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1. DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response

Author:
Wu, Shuo,   et al.   ; Zhong, Ming; Wang, Huiqiang; Ma, Linlin; Yan, Haiyan; Gu, Zhengyi; Li, Yuhuan;     Show all 7 Authors
Source:
Virology journal 2019 v.16 no.1 pp. 21
ISSN:
1743-422X
Subject:
Artemisia rupestris; Influenza A virus; Western blotting; antiviral properties; flavonoids; fluorescent antibody technique; gene expression regulation; genes; heme; luciferase; mitogen-activated protein kinase; new drugs; pandemic; phosphorylation; quantitative polymerase chain reaction; respiratory tract diseases; reverse transcriptase polymerase chain reaction; therapeutics; viral load; virus replication; viruses
Abstract:
... BACKGROUND: As a leading cause of respiratory disease, influenza A virus (IAV) infection remains a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapeutic drugs, development of new drugs is urgently required. Flavonoids extracted from Artemisia rupestris L. have an inhibitory effect on virus infections. Despite this fact, the antiviral properties o ...
DOI:
10.1186/s12985-019-1125-9