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You searched for: Journal name Veterinary immunology and immunopathology Remove constraint Journal name: Veterinary immunology and immunopathology
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1. A ferret model of immunosuppression induced with dexamethasone

Author:
Anna Hundakova; Lenka Leva; Miroslav Toman; Zdenek Knotek
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110362
ISSN:
0165-2427
Subject:
Phytolaccaceae; chemiluminescence; concanavalin A; dexamethasone; ferrets; humans; immunopathology; immunosuppression; ingestion; mitogens; monocytes; neutrophils; phagocytosis; phytohemagglutinin; reactive oxygen species
Abstract:
... Ferrets are nowadays frequently used as animal models for biomedical purposes; in many cases, immunosuppression of experimental animals is necessary. The aim of this study was to evaluate the effect of intramuscular dexamethasone administration (2 mg/kg as the initiation dose continued with 1 mg/kg q 12 h applied 5 times) on ferret’s immune system. In comparison with ferrets which received the sal ...
DOI:
10.1016/j.vetimm.2021.110362

2. Acetoacetate is a trigger of NLRP3 inflammasome activation in bovine peripheral blood mononuclear cells

Author:
Yuri Onizawa; Taiga Katoh; Ryotaro Miura; Kunitoshi Konda; Tatsuo Noguchi; Hisataka Iwata; Takehito Kuwayama; Seizo Hamano; Koumei Shirasuna
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110370
ISSN:
0165-2427
Subject:
acetoacetic acid; blood plasma; caspase-1; estrous cycle; gene expression; immunopathology; inflammasomes; inflammation; ketone bodies; metabolomics; repeat breeder; reproductive disorders; secretion
Abstract:
... Repeat breeding, which is non-pregnancy following three or more breeding attempts, is a serious reproductive disorder in cattle. In the present study, metabolomic profiling was used to identify metabolites in the blood plasma of repeat breeder cows (RBCs) and non-RBCs. Metabolomic analysis showed that acetoacetate (AcAc), a ketone body, was detected in RBCs, but not in non-RBCs. In contrast, β-hyd ...
DOI:
10.1016/j.vetimm.2021.110370

3. Antibodies from healthy or paratuberculosis infected cows have different effects on Mycobacterium avium subspecies paratuberculosis invasion in a calf ileal loop model

Author:
Ana Jolly; Bárbara Fernández; Ana Stempler; Giselle Ingratta; Gabriela Postma; Juan Boviez; Daniel Lombardo; Silvia Hajos; Silvia L. Mundo
Source:
Veterinary immunology and immunopathology 2022 v.245 pp. 110381
ISSN:
0165-2427
Subject:
Mycobacterium avium subsp. paratuberculosis; calves; histology; histopathology; ileum; immunopathology; microbial load; models; paratuberculosis; protective effect; viability
Abstract:
... In this work, we used a calf ileal loop model to evaluate whether the preincubation of Mycobacterium avium subspecies paratuberculosis (MAP) with antibodies from healthy, MAP-positive or Lipoarabinomannan (LAM) immunized cows could affect the results of infection after 3.5 h. Bacterial load in tissue was assessed by Ziehl-Neelsen and by culture for each loop. MAP was detectable in all infected loo ...
DOI:
10.1016/j.vetimm.2022.110381

4. Assessment of heterologous lumpy skin disease vaccine-induced immunity in pregnant cattle vaccinated at different times of gestation period and their influence on maternally derived antibodies

Author:
Ahmed Gaber; Sherin Rouby; Amera Elsaied; Ahmed El-Sherif
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110380
ISSN:
0165-2427
Subject:
cell-mediated immunity; gestation period; humoral immunity; immunopathology; longevity; lumpy skin disease; maternal immunity; parturition; pregnancy; sheep pox; vaccination; vaccines
Abstract:
... The present study aimed to evaluate the cell-mediated and the humoral immune response to Romanian sheep pox vaccine in pregnant cows (n = 12) vaccinated at different times of gestation period and the duration of maternal immunity in calves born to these cows. Evaluation of cellular immunity revealed an increase in lymphocytic proliferation that peaked at 10th day post vaccination (dpv) then gradua ...
DOI:
10.1016/j.vetimm.2021.110380

5. Canine memory T-cell subsets in health and disease

Author:
Annie B. Bauman; Cambri E. Moeller; Aimee M. Soileau; Christine E. Goodermuth; Victoria R. Costa; Jessica C. Schaumburg; Cherie M. Pucheu-Haston; Nancy D. Welborn; Shannon D. Dehghanpir; Mark A. Mitchell; Sita S. Withers
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110401
ISSN:
0165-2427
Subject:
T-lymphocytes; antigens; atopic dermatitis; dogs; drug therapy; flow cytometry; immunopathology; immunotherapy; inflammation; lymph nodes; lymphoma; memory; prednisone
Abstract:
... A more complete understanding of canine T-lymphocyte immunity is necessary for improving diagnostic and therapeutic approaches to canine diseases, developing cell-based canine immunotherapeutics, and evaluating dogs as large mammal models for comparative immunology research. The aim of this study was to utilize CD45RA (indicating antigen inexperience) and CD62L (indicating lymph node homing capabi ...
DOI:
10.1016/j.vetimm.2022.110401

6. Characterisation of dendritic cell frequency and phenotype in bovine afferent lymph reveals kinetic changes in costimulatory molecule expression

Author:
Sara Marzo; Mark Gray; Waywen Loh; Lindsey A. Waddell; C. Irene McGuinnes; Jayne C. Hope; Heather A. Mathie
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110363
ISSN:
0165-2427
Subject:
T-lymphocytes; adaptive immunity; cattle; dendritic cells; flow cytometry; immunopathology; lymph; models; phenotype
Abstract:
... The bovine afferent lymphatic cannulation model allows collection of large volumes of afferent lymph and provides an opportunity to study lymphatic cells trafficking from the periphery directly ex-vivo. The technique requires surgical intervention, but influence of the procedure or time post-surgery on cells trafficking in the lymph has not been well documented. Here, we measured the volume of lym ...
DOI:
10.1016/j.vetimm.2021.110363

