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You searched for: Journal name Viruses Remove constraint Journal name: Viruses Publication year rev 7978-2022 Remove constraint Publication year rev: 7978-2022 Source 2022 v.14 no.3 Remove constraint Source: 2022 v.14 no.3
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1. Agreement between In-Clinics and Virus Neutralization Tests in Detecting Antibodies against Canine Distemper Virus (CDV)

Author:
Sara Meazzi; Joel Filipe; Alessandra Fiore; Santina Di Bella; Francesco Mira; Paola Dall’Ara
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Canine morbillivirus; antibodies; dogs; neutralization tests; vaccination; vaccines
Abstract:
... Core vaccinations and specific antibody titer evaluations are strongly recommended worldwide by all the vaccination guidelines. Virus neutralization (VN) is considered the gold standard for measuring antibody titer against canine distemper virus, but it is complex and time consuming, and the use of in-clinics tests would allow to obtain quicker results. The aim of this study was to evaluate the ag ...
DOI:
10.3390/v14030517

2. Alcohol Consumption and Its Influence on the Clinical Picture of Puumala Hantavirus Infection

Author:
Laura Tervo; Tuula K. Outinen; Satu Mäkelä; Jenna Mustalahti; Heini Huhtala; Ilkka Pörsti; Jaana Syrjänen; Jukka T. Mustonen; Onni Niemelä
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Hantaviridae infections; Orthohantavirus; acute kidney injury; alanine transaminase; alcohol drinking; alcohols; amylases; biomarkers; blood serum; disease course; fever; gamma-glutamyltransferase; liver; pancreatitis; risk; thrombocytopenia; transferrin
Abstract:
... Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. Characteristic clinical findings include acute kidney injury (AKI), thrombocytopenia, and capillary leakage. Smoking increases the risk of severe AKI, but it is not known whether alcohol consumption predisposes patients to a more severe infection. Liver and pancreatic enzymes, as well as biomarkers of alcohol consumption (gamm ...
DOI:
10.3390/v14030500

3. Analyses of Long-Term Epidemic Trends and Evolution Characteristics of Haplotype Subtypes Reveal the Dynamic Selection on SARS-CoV-2

Author:
Binbin Xi; Yuhuan Meng; Dawei Jiang; Yunmeng Bai; Zixi Chen; Yimo Qu; Shuhua Li; Jinfen Wei; Lizhen Huang; Hongli Du
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Severe acute respiratory syndrome coronavirus 2; death; evolution; genome; genomics; haplotypes; pandemic
Abstract:
... The scale of SARS-CoV-2 infection and death is so enormous that further study of the molecular and evolutionary characteristics of SARS-CoV-2 will help us better understand and respond to SARS-CoV-2 outbreaks. The present study analyzed the epidemic and evolutionary characteristics of haplotype subtypes or regions based on 1.8 million high-quality SARS-CoV-2 genomic data. The estimated ratio of th ...
DOI:
10.3390/v14030454

4. Ancient Evolutionary History of Human Papillomavirus Type 16, 18 and 58 Variants Prevalent Exclusively in Japan

Author:
Kohsei Tanaka; Gota Kogure; Mamiko Onuki; Koji Matsumoto; Takashi Iwata; Daisuke Aoki; Iwao Kukimoto
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
DNA; Human papillomavirus type 16; Japan; ancestry; chronic diseases; genes; humans; phylogeny; statistical analysis; viruses
Abstract:
... Human papillomavirus (HPV) is a sexually transmitted virus with an approximately 8-kilo base DNA genome, which establishes long-term persistent infection in anogenital tissues. High levels of genetic variations, including viral genotypes and intra-type variants, have been described for HPV genomes, together with geographical differences in the distribution of genotypes and variants. Here, by emplo ...
DOI:
10.3390/v14030464

5. Angiotensin Converting Enzyme Inhibitors May Increase While Active Vitamin D May Decrease the Risk of Severe Pneumonia in SARS-CoV-2 Infected Patients with Chronic Kidney Disease on Maintenance Hemodialysis

Author:
Piotr Tylicki; Karolina Polewska; Aleksander Och; Anna Susmarska; Ewelina Puchalska-Reglińska; Aleksandra Parczewska; Bogdan Biedunkiewicz; Krzysztof Szabat; Marcin Renke; Leszek Tylicki; Alicja Dębska-Ślizień
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
C-reactive protein; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; blood serum; chest; death; dialysis; disease course; enzymes; ferritin; fever; hemodialysis; hospitals; kidney diseases; oxygen; oxygen partial pressure; parenchyma (animal tissue); pneumonia; risk
Abstract:
... The group most at risk of death due to COVID-19 are patients on maintenance hemodialysis (HD). The study aims to describe the clinical course of the early phase of SARS-CoV-2 infection and find predictors of the development of COVID-19 severe pneumonia in this population. This is a case series of HD nonvaccinated patients with COVID-19 stratified into mild pneumonia and severe pneumonia group acco ...
DOI:
10.3390/v14030451

6. Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine

Author:
Lauren M. Hook; Sita Awasthi; Tina M. Cairns; Mohamad-Gabriel Alameh; Bernard T. Fowler; Kevin P. Egan; Molly M. H. Sung; Drew Weissman; Gary H. Cohen; Harvey M. Friedman
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
blood serum; epitopes; glycoproteins; humans; toxicity; vaccines; viruses
Abstract:
... The toxicity of mRNA-lipid nanoparticle (LNP) vaccines depends on the total mRNA-LNP dose. We established that the maximum tolerated dose of our trivalent mRNA-LNP genital herpes vaccine was 10 μg/immunization in mice. We then evaluated one of the mRNAs, gD2 mRNA-LNP, to determine how much of the 10 μg total dose to assign to this immunogen. We immunized mice with 0.3, 1.0, 3.0, or 10 μg of gD2 mR ...
DOI:
10.3390/v14030540

7. Apples to Apples? A Comparison of Real-World Tolerability of Antiretrovirals in Patients with Human Immunodeficiency Virus Infection and Patients with Primary Biliary Cholangitis

Author:
Shannon L. Turvey; Lynora Saxinger; Andrew L. Mason
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Betaretrovirus; HIV infections; Human immunodeficiency virus; RNA-directed DNA polymerase; antiretroviral agents; blood serum; gastrointestinal system; humans; integrases; liver; nucleosides; people; proteinase inhibitors; randomized clinical trials; therapeutics
Abstract:
... We previously characterized a human betaretrovirus and linked infection with the development of primary biliary cholangitis (PBC). There are in vitro and in vivo data demonstrating that antiretroviral therapy used to treat human immunodeficiency virus (HIV) can be repurposed to treat betaretroviruses. As such, PBC patients have been treated with nucleoside/nucleotide reverse transcriptase inhibito ...
DOI:
10.3390/v14030516

8. Applications of Atomic Force Microscopy in HIV-1 Research

Author:
Itay Rousso; Akshay Deshpande
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
atomic force microscopy; biophysics; capsid; viruses
Abstract:
... Obtaining an understanding of the mechanism underlying the interrelations between the structure and function of HIV-1 is of pivotal importance. In previous decades, this mechanism was addressed extensively in a variety of studies using conventional approaches. More recently, atomic force microscopy, which is a relatively new technique with unique capabilities, has been utilized to study HIV-1 biol ...
DOI:
10.3390/v14030648

9. Avidity of IgG to SARS-CoV-2 RBD as a Prognostic Factor for the Severity of COVID-19 Reinfection

Author:
Victor Manuylov; Olga Burgasova; Olga Borisova; Svetlana Smetanina; Daria Vasina; Igor Grigoriev; Alexandra Kudryashova; Maria Semashko; Bogdan Cherepovich; Olga Kharchenko; Denis Kleymenov; Elena Mazunina; Artem Tkachuk; Vladimir Gushchin
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; hospitals; patients; risk
Abstract:
... The avidity index (AI) of IgG to the RBD of SARS-CoV-2 was determined for 71 patients with a mild (outpatient) course of COVID-19, including 39 primarily and 36 secondarily reinfected, and 92 patients with a severe (hospital) course of COVID-19, including 82 primarily and 10 secondarily infected. The AI was shown to correlate with the severity of repeated disease. In the group of outpatients with ...
DOI:
10.3390/v14030617

10. A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Author:
Danielle G. May; Laura Martin-Sancho; Valesca Anschau; Sophie Liu; Rachel J. Chrisopulos; Kelsey L. Scott; Charles T. Halfmann; Ramon Díaz Peña; Dexter Pratt; Alexandre R. Campos; Kyle J. Roux
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
COVID-19 infection; Internet; Severe acute respiratory syndrome coronavirus 2; antiviral agents; biotinylation; humans; lungs; pathogenesis; proteome; proteomics; therapeutics
Abstract:
... The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral therapies. Here, the cellular impact of expressing SARS-CoV-2 viral proteins was studied by global prote ...
DOI:
10.3390/v14030611

11. COVID-19 at a Glance: An Up-to-Date Overview on Variants, Drug Design and Therapies

Author:
Domenico Iacopetta; Jessica Ceramella; Alessia Catalano; Carmela Saturnino; Michele Pellegrino; Annaluisa Mariconda; Pasquale Longo; Maria Stefania Sinicropi; Stefano Aquaro
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; adrenal cortex hormones; antimalarials; bradykinin; dietary supplements; direct contact; drug design; humans; immunomodulators; pandemic; probiotics; public health; respiratory tract diseases; therapeutics
Abstract:
... Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a member of the Coronavirus family which caused the worldwide pandemic of human respiratory illness coronavirus disease 2019 (COVID-19). Presumably emerging at the end of 2019, it poses a severe threat to public health and safety, with a high incidence of transmission, predominately through aerosols and/or direct contact with infected ...
DOI:
10.3390/v14030573

12. Campylobacter jejuni Developed the Resistance to Bacteriophage CP39 by Phase Variable Expression of 06875 Encoding the CGPTase

Author:
Yuanyue Tang; Jie Li; Yuexuan Wang; Zhaojun Song; Hangning Ying; Linghua Kong; Xin’an Jiao; Jinlin Huang
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Campylobacter jejuni; Myoviridae; adsorption; bacteriophages; flagellum; food production; genes; industry; mutants; mutation rate; phylogeny; polysaccharides
Abstract:
... Bacteriophage (phage) is regarded as an antimicrobial alternative for Campylobacter in food production. However, the development of phage resistance to the host is a main concern for the phage application. This study characterized the phage CP39 and investigated the phage resistance of CP39 in Campylobacter jejuni NCTC12662. We determined that phage CP39 belonged to the Myoviridae family by the WG ...
DOI:
10.3390/v14030485

13. Characterisation of Particle Size and Viability of SARS-CoV-2 Aerosols from a Range of Nebuliser Types Using a Novel Sampling Technique

Author:
Susan Paton; Simon Clark; Antony Spencer; Isobel Garratt; Ikshitaa Dinesh; Katy-Anne Thompson; Allan Bennett; Thomas Pottage
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Severe acute respiratory syndrome coronavirus 2; aerodynamics; aerosols; animals; atomization; geometry; liquids; lungs; particle size; particle size distribution; regression analysis; relative humidity; standard deviation; viability; viruses
Abstract:
... Little is understood about the impact of nebulisation on the viability of SARS-CoV-2. In this study, a range of nebulisers with differing methods of aerosol generation were evaluated to determine SARS-CoV-2 viability following aerosolization. The aerosol particle size distribution was assessed using an aerosol particle sizer (APS) and SARS-CoV-2 viability was determined after collection into liqui ...
DOI:
10.3390/v14030639

14. Characterization of Serum and Mucosal SARS-CoV-2-Antibodies in HIV-1-Infected Subjects after BNT162b2 mRNA Vaccination or SARS-CoV-2 Infection

Author:
Katja G. Schmidt; Ellen G. Harrer; Koray Tascilar; Sabrina Kübel; Boutaina El Kenz; Fabian Hartmann; David Simon; Georg Schett; Krystelle Nganou-Makamdop; Thomas Harrer
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
HIV infections; Severe acute respiratory syndrome coronavirus 2; antibody formation; antiretroviral agents; blood serum; humoral immunity; immunogenicity; neutralization; neutralization tests; saliva; vaccination; vaccines
Abstract:
... Only limited data are available regarding the immunogenicity of the BNT162b2 mRNA vaccine in HIV-1⁺ patients. Therefore, we investigated the humoral immune response after BNT162b2-mRNA vaccination or SARS-CoV-2 infection in HIV-1⁺ patients on antiretroviral therapy compared to HIV-1-uninfected subjects. Serum and saliva samples were analysed by SARS-CoV-2 spike-specific IgG and IgA ELISAs and a su ...
DOI:
10.3390/v14030651

15. The Characterization of a Novel Virus Discovered in the Yeast Pichia membranifaciens

Author:
Mark D. Lee; Jack W. Creagh; Lance R. Fredericks; Angela M. Crabtree; Jagdish Suresh Patel; Paul A. Rowley
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Pichia membranifaciens; RNA replication; Saccharomyces cerevisiae virus L-A; ancestry; animal diseases; double-stranded RNA; mammals; monophyly; mycoviruses; yeasts
Abstract:
... Mycoviruses are widely distributed across fungi, including the yeasts of the Saccharomycotina subphylum. This manuscript reports the first double-stranded RNA (dsRNA) virus isolated from Pichia membranifaciens. This novel virus has been named Pichia membranifaciens virus L-A (PmV-L-A) and is a member of the Totiviridae. PmV-L-A is 4579 bp in length, with RNA secondary structures similar to the pac ...
DOI:
10.3390/v14030594

16. Clinical Evaluation of a Fully-Automated High-Throughput Multiplex Screening-Assay to Detect and Differentiate the SARS-CoV-2 B.1.1.529 (Omicron) and B.1.617.2 (Delta) Lineage Variants

