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You searched for: Journal Zeitschrift für Naturforschung Remove constraint Journal: Zeitschrift für Naturforschung Subject Alzheimer disease Remove constraint Subject: Alzheimer disease Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Acetylcholinesterase Inhibitory Activity of Uleine from Himatanthus lancifolius

Author:
Seidl, Cláudia; Correia, Beatriz L.; Stinghen, Andréa E. M.; Santos, Cid A. M.
Source:
Zeitschrift für Naturforschung 2014 v.65 no.7-8 pp. 440-444
ISSN:
1865-7125
Subject:
Alzheimer disease; Apocynaceae; acetylcholinesterase; colorimetry; ethyl acetate; inhibitory concentration 50; methylene chloride; physostigmine; thin layer chromatography
Abstract:
... Application of acetylcholinesterase (AChE) inhibitors is the primary treatment for Alzheimer’s disease. Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. The aim of this work was to evaluate Himatanthus lancifolius (Muell. Arg.) Woodson, a Brazilian species of Apocynaceae, and its main indole alkaloid uleine, in order to identify new AChE i ...
DOI:
10.1515/znc-2010-7-804

2. Alkaloid Variability in Leucojum aestivum from Wild Populations

Author:
Georgievaa, Liliya; Berkov, Strahil; Kondakova, Violeta; Bastida, Jaume; Viladomat, Francesc; Atanassov, Atanas; Codina, Carles
Source:
Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
ISSN:
1865-7125
Subject:
Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
Abstract:
... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
DOI:
10.1515/znc-2007-9-1002

3. Assessment of Enzyme Inhibitory and Antioxidant Activities of Lignans from Taxus baccata L.

Author:
Kucukboyacı, Nurgun; Orhan, Ilkay; Şener, Bilge; Nawaz, S. Ahmad; Choudhary, M. Iqbal
Source:
Zeitschrift für Naturforschung 2014 v.65 no.3-4 pp. 187-194
ISSN:
1865-7125
Subject:
Alzheimer disease; acetylcholinesterase; ions; Taxus baccata; 2,2-diphenyl-1-picrylhydrazyl; iron; linoleate 13S-lipoxygenase; chromatography; pathogenesis; lignans; cholinesterase; chlorogenic acid; antioxidant activity
Abstract:
... Phytochemical investigations of Taxus baccata L. by successive chromatographic methods resulted in the isolation of the lignans lariciresinol (1), taxiresinol (2), 3´-demethylisolariciresinol- 9´-hydroxyisopropylether (3), isolariciresinol (4), and 3-demethylisolariciresinol (5) as well as taxoids. Compounds 1 - 5 were evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ...
DOI:
10.1515/znc-2010-3-404

4. Binding of an Oxindole Alkaloid from Uncaria tomentosa to Amyloid Protein (Aβ1-40)

Author:
Frąckowiak, Teresa; Bączek, Tomasz; Kaliszan, Roman; Żbikowska, Beata; Gleńsk, Michał; Fecka, Izabela; Cisowski, Wojciech
Source:
Zeitschrift für Naturforschung 2014 v.61 no.11-12 pp. 821-826
ISSN:
1865-7125
Subject:
Alzheimer disease; Uncaria tomentosa; alkaloids; amyloid; capillary electrophoresis; electrospray ionization mass spectrometry; high performance liquid chromatography; therapeutics; thin layer chromatography
Abstract:
... The primary aim of this work was to determine the interactions of an oxindole alkaloid (mitraphylline) isolated from Uncaria tomentosa with β-amyloid 1-40 (Aβ1-40 protein) apply­ing the capillary electrophoresis (CE) method. Specifically the Hummel-Dreyer method and Scatchard analysis were performed to study the binding of oxindole alkaloids with Aβ1-40 protein. Prior to these studies extraction o ...
DOI:
10.1515/znc-2006-11-1209

5. Contribution of a Metal-Peroxide Adduct to Neurodegeneration Is Due to Its Oxidative Protease Activity

Author:
Nishida, Yuzo; Nishino, Satoshi
Source:
Zeitschrift für Naturforschung 2014 v.54 no.12 pp. 1107-1114
ISSN:
1865-7125
Subject:
Alzheimer disease; amyotrophic lateral sclerosis; brain; copper; enzyme activity; hydrogen peroxide; oxidative stress; patients; prion diseases; protein degradation; proteinases; proteins
Abstract:
... Many hypotheses have been developed to explain aging and age-related neurodegenerative disorders; one of the most compelling is the role of oxidative stress to induce changes in protease activity in brains of patients of Alzheimer’s disease and prion disease. At the moment however, there is no clear answer how protein degradation may be achieved in the brain. We have observed that several metal co ...
DOI:
10.1515/znc-1999-1217

