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You searched for: Journal name Zeitschrift für Naturforschung Remove constraint Journal name: Zeitschrift für Naturforschung Subject Alzheimer disease Remove constraint Subject: Alzheimer disease Subject acetylcholinesterase Remove constraint Subject: acetylcholinesterase
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1. Acetylcholinesterase Inhibitory Activity of Uleine from Himatanthus lancifolius

Author:
Cláudia Seidl; Beatriz L. Correia; Andréa E. M. Stinghen; Cid A. M. Santos
Source:
Zeitschrift für Naturforschung 2014 v.65 no.7-8 pp. 440-444
ISSN:
1865-7125
Subject:
Alzheimer disease; Apocynaceae; acetylcholinesterase; colorimetry; ethyl acetate; inhibitory concentration 50; methylene chloride; physostigmine; thin layer chromatography
Abstract:
... Application of acetylcholinesterase (AChE) inhibitors is the primary treatment for Alzheimer’s disease. Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. The aim of this work was to evaluate Himatanthus lancifolius (Muell. Arg.) Woodson, a Brazilian species of Apocynaceae, and its main indole alkaloid uleine, in order to identify new AChE i ...
DOI:
10.1515/znc-2010-7-804

2. Alkaloid Variability in Leucojum aestivum from Wild Populations

Author:
Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
Source:
Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
ISSN:
1865-7125
Subject:
Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
Abstract:
... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
DOI:
10.1515/znc-2007-9-1002

3. Assessment of Enzyme Inhibitory and Antioxidant Activities of Lignans from Taxus baccata L.

Author:
Nurgun Kucukboyacı; Ilkay Orhan; Bilge Şener; S. Ahmad Nawaz; M. Iqbal Choudhary
Source:
Zeitschrift für Naturforschung 2014 v.65 no.3-4 pp. 187-194
ISSN:
1865-7125
Subject:
Alzheimer disease; acetylcholinesterase; ions; Taxus baccata; 2,2-diphenyl-1-picrylhydrazyl; iron; linoleate 13S-lipoxygenase; chromatography; pathogenesis; lignans; cholinesterase; chlorogenic acid; antioxidant activity
Abstract:
... Phytochemical investigations of Taxus baccata L. by successive chromatographic methods resulted in the isolation of the lignans lariciresinol (1), taxiresinol (2), 3´-demethylisolariciresinol- 9´-hydroxyisopropylether (3), isolariciresinol (4), and 3-demethylisolariciresinol (5) as well as taxoids. Compounds 1 - 5 were evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ...
DOI:
10.1515/znc-2010-3-404

4. Coumarin, Anthroquinone and Stilbene Derivatives with Anticholinesterase Activity

Author:
Ilkay Orhan; Fatma Tosun; Bilge Şener
Source:
Zeitschrift für Naturforschung 2014 v.63 no.5-6 pp. 366-370
ISSN:
1865-7125
Subject:
Alzheimer disease; Heracleum; acetylcholinesterase; bergapten; cholinesterase; coumarin; enzyme-linked immunosorbent assay; methoxsalen; pathogenesis; scopoletin; spectrophotometers; umbelliferones
Abstract:
... Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the key enzymes in pathogenesis of Alzheimer’s disease (AD), which is characterized by a deficit in central cholinergic transmission. In the current study, AChE and BChE inhibitory activities of seven coumarin derivatives [umbelliferone (1), 4-methylumbelliferone (2), 4-hydroxycoumarin (3), scopoletin (4), 8-methoxypsoralen (5), berg ...
DOI:
10.1515/znc-2008-5-610

5. Half-inhibition Concentrations of New Cholinesterase Inhibitors

Author:
Pavla Zdražilová; Šárka Štĕpánková; Karel Komers; Karel Ventura; Alexander Čegan
Source:
Zeitschrift für Naturforschung 2014 v.59 no.3-4 pp. 293-296
ISSN:
1865-7125
Subject:
Alzheimer disease; acetylcholinesterase; carbamates; cholinesterase; cholinesterase inhibitors; drugs; enzyme activity; hydrolysis; therapeutics
Abstract:
... The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI₅₀ values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI₅₀ values of the commercially used drugs for the Alzheimer’ ...
DOI:
10.1515/znc-2004-3-430

6. PEPPSI complexes as potential prodrugs: enzyme inhibition, antioxidant activity, electrochemical characterization, molecular docking analysis

Author:
Elvan Üstün; Mutlu S. Çelebi; Melek Ç. Ayvaz; Neslihan Şahin
Source:
Zeitschrift für Naturforschung 2021 v.76 no.5-6 pp. 219-227
ISSN:
1865-7125
Subject:
Alzheimer disease; Parkinson disease; acetylcholinesterase; antioxidant activity; carbenes; cholinesterase; electrochemistry; enzyme inhibition; humans; ligands; palladium; pyridines; voltammetry
Abstract:
... In this study, enzyme inhibition and antioxidant activity analyzes of previously characterized pyridine-enhanced precatalyst preparation stabilization and initiation (PEPPSI)-type Palladium(II) complexes with benzimidazole-type ligands {dichloro[L]pyridine palladium(II), L1: 1-(2-methyl-2-propenyl)-3-[benzylbenzimidazole]-2-ylidene, L2: 1-(2-methyl-2-propenyl)-3-[4-chloro benzylbenzimidazole]-2-yl ...
DOI:
10.1515/znc-2020-0295

7. Screening of Various Phenolic Acids and Flavonoid Derivatives for their Anticholinesterase Potential

Author:
Ilkay Orhan; Murat Kartal; Fatma Tosun; Bilge Şener
Source:
Zeitschrift für Naturforschung 2014 v.62 no.11-12 pp. 829-832
ISSN:
1865-7125
Subject:
Alzheimer disease; acetylcholine; acetylcholinesterase; apigenin; behavior change; biochanin A; cholinesterase; cognition; naringin; neurodegenerative diseases; neurotransmitters; phenolic acids; quercetin; screening; silymarin
Abstract:
... Alzheimer’s disease (AD), the most common form of dementia, is a neurodegenerative disease characterized by progressive cognitive deterioration together with declining activities of daily living and neuropsychiatric symptoms or behavioural changes. The oldest, on which most currently available drug therapies are based, is known as the “cholinergic hypothesis” and suggests that AD begins as a defic ...
DOI:
10.1515/znc-2007-11-1210