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genes
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- Author:
- Madsen, Sally A.; Weber, Patty S.D.; Burton, Jeanne L.
- Source:
- Veterinary immunology and immunopathology 2002 v.86 no.3-4 pp. 159-175
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; DNA-binding proteins; Northern blotting; animal health; blood serum; complementary DNA; cytochrome b; dairy cows; estradiol; gene expression; gene expression regulation; genes; mastitis; messenger RNA; metabolism; neutrophils; nucleic acid hybridization; nucleotide sequences; parturition; progesterone; radioimmunoassays; reverse transcriptase polymerase chain reaction; screening; sequence homology; steroid hormones; tricarboxylic acid cycle; Show all 26 Subjects
- Abstract:
- ... The periparturient dairy cow undergoes a plethora of physiological changes, including changes in the immune system that lead to profound effects on animal health. Of the immune cells affected at parturition, the neutrophil has been of particular interest due to its primary role in innate immune defense against mastitis. Immune functions of bovine neutrophils are known to be depressed around partur ...
- DOI:
- 10.1016/S0165-2427(02)00020-X
- http://dx.doi.org/10.1016/S0165-2427(02)00020-X
- Author:
- Luff, Jennifer A.; Yuan, Hang; Suter, Maja M.; Müller, Eliane J.; Schlegel, Richard; Moore, Peter F.
- Source:
- Veterinary immunology and immunopathology 2013 v.153 no.3-4 pp. 177-186
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Papillomaviridae; messenger RNA; transmembrane proteins; melanoma; necrosis; dogs; epithelial cells; interleukin-6; pathogens; gene expression; immune system; viruses; genes; double-stranded RNA; keratinocytes; receptors; interferons; Show all 18 Subjects
- Abstract:
- ... Papillomaviruses (PV) are double stranded (ds) DNA viruses that infect epithelial cells within the skin or mucosa, most often causing benign neoplasms that spontaneously regress. The immune system plays a key role in the defense against PVs. Since these viruses infect keratinocytes, we wanted to investigate the role of the keratinocyte in initiating an immune response to canine papillomavirus-2 (C ...
- DOI:
- 10.1016/j.vetimm.2013.02.001
- PubMed:
- 23557936
- PubMed Central:
- PMC4425420
- https://dx.doi.org/10.1016/j.vetimm.2013.02.001
- Author:
- Okui, Y.; Kano, R.; Maruyama, H.; Hasegawa, A.
- Source:
- Veterinary immunology and immunopathology 2008 v.121 no.1-2 pp. 156-160
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; interspecific variation; messenger RNA; complementary DNA; physiological regulation; normal values; dogs; reverse transcriptase polymerase chain reaction; amino acid sequences; gene expression; animal organs; genes; immune system; molecular cloning; receptors; nucleotide sequences; animal tissues; interferons; Show all 18 Subjects
- Abstract:
- ... Toll-like receptor 7 (TLR7) is activated by single strand RNA and imidazoquinoline compounds, and induces interferon production. In this study, canine TLR7 cDNA was cloned and sequenced. The full-length cDNA of canine TLR7 gene was 3419 bp, encoding 1032 amino acids. The similarities of canine TLR7 with human and mouse TLR7 were 84 and 80% at the nucleotide sequence level, and 86 and 79% at amino ...
- DOI:
- 10.1016/j.vetimm.2007.08.012
- http://dx.doi.org/10.1016/j.vetimm.2007.08.012
- Author:
- Oliveira Filho, José P.; Badial, Peres R.; Cunha, Paulo H.J.; Cruz, Taís F.; Araújo, João P.; Divers, Thomas J.; Winand, Nena J.; Borges, Alexandre S.
- Source:
- Veterinary immunology and immunopathology 2010 v.135 no.1-2 pp. 34-42
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; genes; macrophages; iron; gene expression; amino acids; disease resistance; homeostasis; biochemical mechanisms; animal tissues; antimicrobial properties; sequence analysis; messenger RNA; polymerase chain reaction; intestinal absorption; molecular cloning; horse diseases; liver; inflammation; nucleotide sequences; horses; Show all 21 Subjects
- Abstract:
- ... Equine serum or plasma iron concentration drops quickly during inflammation. Accumulation of iron inside macrophages and reduction of the intestinal absorption of this element cause hypoferremia during systemic inflammatory processes. These mechanisms are mediated by hepcidin, a 25 amino acids peptide synthesized mainly in the liver in response to iron stores and inflammation. Hepcidin is an impor ...
