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You searched for: Journal name Veterinary immunology and immunopathology Remove constraint Journal name: Veterinary immunology and immunopathology
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1. A ferret model of immunosuppression induced with dexamethasone

Author:
Anna Hundakova; Lenka Leva; Miroslav Toman; Zdenek Knotek
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110362
ISSN:
0165-2427
Subject:
Phytolaccaceae; chemiluminescence; concanavalin A; dexamethasone; ferrets; humans; immunopathology; immunosuppression; ingestion; mitogens; monocytes; neutrophils; phagocytosis; phytohemagglutinin; reactive oxygen species
Abstract:
... Ferrets are nowadays frequently used as animal models for biomedical purposes; in many cases, immunosuppression of experimental animals is necessary. The aim of this study was to evaluate the effect of intramuscular dexamethasone administration (2 mg/kg as the initiation dose continued with 1 mg/kg q 12 h applied 5 times) on ferret’s immune system. In comparison with ferrets which received the sal ...
DOI:
10.1016/j.vetimm.2021.110362

2. Acetoacetate is a trigger of NLRP3 inflammasome activation in bovine peripheral blood mononuclear cells

Author:
Yuri Onizawa; Taiga Katoh; Ryotaro Miura; Kunitoshi Konda; Tatsuo Noguchi; Hisataka Iwata; Takehito Kuwayama; Seizo Hamano; Koumei Shirasuna
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110370
ISSN:
0165-2427
Subject:
acetoacetic acid; blood plasma; caspase-1; estrous cycle; gene expression; immunopathology; inflammasomes; inflammation; ketone bodies; metabolomics; repeat breeder; reproductive disorders; secretion
Abstract:
... Repeat breeding, which is non-pregnancy following three or more breeding attempts, is a serious reproductive disorder in cattle. In the present study, metabolomic profiling was used to identify metabolites in the blood plasma of repeat breeder cows (RBCs) and non-RBCs. Metabolomic analysis showed that acetoacetate (AcAc), a ketone body, was detected in RBCs, but not in non-RBCs. In contrast, β-hyd ...
DOI:
10.1016/j.vetimm.2021.110370

3. An allergen-fused dendritic cell-binding peptide enhances in vitro proliferation of equine T-cells and cytokine production

Author:
Anja Ziegler; Judith Olzhausen; Eman Hamza; Ana Stojiljkovic; Michael H. Stoffel; Mattia Garbani; Claudio Rhyner; Eliane Marti
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110351
ISSN:
0165-2427
Subject:
Culicoides; T-lymphocytes; Toll-like receptor 4; adjuvants; agonists; allergens; asthma; cancer therapy; cell proliferation; dendritic cells; dermatitis; horses; humans; immune response; immunogenicity; immunomodulators; immunopathology; immunotherapy; insects; interleukin-10; interleukin-17; interleukin-4; mice; oligodeoxyribonucleotides; ovalbumin
Abstract:
... Allergen-specific immunotherapy (AIT) constitutes the only curative approach for allergy treatment. There is need for improvement of AIT in veterinary medicine, such as in horses suffering from insect bite hypersensitivity, an IgE-mediated dermatitis to Culicoides. Dendritic cell (DC)-targeting represents an efficient method to increase antigen immunogenicity. It is studied primarily for its use i ...
DOI:
10.1016/j.vetimm.2021.110351

4. Antibodies from healthy or paratuberculosis infected cows have different effects on Mycobacterium avium subspecies paratuberculosis invasion in a calf ileal loop model

Author:
Ana Jolly; Bárbara Fernández; Ana Stempler; Giselle Ingratta; Gabriela Postma; Juan Boviez; Daniel Lombardo; Silvia Hajos; Silvia L. Mundo
Source:
Veterinary immunology and immunopathology 2022 v.245 pp. 110381
ISSN:
0165-2427
Subject:
Mycobacterium avium subsp. paratuberculosis; calves; histology; histopathology; ileum; immunopathology; microbial load; models; paratuberculosis; protective effect; viability
Abstract:
... In this work, we used a calf ileal loop model to evaluate whether the preincubation of Mycobacterium avium subspecies paratuberculosis (MAP) with antibodies from healthy, MAP-positive or Lipoarabinomannan (LAM) immunized cows could affect the results of infection after 3.5 h. Bacterial load in tissue was assessed by Ziehl-Neelsen and by culture for each loop. MAP was detectable in all infected loo ...
DOI:
10.1016/j.vetimm.2022.110381

