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You searched for: Journal name Veterinary immunology and immunopathology Remove constraint Journal name: Veterinary immunology and immunopathology
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1. 16α-Bromo-epiandrosterone therapy modulates experimental feline immunodeficiency virus viremia: initial enhancement leading to long-term suppression

Author:
Pedersen, Niels C.; North, Thomas W.; Rigg, Richard; Reading, Chris; Higgins, Joanne; Leutenegger, Christian; Henderson, Gary L.
Source:
Veterinary immunology and immunopathology 2003 v.94 no.3-4 pp. 133-148
ISSN:
0165-2427
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Feline immunodeficiency virus; Human immunodeficiency virus 1; antibodies; antigens; antiviral properties; cats; chemokine CCL5; drugs; feces; hemocyanin; interferon-gamma; interleukin-10; interleukin-12; interleukin-4; interleukin-6; messenger RNA; metabolites; mice; mortality; neutrophils; pharmacokinetics; prasterone; therapeutics; urine; viral load; viremia; viruses
Abstract:
... 16α-Bromo-epiandrosterone (epiBr), a synthetic derivative of the natural hormone dehyroepiandrosterone (DHEA), was evaluated for its effects on feline immunodeficiency virus (FIV) infection in experimental cats. The rationale for this study was based on the ability of DHEA to significantly reduce the mortality to viral infections in mice. DHEA and epiBr also have demonstrable in vitro anti-viral a ...
DOI:
10.1016/S0165-2427(03)00081-3

2. 17β-Estradiol and progesterone decrease MDP induced NOD2 expression in bovine mammary epithelial cells

Author:
Dan-dan Xu; Gang Wang; Xian-jing He; Jian-fa Wang; Bin Yang; Zhi-peng Sun; Dong-bo Sun; Qian-yu He; Xu Zhang; Rui Wu
Source:
Veterinary immunology and immunopathology 2017 v.188 pp. 59-64
ISSN:
0165-2427
Subject:
Western blotting; animal tissues; chemical elements; dairy cows; epithelial cells; estradiol; humans; innate immunity; interleukin-6; interleukin-8; intracellular signaling peptides and proteins; laboratory animals; mammary glands; mastitis; messenger RNA; oligomerization; perinatal period; progesterone; protein kinases; protein synthesis; quantitative polymerase chain reaction; receptors; reverse transcriptase polymerase chain reaction; transcription (genetics); tumor necrosis factor-alpha
Abstract:
... During the periparturient period, many neuroendocrine changes develop in cows. Periparturient hormone fluxes may adversely affect mammary gland immunity and mastitis susceptibility. 17β-Estradiol (E2) and progesterone (P4) have been reported to function on immune regulation, and their concentration fluctuates dramatically during the perinatal period. Nucleotide-binding oligomerization domain (NOD) ...
DOI:
10.1016/j.vetimm.2017.04.010

3. 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils

Author:
I. Conejeros; Z.D. Velásquez; M.D. Carretta; P. Alarcón; M.A. Hidalgo; R.A. Burgos
Source:
Veterinary immunology and immunopathology 2012 v.145 no.1-2 pp. 540-545
ISSN:
0165-2427
Subject:
Escherichia coli; Staphylococcus aureus; actin; alkaline phosphatase; borates; cattle; chemotaxis; immunity; neutrophils; new drugs; platelet-activating factor; polymerization; secretion; secretory granules
Abstract:
... 2-Aminoethoxydiphenyl borate (2-APB) interferes with the Ca²⁺ influx and reduces the ROS production, gelatinase secretion and CD11b expression in bovine neutrophils. Moreover, it has been suggested that inhibition of the Ca²⁺ channel involved in the store operated Ca²⁺ entry (SOCE) is a potential target for the development of new anti-inflammatory drugs in cattle, however it is unknown whether 2-A ...
DOI:
10.1016/j.vetimm.2011.12.006
PubMed:
22226550

4. A 14 bp indel polymorphism in the promoter region is associated with different responses to porcine circovirus type 2 infection by regulating MRC1 transcription

Author:
Hao Liu; Changying Wang; Gen Liu; Yanping Li; Li Kang; Yi Sun; Yunliang Jiang
Source:
Veterinary immunology and immunopathology 2021 v.234 pp. 110202
ISSN:
0165-2427
Subject:
Duroc; Porcine circovirus-2; genes; heart; immune response; immunopathology; kidneys; landraces; large intestine; liver; luciferase; lungs; lymph nodes; mannose; pathogens; promoter regions; small intestine; spleen; swine; transcription (genetics)
Abstract:
... Mannose receptor, C type 1 (MRC1) is a key factor in regulating the body's immune response to resist pathogen invasions. In this study, mRNA expressions of MRC1 gene in nine porcine organs/tissues were compared between Laiwu (LW) and Yorkshire × Landrace crossbred (YL) pigs prior to and post PCV2 infection. We found that, for pigs uninfected with PCV2, MRC1 mRNA expressions in the lung, spleen, la ...
DOI:
10.1016/j.vetimm.2021.110202

