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Zeitschrift für Naturforschung
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2014
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Alzheimer disease
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- Author:
- Nurgun Kucukboyacı; Ilkay Orhan; Bilge Şener; S. Ahmad Nawaz; M. Iqbal Choudhary
- Source:
- Zeitschrift für Naturforschung 2014 v.65 no.3-4 pp. 187-194
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; acetylcholinesterase; ions; Taxus baccata; 2,2-diphenyl-1-picrylhydrazyl; iron; linoleate 13S-lipoxygenase; chromatography; pathogenesis; lignans; cholinesterase; chlorogenic acid; antioxidant activity
- Abstract:
- ... Phytochemical investigations of Taxus baccata L. by successive chromatographic methods resulted in the isolation of the lignans lariciresinol (1), taxiresinol (2), 3´-demethylisolariciresinol- 9´-hydroxyisopropylether (3), isolariciresinol (4), and 3-demethylisolariciresinol (5) as well as taxoids. Compounds 1 - 5 were evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ...
- DOI:
- 10.1515/znc-2010-3-404
- https://doi.org/10.1515/znc-2010-3-404
- Author:
- Teresa Frąckowiak; Tomasz Bączek; Roman Kaliszan; Beata Żbikowska; Michał Gleńsk; Izabela Fecka; Wojciech Cisowski
- Source:
- Zeitschrift für Naturforschung 2014 v.61 no.11-12 pp. 821-826
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; Uncaria tomentosa; alkaloids; amyloid; capillary electrophoresis; electrospray ionization mass spectrometry; high performance liquid chromatography; therapeutics; thin layer chromatography
- Abstract:
- ... The primary aim of this work was to determine the interactions of an oxindole alkaloid (mitraphylline) isolated from Uncaria tomentosa with β-amyloid 1-40 (Aβ1-40 protein) applying the capillary electrophoresis (CE) method. Specifically the Hummel-Dreyer method and Scatchard analysis were performed to study the binding of oxindole alkaloids with Aβ1-40 protein. Prior to these studies extraction o ...
- DOI:
- 10.1515/znc-2006-11-1209
- https://doi.org/10.1515/znc-2006-11-1209
- Author:
- Yuzo Nishida; Satoshi Nishino
- Source:
- Zeitschrift für Naturforschung 2014 v.54 no.12 pp. 1107-1114
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; amyotrophic lateral sclerosis; brain; copper; enzyme activity; hydrogen peroxide; oxidative stress; patients; prion diseases; protein degradation; proteinases; proteins
- Abstract:
- ... Many hypotheses have been developed to explain aging and age-related neurodegenerative disorders; one of the most compelling is the role of oxidative stress to induce changes in protease activity in brains of patients of Alzheimer’s disease and prion disease. At the moment however, there is no clear answer how protein degradation may be achieved in the brain. We have observed that several metal co ...
- DOI:
- 10.1515/znc-1999-1217
- https://doi.org/10.1515/znc-1999-1217
- Author:
- Ilkay Orhan; Fatma Tosun; Bilge Şener
- Source:
- Zeitschrift für Naturforschung 2014 v.63 no.5-6 pp. 366-370
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; Heracleum; acetylcholinesterase; bergapten; cholinesterase; coumarin; enzyme-linked immunosorbent assay; methoxsalen; pathogenesis; scopoletin; spectrophotometers; umbelliferones
- Abstract:
- ... Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the key enzymes in pathogenesis of Alzheimer’s disease (AD), which is characterized by a deficit in central cholinergic transmission. In the current study, AChE and BChE inhibitory activities of seven coumarin derivatives [umbelliferone (1), 4-methylumbelliferone (2), 4-hydroxycoumarin (3), scopoletin (4), 8-methoxypsoralen (5), berg ...
- DOI:
- 10.1515/znc-2008-5-610
- https://doi.org/10.1515/znc-2008-5-610
- Author:
- Roberto D. Lins; Thereza A. Soares; Ricardo Ferreira; Ricardo L. Longo
- Source:
- Zeitschrift für Naturforschung 2014 v.54 no.3-4 pp. 264-270
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; amyloid; chemical residues; peptides; solvents
- Abstract:
- ... The water accessibilities to aspartyl residues at positions 7 and 23 in the amyloid β 1–28 peptide associated with Alzheimer's Disease have been calculated using different techniques. These accessibilities of water were compared to those of the succinimidyl residues (SUC) replacing the aspartyl ones (ASP). It has been possible to ascertain that these modifications (ASP → SUC) lead to a significant ...