7. Effect of major versus minor mastectomy on host immunity in canine mammary cancer

Author:
Maria Karayannopoulou; Tilemachos Anagnostou; Apostolia Margariti; Maria Kritsepi-Konstantinou; Dimitra Psalla; Angelos-Lauris Thomas; Ioannis Savvas
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110403
ISSN:
0165-2427
Subject:
T-lymphocytes; anesthesia; cell-mediated immunity; immunopathology; immunosuppression; innate immunity; mammary neoplasms (animal); metastasis; neutrophils; surgery
Abstract:
... Surgical procedures can affect host immunity proportionally to the extent of surgical trauma. In cancer cases, surgery-induced immunosuppression can potentially promote tumour metastasis. The aim of this study was to investigate, in bitches with malignant mammary tumours, whether major surgery (total unilateral mastectomy or bilateral regional mastectomy) has a more negative effect than minor surg ...
DOI:
10.1016/j.vetimm.2022.110403

8. Effects of intra-articular inoculation with Mycoplasma bovis on immunological responses in calf joints

Author:
Koji Nishi; Yuki Hirano; Ayano Sato; Ayako Eguchi; Kazuya Matsuda; Miyuki Toda; Takafumi Watanabe; Tomohito Iwasaki; Naoki Takahashi; Marina Hosotani; Reina Watanabe; Toshihide Kato; Hiromichi Ohtsuka; Satoshi Gondaira; Hidetoshi Higuchi
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110364
ISSN:
0165-2427
Subject:
Mycoplasma bovis; arthritis; calves; cartilage; fibrin; immunohistochemistry; immunopathology; inflammation; interleukin-12; interleukin-17; interleukin-6; interleukin-8; lameness; messenger RNA; monitoring; phosphates; stifle; synovial fluid; transmission electron microscopy
Abstract:
... Mycoplasma arthritis that caused by Mycoplasma bovis exhibit severe lameness. This disease is difficult to cure with antibiotics, but the detailed pathological mechanisms have not been fully clarified. In this study, we examined the effects of intra-articular inoculation with M. bovis on immunological responses in calf joints. We inoculated three calves each with M. bovis or phosphate buffer salin ...
DOI:
10.1016/j.vetimm.2021.110364

9. Evaluation of the efficacy of cow colostrum in the treatment and its effect on serum proteomes in calves with cryptosporidiosis

Author:
Yiğit KAÇAR; Ahmet Tarık BAYKAL; Levent AYDIN; Hasan BATMAZ
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110429
ISSN:
0165-2427
Subject:
Cryptosporidium; Holstein; amyloid; blood serum; calves; cow colostrum; cryptosporidiosis; gamma-glutamyltransferase; immunoglobulin G; immunopathology; oocysts; protein content; proteome; proteomics; sodium bicarbonate; zinc
Abstract:
... This study aimed to investigate the effect of using high-quality colostrum in addition to paromomycin on the treatment outcomes and serum proteomes of calves naturally affected by cryptosporidiosis. Thirty Holstein calves infected with only Cryptosporidium spp. were divided into three equal groups. Calves in the PC group received paromomycin orally at a dose of 100 mg/kg once daily for 5 days. Cal ...
DOI:
10.1016/j.vetimm.2022.110429

10. Influenza A pathway analysis of highly pathogenic avian influenza virus (H5N1) infection in genetically disparate Ri chicken lines

Author:
Jiae Lee; Yeojin Hong; Thi Hao Vu; Sooyeon Lee; Jubi Heo; Anh Duc Truong; Hyun S. Lillehoj; Yeong Ho Hong
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110404
ISSN:
0165-2427
Subject:
Influenza A virus; RNA; chickens; cytokines; gene expression; gene expression regulation; immune system; immunity; immunopathology; influenza; interferons; quantitative polymerase chain reaction; reverse transcription; viruses; Vietnam
Abstract:
... Influenza A/H5N1 virus is a highly pathogenic (HPAIV) and contagious zoonotic virus that can be transmitted to humans. In the present study, infection with this virus and differential gene expression analyses were carried out with genetically resistant and susceptible Ri chicken lines that are native to Vietnam. A total of 20 four-week-old Ri chickens from each line were inoculated with the highly ...
DOI:
10.1016/j.vetimm.2022.110404

11. Potential for improved detection of bovine tuberculosis by targeting combined blood biomarkers in multi-test algorithms

Author:
Archana A. Sridhara; Ashley Johnathan-Lee; Rubyat Elahi; Alina Sikar-Gang; Paul Lambotte; Javan Esfandiari; Lucia de Juan; Christian Gortazar; Breanne N. Marpe; Tyler C. Thacker; Mitchell V. Palmer; W. Ray Waters; Konstantin P. Lyashchenko
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110419
ISSN:
0165-2427
Subject:
Mycobacterium bovis; antibodies; biomarkers; blood; bovine tuberculosis; cattle; diagnostic sensitivity; immunopathology; interferon-gamma; tuberculin; Spain
Abstract:
... Bovine tuberculosis (bTB) control programs can be improved by combined use of tests for humoral and cell-mediated immune responses targeting multiple biomarkers of Mycobacterium bovis. To further the diagnostic benefits of this approach, we used Dual Path Platform (DPP) technology to test sera from cattle with naturally acquired bTB in the United States (US) and Spain for the presence of M. bovis ...
DOI:
10.1016/j.vetimm.2022.110419

12. Residue of thiram in food, suppresses immune system stress signals and disturbs sphingolipid metabolism in chickens

Author:
Yingwei Liu; Jiangnan Yi; Yuanliang Li; Riaz Hussain; Shanshan Zhu; Yangwei Li; Zhuanxu Ouyang; Khalid Mehmood; Lianmei Hu; Jiaqing Pan; Zhaoxin Tang; Ying Li; Hui Zhang
Source:
Veterinary immunology and immunopathology 2022 v.247 pp. 110415
ISSN:
0165-2427
Subject:
angiogenesis; apoptosis; autophagy; cell membranes; immunology; immunopathology; immunotoxicity; metabolites; metabolome; necropsy; pollution; public health; sphingolipids; spleen; sulfur; thiram
Abstract:
... Thiram, a well-known sulfur containing organic compound is frequently and extensively used in agriculture because of high biological activity to control different pests. In certain cases, due to long persistence in the environment pesticides and other environmental contaminants induce undesirable toxic impacts to public health and environment. To ascertain the potential mechanisms of toxicity of t ...
DOI:
10.1016/j.vetimm.2022.110415