5. A 3-D airway epithelial cell and macrophage co-culture system to study Rhodococcus equi infection

Author:
Ute Schwab; Shannon Caldwell; Mary-Beth Matychak; Julia Felippe
Source:
Veterinary immunology and immunopathology 2013 v.154 no.1-2 pp. 54-61
ISSN:
0165-2427
Subject:
Rhodococcus equi; bacteria; coculture; collagen; epithelial cells; epithelium; foals; gene expression; light microscopy; macrophages; messenger RNA; mucins; mucus
Abstract:
... We developed a 3-D equine bronchial epithelial cell (BEC) culture that fully differentiates into ciliary beating and mucus producing cells. Using this system, we evaluated how mucus affects the phagocytic activity of macrophages. Adult horse monocyte-derived macrophages were incubated with Rhodococcus equi for 4h either in the mucus layer of in vitro generated airway epithelium or on collagen coat ...
DOI:
10.1016/j.vetimm.2013.05.003
PubMed:
23721971

6. A 7872 cDNA microarray and its use in bovine functional genomics

Author:
Everts, R.E.; Band, M.R.; Liu, Z.L.; Kumar, C.G.; Liu, L.; Loor, J.J.; Oliveira, R.; Lewin, H.A.
Source:
Veterinary immunology and immunopathology 2005 v.105 no.3-4 pp. 235-245
ISSN:
0165-2427
Subject:
microarray technology; complementary DNA; cattle; animal genetics; placenta; spleen; sequence homology; transcription factors; signal transduction; cell cycle; gene expression regulation
Abstract:
... The strategy used to create and annotate a 7872 cDNA microarray from cattle placenta and spleen cDNA sequences is described. This microarray contains approximately 6300 unique genes, as determined by BLASTN and TBLASTX similarity search against the human and mouse UniGene and draft human genome sequence databases (build 34). Sequences on the array were annotated with gene ontology (GO) terms, ther ...
Handle:
10113/7206

7. A DNA prime-protein boost vaccination strategy targeting turkey coronavirus spike protein fragment containing neutralizing epitope against infectious challenge

Author:
Yi-Ning Chen; Ching Ching Wu; Yoon Yeo; Peisheng Xu; Tsang Long Lin
Source:
Veterinary immunology and immunopathology 2013 v.152 no.3-4 pp. 359-369
ISSN:
0165-2427
Subject:
DNA; Turkey coronavirus; antibodies; epitopes; fluorescent antibody technique; genes; humoral immunity; immune response; neutralization; neutralization tests; recombinant proteins; recombinant vaccines; reverse transcriptase polymerase chain reaction; sodium; turkeys; vaccination; viral load
Abstract:
... The present study was undertaken to determine immune response and protection efficacy of a spike (S) protein fragment containing neutralizing epitopes (4F/4R) of turkey coronavirus (TCoV) by priming with DNA vaccine and boosting with the recombinant protein from the corresponding DNA vaccine gene segment. Turkeys were vaccinated by priming with either one dose (G1-750DP) or two doses (G3-750DDP) o ...
DOI:
10.1016/j.vetimm.2013.01.009
PubMed:
23428360

8. A DNA vaccine against dolphin morbillivirus is immunogenic in bottlenose dolphins

Author:
Vaughan, K.; Del Crew, J.; Hermanson, G.; Wloch, M.K.; Riffenburgh, R.H.; Smith, C.R.; Van Bonn, W.G.
Source:
Veterinary immunology and immunopathology 2007 v.120 no.3-4 pp. 260-266
ISSN:
0165-2427
Subject:
protective effect; Tursiops truncatus; dolphins; viral fusion proteins; immunogenetics; antibody formation; viral diseases of animals and humans; humoral immunity; disease prevention; Morbillivirus; wildlife diseases; plasmids; hemagglutinins; vaccination; vaccine development; lymphocyte proliferation; viral antigens
Abstract:
... The immunization of exotic species presents considerable challenges. Nevertheless, for facilities like zoos, animal parks, government facilities and non-profit conservation groups, the protection of valuable and endangered species from infectious disease is a growing concern. The rationale for immunization in these species parallels that for human and companion animals; to decrease the incidence o ...
DOI:
10.1016/j.vetimm.2007.06.036

