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You searched for: Author "Wu, Shuo" Remove constraint Author: "Wu, Shuo" Journal Virology journal Remove constraint Journal: Virology journal Subject mitogen-activated protein kinase Remove constraint Subject: mitogen-activated protein kinase
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1. DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response

Author:
Wu, Shuo,   et al.   ; Zhong, Ming; Wang, Huiqiang; Ma, Linlin; Yan, Haiyan; Gu, Zhengyi; Li, Yuhuan;     Show all 7 Authors
Source:
Virology journal 2019 v.16 no.1 pp. 21
ISSN:
1743-422X
Subject:
Artemisia rupestris; Influenza A virus; Western blotting; antiviral properties; flavonoids; fluorescent antibody technique; gene expression regulation; genes; heme; luciferase; mitogen-activated protein kinase; new drugs; pandemic; phosphorylation; quantitative polymerase chain reaction; respiratory tract diseases; reverse transcriptase polymerase chain reaction; therapeutics; viral load; virus replication; viruses
Abstract:
... BACKGROUND: As a leading cause of respiratory disease, influenza A virus (IAV) infection remains a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapeutic drugs, development of new drugs is urgently required. Flavonoids extracted from Artemisia rupestris L. have an inhibitory effect on virus infections. Despite this fact, the antiviral properties o ...
DOI:
10.1186/s12985-019-1125-9

2. Cirsimaritin inhibits influenza A virus replication by downregulating the NF-κB signal transduction pathway

Author:
Wu, Shuo,   et al.   ; Yan, Haiyan; Wang, Huiqiang; Ma, Linlin; Ma, Xueping; Yin, Jinqiu; Huang, Hua; Li, Yuhuan;     Show all 8 Authors
Source:
Virology journal 2018 v.15 no.1 pp. 88
ISSN:
1743-422X
Subject:
Artemisia scoparia; Influenza A virus; Oriental traditional medicine; RNA; Western blotting; antiviral properties; dogs; dose response; flavonoids; fluorescent antibody technique; hemagglutination; human cell lines; humans; interleukin-10; interleukin-1beta; interleukin-8; kidneys; mitogen-activated protein kinase; monocytes; protein synthesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; sialidase; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha; viral load; virus replication; viruses; China
Abstract:
... BACKGROUND: Artemisia scoparia Waldst and Kit is a famous traditional Chinese medicine widely distributed in Xinjiang, China. Flavonoids extracted from it exhibits inhibitory activities against several influenza virus strains. Despite this fact, the antiviral properties of CST, one of such flavonoids, against the influenza virus has not been reported. Thus, the aim of this study is to investigate ...
DOI:
10.1186/s12985-018-0995-6
PubMed:
29783993
PubMed Central:
PMC5963025

3. Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy

Author:
Wu, Shuo,   et al.   ; Wang, Huiqiang; Li, Ke; Ma, Linlin; Hu, Jin; Yan, Haiyan; Jiang, Jiandong; Li, Yuhuan;     Show all 8 Authors
Source:
Virology journal 2017 v.14 no.1 pp. 2
ISSN:
1743-422X
Subject:
Berberis vulgaris; Enterovirus A; RNA; Western blotting; antiviral properties; autophagy; berberine; cytopathogenicity; fluorescent antibody technique; mitogen-activated protein kinase; phosphorylation; protein synthesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction
Abstract:
... BACKGROUND: The MEK-ERK signaling pathway and autophagy play an important role for enterovirus71(EV71) replication. Inhibition of MEK-ERK signaling pathway and autophagy is shown to impair EV71 replication. Berberine (BBR), an isoquinoline alkaloid isolated from Berberis vulgaris L., has been reported to have ability to regulate this signaling pathway and autophagy. Herein, we want to determine wh ...
DOI:
10.1186/s12985-016-0674-4
PubMed:
28081706
PubMed Central:
PMC5234143