13. Thymic changes due to leishmaniasis in dogs: An immunohistochemical study

Author:
Giulia Gonçalves Jussiani; Karen Santos Março; Paulo Henrique Leal Bertolo; Rosemeri de Oliveira Vasconcelos; Gisele Fabrino Machado
Source:
Veterinary immunology and immunopathology 2022 v.247 pp. 110416
ISSN:
0165-2427
Subject:
Leishmania infantum; apoptosis; atrophy; collagen; death; epithelium; histopathology; immune response; immunohistochemistry; immunopathology; leishmaniasis; macrophages; mitosis; morphometry; parasites; pathophysiology; thymocytes; tissue distribution
Abstract:
... The thymus is necessary for the differentiation of T cells, a process that is regulated by the type of antigens found in thymocytes, the environment of surrounding cells and the thymus architecture. There is evidence that infectious diseases may result in morphological changes in this organ, such as premature atrophy and decreased thymocyte proliferation, that can affect the immune response. We ch ...
DOI:
10.1016/j.vetimm.2022.110416

14. APB-F1, a long-acting feline granulocyte colony-stimulating factor fusion protein, created by exploiting FL335, a chimeric Fab specific for feline serum albumin

Author:
Hyun-jin Chi; Mihyun Park; Jae-kyu Han; Sun-mi Kim; SeungGoo Kang; Jin-hyuk Yang; Sang-hoon Cha
Source:
Veterinary immunology and immunopathology 2021 v.240 pp. 110322
ISSN:
0165-2427
Subject:
Cricetulus griseus; antibodies; bioactive properties; blood serum; cats; granulocyte colony-stimulating factor; half life; humans; immunopathology; neutropenia; neutrophils; pharmacodynamics; pharmacokinetics; recombinant fusion proteins; serum albumin; therapeutics
Abstract:
... Off-label use of a human granulocyte colony stimulating factor (hG-CSF) has been allowed to treat dogs and cats with neutropenia. However, repeated administration of hG-CSF induces undesirable anti-drug antibody (ADA) responses, implying the necessity of animal-derived G-CSF as a therapeutic reagent, preferably with a long-acting capability. Herein, we generated a recombinant fusion protein by gen ...
DOI:
10.1016/j.vetimm.2021.110322

15. Activation of canine neutrophils by platelet-activating factor

Author:
Ken Okabayashi; Shuichiro Kanai; Fumihiko Katakura; Riku Takeuchi; Takashi Yamauchi; Shunya Nakayama; Rie Kinoshita; Hiroshi Koie; Takanori Narita
Source:
Veterinary immunology and immunopathology 2021 v.241 pp. 110336
ISSN:
0165-2427
Subject:
calcium; dogs; endoplasmic reticulum; immunopathology; inflammation; inositols; neutrophils; phagocytosis; platelet aggregation; platelet-activating factor; respiratory burst; signal transduction; suramin
Abstract:
... Neutrophils are essential for innate immunity as the first line of defence. Neutrophils act as phagocytic white blood cells to kill bacteria and other microorganisms. A strong respiratory burst of neutrophils, dependent on reactive oxygen species, is produced during phagocytosis. Platelet-activating factor (PAF) is a signalling molecule with several prominent roles in tissue injury, inflammation, ...
DOI:
10.1016/j.vetimm.2021.110336

16. An allergen-fused dendritic cell-binding peptide enhances in vitro proliferation of equine T-cells and cytokine production

Author:
Anja Ziegler; Judith Olzhausen; Eman Hamza; Ana Stojiljkovic; Michael H. Stoffel; Mattia Garbani; Claudio Rhyner; Eliane Marti
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110351
ISSN:
0165-2427
Subject:
Culicoides; T-lymphocytes; Toll-like receptor 4; adjuvants; agonists; allergens; asthma; cancer therapy; cell proliferation; dendritic cells; dermatitis; horses; humans; immune response; immunogenicity; immunomodulators; immunopathology; immunotherapy; insects; interleukin-10; interleukin-17; interleukin-4; mice; oligodeoxyribonucleotides; ovalbumin
Abstract:
... Allergen-specific immunotherapy (AIT) constitutes the only curative approach for allergy treatment. There is need for improvement of AIT in veterinary medicine, such as in horses suffering from insect bite hypersensitivity, an IgE-mediated dermatitis to Culicoides. Dendritic cell (DC)-targeting represents an efficient method to increase antigen immunogenicity. It is studied primarily for its use i ...
DOI:
10.1016/j.vetimm.2021.110351

17. Anti-inflammatory activity of citrus pectin on chicken monocytes' immune response

Author:
G. Ávila; D. De Leonardis; G. Grilli; C. Lecchi; F. Ceciliani
Source:
Veterinary immunology and immunopathology 2021 v.237 pp. 110269
ISSN:
0165-2427
Subject:
Citrus; Escherichia coli; anti-inflammatory activity; apoptosis; biochemical pathways; caspase-3; chemotaxis; dietary fiber; digestibility; dose response; energy; galacturonic acid; immune response; immunopathology; monocytes; pectins; phagocytosis; toxicity testing; viability
Abstract:
... Pectin is a dietary fibre composed of galacturonic acid, primarily found in the citrus fruits' cell walls. Citrus pectin (CP) has demonstrated antioxidative, anticancer, and anti-inflammatory properties in humans and animals. In broilers, CP supplementation improves energy utilization and nutrient digestibility, but limited information on its effects on chicken immunity is available so far. This s ...
DOI:
10.1016/j.vetimm.2021.110269

18. Antibodies that react with bovine T lymphocytes expressing the T cell receptor β chain subgroup BV20 inhibit antigen recognition

Author:
W. Ivan Morrison; Tara Sheldrake; Timothy Connelley
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110392
ISSN:
0165-2427
Subject:
antigens; cattle; cytotoxicity; gene duplication; genes; immunopathology
Abstract:
... In recent years, molecular studies have provided detailed information on the bovine T cell receptor (TCR) variable gene repertoire, both in resting T cells and during T cell responses. However, studies of the biological function of the receptor have been hampered by a lack of reagents that recognise the protein. Herein, we describe the characterisation of two antibodies (IL-A47 and IL-A98) that re ...
DOI:
10.1016/j.vetimm.2022.110392

19. Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate

Author:
Matthew J. Cascio; Elizabeth M. Whitley; Bikash Sahay; Galaxia Cortes-Hinojosa; Lung-Ji Chang; Jonathan Cowart; Marc Salute; Elias Sayour; Michael Dark; Zachary Sandoval; Duane A. Mitchell; Rowan J. Milner
Source:
Veterinary immunology and immunopathology 2021 v.232 pp. 110169
ISSN:
0165-2427
Subject:
T-lymphocytes; dogs; humans; immunohistochemistry; immunopathology; ligands; metastasis; osteosarcoma; patients
Abstract:
... Immune-targeted therapies are being successfully implemented into cancer clinical practice. In particular checkpoint inhibitors are employed to modulate the immune microenvironment of solid tumors. We sought to determine the expression of PD-L1, HVEM, and B7H3 in human and canine osteosarcoma, and correlate expression with clinical features and tumor infiltrating lymphocytes in naturally-occurring ...
DOI:
10.1016/j.vetimm.2020.110169