- DOI:
- 10.1016/j.vetimm.2009.10.027
- PubMed:
- 19945753
- http://dx.doi.org/10.1016/j.vetimm.2009.10.027
- Author:
- Charerntantanakul, Wasin; Pongjaroenkit, Saengtong
- Source:
- Veterinary immunology and immunopathology 2018 v.205 pp. 24-34
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Porcine reproductive and respiratory syndrome virus; animal use reduction; cross immunity; enzymes; gene expression regulation; genes; immunostimulants; interferon regulatory factor-3; interferons; interleukin-13; interleukin-2; messenger RNA; mononuclear leukocytes; neutralization; neutralizing antibodies; osteopontin; saponins; solvents; swine; temperature; tumor necrosis factor-alpha; vaccination; vaccines; viremia; viruses; weight gain; Show all 27 Subjects
- Abstract:
- ... Porcine reproductive and respiratory syndrome virus (PRRSV) is a devastating virus which suppresses the expression of type I and II interferons (IFNs) as well as several pro-inflammatory cytokines. Our previous study reported that saponin quil A had a potential to up-regulate the expression of type I IFN-regulated genes and type I and II IFNs in porcine peripheral blood mononuclear cells (PBMC) in ...
- DOI:
- 10.1016/j.vetimm.2018.10.005
- https://dx.doi.org/10.1016/j.vetimm.2018.10.005
- Author:
- Liu, Fuguo; Tang, Xiaoqian; Sheng, Xiuzhen; Xing, Jing; Zhan, Wenbin
- Source:
- Veterinary immunology and immunopathology 2017 v.185 pp. 38-47
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Edwardsiella tarda; Paralichthys olivaceus; Toll-like receptor 2; Western blotting; antibodies; blood serum; flounder; gene expression regulation; genes; interferon-gamma; interleukin-1beta; lymphocytes; messenger RNA; outer membrane proteins; spleen; tumor necrosis factor-alpha; vaccination; vaccines; Show all 19 Subjects
- Abstract:
- ... To obtain effective vaccine candidates for Edwardsiella tarda, six outer membrane proteins (OMPs) of E. tarda were selected and recombinantly expressed. Western blotting analysis showed that flounder anti-E. tarda serum could recognize rOmpV, rOmpK, rOmpX and rOmpI, but not rOmpH and rOmpR. Immunization of flounder with different rOMPs resulted in high levels of protection following the E. tarda c ...
- DOI:
- 10.1016/j.vetimm.2017.01.008
- https://dx.doi.org/10.1016/j.vetimm.2017.01.008
- Author:
- Zhang, Yu-qing; Zhang, Ting-ting; Li, Jin-nian; Liu, Xue-lan; Li, Lin
- Source:
- Veterinary immunology and immunopathology 2014 v.160 no.1-2 pp. 61-69
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Ctenopharyngodon idella; Vibrio mimicus; antibodies; antigens; ascites; enzyme-linked immunosorbent assay; fish; genes; immunization; immunoglobulin M; interleukin-10; interleukin-1beta; intraperitoneal injection; kidneys; messenger RNA; necrosis; outer membrane proteins; pathogens; spleen; transcription (genetics); tumor necrosis factor-alpha; vaccines; Show all 23 Subjects
- Abstract:
- ... Vibrio mimicus (V. mimicus) is an extracellular pathogen that causes ascites disease in aquatic animals. In our previous studies, the outer membrane protein U (OmpU) of V. mimicus has been proven to be a protective antigen, and several mimotopes of the protein were identified. Here, a tandemly arranged multi-epitope peptide (named 6EPIS) was designed with six mimotopes and heterologously expressed ...
- DOI:
- 10.1016/j.vetimm.2014.03.016
- https://dx.doi.org/10.1016/j.vetimm.2014.03.016
- Author:
- Zhang, Yuwen W.; Davis, Elizabeth G.; Bai, Jianfa
- Source:
- Veterinary immunology and immunopathology 2009 v.130 no.1-2 pp. 114-119
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; gene expression; in vitro studies; animal tissues; cell culture; blood cells; genes; complementary DNA; messenger RNA; microarray technology; reverse transcriptase polymerase chain reaction; fluorescent labeling; biomarkers; ribosomal RNA; validity; accuracy; reference standards; statistical analysis; horses; Show all 19 Subjects
- Abstract:
- ... Quantitative reverse transcription polymerase chain reaction (RT-PCR) has become a basic, reliable and sensitive modern technique, in both biological research and clinical diagnosis, for investigation of gene expression and validation of cDNA microarray analysis. Accurate mRNA quantification using quantitative RT-PCR commonly requires data normalization through stable housekeeping genes (HKGs). Se ...
