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- Kerner, Katharina; Bridger, Philip S; Köpf, Gabriele; Fröhlich, Julia; Barth, Stefanie; Willems, Hermann; Bauerfeind, Rolf; Baljer, Georg; Menge, Christian
- Veterinary research 2015 v.46 no.1 pp. 38
- vaccination, etc ; T-lymphocytes; calves; enterohemorrhagic Escherichia coli; humans; ileum; immune response; infectious diseases; interleukin-4; macrophages; messenger RNA; neutralizing antibodies; site-directed mutagenesis; toxoids; vaccines; verotoxins; Show all 16 Subjects
- ... Cattle are the most important reservoir for enterohemorrhagic Escherichia coli (EHEC), a subset of shigatoxigenic E. coli (STEC) capable of causing life-threatening infectious diseases in humans. In cattle, Shiga toxins (Stx) suppress the immune system thereby promoting long-term STEC shedding. First infections of animals at calves’ age coincide with the lack of Stx-specific antibodies. We hypothe ...
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- Gray, Darren W; Welsh, Michael D; Doherty, Simon; Mansoor, Fawad; Chevallier, Olivier P; Elliott, Christopher T; Mooney, Mark H
- Veterinary research 2015 v.46 no.1 pp. 7
- vaccination, etc ; Holstein; antigens; calves; disease control; glycocholic acid; hippuric acid; immune response; immune system; industry; mass spectrometry; metabolites; metabolomics; pathogens; screening; signal transduction; technology; ultra-performance liquid chromatography; uric acid; vaccine development; vaccines; Show all 21 Subjects
- ... Vaccination procedures within the cattle industry are important disease control tools to minimize economic and welfare burdens associated with respiratory pathogens. However, new vaccine, antigen and carrier technologies are required to combat emerging viral strains and enhance the efficacy of respiratory vaccines, particularly at the point of pathogen entry. New technologies, specifically metabol ...
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