20. Characterization of a variant CD4 molecule in Japanese Black cattle

Author:
Yuko Kato-Mori; Taku Okamura; Norihito Kawashita; Katsuro Hagiwara
Source:
Veterinary immunology and immunopathology 2021 v.232 pp. 110167
ISSN:
0165-2427
Subject:
Wagyu; amino acid substitution; amino acids; cytokines; epitopes; farms; flow cytometry; gene expression; genes; glycoproteins; immunopathology; macrophages; mitogens; monocytes
Abstract:
... Monoclonal antibodies (mAbs) that recognize cluster of differentiation (CD) molecules on lymphocytes are useful tools for the study of different lymphocyte subsets in flow cytometry (FCM) analysis. CD4 is a glycoprotein found on the surfaces of helper T cells, monocytes, macrophages, and dendritic cells. In this study, we describe Japanese Black (JB) calves in a farm whose peripheral blood mononuc ...
DOI:
10.1016/j.vetimm.2020.110167

21. Chitosan-based formulation of hemagglutinin antigens for oculo-nasal booster vaccination of chickens against influenza viruses

Author:
Violetta Sączyńska; Agnieszka Romanik-Chruścielewska; Katarzyna Florys-Jankowska; Violetta Cecuda-Adamczewska; Małgorzata Kęsik-Brodacka
Source:
Veterinary immunology and immunopathology 2022 v.247 pp. 110406
ISSN:
0165-2427
Subject:
Escherichia coli; aluminum hydroxide; avian influenza; chitosan; glutamic acid; hemagglutination; hemagglutinins; immunopathology; pH; public health; recombinant proteins; secondary immunization; viral antigens
Abstract:
... Avian influenza viruses (AIVs) and especially highly pathogenic (HP) AIVs of the H5 and H7 subtypes are of both veterinary and public health concern worldwide. In response to the demand for effective vaccines against H5N1 HPAIVs, we produced recombinant protein based on hemagglutinin (HA), a protective viral antigen. A fragment of the HA ectodomain, with a multibasic cleavage site deletion, was ex ...
DOI:
10.1016/j.vetimm.2022.110406

22. Comparative profiling of the resistance of different genotypes of mannose-binding lectin to Mycoplasma pneumoniae infection in Chinese Merino sheep based on high-throughput sequencing technology

Author:
Mengting Zhu; Ying Nan; Mengting Zhai; Mingyuan Wang; Yanyan Shao; Hugh T. Blair; Stephen Todd Morris; Paul Richard Kenyon; Zongsheng Zhao; Hongmei Zhang
Source:
Veterinary immunology and immunopathology 2021 v.233 pp. 110183
ISSN:
0165-2427
Subject:
GATA transcription factors; Merino; Mycoplasma pneumoniae; blood; gene expression; gene expression regulation; glycoproteins; immunopathology; immunotherapy; innate immunity; lectins; liver; microRNA; sheep
Abstract:
... Mannose-binding lectin (MBL) glycoproteins in blood can selectively recognise lectins on the surface of bacteria, and play an important role in natural immunity. Micro RNAs (miRNAs) are key molecules that regulate gene expression at the post-transcriptional level in vivo, and their pathways are specific and effective. Previous studies indicate that small RNAs such as miRNAs perform regulatory role ...
DOI:
10.1016/j.vetimm.2021.110183

23. Comparison of the mucosal adjuvanticities of two Toll-like receptor ligands for recombinant adenovirus-delivered African swine fever virus fusion antigens

Author:
Huipeng Lu; Xiaohui Zhou; Zhi Wu; Xinyu Zhang; Liqi Zhu; Xiaoyu Guo; Quan Zhang; Shanyuan Zhu; Hongfei Zhu; Huaichang Sun
Source:
Veterinary immunology and immunopathology 2021 v.239 pp. 110307
ISSN:
0165-2427
Subject:
Adenoviridae; African swine fever virus; Mycobacterium tuberculosis; Toll-like receptors; Vibrio; antibodies; antibody formation; antigens; flagellin; heat-shock protein 70; immunopathology; interleukin-10; interleukin-4; ligands; lungs; macrophages; mucosal immunity; nose; secondary immunization; swine; vaccination; vaccine adjuvants; vaccine development
Abstract:
... The mucosal immunity plays an important role against African swine fever virus (ASFV) infection and the efficacy of mucosal vaccination is highly dependent on the adjuvant. However, the mucosal adjuvant for ASFV vaccination is poorly studied. Toll-like receptor (TLR) ligands such as the FlaB flagellin from Vibrio vulnificus and the heat shock protein 70 from Mycobacterium tuberculosis (mHsp70) hold ...
DOI:
10.1016/j.vetimm.2021.110307

24. Comparison of the response of mammary gland tissue from two divergent lines of goat with high and low milk somatic cell scores to an experimental Staphylococcus aureus infection

Author:
Rossana Capoferri; Paola Cremonesi; Bianca Castiglioni; Giuliano Pisoni; Paola Roccabianca; Federica Riva; Joel Filipe; Marcello del Corvo; Alessandra Stella; John L. Williams; Rachel Rupp; Paolo Moroni
Source:
Veterinary immunology and immunopathology 2021 v.234 pp. 110208
ISSN:
0165-2427
Subject:
Staphylococcus aureus; chemotaxis; goats; histology; histopathology; immune response; immunopathology; inflammation; interleukin-6; livestock and meat industry; mammary glands; milk; milk quality; neutrophils; somatic cells; transcriptomics; udders
Abstract:
... Mastitis represents one of the major economic and health threats to the livestock sector associated with reduction in milk quality, loss of production and is a major reason for culling. Somatic cell score (SCS) is used as a criterion in breeding programmes to select cows genetically less susceptible to mastitis. The relevance of SCS as a predictor of udder health and susceptibility to mastitis is ...
DOI:
10.1016/j.vetimm.2021.110208