- DOI:
- 10.1016/j.vetimm.2009.01.012
- PubMed:
- 19269038
- http://dx.doi.org/10.1016/j.vetimm.2009.01.012
- Author:
- Powell, Fiona; Rothwell, Lisa; Clarkson, Michael; Kaiser, Pete
- Source:
- Veterinary immunology and immunopathology 2012 v.147 no.1-2 pp. 97-103
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; chickens; messenger RNA; complementary DNA; interleukins; DNA primers; turkeys; gene expression; amino acids; splenocytes; genes; digestive system; Show all 12 Subjects
- Abstract:
- ... The cDNAs of two turkey cytokines, interleukin (IL)-10 and IL-13, were cloned using oligonucleotide primers designed from their chicken orthologues. The coding regions of the chicken and turkey genes are highly conserved, with IL-10 and IL-13 exhibiting 94.1% and 90% nucleotide and 92% and 79.9% amino acid identity respectively. Both showed consistent mRNA expression in turkey lymphoid and gut tis ...
- DOI:
- 10.1016/j.vetimm.2012.03.013
- PubMed:
- 22521280
- http://dx.doi.org/10.1016/j.vetimm.2012.03.013
- Author:
- Pisoni, G.; Moroni, P.; Genini, S.; Stella, A.; Boettcher, P.J.; Cremonesi, P.; Scaccabarozzi, L.; Giuffra, E.; Castiglioni, B.
- Source:
- Veterinary immunology and immunopathology 2010 v.135 no.3-4 pp. 208-217
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Staphylococcus aureus; goats; bioinformatics; milk; genes; dairy animals; mammary glands; temporal variation; messenger RNA; somatic cells; transcription (genetics); immunologic factors; immune system; in vitro studies; mastitis; transcriptional activation; biosynthesis; immunogenetics; microarray technology; goat diseases; Show all 21 Subjects
- Abstract:
- ... To study gene expression within the mammary glands of dairy goats with mastitis, mRNA was collected from milk somatic cells (MSCs) of left udder halves challenged with Staphylococcus aureus and right udder halves infused with PBS, as control, at different time points (0, 12, 24 and 48h post-infection). Transcriptional profiles were investigated using bovine cDNA microarrays; of the total 288 diffe ...
- DOI:
- 10.1016/j.vetimm.2009.11.016
- PubMed:
- 20060596
- http://dx.doi.org/10.1016/j.vetimm.2009.11.016
11. Effect of Marek’s disease vaccines on interferon and toll like receptors when administered in ovo
- Author:
- Gimeno, Isabel M.; Glaize, Ayanna; Cortes, Aneg L.
- Source:
- Veterinary immunology and immunopathology 2018 v.201 pp. 62-66
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Marek disease; chickens; embryo (animal); gene expression regulation; genes; interferon-alpha; interferon-beta; interferon-gamma; lungs; messenger RNA; receptors; spleen; thymus gland; transcription (genetics); vaccination; vaccines; Show all 17 Subjects
- Abstract:
- ... The effect of two Marek’s disease (MD) vaccines on the chicken embryo immune responses were evaluated. Transcription of interferon (IFN-α, IFN-β, IFN-λ, and IFN-γ) and interferon-I receptors (IFN-AR1 and IFN-AR2), as well as transcription of toll like receptors (TLR-3, TLR-7, and TLR-21) were evaluated in the bursa, thymus, spleen and lung of 1-day-old chickens that had been vaccinated with HVT, C ...
- DOI:
- 10.1016/j.vetimm.2018.05.012
- https://dx.doi.org/10.1016/j.vetimm.2018.05.012
- Author:
- Mignot, Clémence C.; Pirottin, Dimitri; Farnir, Frédéric; de Moffarts, Brieuc; Molitor, Céline; Lekeux, Pierre; Art, Tatiana
- Source:
- Veterinary immunology and immunopathology 2012 v.147 no.3-4 pp. 127-135
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; exercise; exercise equipment; gene expression; gene targeting; genes; interferons; interleukin-6; leukocytes; lipopolysaccharides; mares; messenger RNA; polyinosinic-polycytidylic acid; polymerase chain reaction; proteins; tumor necrosis factor-alpha; Show all 16 Subjects
- Abstract:
- ... The effects of strenuous exercise and ex vivo stimulation of TLR3 and TLR4 pathways on the expression of six inflammatory genes in equine pulmonary leukocytes were investigated. The genes tested were interferon-beta (IFN-β), interleukin-1-beta (IL-1β), interleukin-6 (IL-6), interferon gamma-induced protein 10 (IP-10), chemokine (c-c motif) ligand 5 (RANTES) and tumor necrosis factor-alpha (TNF-α). ...
