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- Wesołowska, Agnieszka; Basałaj, Katarzyna; Norbury, Luke J; Sielicka, Alicja; Wędrychowicz, Halina; Zawistowska-Deniziak, Anna
- Veterinary parasitology 2018 v.250 pp. 15-21
- vaccination, etc ; Fasciola hepatica; animal models; antibodies; antigens; cathepsins; drug resistance; fascioliasis; immune response; immunoglobulin G; juveniles; liver; liver flukes; livestock; migratory behavior; rats; vaccines; Show all 17 Subjects
- ... No licensed vaccine is currently available for prevention of Fasciola hepatica infections. However, considering the alarming increase in drug resistance, there is an urgent need for a safe and fully effective vaccine against fasciolosis. Here, we tested if cathepsins L (FhCL3-1, FhCL3-2) and B (FhCB3) secreted by juvenile liver flukes are viable vaccine targets when delivered alone or in combinati ...