25. Dynamic changes in Holstein heifer circulatory stress biomarkers in response to lipopolysaccharide immune challenge

Author:
T. Sullivan; A. Sharma; K. Lamers; C. White; B.A. Mallard; A. Cánovas; N.A. Karrow
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110426
ISSN:
0165-2427
Subject:
Holstein; acidosis; biomarkers; blood flow; blood serum; body temperature; climate change; cortisol; heat stress; immunopathology; inflammation; interleukin-10; intestinal mucosa; leukopenia; lipopolysaccharides; microRNA; septicemia; stress response; thrombocytopenia
Abstract:
... Dairy cattle routinely face a variety of stressors. For example, climate change has resulted in more frequent heat stress events that increase the incidence of bacterial infections by inducing conditions like leaky gut syndrome, whereby the integrity of the intestinal epithelium is compromised allowing for luminal bacteria and their membrane components to infiltrate the host’s bloodstream resultin ...
DOI:
10.1016/j.vetimm.2022.110426

26. Dynamics of local gene regulations in synovial fluid leukocytes from horses with lipopolysaccharide-induced arthritis

Author:
Marie Walters; Kerstin Skovgaard; Pia Haubro Andersen; Peter M.H. Heegaard; Stine Jacobsen
Source:
Veterinary immunology and immunopathology 2021 v.241 pp. 110325
ISSN:
0165-2427
Subject:
antagonists; arthritis; cartilage; chemokines; chondrocytes; gene expression; genes; immunopathology; inflammation; interleukin-10; interleukin-6; lipopolysaccharides; models; neutrophil collagenase; prostaglandin synthase; superoxide dismutase; synovial fluid; tumor necrosis factors
Abstract:
... The role of resident cells such a synoviocytes and chondrocytes in intra-articular inflammation is well-characterized, however the in vivo gene expression patterns of cells (predominantly leukocytes) in the synovial fluid (SF) of an inflamed joint have never previously been investigated. The aim of this study was to investigate gene expression in SF leukocytes from the inflamed joint cavity after ...
DOI:
10.1016/j.vetimm.2021.110325

27. Effect of IL-8 haplotype on temporal profile in circulating concentrations of interleukin 8 and 25(OH) vitamin D in Holstein-Friesian calves

Author:
Megan B. O’Brien; Rachel M. McLoughlin; Colm Roche; Corwin D. Nelson; Kieran G. Meade
Source:
Veterinary immunology and immunopathology 2021 v.238 pp. 110287
ISSN:
0165-2427
Subject:
Holstein; blood serum; disease susceptibility; genes; haplotypes; immune response; immunopathology; innate immunity; interleukin-8; monocytes; neutrophils; temporal variation; vitamin D
Abstract:
... Interleukin-8 (IL-8) is an inflammatory chemokine released during the primary innate immune response to recruit neutrophils to the site of infection. Two distinct gene promoter haplotypes have been previously reported to segregate in the Holstein-Friesian breed (IL8-h1 and IL8-h2). Our earlier work showed how these divergent IL8 haplotypes influence IL-8 concentration and other immune response par ...
DOI:
10.1016/j.vetimm.2021.110287

28. Effect of IL8 haplotype on immunological traits in periparturient dairy cows

Author:
Giovanna De Matteis; Maria Carmela Scatà; Francesco Grandoni; Alessandra Crisà; Megan B. O’Brien; Kieran G. Meade; Gennaro Catillo
Source:
Veterinary immunology and immunopathology 2021 v.238 pp. 110288
ISSN:
0165-2427
Subject:
CD4-positive T-lymphocytes; Holstein; Simmental; amyloid; blood serum; cytotoxicity; early lactation; genes; genotyping; haplotypes; haptoglobins; homozygosity; immune response; immunopathology; innate immunity; interleukin-8; monocytes; reactive oxygen species
Abstract:
... Interleukin 8 (IL8) is a major mediator of the innate immune response. Polymorphisms in this gene are associated with susceptibility to inflammatory disease in humans. Two major promoter polymorphic haplotypes (IL8-h1 and IL8-h2) segregating in cattle populations have shown a significant effect on the immune response profile in calves but their implications for transition cow immunity have not bee ...
DOI:
10.1016/j.vetimm.2021.110288

29. Effect of In-vivo heat challenge on physiological parameters and function of peripheral blood mononuclear cells in immune phenotyped dairy cattle

Author:
S.L. Cartwright; J. Schmied; A. Livernois; B.A. Mallard
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110405
ISSN:
0165-2427
Subject:
barns; body temperature; cell proliferation; cell respiration; climate change; dairy cattle; disease incidence; heat; heat stress; heat tolerance; heat-shock protein 70; humidity; immunology; immunopathology; vaccines
Abstract:
... The frequency of heat waves and hot days are increasing due to climate change, which leads to an increase in the occurrence of heat stress in dairy cattle. Previous studies have shown that dairy cattle identified as high immune responders have a reduced incidence of disease and improved vaccine response compared to average and low responders. Additionally, it has been observed that when cells from ...
DOI:
10.1016/j.vetimm.2022.110405

30. Effect of quercetin on formation of porcine neutrophil extracellular trap

Author:
Hyun-Min Jo; Changhwan Ahn; Hakhyun Kim; Byeong-Teck Kang; Eui-Bae Jeung; Mhan-Pyo Yang
Source:
Veterinary immunology and immunopathology 2021 v.241 pp. 110335
ISSN:
0165-2427
Subject:
anti-inflammatory activity; dyes; gene expression; immune response; immunopathology; lipopolysaccharides; neutrophils; propidium; quercetin; swine
Abstract:
... Neutrophil extracellular trap (NET) formation is an immune response to the invasion of external microorganisms. Quercetin, a member of the flavonoid family found in fruits and vegetables, has been examined in multiple biological contexts. The objective of this study was to examine the effect of quercetin on porcine NET formation. We measured NET formation by peripheral blood polymorphonuclear cell ...
DOI:
10.1016/j.vetimm.2021.110335

31. Effects of frequent teat stimulation on antimicrobial component production in mammary glands of lactating goats

Author:
Yusaku Tsugami; Rika Harada; Takahiro Nii; Naoki Suzuki; Naoki Isobe
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110431
ISSN:
0165-2427
Subject:
Japan; calcium-binding proteins; epithelium; humans; immunopathology; keratinocytes; lactoferrin; milk; milk yield
Abstract:
... Various antimicrobial components, such as lactoferrin, S100 calcium-binding protein A7 (S100A7), and IgA, produced by epithelial cells and leukocytes in lactating mammary glands are important for host defense against invading pathogens. Increase in milking frequency enhances milk yield in ruminants and implies an increase in frequency of teat stimulation. However, the influence of frequent teat st ...
DOI:
10.1016/j.vetimm.2022.110431

