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- Pu, Xiao-Ying; Zhang, Qijing; Pan, Jing-Cao; Shen, Zhangqi; Zhang, Wei
- World journal of microbiology & biotechnology 2013 v.29 no.2 pp. 365-371
- Shigella flexneri; antibiotic resistance; antibiotics; ciprofloxacin; genes; minimum inhibitory concentration; phenotype; plasmids; point mutation; polymerase chain reaction
- ... The incidence of fluoroquinolone-resistant Shigella strains has risen rapidly, presumably in response to ciprofloxacin antibiotic stress. Understanding the molecular mechanisms underlying this resistance phenotype is critical to developing novel and effective therapeutic strategies. In this study, the frequency of ciprofloxacin-induced mutation was measured in antibiotic resistance genes (gyrA, gy ...