9. A GeNorm algorithm-based selection of reference genes for quantitative real-time PCR in skin biopsies of healthy dogs and dogs with atopic dermatitis

Author:
Schlotter, Yvette M.; Veenhof, Eveline Z.; Brinkhof, Bas; Rutten, Victor P.M.G.; Spee, Bart; Willemse, Ton; Penning, Louis C.
Source:
Veterinary immunology and immunopathology 2009 v.129 no.1-2 pp. 115-118
ISSN:
0165-2427
Subject:
messenger RNA; dog diseases; dogs; polymerase chain reaction; risk assessment; gene expression; ribosomal proteins; genes; genomics; reference standards; atopic dermatitis; computer software; biopsy; algorithms; beta-glucuronidase
Abstract:
... Quantitative real time PCR (Q-PCR) is the method of choice to study mRNA expression levels. Since Q-PCR is very sensitive, normalization of the data with stably expressed reference genes if of utmost importance. The stability of reference genes depends on the tissue and the species of interest. Therefore, evaluation of the stability of reference genes must be performed for each new tissue and spec ...
DOI:
10.1016/j.vetimm.2008.12.004
PubMed:
19131113

10. A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum

Author:
Molano, I.; Alonso, M. Garcia; Miron, C.; Redondo, E.; Requena, J.M.; Soto, M.; Nieto, C. Gómez; Alonso, C.
Source:
Veterinary immunology and immunopathology 2003 v.92 no.1-2 pp. 1-13
ISSN:
0165-2427
Subject:
Leishmania infantum; delayed hypersensitivity; dog diseases; dogs; epitopes; humoral immunity; liver; lymph nodes; parasites; proteins; spleen; visceral leishmaniasis
Abstract:
... The capacity of a quimeric protein, formed by the genetic fusion of five antigenic determinants from four Leishmania proteins, formulated with BCG, to protect dogs against Leishmania infantum infection is described. The data showed that after i.v. administration of 500,000 parasites of the L. infantum M/CAN/ES/96/BCN150 strain, zymodeme MON-1, the animals became infected as suggested by the humora ...
DOI:
10.1016/S0165-2427(02)00315-X

11. A Neospora caninum vaccine using recombinant proteins fails to prevent foetal infection in pregnant cattle after experimental intravenous challenge

Author:
Yanina P. Hecker; Verónica Cóceres; Silvina E. Wilkowsky; José M. Jaramillo Ortiz; Eleonora L. Morrell; Andrea E. Verna; Agustina Ganuza; Dora B. Cano; Lilian Lischinsky; Sergio O. Ángel; Patricia Zamorano; Anselmo C. Odeón; María R. Leunda; Carlos M. Campero; Bror Morein; Dadín P. Moore
Source:
Veterinary immunology and immunopathology 2014 v.162 no.3-4 pp. 142-153
ISSN:
0165-2427
Subject:
Escherichia coli; Neospora caninum; Western blotting; antibodies; antigens; fetus; heifers; immune response; immunization; immunohistochemistry; interferon-gamma; intravenous injection; nickel; polymerase chain reaction; pregnancy; protein synthesis; recombinant proteins; transplacental transmission; vaccines
Abstract:
... The aim of the present study was to evaluate the immunogenicity and protective efficacy of rNcSAG1, rNcHSP20 and rNcGRA7 recombinant proteins formulated with immune stimulating complexes (ISCOMs) in pregnant heifers against vertical transmission of Neospora caninum. Twelve pregnant heifers were divided into 3 groups of 4 heifers each, receiving different formulations before mating. Immunogens were ...
DOI:
10.1016/j.vetimm.2014.11.001

12. A ROS-dependent and Caspase-3-mediated apoptosis in sheep bronchial epithelial cells in response to Mycoplasma Ovipneumoniae infections

Author:
Di Xue; Yanan Li; Zhongjia Jiang; Guangcun Deng; Min Li; Xiaoming Liu; Yujiong Wang
Source:
Veterinary immunology and immunopathology 2017 v.187 pp. 55-63
ISSN:
0165-2427
Subject:
Mycoplasma ovipneumoniae; apoptosis; caspase-3; caspase-8; enzootic diseases; epithelial cells; epithelium; flow cytometry; goats; nitric oxide; pathogens; phosphorylation; pneumonia; pro-apoptotic proteins; reactive oxygen species; sheep
Abstract:
... Mycoplasma Ovipneumoniae (M. ovipneumoniae) is a primary etiological agent of enzootic pneumonia in sheep and goats. It can enter and colonize ovine respiratory epithelial cells to establish an infection, which leads a serious cell death of epithelial cells. However, the nature of the interaction between pathogen of M. ovipneumoniae and host cells in the cell injury is currently not well understoo ...
DOI:
10.1016/j.vetimm.2017.04.004