32. Effects of immunostimulators of microbial origin on T cells of pigs vaccinated with attenuated vaccine against Aujeszkyʼs disease

Author:
Miroslav Andrišić; Irena Žarković; Ksenija Šandor; Anja Vujnović; Eleonora Perak Junaković; Krešo Bendelja; Ana Savić Mlakar; Nada Oršolić; Lidija Šver; Miroslav Benić; Svjetlana Terzić
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110365
ISSN:
0165-2427
Subject:
Escherichia coli; Parapoxvirus; Propionibacterium granulosum; Suid alphaherpesvirus 1; T-lymphocytes; cell-mediated immunity; immunopathology; live vaccines; vaccination
Abstract:
... Aujeszky’s disease (AD) is a viral infectious disease caused by Suid herpesvirus 1 (SuHV-1). Vaccination and eradication of AD in domestic pigs is possible using marker vaccines with attenuated or inactivated SuHV-1, or subunit vaccines. However, vaccines with attenuated SuHV-1 have shown to be more potent in inducing strong cell-mediated immune response. The studies have shown that Parapoxvirus o ...
DOI:
10.1016/j.vetimm.2021.110365

33. Establishing a reference interval for acute phase proteins, cytokines, antioxidants and commonly measured biochemical and hematologic parameters in the northern fur seal (Callorhinus ursinus)

Author:
Valerie Johnson; A. Russell Moore; Rachel Conway; Tonya Zeppelin; Tom Gelatt; Colleen Duncan
Source:
Veterinary immunology and immunopathology 2021 v.242 pp. 110348
ISSN:
0165-2427
Subject:
C-reactive protein; Callorhinus ursinus; adults; biomarkers; blood serum; dogs; electrophoresis; females; fur; hydrogen peroxide; immunopathology; inflammation; interleukin-10; interleukin-6; interleukin-8; malondialdehyde; oxidative stress; selenium; vitamin E; Bering Sea
Abstract:
... Over the past several decades there has been a precipitous decline of northern fur seals (Callorhinus ursinus; NFS) at their breeding grounds on the Pribilof Islands in the Bering Sea. The cause of this decline is likely multifactorial and could include changes in environmental parameters, prey abundance and distribution as well as exposure to pathogens and pollutants. Evaluation of inflammatory m ...
DOI:
10.1016/j.vetimm.2021.110348

34. Evaluation of PD-1 and PD-L1 expression in canine urothelial carcinoma cell lines

Author:
Christopher J. Pinard; Samuel E. Hocker; Andrew C. Poon; Jordon M. Inkol; Arata Matsuyama; R. Darren Wood; Geoffrey A. Wood; J. Paul Woods; Anthony J. Mutsaers
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110367
ISSN:
0165-2427
Subject:
Western blotting; carcinoma; cell lines; dogs; flow cytometry; fluorescence microscopy; gene expression; humans; immunopathology; immunotherapy; neoplasm cells; reverse transcriptase polymerase chain reaction
Abstract:
... Urothelial carcinoma (UC) is the most common urinary tumor in dogs and despite combinational therapies, only modest improvements in survival have been achieved in recent years. Given the utility of monoclonal antibodies against PD-1 and PD-L1 in human UC, we evaluated the protein and mRNA expression in three established canine urothelial carcinoma cell lines. Flow cytometry and western blot analys ...
DOI:
10.1016/j.vetimm.2021.110367

35. Evaluation of candidate reference genes for quantitative RTqPCR analysis in goldfish (Carassius auratus L.) in healthy and CyHV-2 infected fish

Author:
Arathi Dharmaratnam; Arun Sudhagar; Sundar Raj Nithianantham; Sweta Das; Thangaraj Raja Swaminathan
Source:
Veterinary immunology and immunopathology 2021 v.237 pp. 110270
ISSN:
0165-2427
Subject:
Carassius auratus; algorithms; disease control; gene expression; goldfish; heart; immunology; immunopathology; intestines; kidneys; liver; muscles; pathogens; peptide elongation factors; quantitative polymerase chain reaction; ribosomal RNA; spleen; world wide web
Abstract:
... The accuracy of quantitative real time PCR (RTqPCR) can be attained only when a suitable reference gene is used. The gene expression for a particular gene may vary within different cells at different conditions. Hence, the suitability and stability of various potential reference genes have to be determined for expression studies. In this study, we have examined the potential of four different refe ...
DOI:
10.1016/j.vetimm.2021.110270

36. Evaluation of equine xenogeneic mixed lymphocyte reactions using 5-ethynyl-2’-deoxyuridine (EdU)

Author:
Kate E. Birdwhistell; David J. Hurley; Bradley Heins; John F. Peroni
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110430
ISSN:
0165-2427
Subject:
T-lymphocytes; cell proliferation; cytokines; flow cytometry; horses; immunopathology; nucleobases; organ transplantation; swine; thymidine
Abstract:
... Allogeneic solid organ transplantation is currently the only treatment option for end stage organ disease. The shortage of available donor organs has driven efforts to utilize xenogeneic organs for transplantation. In vitro methods for evaluating immune-compatibility are a quick and low cost means of screening novel tissue products prior to more involved, expensive, and invasive live animal studie ...
DOI:
10.1016/j.vetimm.2022.110430

37. Evaluation of immunogenicity and protection mediated by Lawsonia intracellularis subunit vaccines

Author:
Kezia R. Fourie; Pooja Choudhary; Siew Hon Ng; Milan Obradovic; Robert Brownlie; Sanjeev K. Anand; Heather L. Wilson
Source:
Veterinary immunology and immunopathology 2021 v.237 pp. 110256
ISSN:
0165-2427
Subject:
Lawsonia intracellularis; adjuvants; bacteria; blood serum; dipeptides; feces; flagellum; glycoproteins; humoral immunity; ileum; immunogenicity; immunopathology; intestinal mucosa; jejunum; methionine adenosyltransferase; monitoring; polyinosinic-polycytidylic acid; proteinases; proteolysis; quantitative polymerase chain reaction; stress response; subunit vaccines; viral antigens
Abstract:
... Lawsonia intracellularis is an economically important bacterium that causes ileitis in pigs. Current vaccines for L. intracellularis do not allow for differentiation between infected and vaccinated animals (DIVA), which is beneficial for disease tracking and surveillance. Previously, we identified five putative surface L. intracellularis proteins that were targeted by antibodies from pigs infected ...
DOI:
10.1016/j.vetimm.2021.110256

