Jump to Main Content
- Lundstrom, Kenneth
- Virus research 2016 v.216 pp. 16-25
- Alphavirus; animal models; brain; electrophysiology; gene therapy; genes; genetic vectors; immunization; ion channels; neurons; neurophysiology; rodents
- ... Alphavirus-based vectors have been engineered for in vitro and in vivo expression of heterelogous genes. The rapid and easy generation of replication-deficient recombinant particles and the broad range of host cell infection have made alphaviruses attractive vehicles for applications in neuroscience and gene therapy. Efficient delivery to primary neurons and hippocampal slices has allowed localiza ...
- Ghanem, Alexander; Conzelmann, Karl-Klaus
- Virus research 2016 v.216 pp. 41-54
- Rabies virus; axons; glycoproteins; image analysis; immunization; membrane proteins; neurophysiology; optogenetics; peripheral nervous system; rabies; tracer techniques; viral envelope proteins; viruses
- ... Rhabdoviruses like the neurotropic rabies virus are fully amenable to pseudotyping with homologous and heterologous membrane proteins, which is being harnessed for the study of viral envelope proteins, viral retargeting, or immunization purposes. Particularly, pseudotyped delta G rabies viruses are emerging as safe and superb tools for mapping direct synaptic connections and analyzing neuronal cir ...