- DOI:
- 10.1016/j.vetimm.2012.04.004
- PubMed:
- 22578853
- http://dx.doi.org/10.1016/j.vetimm.2012.04.004
- Author:
- Burkey, T.E.; Skjolaas, K.A.; Dritz, S.S.; Minton, J.E.
- Source:
- Veterinary immunology and immunopathology 2009 v.130 no.1-2 pp. 96-101
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; bacterial enteritis; messenger RNA; Salmonella choleraesuis Choleraesuis; ileum; lipopolysaccharides; swine diseases; epithelial cells; Salmonella Typhimurium; gene expression; jejunum; salmonellosis; phagocytes; intestinal mucosa; genes; receptors; swine; Show all 17 Subjects
- Abstract:
- ... Salmonella enterica serovar Typhimurium (ST) and Choleraesuis (SC) are among the most frequently isolated salmonellae serovars causing enteric disease in swine. Enteric disease in young pigs is of major concern in modern production systems due to the negative implications on animal health, food safety and economic return. Epithelial cells express Toll-like receptors (TLR) that recognize conserved ...
- DOI:
- 10.1016/j.vetimm.2008.12.027
- http://dx.doi.org/10.1016/j.vetimm.2008.12.027
- Author:
- Dvorak, Cheryl M.T.; Hirsch, Geoffrey N.; Murtaugh, Michael P.
- Source:
- Veterinary immunology and immunopathology 2009 v.128 no.1-3 pp. 119-125
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Peyer's patches; adjuvants; antigen-antibody complex; antigens; cDNA libraries; cholera toxin; complementary DNA; cultured cells; databases; gene expression; gene expression regulation; genes; genomics; hosts; infectious diseases; messenger RNA; mucosal immunity; pathogens; proteins; small intestine; swine; vaccines; Show all 23 Subjects
- Abstract:
- ... The vast majority of infectious diseases of animals and humans occur at mucosal surfaces, especially in the intestinal tract. However, vaccines to stimulate durable immunity to intestinal pathogens often do not produce effective protection. A better understanding of the molecules and molecular mechanisms that mediate effective immune induction at mucosal surfaces may facilitate the development of ...
- DOI:
- 10.1016/j.vetimm.2008.10.304
- PubMed:
- 19027174
- http://dx.doi.org/10.1016/j.vetimm.2008.10.304
- Author:
- Truong, Anh Duc; Hong, Yeong Ho; Lillehoj, Hyun S.
- Source:
- Veterinary immunology and immunopathology 2015 v.166 no.3-4 pp. 116
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Clostridium perfringens; Eimeria maxima; Gallus gallus; Marek disease; White Leghorn; breeding; chickens; cluster analysis; coccidiosis; cytokine receptors; cytokines; databases; gene expression; gene expression regulation; genes; genetic markers; haplotypes; high-throughput nucleotide sequencing; host-pathogen relationships; inbred lines; intestinal mucosa; messenger RNA; mixed infection; necrotic enteritis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcriptome; Show all 28 Subjects
- Abstract:
- ... We investigated the necrotic enteritis (NE)-induced transcripts of immune-related genes in the intestinal mucosa of two highly inbred White Leghorn chicken lines, line 6.3 and line 7.2, which share the same MHC haplotype and show different levels of NE susceptibility using high-throughput RNA sequencing (RNA-Seq) technology. NE was induced by the previously described co-infection model using Eimer ...
- Handle:
- 10113/61648
- DOI:
- 10.1016/j.vetimm.2015.06.008
- https://dx.doi.org/10.1016/j.vetimm.2015.06.008
- Author:
- Kalmar, Isabelle; Berndt, Angela; Yin, Lizi; Chiers, Koen; Sachse, Konrad; Vanrompay, Daisy
- Source:
- Veterinary immunology and immunopathology 2015 v.164 no.1-2 pp. 30-39
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Chlamydia; Chlamydophila psittaci; air sacs; animal welfare; chickens; chicks; epithelium; financial economics; gene expression; genes; host-pathogen relationships; hyperplasia; inducible nitric oxide synthase; interferon-gamma; interleukin-17; interleukin-1beta; interleukin-6; messenger RNA; poultry production; specific pathogen-free animals; Show all 21 Subjects
- Abstract:
- ... Although Chlamydia (C.) psittaci infections are recognized as an important factor causing economic losses and impairing animal welfare in poultry production, the specific mechanisms leading to severe clinical outcomes are poorly understood. In the present study, we comparatively investigated pathology and host immune response, as well as systemic dissemination and expression of essential chlamydia ...