38. Evidence for transfer of maternal antigen specific cellular immunity against Mycobacterium avium ssp. paratuberculosis via colostrum in a goat twin model

Author:
L. Robbers; R. van de Mheen; L. Benedictus; R. Jorritsma; M. Nielen; H.J.C. Bijkerk; S.G. van der Grein; L. Ravesloot; A.P. Koets
Source:
Veterinary immunology and immunopathology 2022 v.246 pp. 110402
ISSN:
0165-2427
Subject:
Mycobacterium avium subsp. paratuberculosis; blood serum; cell-mediated immunity; cow colostrum; epithelium; histology; immune response; immunopathology; injection site; intestines; models; tuberculin; vaccines
Abstract:
... Colostrum intake is one of the most important factors in neonatal health in ruminants, mainly because of its unique immunological properties. Both in practice as well as in research, the attention of lactogenic immunity is focused on the importance of colostral antibodies and less attention is given to the functional role of maternal cells in colostrum. Here we study the transfer of maternal leuko ...
DOI:
10.1016/j.vetimm.2022.110402

39. Ex vivo activated CD4+ T cells from young calves exhibit Th2-biased effector function with distinct metabolic reprogramming compared to adult cows

Author:
Jordan M. Eder; Randy E. Sacco
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110418
ISSN:
0165-2427
Subject:
acidification; adults; gene expression; glycolysis; immunopathology; interleukin-4; mitochondria; oxygen consumption; passive immunity; phenotype
Abstract:
... As maternal passive immunity wanes at 6–8 weeks, young calves must rely on their own naïve and developing immune system for protection against pathogens. Typically, an infection in the young induces a T cell-mediated response, which skews towards a Th2 phenotype and results in a reduced effector response. Our study examines the implications this transitional period of immunocompetency has on cellu ...
DOI:
10.1016/j.vetimm.2022.110418

40. Exonic SNP in MHC-DMB2 is associated with gene expression and humoral immunity in Japanese quails

Author:
Hassan Chenani; Mahmood Nazari; Mohamad Taghi Beigi Nassiri; Hedaiatollah Roshanfekr; Ali Aghaie
Source:
Veterinary immunology and immunopathology 2021 v.239 pp. 110302
ISSN:
0165-2427
Subject:
DNA; DNA fragmentation; antibody formation; birds; breast muscle; computer simulation; erythrocytes; exons; gene expression; genotype; humoral immunity; immunopathology; protein structure; sheep; single nucleotide polymorphism
Abstract:
... The DMB2 gene is widely expressed at high levels in avian. This gene plays an important role in humoral immunity. The aim of this study was to investigate the effects of 361 G > C Single nucleotide polymorphism (SNP) on DMB2 protein structure and gene expression to determine how the 361 G > C SNP affects humoral immune response in Japanese quails. 0.2 mL of 5% sheep red blood cell (SRBC) was injec ...
DOI:
10.1016/j.vetimm.2021.110302

41. Flow cytometry panels for immunophenotyping dairy cattle peripheral blood leukocytes

Author:
S. Casaro; M.G. Marrero; D.M.C. Madrid; J.G. Prim; C.D. Nelson; K.N. Galvão; J. Laporta; J.P. Driver
Source:
Veterinary immunology and immunopathology 2022 v.248 pp. 110417
ISSN:
0165-2427
Subject:
Holstein; calves; dairy cows; flow cytometry; immunopathology; immunophenotyping; monocytes; phenotype; pregnancy
Abstract:
... Many aspects of the bovine immune system remain poorly characterized, which poses an obstacle to improving dairy cow health. Herein, we describe two flow cytometry panels that included antibodies against CD8α, CD4, TCR-δ, CD172α, CD14, MHCII, CD21, CD62L, and CD11b. These panels were used to characterize the phenotype of leukocyte subpopulations from the peripheral blood of 30-day old Holstein cal ...
DOI:
10.1016/j.vetimm.2022.110417
CHORUS:
10.1016/j.vetimm.2022.110417

42. Haemonchus contortus infection induces a variable immune response in resistant and susceptible Pelibuey sheep

Author:
Alvar Alonzo Cruz-Tamayo; Ma. Eugenia López-Arellano; Roberto González-Garduño; Glafiro Torres-Hernández; Alfonso de la Mora-Valle; Carlos Becerril-Pérez; Omar Hernández-Mendo; Efrén Ramírez-Bribiesca; Miguel Huchin-Cab
Source:
Veterinary immunology and immunopathology 2021 v.234 pp. 110218
ISSN:
0165-2427
Subject:
Haemonchus contortus; Pelibuey (sheep breed); body weight; gene expression; granuloma; hemoglobin; histopathology; immune response; immunoglobulin A; immunopathology; interleukin-5; interleukin-8; leukocytes; males; phenotype; protein content
Abstract:
... The immune response and phenotypic characteristics of Pelibuey lambs were analysed after the induction of a Haemonchus contortus trickle infection. Male lambs (n = 29; 20 kg live weight) were infected with 100 H. contortus infective larvae per kg of live weight on day 3, 5 and 7 of the experiment. The number of eggs per gram (epg), seven haematological parameters and the immunoglobulin A (IgA) lev ...
DOI:
10.1016/j.vetimm.2021.110218

43. Heterogeneous populations from in vitro cultures of antigen presenting cells in pigs

Author:
Myriam Pujol; Efrain Guzman; Sergio Montaner-Tarbes; Maria Montoya
Source:
Veterinary immunology and immunopathology 2021 v.234 pp. 110215
ISSN:
0165-2427
Subject:
antigens; bone marrow; immunopathology; macrophages; monocytes; phenotype; swine
Abstract:
... Dendritic cells (DCs) are the most potent antigen presenting cells (APCs). Because of the difficulty in obtaining these cells directly from tissues, different sources of DCs are frequently used for in vitro experimentation and many of their biological and functional characteristics were studied using these systems. Until recently, it was assumed that specific culture conditions polarized the diffe ...
DOI:
10.1016/j.vetimm.2021.110215

44. Identification of EDIL3 biomarkers as a biomarker and potential therapeutic target of canine mammary carcinomas based on integrated bioinformatics analysis