13. A T-cell epitope on NS3 non-structural protein enhances the B and T cell responses elicited by dendrimeric constructions against CSFV in domestic pigs

Author:
Joan Tarradas; Marta Monsó; Lorenzo Fraile; Beatriz G. de la Torre; Marta Muñoz; Rosa Rosell; Cristina Riquelme; Lester Josué Pérez; Miquel Nofrarías; Mariano Domingo; Francisco Sobrino; David Andreu; Llilianne Ganges
Source:
Veterinary immunology and immunopathology 2012 v.150 no.1-2 pp. 36-46
ISSN:
0165-2427
Subject:
Classical swine fever virus; RNA; T-lymphocytes; antibodies; epitopes; glycoproteins; immune response; neutralization; swine; vaccination; viral load
Abstract:
... It has been recently reported by our group that dendrimeric constructs combining B- and T-cell epitopes from classical swine fever virus (CSFV) provided partial protection against experimental infection. This research evaluated four newly designed constructions while taking into account our previous work, including the direct implication that a T-cell epitope from the NS3 protein contributes to th ...
DOI:
10.1016/j.vetimm.2012.08.006
PubMed:
22959286

14. A Toxocara canis infection influences the immune response to house dust mite allergens in dogs

Author:
N. Fischer; A. Rostaher; L. Zwickl; P. Deplazes; T. Olivry; C. Favrot
Source:
Veterinary immunology and immunopathology 2018 v.202 pp. 11-17
ISSN:
0165-2427
Subject:
Beagle; Dermatophagoides farinae; Toxocara canis; allergens; dogs; drugs; dust mites; hygiene; immune response; immunoglobulin E; immunoglobulin G; microorganisms; protective effect; pruritus; skin lesions; toxocariasis
Abstract:
... The “hygiene hypothesis” suggests that a western way of life, including the extended use of anti-infective drugs, a high standard of hygiene and the resulting reduced exposure to microorganisms, could be one of the possible explanations for the increasing prevalence of allergic diseases in humans and animals.we wished to evaluate if a nematode infection influenced IgE sensitization and allergic re ...
DOI:
10.1016/j.vetimm.2018.06.009

15. A West Nile virus (WNV) recombinant canarypox virus vaccine elicits WNV-specific neutralizing antibodies and cell-mediated immune responses in the horse

Author:
El Garch, H.; Minke, J.M.; Rehder, J.; Richard, S.; Edlund Toulemonde, C.; Dinic, S.; Andreoni, C.; Audonnet, J.C.; Nordgren, R.; Juillard, V.
Source:
Veterinary immunology and immunopathology 2008 v.123 no.3-4 pp. 230-239
ISSN:
0165-2427
Subject:
transgenes; antibody formation; viral diseases of animals and humans; cell-mediated immunity; West Nile virus; vaccination; recombinant vaccines; horse diseases; horses; interferons
Abstract:
... Successful vaccination against West Nile virus (WNV) requires induction of both neutralizing antibodies and cell-mediated immune responses. In this study, we have assessed the ability of a recombinant ALVAC®-WNV vaccine (RECOMBITEK® WNV) to elicit neutralizing antibodies and virus-specific cell-mediated immune responses in horses. In addition, we examined whether prior exposure to ALVAC®-WNV vacci ...
DOI:
10.1016/j.vetimm.2008.02.002
PubMed:
18372050

16. A cDNA microarray analysis to identify genes involved in the acute-phase response pathway of the olive flounder after infection with Edwardsiella tarda

Author:
Ji Young Moon; Yong-Ki Hong; Hee Jeong Kong; Dong-Gyun Kim; Young-Ok Kim; Woo-Jin Kim; Young Joo Ji; Cheul Min An; Bo-Hye Nam
Source:
Veterinary immunology and immunopathology 2014 v.161 no.1-2 pp. 49-56
ISSN:
0165-2427
Subject:
Paralichthys olivaceus; liver; complementary DNA; microarray technology; flounder; Toll-like receptor 5; gene expression regulation; expressed sequence tags; mammals; catechol O-methyltransferase; Edwardsiella tarda; haptoglobins; pathogens
Abstract:
... The acute-phase response (APR) is an important systemic reaction that occurs within hours of an inflammatory signal caused by physical bodily injury or microbial infection. To investigate the APR of the olive flounder (Paralichthys olivaceus) following infection with a pathogen, we established an expressed sequence tag (EST)-based cDNA microarray chip composed of 13,061 PCR-amplified cDNAs encodin ...
DOI:
10.1016/j.vetimm.2014.07.002