- DOI:
- 10.1016/j.vetimm.2014.12.014
- https://dx.doi.org/10.1016/j.vetimm.2014.12.014
- Author:
- Willcocks, S.; Yamakawa, Y.; Stalker, A.; Coffey, T.J.; Goldammer, T.; Werling, D.
- Source:
- Veterinary immunology and immunopathology 2006 v.113 no.1-2 pp. 234-242
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; cattle; lectins; receptors; gene expression; protein synthesis; outer membrane proteins; signal transduction; nucleotide sequences; amino acid sequences; chromosome mapping; isomers; messenger RNA; transcription (genetics); bone marrow; monocytes; macrophages; dendritic cells; natural killer cells; CD4-positive T-lymphocytes; B-lymphocytes; genes; genomics; Show all 23 Subjects
- Abstract:
- ... C-type lectin receptors (CTLR) are cell-surface signalling molecules that recognize a range of highly conserved pathogen molecules and instigate the appropriate immune response. Here, we report the cloning, sequencing, mapping and expression pattern of the bovine C-type lectin domain family 7, member A (CLEC7A; synonyms CLCSF12, Dectin-1). We identified two isoforms, similar to the human system, w ...
- DOI:
- 10.1016/j.vetimm.2006.04.007
- http://dx.doi.org/10.1016/j.vetimm.2006.04.007
- Author:
- Setta, Ahmed; Barrow, Paul A.; Kaiser, Pete; Jones, Michael A.
- Source:
- Veterinary immunology and immunopathology 2012 v.146 no.3-4 pp. 212-224
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; foods; reactive oxygen species; epithelial cells; Salmonella Typhimurium; genes; chicks; macrophages; gene expression; fowl typhoid; gene expression regulation; oxygen; host range; messenger RNA; cytotoxicity; serotypes; pullorum disease; chickens; nitric oxide; host-pathogen relationships; kidney cells; salmonellosis; nitrates; Show all 23 Subjects
- Abstract:
- ... Poultry-derived food is a common source of infection of human with the non-host-adapted salmonellae while fowl typhoid and pullorum disease are serious diseases in poultry. Development of novel immune-based control strategies against Salmonella infection necessitates a better understanding of the host–pathogen interactions at the cellular level. Intestinal epithelial cells are the first line of de ...
- DOI:
- 10.1016/j.vetimm.2012.03.008
- PubMed:
- 22475571
- http://dx.doi.org/10.1016/j.vetimm.2012.03.008
- Author:
- Sheridan, Michael P.; Browne, John A.; MacHugh, David E.; Costello, Eamon; Gormley, Eamonn
- Source:
- Veterinary immunology and immunopathology 2012 v.145 no.1-2 pp. 199-205
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; ambient temperature; blood cells; blood sampling; cattle; enzyme-linked immunosorbent assay; gene expression; gene expression regulation; genes; heparin; lithium; messenger RNA; proteins; Show all 13 Subjects
- Abstract:
- ... RT-qPCR can be used to accurately determine expression levels of genes following RNA extraction from tissue samples. If blood is the source of total RNA, it is often desirable to process the samples immediately following collection because delays in processing for RNA extraction may influence mRNA expression estimates obtained from RT-qPCR analyses. However, this may not be feasible if the site of ...
- DOI:
- 10.1016/j.vetimm.2011.11.006
- PubMed:
- 22138316
- http://dx.doi.org/10.1016/j.vetimm.2011.11.006
- Author:
- Sylte, Matthew J.; Johnson, Timothy A.; Meyer, Ella L.; Inbody, Matt H.; Trachsel, Julian; Looft, Torey; Susta, Leonardo; Wu, Zuowei; Zhang, Qijing
- Source:
- Veterinary immunology and immunopathology 2019 v.210 pp. 6-14
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Campylobacter jejuni subsp. jejuni; antibiotic resistance; antigens; campylobacteriosis; cecum; chickens; chloramphenicol; food safety; gene expression regulation; genes; humans; ileum; immunohistochemistry; inflammation; interleukin-10; interleukin-13; interleukin-17; interleukin-1beta; interleukin-6; interleukin-8; kanamycin; loci; messenger RNA; poultry products; poults; reverse transcriptase polymerase chain reaction; slaughter; turkeys; villi; Show all 30 Subjects
- Abstract:
- ... Consumption of contaminated poultry products is one of the main sources of human campylobacteriosis, of which Campylobacter jejuni subsp. jejuni (C. jejuni) is responsible for approximately 90% of the cases. At slaughter, the ceca of commercial chickens and turkeys are the main anatomical site where C. jejuni asymptomatically colonizes. We have previously colonized commercial turkey poults with di ...