Author:
Zixiang Lin; Ce Jiang; Di Lv; Degui Lin
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110432
ISSN:
0165-2427
Subject:
bioinformatics; biomarkers; carcinogenesis; data collection; dogs; genes; immunity; immunopathology; mammary neoplasms (animal); therapeutics
Abstract:
... As the fierce battle with cancer is now expanding to companion animals, effective treatment of canine mammary carcinomas (CMT), as the most frequently diagnosed tumor in intact dogs, is becoming a crucial issue. Although many studies have been carried out concerning the clinical application of mammary tumor biomarkers, no ideal biomarker has yet been identified in CMT. Therefore, in this work, we ...
DOI:
10.1016/j.vetimm.2022.110432

45. Immune responses induced by inactivated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in neonatal pigs using different adjuvants

Author:
Sandra Vreman; Norbert Stockhofe-Zurwieden; Ditta J. Popma-de Graaf; Huub F.J. Savelkoul; C. Barnier-Quer; N. Collin; Damien Collins; Dennis McDaid; Anne C. Moore; Johanna M.J. Rebel
Source:
Veterinary immunology and immunopathology 2021 v.232 pp. 110170
ISSN:
0165-2427
Subject:
T-lymphocytes; antibody formation; emulsions; immunogenicity; immunopathology; lungs; lymph; necropsy; pathogens; porcine reproductive and respiratory syndrome; secondary immunization; squalene; vaccination; vaccines; viremia; viruses
Abstract:
... Vaccination of neonatal pigs could be supportive to prevent porcine reproductive and respiratory syndrome virus (PRRSV), which is an important porcine pathogen causing worldwide welfare and health problems in pigs of different age classes. However, neonatal immunity substantially differs to adults, thus different vaccines may be required in neonateal pigs. We examined if the immunogenicity and eff ...
DOI:
10.1016/j.vetimm.2020.110170

46. Immunoproteomic analysis of the secretome of bovine-adapted strains of Staphylococcus aureus demonstrates a strain-specific humoral response

Author:
Shauna D. Drumm; Paul Cormican; Padraig O’Boyle; Rebecca A. Owens; Jennifer Mitchell; Orla M. Keane
Source:
Veterinary immunology and immunopathology 2022 v.249 pp. 110428
ISSN:
0165-2427
Subject:
Staphylococcus aureus; antigens; blood serum; cows; genes; humoral immunity; immunopathology; mass spectrometry; molecular weight; pathogens; vaccines; virulence
Abstract:
... Staphylococcus aureus is a common pathogen associated with bovine intramammary infection. A number of distinct S. aureus lineages are associated with such infections although there is a dearth of knowledge regarding the major immunogenic antigens associated with each lineage and whether these antigens provide protection against heterologous strains. Identification of the major immunogenic antigens ...
DOI:
10.1016/j.vetimm.2022.110428

47. Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues

Author:
J.J. Rosales; M.V. Nieto Farías; M. Burucúa; M.S. Marin; S.E. Pérez
Source:
Veterinary immunology and immunopathology 2022 v.245 pp. 110391
ISSN:
0165-2427
Subject:
Bovine alphaherpesvirus 1; bioactive properties; brain; epithelium; ganglia; immunopathology; innate immunity; transcription (genetics); virus replication; viruses
Abstract:
... Type III interferons (IFNs) are components of the innate immunity, with IFN lambda- (λ)3 having the most potent bioactivity in humans. IFN-λ has a predominant role in epithelial cells. However, antiviral function in certain infections of the central nervous system has also been demonstrated. IFN-λ3 expression in neural tissues of cattle has not been investigated. Thus, the aim of this study was to ...
DOI:
10.1016/j.vetimm.2022.110391

48. Insufficiency of CD205-positive cortical thymic epithelial cells in immature Japanese Black cattle with severe thymic abnormalities and poor prognosis

Author:
Shoichi Wakitani; Risako Kawabata; Masahiro Yasuda
Source:
Veterinary immunology and immunopathology 2022 v.245 pp. 110379
ISSN:
0165-2427
Subject:
Wagyu; cortex; epithelium; histopathology; immunohistochemistry; immunopathology; interleukin-7; prognosis; surveys
Abstract:
... To investigate the involvement of thymic function in the development of diseases with poor prognosis in calves, this study conducted a survey for the assessment of thymus cell composition in immature Japanese Black cattle with poor prognosis. Histopathological evaluation of 47 cattle showed signs of acute thymic involution in most cases. Less than half of the cases had a cortex predominant over th ...
DOI:
10.1016/j.vetimm.2021.110379

49. Interferon gamma protective against Sarcocystis neurona encephalitis in susceptible murine model

Author:
Alayna N. Hay; Ashley Potter; David Lindsay; Tanya LeRoith; Jing Zhu; Sarah Cashwell; Sharon Witonsky; Caroline Leeth
Source:
Veterinary immunology and immunopathology 2021 v.240 pp. 110319
ISSN:
0165-2427
Subject:
Protozoa; Sarcocystis neurona; T-lymphocytes; animal models; cerebellum; cytokines; disease resistance; disease susceptibility; equine protozoal myeloencephalitis; etiological agents; histology; horses; immune response; immunopathology; interferon-gamma; mice; protective effect
Abstract:
... Sarcocystis neurona is the predominant etiological agent of the infectious equine neurologic disease, equine protozoal myeloencephalitis (EPM), which is prevalent in the United States. A wealth of knowledge about S. neurona biology and its life cycle has accumulated over the last several decades. However, much remains unknown about the aberrant equine host’s immune response to S. neurona and the r ...
DOI:
10.1016/j.vetimm.2021.110319

50. Interferon gamma, lipopolysaccharide, and modified-live viral vaccines stimulation alter the mRNA expression of tumor necrosis factor α, inducible nitric oxide synthase, and interferon β in bovine alveolar macrophages

Author:
Shingo Ishikawa; Masataka Miyazawa; Chiho Tanaka; Ryoma Uesawa; Juri Nishizawa; Ryoko Uemura; Ikuo Kobayashi; Seiji Hobo
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110378
ISSN:
0165-2427
Subject:
bovine respiratory disease; cattle; gene expression; immunopathology; inducible nitric oxide synthase; interferon-gamma; lipopolysaccharides; macrophages; pathogenesis; polyinosinic-polycytidylic acid; sodium; therapeutics; tumor necrosis factor-alpha
Abstract:
... To understand the pathogenesis of bovine respiratory disease (BRD), it is necessary to elucidate the mechanisms of alveolar macrophage regulation by cytokines and pathogen-associated molecular patterns (PAMPs). Moreover, "non-specific effects (NSEs)” an innate immune regulatory mechanism in response to vaccines containing PAMPs, has recently attracted attention. It may be applied to BRD control, b ...
DOI:
10.1016/j.vetimm.2021.110378