- Subject:
- Clostridium; antibodies; antibody formation; antigens; burden of disease; disease control; enzyme-linked immunosorbent assay; sheep; toxoids; vaccination; vaccines
- Abstract:
- ... Polyvalent clostridial vaccines, composed of a complex mixture of toxoids from up to 9 different species, are highly effective in controlling clostridial diseases in cattle and sheep. Commercially available vaccines usually state that in normal field conditions two doses administered 4 to 6 weeks apart elicit protective antibody levels that will last for one year. However, studies on the developme ...
- DOI:
- 10.1016/j.vetimm.2018.06.010
- https://doi.org/10.1016/j.vetimm.2018.06.010
- Author:
- Zhitao Qi; Qihuan Zhang; Zisheng Wang; Tianyi Ma; Jie Zhou; Jason W. Holland; Qian Gao
- Source:
- Veterinary immunology and immunopathology 2016 v.169 pp. 85-95
- ISSN:
- 0165-2427
- Subject:
- Aeromonas hydrophila; Andrias; bacterial infections; breeding; control methods; disease control; disease outbreaks; evolution; gene expression regulation; habitats; immune system; immunity; pathogens; salamanders and newts; transcriptomics; unigenes; viability
- Abstract:
- ... The endangered Chinese giant salamander (Andrias davidianus) is the largest extant amphibian species. Disease outbreaks represent one of the major factors threatening A. davidianus populations in the wild and the viability of artificial breeding programmes. Development of future immune therapies to eliminate infectious disease in A. davidianus is dependent on a thorough understanding of the immune ...
- DOI:
- 10.1016/j.vetimm.2015.11.004
- https://doi.org/10.1016/j.vetimm.2015.11.004
- Author:
- Baigent, S.J.; Smith, L.P.; Nair, V.K.; Currie, R.J.W.
- Source:
- Veterinary immunology and immunopathology 2006 v.112 no.1-2 pp. 78-86
- ISSN:
- 0165-2427
- Subject:
- immunology; immunopathology; Marek disease; vaccines; disease control; chickens; oncogenic viruses; feathers; vaccine development; vaccination
- Abstract:
- ... Marek's disease is an economically important lymphoid neoplasm of chickens, caused by oncogenic strains of Marek's disease herpesvirus. The disease can be successfully controlled by vaccination with attenuated or non-pathogenic MDV strains. However, vaccine failures do occur as field strains continue to evolve towards pathotypes of greater virulence, and this evolution is likely to be driven by th ...
- DOI:
- 10.1016/j.vetimm.2006.03.014
- https://doi.org/10.1016/j.vetimm.2006.03.014
- Author:
- H.L.B.M. Klaasen; M. van der Veen; D. Sutton; M.J.C.H. Molkenboer
- Source:
- Veterinary immunology and immunopathology 2014 v.158 no.1-2 pp. 26-29
- ISSN:
- 0165-2427
- Subject:
- Leptospira interrogans; antigens; blood platelets; body temperature; carrier state; disease control; dogs; excretion; humans; immunity; kidneys; leptospirosis; leukocyte count; necropsy; nephritis; serotypes; urine; vaccination; vaccines; zoonoses
- Abstract:
- ... A key success factor in the vaccination of dogs against leptospirosis is long term protection against establishment of the renal carrier state, in order to protect other dogs, as well as humans, against this re-emerging zoonotic disease. In this paper, we describe the ability of a new European tetravalent vaccine containing antigen from Leptospira interrogans (sensu lato) serogroups Icterohaemorrh ...
- DOI:
- 10.1016/j.vetimm.2013.08.002
- https://doi.org/10.1016/j.vetimm.2013.08.002