5. Antibodies that react with bovine T lymphocytes expressing the T cell receptor β chain subgroup BV20 inhibit antigen recognition

Author:
W. Ivan Morrison; Tara Sheldrake; Timothy Connelley
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110392
ISSN:
0165-2427
Subject:
antigens; cattle; cytotoxicity; gene duplication; genes; immunopathology
Abstract:
... In recent years, molecular studies have provided detailed information on the bovine T cell receptor (TCR) variable gene repertoire, both in resting T cells and during T cell responses. However, studies of the biological function of the receptor have been hampered by a lack of reagents that recognise the protein. Herein, we describe the characterisation of two antibodies (IL-A47 and IL-A98) that re ...
DOI:
10.1016/j.vetimm.2022.110392

6. Assessment of heterologous lumpy skin disease vaccine-induced immunity in pregnant cattle vaccinated at different times of gestation period and their influence on maternally derived antibodies

Author:
Ahmed Gaber; Sherin Rouby; Amera Elsaied; Ahmed El-Sherif
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110380
ISSN:
0165-2427
Subject:
cell-mediated immunity; gestation period; humoral immunity; immunopathology; longevity; lumpy skin disease; maternal immunity; parturition; pregnancy; sheep pox; vaccination; vaccines
Abstract:
... The present study aimed to evaluate the cell-mediated and the humoral immune response to Romanian sheep pox vaccine in pregnant cows (n = 12) vaccinated at different times of gestation period and the duration of maternal immunity in calves born to these cows. Evaluation of cellular immunity revealed an increase in lymphocytic proliferation that peaked at 10th day post vaccination (dpv) then gradua ...
DOI:
10.1016/j.vetimm.2021.110380

7. Canine memory T-cell subsets in health and disease

Author:
Annie B. Bauman; Cambri E. Moeller; Aimee M. Soileau; Christine E. Goodermuth; Victoria R. Costa; Jessica C. Schaumburg; Cherie M. Pucheu-Haston; Nancy D. Welborn; Shannon D. Dehghanpir; Mark A. Mitchell; Sita S. Withers
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110401
ISSN:
0165-2427
Subject:
T-lymphocytes; antigens; atopic dermatitis; dogs; drug therapy; flow cytometry; immunopathology; immunotherapy; inflammation; lymph nodes; lymphoma; memory; prednisone
Abstract:
... A more complete understanding of canine T-lymphocyte immunity is necessary for improving diagnostic and therapeutic approaches to canine diseases, developing cell-based canine immunotherapeutics, and evaluating dogs as large mammal models for comparative immunology research. The aim of this study was to utilize CD45RA (indicating antigen inexperience) and CD62L (indicating lymph node homing capabi ...
DOI:
10.1016/j.vetimm.2022.110401

8. Characterisation of dendritic cell frequency and phenotype in bovine afferent lymph reveals kinetic changes in costimulatory molecule expression

Author:
Sara Marzo; Mark Gray; Waywen Loh; Lindsey A. Waddell; C. Irene McGuinnes; Jayne C. Hope; Heather A. Mathie
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110363
ISSN:
0165-2427
Subject:
T-lymphocytes; adaptive immunity; cattle; dendritic cells; flow cytometry; immunopathology; lymph; models; phenotype
Abstract:
... The bovine afferent lymphatic cannulation model allows collection of large volumes of afferent lymph and provides an opportunity to study lymphatic cells trafficking from the periphery directly ex-vivo. The technique requires surgical intervention, but influence of the procedure or time post-surgery on cells trafficking in the lymph has not been well documented. Here, we measured the volume of lym ...
DOI:
10.1016/j.vetimm.2021.110363

