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- Gronkiewicz, Kristina M.; Giuliano, Elizabeth A.; Sharma, Ajay; Mohan, Rajiv R.
- Veterinary ophthalmology 2016 v.19 no.6 pp. 480-487
- Western blotting; cornea; dogs; fibroblasts; fibrosis; gene expression; messenger RNA; metalloproteinases; mitogen-activated protein kinase; models; ophthalmology; phosphorylation; proteins; quantitative polymerase chain reaction; signal transduction; transforming growth factor beta 1
- ... OBJECTIVE: To investigate molecular mechanisms mediating anti‐fibrotic effect of SAHA in the canine cornea using an in vitro model. We hypothesized that SAHA attenuates corneal fibrosis by modulating Smad‐dependent and, to a lesser extent, Smad‐independent signaling pathways activated by TGF‐β1, as well as matrix metalloproteinase (MMP) activity. METHODS: Cultured canine corneal fibroblasts (CCF) ...
- PubMed Central: