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- Das, Atze T.; Berkhout, Ben
- Virus research 2016 v.216 pp. 66-75
- Human immunodeficiency virus; Macaca; Simian immunodeficiency virus; doxycycline; evolution; gene expression; humans; immune response; immune system; mice; tissue culture; transcription (genetics); vaccines; virus replication
- ... Conditionally replicating human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) variants that can be switched on and off at will are attractive tools for HIV and SIV research. We constructed HIV and SIV variants in which the natural transcription control mechanism was replaced by the doxycycline (dox)-inducible Tet-On gene expression mechanism. These HIV-rtTA and SIV-rtTA vari ...