9. Chitosan-based formulation of hemagglutinin antigens for oculo-nasal booster vaccination of chickens against influenza viruses

Author:
Violetta Sączyńska; Agnieszka Romanik-Chruścielewska; Katarzyna Florys-Jankowska; Violetta Cecuda-Adamczewska; Małgorzata Kęsik-Brodacka
Source:
Veterinary immunology and immunopathology 2022 v.247 pp. 110406
ISSN:
0165-2427
Subject:
Escherichia coli; aluminum hydroxide; avian influenza; chitosan; glutamic acid; hemagglutination; hemagglutinins; immunopathology; pH; public health; recombinant proteins; secondary immunization; viral antigens
Abstract:
... Avian influenza viruses (AIVs) and especially highly pathogenic (HP) AIVs of the H5 and H7 subtypes are of both veterinary and public health concern worldwide. In response to the demand for effective vaccines against H5N1 HPAIVs, we produced recombinant protein based on hemagglutinin (HA), a protective viral antigen. A fragment of the HA ectodomain, with a multibasic cleavage site deletion, was ex ...
DOI:
10.1016/j.vetimm.2022.110406

10. Dynamic changes in Holstein heifer circulatory stress biomarkers in response to lipopolysaccharide immune challenge

Author:
T. Sullivan; A. Sharma; K. Lamers; C. White; B.A. Mallard; A. Cánovas; N.A. Karrow
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110426
ISSN:
0165-2427
Subject:
Holstein; acidosis; biomarkers; blood flow; blood serum; body temperature; climate change; cortisol; heat stress; immunopathology; inflammation; interleukin-10; intestinal mucosa; leukopenia; lipopolysaccharides; microRNA; septicemia; stress response; thrombocytopenia
Abstract:
... Dairy cattle routinely face a variety of stressors. For example, climate change has resulted in more frequent heat stress events that increase the incidence of bacterial infections by inducing conditions like leaky gut syndrome, whereby the integrity of the intestinal epithelium is compromised allowing for luminal bacteria and their membrane components to infiltrate the host’s bloodstream resultin ...
DOI:
10.1016/j.vetimm.2022.110426

11. Effect of In-vivo heat challenge on physiological parameters and function of peripheral blood mononuclear cells in immune phenotyped dairy cattle

Author:
S.L. Cartwright; J. Schmied; A. Livernois; B.A. Mallard
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110405
ISSN:
0165-2427
Subject:
barns; body temperature; cell proliferation; cell respiration; climate change; dairy cattle; disease incidence; heat; heat stress; heat tolerance; heat-shock protein 70; humidity; immunology; immunopathology; vaccines
Abstract:
... The frequency of heat waves and hot days are increasing due to climate change, which leads to an increase in the occurrence of heat stress in dairy cattle. Previous studies have shown that dairy cattle identified as high immune responders have a reduced incidence of disease and improved vaccine response compared to average and low responders. Additionally, it has been observed that when cells from ...
DOI:
10.1016/j.vetimm.2022.110405

12. Effect of major versus minor mastectomy on host immunity in canine mammary cancer

Author:
Maria Karayannopoulou; Tilemachos Anagnostou; Apostolia Margariti; Maria Kritsepi-Konstantinou; Dimitra Psalla; Angelos-Lauris Thomas; Ioannis Savvas
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110403
ISSN:
0165-2427
Subject:
T-lymphocytes; anesthesia; cell-mediated immunity; immunopathology; immunosuppression; innate immunity; mammary neoplasms (animal); metastasis; neutrophils; surgery
Abstract:
... Surgical procedures can affect host immunity proportionally to the extent of surgical trauma. In cancer cases, surgery-induced immunosuppression can potentially promote tumour metastasis. The aim of this study was to investigate, in bitches with malignant mammary tumours, whether major surgery (total unilateral mastectomy or bilateral regional mastectomy) has a more negative effect than minor surg ...
DOI:
10.1016/j.vetimm.2022.110403