- DOI:
- 10.1016/j.vetimm.2019.02.003
- CHORUS:
- 10.1016/j.vetimm.2019.02.003
- https://dx.doi.org/10.1016/j.vetimm.2019.02.003
- Author:
- Daly, Kerry A.; Mailer, Sonia L.; Digby, Matthew R.; Lefévre, Christophe; Thomson, Peter; Deane, Elizabeth; Nicholas, Kevin R.; Williamson, Peter
- Source:
- Veterinary immunology and immunopathology 2009 v.129 no.1-2 pp. 36-48
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; lipopolysaccharides; cell growth; epithelial cells; genes; maternal milk; protective effect; leukocytes; gene expression; transcriptome; mammary glands; apoptosis; transcriptomics; messenger RNA; physiological response; cell proliferation; antigen presentation; microarray technology; inflammation; genomics; Macropus eugenii; Show all 21 Subjects
- Abstract:
- ... The immunological function of the metatherian mammary gland plays a crucial part in neonatal survival of the marsupial young. Marsupial pouch young do not develop adult like immune responses until just prior to leaving the pouch. The immune components of the maternal milk secretions are important during this vulnerable early post-partum period. In addition, infection of the mammary gland has not b ...
- DOI:
- 10.1016/j.vetimm.2008.12.001
- PubMed:
- 19157568
- http://dx.doi.org/10.1016/j.vetimm.2008.12.001
- Author:
- Kim, Seon-Soo; Kim, Sang-Hoon; Kang, Hyung-Sik; Chung, Hee Yong; Choi, Inho; Cheon, Yong-Pil; Lee, Ki Ho; Lee, Dong-Mok; Park, Jongsun; Lee, Sang Yeol; Chun, Taehoon
- Source:
- Veterinary immunology and immunopathology 2010 v.133 no.1 pp. 72-79
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; sequence analysis; phytohemagglutinin; transcriptional activation; messenger RNA; complementary DNA; T-lymphocytes; open reading frames; amino acid sequences; gene expression; genes; genomics; molecular cloning; receptors; lymphocyte proliferation; swine; Show all 16 Subjects
- Abstract:
- ... Lymphocyte activation gene-3 (LAG-3; CD223) is a co-receptor that may function as a down-modulator of T cell activity via an interaction with MHC class II molecules. In this study, we cloned and sequenced the complete cDNA sequence of pig Lag3. Pig Lag3 cDNA contains an open reading frame (1524bp) encoding 507 amino acids. The putative amino acid identity of pig LAG-3 with those of the human, rat, ...
- DOI:
- 10.1016/j.vetimm.2009.07.001
- PubMed:
- 19631993
- http://dx.doi.org/10.1016/j.vetimm.2009.07.001
- Author:
- Cantón, Germán; Bartley, Paul; Bartley, Kathryn; Todd, Helen; Chianini, Francesca; Katzer, Frank
- Source:
- Veterinary immunology and immunopathology 2013 v.151 no.3-4 pp. 342-347
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; cattle; genes; goats; in situ hybridization; messenger RNA; neoplasms; nucleotide sequences; sheep; Show all 9 Subjects
- Abstract:
- ... Pro-inflammatory cytokines (particularly IL-12) are important for initiating protective T helper 1 (Th1)-type immune responses and hence vital for combating intracellular infections and tumours. In situ hybridization (ISH) provides a powerful diagnostic tool allowing the identification and localization of cells producing these mediators in fixed tissues. The objective of this work was to produce a ...
- DOI:
- 10.1016/j.vetimm.2012.11.019
- PubMed:
- 23266096
- https://dx.doi.org/10.1016/j.vetimm.2012.11.019
- Author:
- Bridle, A.R.; Morrison, R.N.; Cunningham, P.M.C.; Nowak, B.F.
- Source:
- Veterinary immunology and immunopathology 2006 v.114 no.1-2 pp. 121-134
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Salmo salar; salmon; gene expression; quantitative analysis; interleukin-1; messenger RNA; protein synthesis; amebiasis; Amoebida; fish diseases; reverse transcriptase polymerase chain reaction; nucleic acid hybridization; genes; nitric oxide synthase; animal proteins; gills; liver; kidneys; gene expression regulation; infection; Show all 21 Subjects
- Abstract:
- ... The characterisation of selected immune response genes during amoebic gill disease (AGD) in Atlantic salmon, Salmo salar L., was performed using semi-quantitative RT-PCR, quantitative real-time RT-PCR (qRT-PCR), and in situ hybridisation (ISH). The immune response genes of interest were interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), serum amyloid A (SAA), and serum amyloid P-like ...
