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- Jiang, Xiao; Wang, Shuguang; Zhao, Yuewei; Xia, Qingsu; Cai, Lining; Sun, Xin; Fu, Peter P.
- Yàowù shípǐn fēnxī 2015 v.23 no.2 pp. 318-326
- poisonous plants, etc ; DNA; drugs; genotoxicity; hepatotoxicity; humans; isomers; isothiocyanates; livestock; proteins; pyrrolizidine alkaloids; valine; wildlife; Show all 13 Subjects
- ... Pyrrolizidine alkaloid-containing plants are widespread in the world and probably the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids require metabolic activation to form dehydropyrrolizidine alkaloids that bind to cellular proteins and DNA leading to hepatotoxicity, genotoxicity, and tumorigenicity. At present, it is not clear how dehydropyrrolizidi ...
- Ma, Liang; Zhao, Hengqiang; Xia, Qingsu; Cai, Lining; Fu, Peter P.
- Yàowù shípǐn fēnxī 2015 v.23 no.3 pp. 577-586
- poisonous plants, etc ; drugs; enantiomers; glutathione; hepatotoxicity; high performance liquid chromatography; humans; irradiation; laboratory animals; lipid peroxidation; livestock; metabolism; metabolites; methanol; mutagens; nuclear magnetic resonance spectroscopy; phototoxicity; pyrrolizidine alkaloids; singlet oxygen; sodium azide; spectral analysis; superoxide dismutase; ultraviolet radiation; wildlife; Show all 24 Subjects
- ... Pyrrolizidine alkaloids (PAs) are hepatotoxic, genotoxic, and carcinogenic in experimental animals. Because of their widespread distribution in the world, PA-containing plants are probably the most common poisonous plants affecting livestock, wildlife, and humans. Upon metabolism, PAs generate reactive dehydro-PAs and other pyrrolic metabolites that lead to toxicity. Dehydro-PAs are known to react ...