13. Effects of frequent teat stimulation on antimicrobial component production in mammary glands of lactating goats

Author:
Yusaku Tsugami; Rika Harada; Takahiro Nii; Naoki Suzuki; Naoki Isobe
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110431
ISSN:
0165-2427
Subject:
Japan; calcium-binding proteins; epithelium; humans; immunopathology; keratinocytes; lactoferrin; milk; milk yield
Abstract:
... Various antimicrobial components, such as lactoferrin, S100 calcium-binding protein A7 (S100A7), and IgA, produced by epithelial cells and leukocytes in lactating mammary glands are important for host defense against invading pathogens. Increase in milking frequency enhances milk yield in ruminants and implies an increase in frequency of teat stimulation. However, the influence of frequent teat st ...
DOI:
10.1016/j.vetimm.2022.110431

14. Effects of immunostimulators of microbial origin on T cells of pigs vaccinated with attenuated vaccine against Aujeszkyʼs disease

Author:
Miroslav Andrišić; Irena Žarković; Ksenija Šandor; Anja Vujnović; Eleonora Perak Junaković; Krešo Bendelja; Ana Savić Mlakar; Nada Oršolić; Lidija Šver; Miroslav Benić; Svjetlana Terzić
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110365
ISSN:
0165-2427
Subject:
Escherichia coli; Parapoxvirus; Propionibacterium granulosum; Suid alphaherpesvirus 1; T-lymphocytes; cell-mediated immunity; immunopathology; live vaccines; vaccination
Abstract:
... Aujeszky’s disease (AD) is a viral infectious disease caused by Suid herpesvirus 1 (SuHV-1). Vaccination and eradication of AD in domestic pigs is possible using marker vaccines with attenuated or inactivated SuHV-1, or subunit vaccines. However, vaccines with attenuated SuHV-1 have shown to be more potent in inducing strong cell-mediated immune response. The studies have shown that Parapoxvirus o ...
DOI:
10.1016/j.vetimm.2021.110365

15. Effects of intra-articular inoculation with Mycoplasma bovis on immunological responses in calf joints

Author:
Koji Nishi; Yuki Hirano; Ayano Sato; Ayako Eguchi; Kazuya Matsuda; Miyuki Toda; Takafumi Watanabe; Tomohito Iwasaki; Naoki Takahashi; Marina Hosotani; Reina Watanabe; Toshihide Kato; Hiromichi Ohtsuka; Satoshi Gondaira; Hidetoshi Higuchi
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110364
ISSN:
0165-2427
Subject:
Mycoplasma bovis; arthritis; calves; cartilage; fibrin; immunohistochemistry; immunopathology; inflammation; interleukin-12; interleukin-17; interleukin-6; interleukin-8; lameness; messenger RNA; monitoring; phosphates; stifle; synovial fluid; transmission electron microscopy
Abstract:
... Mycoplasma arthritis that caused by Mycoplasma bovis exhibit severe lameness. This disease is difficult to cure with antibiotics, but the detailed pathological mechanisms have not been fully clarified. In this study, we examined the effects of intra-articular inoculation with M. bovis on immunological responses in calf joints. We inoculated three calves each with M. bovis or phosphate buffer salin ...
DOI:
10.1016/j.vetimm.2021.110364

16. Evaluation of PD-1 and PD-L1 expression in canine urothelial carcinoma cell lines

Author:
Christopher J. Pinard; Samuel E. Hocker; Andrew C. Poon; Jordon M. Inkol; Arata Matsuyama; R. Darren Wood; Geoffrey A. Wood; J. Paul Woods; Anthony J. Mutsaers
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110367
ISSN:
0165-2427
Subject:
Western blotting; carcinoma; cell lines; dogs; flow cytometry; fluorescence microscopy; gene expression; humans; immunopathology; immunotherapy; neoplasm cells; reverse transcriptase polymerase chain reaction
Abstract:
... Urothelial carcinoma (UC) is the most common urinary tumor in dogs and despite combinational therapies, only modest improvements in survival have been achieved in recent years. Given the utility of monoclonal antibodies against PD-1 and PD-L1 in human UC, we evaluated the protein and mRNA expression in three established canine urothelial carcinoma cell lines. Flow cytometry and western blot analys ...
DOI:
10.1016/j.vetimm.2021.110367