6. Coumarin, Anthroquinone and Stilbene Derivatives with Anticholinesterase Activity

Author:
Orhan, Ilkay; Tosun, Fatma; Şener, Bilge
Source:
Zeitschrift für Naturforschung 2014 v.63 no.5-6 pp. 366-370
ISSN:
1865-7125
Subject:
Alzheimer disease; Heracleum; acetylcholinesterase; bergapten; cholinesterase; coumarin; enzyme-linked immunosorbent assay; methoxsalen; pathogenesis; scopoletin; spectrophotometers; umbelliferones
Abstract:
... Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the key enzymes in pathogenesis of Alzheimer’s disease (AD), which is characterized by a deficit in central cholinergic transmission. In the current study, AChE and BChE inhibitory activities of seven coumarin derivatives [umbelliferone (1), 4-methylumbelliferone (2), 4-hydroxycoumarin (3), scopoletin (4), 8-methoxypsoralen (5), berg ...
DOI:
10.1515/znc-2008-5-610

7. Half-inhibition Concentrations of New Cholinesterase Inhibitors

Author:
Zdražilová, Pavla; Štĕpánková, Šárka; Komers, Karel; Ventura, Karel; Čegan, Alexander
Source:
Zeitschrift für Naturforschung 2014 v.59 no.3-4 pp. 293-296
ISSN:
1865-7125
Subject:
Alzheimer disease; acetylcholinesterase; carbamates; cholinesterase; cholinesterase inhibitors; drugs; enzyme activity; hydrolysis; therapeutics
Abstract:
... The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI₅₀ values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI₅₀ values of the commercially used drugs for the Alzheimer’ ...
DOI:
10.1515/znc-2004-3-430

8. Inhibition of Cholinesterase by Dialkylcarbamates

Author:
Štĕpánková, Šárka; Komers, Karel; Komersová, Alena; Masopustová, Markéta; Čegan, Alexander
Source:
Zeitschrift für Naturforschung 2014 v.62 no.3-4 pp. 308-310
ISSN:
0939-5075
Subject:
Alzheimer disease; blood-brain barrier; cholinesterase; drugs; enzyme activity
Abstract:
... The pI₅₀ index and separation coefficients of chosen 3-N,N-diethylaminophenyl-N′,N′-dialkylcarbamates were determined. Index pI₅₀ (pI₅₀ = negative logarithm of molar concentration of inhibitor inhibiting the enzyme activity by 50%) describes the effectiveness of the inhibitor. The rate of ability of the inhibitor to pass the blood-brain barrier is usually described by the separation coefficient in ...
DOI:
10.1515/znc-2007-3-423

9. Neuroprotective and Neurotrophic Effects of Isorosmanol

Author:
Park, So-Young
Source:
Zeitschrift für Naturforschung 2014 v.64 no.5-6 pp. 395-398
ISSN:
0939-5075
Subject:
Alzheimer disease; actin; cell death; death; diterpenoids; nerve growth factor; neurites; neurotoxicity; synapse
Abstract:
... The neurotoxicity induced by beta-amyloid (Aβ), which is one of the major causes of Alzheimer’s disease (AD), leads to synaptic loss and subsequent neuronal death. Therefore, modulation of Aβ-induced neurotoxicity, as well as regeneration of damaged synapses could be important therapeutic approaches to control AD. In this study, we found that isorosmanol, an abietane-type diterpene, protected PC12 ...
DOI:
10.1515/znc-2009-5-616

10. Screening of Various Phenolic Acids and Flavonoid Derivatives for their Anticholinesterase Potential

Author:
Orhan, Ilkay; Kartal, Murat; Tosun, Fatma; Şener, Bilge
Source:
Zeitschrift für Naturforschung 2014 v.62 no.11-12 pp. 829-832
ISSN:
1865-7125
Subject:
Alzheimer disease; acetylcholine; acetylcholinesterase; apigenin; behavior change; biochanin A; cholinesterase; cognition; naringin; neurodegenerative diseases; neurotransmitters; phenolic acids; quercetin; screening; silymarin
Abstract:
... Alzheimer’s disease (AD), the most common form of dementia, is a neurodegenerative disease characterized by progressive cognitive deterioration together with declining activities of daily living and neuropsychiatric symptoms or behavioural changes. The oldest, on which most currently available drug therapies are based, is known as the “cholinergic hypothesis” and suggests that AD begins as a defic ...
DOI:
10.1515/znc-2007-11-1210

11. Solvent Accessibility to Aspartyl and Succinimidyl Residues at Positions 7 and 23 in the Amyloid β 1 - 28 Peptide

Author:
Lins, Roberto D.; Soares, Thereza A.; Ferreira, Ricardo; Longo, Ricardo L.
Source:
Zeitschrift für Naturforschung 2014 v.54 no.3-4 pp. 264-270
ISSN:
1865-7125
Subject:
Alzheimer disease; amyloid; chemical residues; peptides; solvents
Abstract:
... The water accessibilities to aspartyl residues at positions 7 and 23 in the amyloid β 1–28 peptide associated with Alzheimer's Disease have been calculated using different techniques. These accessibilities of water were compared to those of the succinimidyl residues (SUC) replacing the aspartyl ones (ASP). It has been possible to ascertain that these modifications (ASP → SUC) lead to a significant ...
DOI:
10.1515/znc-1999-3-418