Author:
Dominik Nörz; Moritz Grunwald; Hui Ting Tang; Celine Weinschenk; Thomas Günther; Alexis Robitaille; Katja Giersch; Nicole Fischer; Adam Grundhoff; Martin Aepfelbacher; Susanne Pfefferle; Marc Lütgehetmann
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
DNA; RNA; Severe acute respiratory syndrome coronavirus 2; cell culture; clinical examination; computer simulation; decision making; genome; health services; humans; monoclonal antibodies; patients; public health; risk
Abstract:
... Background: The recently emerged SARS-CoV-2 B.1.1.529 lineage and its sublineages (Omicron variant) pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available monoclonal antibody therapies. RT-PCR-based variant tests can be used to screen large sample-sets rapidly and accurately for relevant varia ...
DOI:
10.3390/v14030608

17. Clinical and Immunological Predictors of Hemorrhagic Fever with Renal Syndrome Outcome during the Early Phase

Author:
Geum-Young Lee; Won-Keun Kim; Jin Sun No; Yongjin Yi; Hayne Cho Park; Jaehun Jung; Seungchan Cho; Jingyeong Lee; Seung-Ho Lee; Kyungmin Park; Jongwoo Kim; Jin-Won Song
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
biomarkers; blood serum; disease severity; enzyme-linked immunosorbent assay; fever; hemoglobin; interleukin-10; ligands; morbidity; mortality; u-plasminogen activator; urine; vascular endothelial growth factors
Abstract:
... The ability to accurately predict the early progression of hemorrhagic fever with renal syndrome (HFRS) is crucial for reducing morbidity and mortality rates in severely affected patients. However, the utility of biomarkers for predicting clinical outcomes remains elusive in HFRS. The aims of the current study were to analyze the serum levels of immune function-related proteins and identify novel ...
DOI:
10.3390/v14030595

18. Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in Healthcare Workers and COVID-19 Patients

Author:
Luzia Maria de-Oliveira-Pinto; Victor Edgar Fiestas Solórzano; Maria de Lourdes Martins; Caroline Fernandes-Santos; Paula Hesselberg Damasco; Marilda Agudo Mendonça Teixeira de Siqueira; Helver Gonçalves Dias; Alex Pauvolid-Corrêa; Paulo Vieira Damasco; Elzinandes Leal de Azeredo
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; disease course; health services; inflammation; interleukin-10; interleukin-6; pathophysiology
Abstract:
... Advances in knowledge of the pathophysiology of COVID-19 have been acquired; however, the host factors that could explain the mild and severe forms of the disease are not fully understood. Thus, we proposed to evaluate anti-SARS-CoV-2 antibodies and the inflammatory response of different groups of individuals, including healthcare workers (HCW), sick and dead COVID-19 patients and also recovered p ...
DOI:
10.3390/v14030455

19. Comparative Evaluation of Rapid Isothermal Amplification and Antigen Assays for Screening Testing of SARS-CoV-2

Author:
Nol Salcedo; Brena F. Sena; Xiying Qu; Bobby Brooke Herrera
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
COVID-19 infection; RNA; Severe acute respiratory syndrome coronavirus 2; antigens; detection limit; humans; immunoaffinity chromatography; nose; public health; vaccination; viruses
Abstract:
... Human transmission of SARS-CoV-2 and emergent variants of concern continue to occur globally, despite mass vaccination campaigns. Public health strategies to reduce virus spread should therefore rely, in part, on frequent screening with rapid, inexpensive, and sensitive tests. We evaluated two digitally integrated rapid tests and assessed their performance using stored nasal swab specimens collect ...
DOI:
10.3390/v14030468

20. A Comparative Evaluation of the Estimation of Rabies Virus Antibodies among Free-Roaming, Vaccinated Dogs in Bengaluru, India

Author:
Lekshmi J. Das; Shrikrishna Isloor; Alur Kotrappa Santosh; Avinash Bhat; Ramakrishnaiah Sharada; Doddamane Rathnamma; Belamaranahally Muniveerappa Veeregowda; Konanduru Lingappa Phaniraj; Nageshkumar Abhijit Kumar; Abi T. Vanak
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Rabies lyssavirus; blood serum; dogs; fluorescent antibody technique; immunogenicity; rabies; vaccination; India
Abstract:
... Vaccination is the practical solution for the prevention of rabies in dogs. Assessment of the immunogenicity of vaccination includes estimation of specific rabies virus neutralizing antibodies (VNA) in the target species. We undertook a study to estimate the levels of VNA in free-roaming dogs with a history of rabies vaccination in Bengaluru city, India. We compared the rapid fluorescent focus inh ...
DOI:
10.3390/v14030484