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- Das, Atze T.; Berkhout, Ben
- Virus research 2016 v.216 pp. 66-75
- Human immunodeficiency virus; Macaca; Simian immunodeficiency virus; doxycycline; evolution; gene expression; humans; immune response; immune system; mice; tissue culture; transcription (genetics); vaccines; virus replication
- ... Conditionally replicating human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) variants that can be switched on and off at will are attractive tools for HIV and SIV research. We constructed HIV and SIV variants in which the natural transcription control mechanism was replaced by the doxycycline (dox)-inducible Tet-On gene expression mechanism. These HIV-rtTA and SIV-rtTA vari ...
- Terasaki, Kaori; Tercero, Breanna R.; Makino, Shinji
- Virus research 2016 v.216 pp. 55-65
- Culicidae; Rift Valley fever; Rift Valley fever virus; arboviruses; direct contact; disease outbreaks; encephalitis; enzootic diseases; fever; health status; hosts; human population; humans; immunity; mosquito bites; mutants; ruminants; vaccination; vaccines
- ... Rift Valley fever virus (RVFV) is an arbovirus circulating between ruminants and mosquitoes to maintain its enzootic cycle. Humans are infected with RVFV through mosquito bites or direct contact with materials of infected animals. The virus causes Rift Valley fever (RVF), which was first recognized in the Great Rift Valley of Kenya in 1931. RVF is characterized by a febrile illness resulting in a ...