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You searched for: Journal Veterinary parasitology Remove constraint Journal: Veterinary parasitology Publication Year 2014 Remove constraint Publication Year: 2014 Source 2014 v.201 no.3-4 Remove constraint Source: 2014 v.201 no.3-4
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1. Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato

Author:
Kunkle, Bruce; Daly, Sean; Dumont, Pascal; Drag, Marlene; Larsen, Diane
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 226-228
ISSN:
0304-4017
Subject:
Rhipicephalus sanguineus; acaricides; adults; dog diseases; dogs; insecticides; oral administration; tick infestations; ticks
Abstract:
... Two studies were conducted to confirm that a single oral dose of the novel insecticide/acaricide afoxolaner is efficacious against existing infestations of Rhipicephalus sanguineus sensu lato in dogs and can control re-infestation for up to 35 days. Each study utilized 16 purpose bred adult dogs using a controlled randomized block design. One or two days prior to treatment, all dogs were infested ...
DOI:
10.1016/j.vetpar.2014.02.018

2. Assessment of the onset of action of afoxolaner against existing adult flea (Ctenocephalides felis) infestations on dogs

Author:
Kunkle, Bruce N.; Drag, Marlene D.; Chester, Theodore S.; Larsen, Diane L.
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 204-206
ISSN:
0304-4017
Subject:
Beagle; Ctenocephalides felis; adults; body weight; dog diseases; dogs; oral administration
Abstract:
... The speed of kill of afoxolaner against experimental infestations by Ctenocephalides felis was evaluated after oral administration of afoxolaner in a soft chew (NEXGARD®) at a dose to achieve 2.5mg/kg bodyweight. Forty beagles were allocated to two treatment groups. Dogs in Treatment Group 1 were untreated controls. Dogs in Treatment Group 2 were treated on Day-0 with afoxolaner, according to thei ...
DOI:
10.1016/j.vetpar.2014.02.023

3. Curative and preventive efficacy of orally administered afoxolaner against Ctenocephalides canis infestation in dogs

Author:
Dumont, Pascal; Gale, Boyd; Chester, Theodore S.; Larsen, Diane L.
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 212-215
ISSN:
0304-4017
Subject:
Ctenocephalides canis; adults; dog diseases; dogs; egg production; eggs; insect infestations; oral administration
Abstract:
... The efficacy of orally administered afoxolaner against adult dog fleas, Ctenocephalides canis, was evaluated in a controlled, blinded study. A total of 32 dogs were infested with 100 adult unfed fleas approximately 24h prior to treatment and then at weekly intervals for 5 weeks after treatment. Live fleas were counted upon removal at 12h (for 16 dogs) and 24h (for the remaining 16 dogs) after trea ...
DOI:
10.1016/j.vetpar.2014.02.014

4. Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs

Author:
Shoop, Wesley L.; Hartline, Eric J.; Gould, Brandon R.; Waddell, Molly E.; McDowell, Richard G.; Kinney, John B.; Lahm, George P.; Long, Jeffrey K.; Xu, Ming; Wagerle, Ty; Jones, Gail S.; Dietrich, Robert F.; Cordova, Daniel; Schroeder, Mark E.; Rhoades, Daniel F.; Benner, Eric A.; Confalone, Pat N.
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 179-189
ISSN:
0304-4017
Subject:
Ctenocephalides felis; Dermacentor variabilis; Drosophila; antiparasitic agents; blood; chloride channels; cross resistance; dogs; insects; mechanism of action; mutation; oral administration; pharmacokinetics; ticks; toxicity testing
Abstract:
... Afoxolaner is an isoxazoline compound characterized by a good safety profile and extended effectiveness against fleas and ticks on dogs following a single oral administration. In vitro membrane feeding assay data and in vivo pharmacokinetic studies in dogs established an afoxolaner blood concentration of 0.1–0.2μg/ml to be effective against both fleas (Ctenocephalides felis) and ticks (Dermacentor ...
DOI:
10.1016/j.vetpar.2014.02.020

5. Efficacy of afoxolaner against Dermacentor variabilis ticks in dogs

Author:
Mitchell, Elizabeth B.; Dorr, Paul; Everett, William R.; Chester, Theodore S.; Larsen, Diane
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 220-222
ISSN:
0304-4017
Subject:
Beagle; Dermacentor variabilis; acaricides; adults; dog diseases; dogs; insecticides; oral administration; ticks
Abstract:
... Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Dermacentor variabilis ticks was confirmed in two laboratory studies. Each study utilized a controlled, randomized block design. One day prior to treatment, beagle dogs were infested with 50 unfed adult ticks. Repeat infestations were performed weekly for four weeks. The number of live ticks remaining on each dog was determ ...
DOI:
10.1016/j.vetpar.2014.02.016

6. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs

Author:
Mitchell, Elizabeth B.; McCall, John W.; Theodore Chester, S.; Larsen, Diane
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 223-225
ISSN:
0304-4017
Subject:
Beagle; Ixodes scapularis; acaricides; adults; dogs; insecticides; oral administration; ticks
Abstract:
... Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Ixodes scapularis was evaluated in a laboratory study. One day prior to treatment, beagle dogs (n=16) were infested with 50 unfed wild adult ticks. Repeat infestations were performed weekly for four additional weeks. The number of live ticks remaining on each dog was determined 48h after treatment and after each subsequent ...
DOI:
10.1016/j.vetpar.2014.02.015

7. Evaluation of the curative and preventive efficacy of a single oral administration of afoxolaner against cat flea Ctenocephalides felis infestations on dogs

Author:
Hunter, James S.; Dumont, Pascal; Chester, Theodore S.; Young, David R.; Fourie, Josephus J.; Larsen, Diane L.
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 207-211
ISSN:
0304-4017
Subject:
Ctenocephalides felis; adults; dogs; egg production; eggs; insect infestations; oral administration
Abstract:
... The efficacy of orally administered afoxolaner for treatment and prevention of repeated infestations with adult Ctenocephalides felis on dogs was evaluated in two studies after administration of a beef-flavored soft chew. In each study, 32 dogs were divided randomly into four equal groups. Dogs in Groups 1 and 3 were not treated and served as controls. Dogs in Groups 2 and 4 were treated on Day 0 ...
DOI:
10.1016/j.vetpar.2014.02.024

8. Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs

Author:
Kondo, Yumi; Kinoshita, Gen; Drag, Marlene; Chester, Theodore S.; Larsen, Diane
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 229-231
ISSN:
0304-4017
Subject:
Beagle; Haemaphysalis longicornis; dog diseases; dogs; oral administration; tick infestations; ticks
Abstract:
... A controlled study to assess the acaricidal efficacy of afoxolaner in dogs after a single oral administration was conducted against Haemaphysalis longicornis ticks. The study was characterized by a negative controlled randomized block design and included sixteen beagle dogs of both sexes. Starting two days before treatment, each dog was infested weekly with 50 ticks over 4 weeks. The number of liv ...
DOI:
10.1016/j.vetpar.2014.02.019

9. Evaluation of the efficacy of afoxolaner against two European dog tick species: Dermacentor reticulatus and Ixodes ricinus

Author:
Dumont, Pascal; Blair, Jeffrey; Fourie, Josephus J.; Chester, Theodore S.; Larsen, Diane L.
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 216-219
ISSN:
0304-4017
Subject:
Beagle; Dermacentor reticulatus; Ixodes ricinus; body weight; dog diseases; dogs; tick infestations; ticks
Abstract:
... The acaricidal efficacy of a novel oral formulation of afoxolaner (NEXGARD®, Merial) against two European tick species was assessed in dogs experimentally infested with Ixodes ricinus and Dermacentor reticulatus. Three studies, each characterized by a negative controlled randomized block design, were conducted with a total of 52 beagle or mongrel dogs of both sexes. Starting 2 days before treatmen ...
DOI:
10.1016/j.vetpar.2014.02.017

10. Safety evaluation of orally administered afoxolaner in 8-week-old dogs

Author:
Drag, Marlene; Saik, Judith; Harriman, Jay; Larsen, Diane
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 198-203
ISSN:
0304-4017
Subject:
Beagle; administered dose; blood; diarrhea; females; males; necropsy; oral administration; puppies; tissues; vomiting
Abstract:
... The safety profile of afoxolaner, a new isoxazoline molecule, was evaluated following the regulatory requirements when administered six times orally in a soft chewable formulation at a dose of at least 1×, 3× or 5× the maximum exposure dose (6.3mg/kg) in 8-week-old Beagle dogs. Thirty-two healthy puppies (16 males and 16 females) were enrolled and allocated randomly to one of four treatment groups ...
DOI:
10.1016/j.vetpar.2014.02.022

11. The intravenous and oral pharmacokinetics of afoxolaner used as a monthly chewable antiparasitic for dogs

Author:
Letendre, Laura; Huang, Rose; Kvaternick, Valerie; Harriman, Jay; Drag, Marlene; Soll, Mark
Source:
Veterinary parasitology 2014 v.201 no.3-4 pp. 190-197
ISSN:
0304-4017
Subject:
Ctenocephalides felis; Dermacentor variabilis; Rhipicephalus sanguineus; antiparasitic agents; bile; binding proteins; bioavailability; blood proteins; dogs; half life; hydroxylation; intravenous injection; metabolites; models; oral administration; pharmacokinetics; urine
Abstract:
... The pharmacokinetics of afoxolaner in dogs was evaluated following either intravenous or after oral administration of NEXGARD®, a soft chewable formulation. Afoxolaner is a member of one of the newest classes of antiparasitic agents, known as antiparasitic isoxazolines. The soft chewable formulation underwent rapid dissolution, and afoxolaner was absorbed quickly following oral administration of t ...
DOI:
10.1016/j.vetpar.2014.02.021