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- Gatkowska, Justyna; Wieczorek, Marek; Dziadek, Bożena; Dzitko, Katarzyna; Dziadek, Jarosław; Długońska, Henryka
- Veterinary parasitology 2018 v.254 pp. 82-94
- vaccination, etc ; adjuvants; alum; antigens; brain; cats; defensive behavior; definitive hosts; dopamine; females; immune response; immunoglobulin G; interferon-gamma; interleukin-10; interleukin-2; males; metabolism; mice; neuroprotective effect; odors; parasites; smell; vaccines; Show all 23 Subjects
- ... The aim of this study was to evaluate the immunogenic and immunoprotective activities and to determine the neuroprotective capacity of the tetravalent vaccine containing selected recombinant T. gondii antigens (ROP2 + ROP4 + SAG1 + MAG1) administered with safe adjuvants (MPL and alum) using male and female inbred mice. The tested antigenic combination provided partial protection against brain cyst ...
- Wesołowska, Agnieszka; Basałaj, Katarzyna; Norbury, Luke J.; Sielicka, Alicja; Wędrychowicz, Halina; Zawistowska-Deniziak, Anna
- Veterinary parasitology 2018 v.255 pp. 91-96
- vaccination, etc ; Fasciola hepatica; antibodies; cathepsins; disease control; experimental design; fascioliasis; females; humoral immunity; immune response; immunoglobulin G; juveniles; liver flukes; males; protective effect; rats; sexual dimorphism; vaccines; Show all 18 Subjects
- ... Most animal research is less evidence-based for females, with the majority of studies conducted on males. Since immune responses vary between males and females, sexual dimorphism in immunity contributes, among other things, to sex-based differences post-vaccination. However, the issue of sex effects in animal vaccine research is rarely considered in vaccine study design. Previously, we have evalua ...