17. Evaluation of equine xenogeneic mixed lymphocyte reactions using 5-ethynyl-2’-deoxyuridine (EdU)

Author:
Kate E. Birdwhistell; David J. Hurley; Bradley Heins; John F. Peroni
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110430
ISSN:
0165-2427
Subject:
T-lymphocytes; cell proliferation; cytokines; flow cytometry; horses; immunopathology; nucleobases; organ transplantation; swine; thymidine
Abstract:
... Allogeneic solid organ transplantation is currently the only treatment option for end stage organ disease. The shortage of available donor organs has driven efforts to utilize xenogeneic organs for transplantation. In vitro methods for evaluating immune-compatibility are a quick and low cost means of screening novel tissue products prior to more involved, expensive, and invasive live animal studie ...
DOI:
10.1016/j.vetimm.2022.110430

18. Evaluation of the efficacy of cow colostrum in the treatment and its effect on serum proteomes in calves with cryptosporidiosis

Author:
Yiğit KAÇAR; Ahmet Tarık BAYKAL; Levent AYDIN; Hasan BATMAZ
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110429
ISSN:
0165-2427
Subject:
Cryptosporidium; Holstein; amyloid; blood serum; calves; cow colostrum; cryptosporidiosis; gamma-glutamyltransferase; immunoglobulin G; immunopathology; oocysts; protein content; proteome; proteomics; sodium bicarbonate; zinc
Abstract:
... This study aimed to investigate the effect of using high-quality colostrum in addition to paromomycin on the treatment outcomes and serum proteomes of calves naturally affected by cryptosporidiosis. Thirty Holstein calves infected with only Cryptosporidium spp. were divided into three equal groups. Calves in the PC group received paromomycin orally at a dose of 100 mg/kg once daily for 5 days. Cal ...
DOI:
10.1016/j.vetimm.2022.110429

19. Evidence for transfer of maternal antigen specific cellular immunity against Mycobacterium avium ssp. paratuberculosis via colostrum in a goat twin model

Author:
L. Robbers; R. van de Mheen; L. Benedictus; R. Jorritsma; M. Nielen; H.J.C. Bijkerk; S.G. van der Grein; L. Ravesloot; A.P. Koets
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110402
ISSN:
0165-2427
Subject:
Mycobacterium avium subsp. paratuberculosis; blood serum; cell-mediated immunity; cow colostrum; epithelium; histology; immune response; immunopathology; injection site; intestines; models; tuberculin; vaccines
Abstract:
... Colostrum intake is one of the most important factors in neonatal health in ruminants, mainly because of its unique immunological properties. Both in practice as well as in research, the attention of lactogenic immunity is focused on the importance of colostral antibodies and less attention is given to the functional role of maternal cells in colostrum. Here we study the transfer of maternal leuko ...
DOI:
10.1016/j.vetimm.2022.110402

20. Ex vivo activated CD4+ T cells from young calves exhibit Th2-biased effector function with distinct metabolic reprogramming compared to adult cows

Author:
Jordan M. Eder; Randy E. Sacco
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110418
ISSN:
0165-2427
Subject:
acidification; adults; gene expression; glycolysis; immunopathology; interleukin-4; mitochondria; oxygen consumption; passive immunity; phenotype
Abstract:
... As maternal passive immunity wanes at 6–8 weeks, young calves must rely on their own naïve and developing immune system for protection against pathogens. Typically, an infection in the young induces a T cell-mediated response, which skews towards a Th2 phenotype and results in a reduced effector response. Our study examines the implications this transitional period of immunocompetency has on cellu ...
DOI:
10.1016/j.vetimm.2022.110418