- DOI:
- 10.1016/j.vetimm.2006.08.002
- http://dx.doi.org/10.1016/j.vetimm.2006.08.002
- Author:
- Cheeseman, Jennifer H.; Lillehoj, Hyun S.; Lamont, Susan J.
- Source:
- Veterinary immunology and immunopathology 2008 v.125 no.3-4 pp. 375
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; chickens; immune system; biochemical pathways; genes; gene expression; messenger RNA; nitric oxide; enzymes; nitric oxide synthase; interferons; signal transduction; in vitro studies; cell lines; macrophages; transfection; RNA interference; gene expression regulation; inhibitors; enzyme inhibition; interferon-gamma; Show all 21 Subjects
- Abstract:
- ... Utilizing RNA interference technology with siRNA in the HD11 macrophage cell line, we determined how the inhibition or knock-down of the iNOS (inducible nitric oxide synthase) gene affected IFN-γ-induced macrophage production of nitric oxide (NO) and mRNA expression of genes involved in this biological pathway in the chicken. Chicken macrophages produce NO when stimulated with recombinant chicken ...
- Handle:
- 10113/21458
- DOI:
- 10.1016/j.vetimm.2008.05.015
- http://dx.doi.org/10.1016/j.vetimm.2008.05.015
- Author:
- Charerntantanakul, Wasin; Fabros, Dante
- Source:
- Veterinary immunology and immunopathology 2018 v.195 pp. 76-83
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Porcine reproductive and respiratory syndrome virus; adaptive immunity; antigen-presenting cells; chronic diseases; gene expression; genes; innate immunity; interferon regulatory factor-3; interferons; interleukin-10; interleukin-13; interleukin-2; lipopolysaccharides; messenger RNA; mononuclear leukocytes; osteopontin; pathogenesis; polyinosinic-polycytidylic acid; quantitative polymerase chain reaction; saponins; swine; transforming growth factor beta; tumor necrosis factor-alpha; Show all 24 Subjects
- Abstract:
- ... Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses innate immune response following infection of myeloid antigen-presenting cells. Poor innate immune response results in weak and delayed PRRSV-specific adaptive immunity, and facilitates PRRSV replication, pathogenesis, and persistent infection. Numerous efforts have been made to enhance the effective innate and adaptive immune ...
- DOI:
- 10.1016/j.vetimm.2017.11.009
- https://dx.doi.org/10.1016/j.vetimm.2017.11.009
27. Simultaneous quantitation of equine cytokine mRNAs using a multi-probe ribonuclease protection assay
- Author:
- Lim, W.S.; Edwards, J.F.; Boyd, N.K.; Payne, S.L.; Ball, J.M.
- Source:
- Veterinary immunology and immunopathology 2003 v.91 no.1 pp. 45-51
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; RNA probes; actin; antisense RNA; genes; horses; interferon-gamma; interleukin-10; interleukin-12; interleukin-1alpha; interleukin-1beta; interleukin-6; interleukin-8; macrophages; messenger RNA; mononuclear leukocytes; plasmids; radiolabeling; ribonucleases; tumor necrosis factor-alpha; Show all 20 Subjects
- Abstract:
- ... A rapid multi-probe ribonuclease protection assay (RPA) was developed to quantitate equine-specific cytokine mRNA levels in activated equine monocyte-derived macrophages (EMDM) and equine peripheral blood mononuclear cells (EPBMC). Eleven template plasmids specific to 10 equine cytokine genes and the β-actin gene were generated from which radiolabeled anti-sense RNA probes were produced. The multi ...
- DOI:
- 10.1016/S0165-2427(02)00263-5
- http://dx.doi.org/10.1016/S0165-2427(02)00263-5
- Author:
- Robert-Tissot, Céline; Rüegger, Vera L.; Cattori, Valentino; Meli, Marina L.; Riond, Barbara; Gomes-Keller, Maria Alice; Vögtlin, Andrea; Wittig, Burghardt; Juhls, Christiane; Hofmann-Lehmann, Regina; Lutz, Hans
- Source:
- Veterinary immunology and immunopathology 2011 v.143 no.3-4 pp. 269-281
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Feline immunodeficiency virus; Feline leukemia virus; cats; defense mechanisms; fibroblasts; gene expression; genes; hosts; humans; in vivo studies; kidneys; messenger RNA; mice; natural killer cells; polyinosinic-polycytidylic acid; receptors; viruses; Show all 18 Subjects
- Abstract:
- ... The innate immune system plays a central role in host defence against viruses. While many studies portray mechanisms in early antiviral immune responses of humans and mice, much remains to be discovered about these mechanisms in the cat. With the objective of shedding light on early host–virus interactions in felids, we have developed 12 real-time TaqMan® qPCR systems for feline genes relevant to ...