17. A canine keratinocyte cell line expresses antimicrobial peptide and cytokine genes upon stimulation with bacteria, microbial ligands and recombinant cytokines

Author:
Suttiwee Chermprapai; Femke Broere; Yvette M. Schlotter; Edwin J.A. Veldhuizen; Victor P.M.G. Rutten
Source:
Veterinary immunology and immunopathology 2018 v.206 pp. 35-40
ISSN:
0165-2427
Subject:
Staphylococcus pseudintermedius; antimicrobial peptides; antimicrobial properties; atopic dermatitis; bacteria; bacterial infections; cell lines; dogs; gene expression; gene expression regulation; genes; interleukins; keratinocytes; ligands; pathogens; receptors; secondary infection; secretion; tumor necrosis factor-alpha
Abstract:
... Keratinocytes (KC) are the main cellular components of the stratum corneum that constitutes a solid physical skin barrier representing the first line of defense against pathogens. Moreover, KC are potent producers of inflammatory mediators and antimicrobial peptides (AMP) when activated through their pattern recognition receptors. In atopic dermatitis (AD) the protective skin barrier may be compro ...
DOI:
10.1016/j.vetimm.2018.11.009

18. A canine vaccine against Leptospira serovars Icterohaemorrhagiae, Canicola and Grippotyphosa provides cross protection against Leptospira serovar Copenhageni

Author:
J. Bouvet; L. Lemaitre; C. Cariou; M. Scotto; C. Blain; F. Oberli; L. Cupillard; P.M. Guigal
Source:
Veterinary immunology and immunopathology 2020 v.219 pp. 109985
ISSN:
0165-2427
Subject:
Leptospira interrogans serovar Copenhageni; cross immunity; dogs; excretion; kidney diseases; leptospirosis; mortality; serotypes; signs and symptoms (animals and humans); vaccination; vaccines; virulence
Abstract:
... Efficacy of the Leptospira components of multivalent vaccine DAPPi-L was previously demonstrated against virulent challenge with three serovars of Leptospira interrogans (Canicola, Icterohaemorrhagiae and Grippotyphosa) carried out 14 days after primary vaccination.In this study we demonstrate that this vaccine provides, two weeks after vaccination, an additional protection (prevention of mortalit ...
DOI:
10.1016/j.vetimm.2019.109985

19. A cell-based MHC stabilization assay for the detection of peptide binding to the canine classical class I molecule, DLA-88

Author:
Peter Ross; Jennifer C. Holmes; Gregory S. Gojanovich; Paul R. Hess
Source:
Veterinary immunology and immunopathology 2012 v.150 no.3-4 pp. 206-212
ISSN:
0165-2427
Subject:
CD8-positive T-lymphocytes; alleles; dogs; epitopes; mice; peptides; proteins
Abstract:
... Identifying immunodominant CTL epitopes is essential for studying CD8+ T-cell responses in populations, but remains difficult, as peptides within antigens typically are too numerous for all to be synthesized and screened. Instead, to facilitate discovery, in silico scanning of proteins for sequences that match the motif, or binding preferences, of the restricting MHC class I allele – the largest d ...
DOI:
10.1016/j.vetimm.2012.08.012
PubMed:
23062801
PubMed Central:
PMC3494747

20. A chimeric protein comprising the immunogenic domains of Mannheimia haemolytica leukotoxin and outer membrane protein PlpE induces antibodies against leukotoxin and PlpE

Author:
Sai Arun Batra; Sudarvili Shanthalingam; Gaetano Donofrio; Subramaniam Srikumaran
Source:
Veterinary immunology and immunopathology 2016 v.175 pp. 36-41
ISSN:
0165-2427
Subject:
Mannheimia haemolytica; Ovis canadensis; antibodies; cytotoxicity; epitopes; habitats; immune response; leukotoxins; mice; mortality; outer membrane proteins; pathogens; pneumonia; recombinant fusion proteins; ruminants; surface antigens; vaccination; vaccine development; vaccines; virulence; North America
Abstract:
... Mannheimia haemolytica is a very important pathogen of pneumonia in ruminants. Bighorn sheep (BHS, Ovis canadensis) are highly susceptible to M. haemolytica-caused pneumonia which has significantly contributed to the drastic decline of bighorn sheep population in North America. Pneumonia outbreaks in wild BHS can cause mortality as high as 90%. Leukotoxin is the critical virulence factor of M. hae ...
DOI:
10.1016/j.vetimm.2016.05.004