- DOI:
- 10.1515/znc-1999-3-418
- https://doi.org/10.1515/znc-1999-3-418
- Author:
- Cláudia Seidl; Beatriz L. Correia; Andréa E. M. Stinghen; Cid A. M. Santos
- Source:
- Zeitschrift für Naturforschung 2014 v.65 no.7-8 pp. 440-444
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; Apocynaceae; acetylcholinesterase; colorimetry; ethyl acetate; inhibitory concentration 50; methylene chloride; physostigmine; thin layer chromatography
- Abstract:
- ... Application of acetylcholinesterase (AChE) inhibitors is the primary treatment for Alzheimer’s disease. Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. The aim of this work was to evaluate Himatanthus lancifolius (Muell. Arg.) Woodson, a Brazilian species of Apocynaceae, and its main indole alkaloid uleine, in order to identify new AChE i ...
- DOI:
- 10.1515/znc-2010-7-804
- https://doi.org/10.1515/znc-2010-7-804
- Author:
- Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
- Source:
- Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
- Abstract:
- ... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
- DOI:
- 10.1515/znc-2007-9-1002
- https://doi.org/10.1515/znc-2007-9-1002
- Author:
- Pavla Zdražilová; Šárka Štĕpánková; Karel Komers; Karel Ventura; Alexander Čegan
- Source:
- Zeitschrift für Naturforschung 2014 v.59 no.3-4 pp. 293-296
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; acetylcholinesterase; carbamates; cholinesterase; cholinesterase inhibitors; drugs; enzyme activity; hydrolysis; therapeutics
- Abstract:
- ... The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI₅₀ values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI₅₀ values of the commercially used drugs for the Alzheimer’ ...
- DOI:
- 10.1515/znc-2004-3-430
- https://doi.org/10.1515/znc-2004-3-430
- Author:
- Šárka Štĕpánková; Karel Komers; Alena Komersová; Markéta Masopustová; Alexander Čegan
- Source:
- Zeitschrift für Naturforschung 2014 v.62 no.3-4 pp. 308-310
- ISSN:
- 0939-5075
- Subject:
- Alzheimer disease; blood-brain barrier; cholinesterase; drugs; enzyme activity
- Abstract:
- ... The pI₅₀ index and separation coefficients of chosen 3-N,N-diethylaminophenyl-N′,N′-dialkylcarbamates were determined. Index pI₅₀ (pI₅₀ = negative logarithm of molar concentration of inhibitor inhibiting the enzyme activity by 50%) describes the effectiveness of the inhibitor. The rate of ability of the inhibitor to pass the blood-brain barrier is usually described by the separation coefficient in ...
- DOI:
- 10.1515/znc-2007-3-423
- https://doi.org/10.1515/znc-2007-3-423
- Author:
- So-Young Park
- Source:
- Zeitschrift für Naturforschung 2014 v.64 no.5-6 pp. 395-398
- ISSN:
- 0939-5075
- Subject:
- Alzheimer disease; actin; cell death; death; diterpenoids; nerve growth factor; neurites; neurotoxicity; synapse
- Abstract:
- ... The neurotoxicity induced by beta-amyloid (Aβ), which is one of the major causes of Alzheimer’s disease (AD), leads to synaptic loss and subsequent neuronal death. Therefore, modulation of Aβ-induced neurotoxicity, as well as regeneration of damaged synapses could be important therapeutic approaches to control AD. In this study, we found that isorosmanol, an abietane-type diterpene, protected PC12 ...
- DOI:
- 10.1515/znc-2009-5-616
- https://doi.org/10.1515/znc-2009-5-616
11. Screening of Various Phenolic Acids and Flavonoid Derivatives for their Anticholinesterase Potential
- Author:
- Ilkay Orhan; Murat Kartal; Fatma Tosun; Bilge Şener
- Source:
- Zeitschrift für Naturforschung 2014 v.62 no.11-12 pp. 829-832
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; acetylcholine; acetylcholinesterase; apigenin; behavior change; biochanin A; cholinesterase; cognition; naringin; neurodegenerative diseases; neurotransmitters; phenolic acids; quercetin; screening; silymarin
- Abstract:
- ... Alzheimer’s disease (AD), the most common form of dementia, is a neurodegenerative disease characterized by progressive cognitive deterioration together with declining activities of daily living and neuropsychiatric symptoms or behavioural changes. The oldest, on which most currently available drug therapies are based, is known as the “cholinergic hypothesis” and suggests that AD begins as a defic ...
- DOI:
- 10.1515/znc-2007-11-1210
- https://doi.org/10.1515/znc-2007-11-1210