- DOI:
- 10.1016/j.vetimm.2011.06.005
- PubMed:
- 21719112
- http://dx.doi.org/10.1016/j.vetimm.2011.06.005
- Author:
- Abasht, B.; Kaiser, M.G.; Lamont, S.J.
- Source:
- Veterinary immunology and immunopathology 2008 v.123 no.3-4 pp. 314-323
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; chickens; messenger RNA; females; microbial load; Salmonella Enteritidis; cecum; poultry diseases; gene expression regulation; males; gender differences; gene expression; spleen; genes; disease resistance; salmonellosis; receptors; line differences; chicks; Show all 19 Subjects
- Abstract:
- ... Understanding the changes in host gene expression that occur with bacterial infection will help to elucidate the basis of molecular genetic control of disease resistance. The effect of infecting chicks with Salmonella enterica serovar Enteritidis on the RNA expression level of Toll-like receptor (TLR) genes, and the correlation between TLR RNA expression level and bacterial burden in the cecum and ...
- DOI:
- 10.1016/j.vetimm.2008.02.010
- PubMed:
- 18394716
- http://dx.doi.org/10.1016/j.vetimm.2008.02.010
30. T-regulatory cells infected with feline immunodeficiency virus up-regulate programmed death-1 (PD-1)
- Author:
- Achleitner, Andrea; Clark, Mary Ellen; Bienzle, Dorothee
- Source:
- Veterinary immunology and immunopathology 2011 v.143 no.3-4 pp. 307-313
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; RNA-directed DNA polymerase; messenger RNA; viral diseases of animals and humans; Human immunodeficiency virus; cats; immunosuppression; polymerase chain reaction; antigen-presenting cells; genes; CD4-positive T-lymphocytes; actin; tyrosine 3-monooxygenase; lymph nodes; Feline immunodeficiency virus; Show all 15 Subjects
- Abstract:
- ... CD4⁺CD25⁺ regulatory T (Treg) cells play a crucial role in the regulation of peripheral tolerance and immune response. Treg cells influence the nature and magnitude of immune responses, in particular to chronic infections with viruses such as HIV in humans and feline immunodeficiency virus (FIV) in cats. The co-stimulatory molecule programmed (cell) death-1 (PD-1) is expressed on T cells and antig ...
- DOI:
- 10.1016/j.vetimm.2011.06.009
- PubMed:
- 21719113
- http://dx.doi.org/10.1016/j.vetimm.2011.06.009
- Author:
- Khalifeh, M.S.; Stabel, J.R.
- Source:
- Veterinary immunology and immunopathology 2004 v.99 no.1-2 pp. 39-46
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Mycobacterium avium subsp. paratuberculosis; cows; diarrhea; disease course; gene expression; genes; ileum; interferon-gamma; interleukin-10; lymph nodes; messenger RNA; reverse transcriptase polymerase chain reaction; tissues; transforming growth factor beta; weight loss; Show all 16 Subjects
- Abstract:
- ... Johne’s disease progresses through distinct stages including a protracted subclinical stage in which the infection appears to be controlled; followed by a more acute stage in which the host animal demonstrates clinical signs such as diarrhea and weight loss. Little is known about the dynamics of the host immune response during these two phases of disease, however, it is possible that immune modula ...
- DOI:
- 10.1016/j.vetimm.2004.01.009
- http://dx.doi.org/10.1016/j.vetimm.2004.01.009
- Author:
- Breathnach, C.C.; Rudersdorf, R.; Lunn, D.P.
- Source:
- Veterinary immunology and immunopathology 2004 v.98 no.3-4 pp. 127-136
- ISSN:
- 0165-2427
- Subject:
- immune response, etc ; Influenza A virus; antibodies; antigens; blood serum; equine influenza; genes; hemagglutinins; homologous recombination; horses; interferon-gamma; loci; messenger RNA; neck; nucleoproteins; pathogens; plasmids; vaccination; viruses; Show all 19 Subjects
- Abstract:
- ... Recombinant modified vaccinia Ankara (MVA) vectors expressing equine influenza virus genes were constructed and evaluated for use in equine vaccination. Two strains of recombinant MVA, expressing either hemagglutinin (HA) or nucleoprotein (NP) genes were constructed. Each influenza virus gene was cloned from A/equine/Kentucky/1/81 (Eq/Ky) into an MVA construction plasmid, and was introduced to the ...
- DOI:
- 10.1016/j.vetimm.2003.11.004
- http://dx.doi.org/10.1016/j.vetimm.2003.11.004