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- Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
- Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
- Leucojum aestivum, etc ; Alzheimer disease; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria; Show all 8 Subjects
- ... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied ...
- Vasil Georgiev; Strahil Berkov; Milen Georgiev; Monique Burrus; Carles Codina; Jaume Bastida; Mladenka Ilieva; Atanas Pavlov
- Zeitschrift für Naturforschung 2014 v.64 no.3-4 pp. 219-224
- Leucojum aestivum, etc ; alkaloids; ammonium nitrate; ammonium sulfate; biosynthesis; potassium dihydrogen phosphate; potassium nitrate; regression analysis; sucrose; Show all 9 Subjects
- ... The common effect of NH₄⁺, NO₃⁻, KH₂PO₄ and sucrose on the biosynthesis of galanthamine by a Leucojum aestivum shoot culture was studied. Polynominal regression models were elaborated for the description of the galanthamine biosynthesis as a consequence of variation of the investigated variables (NH₄⁺ between 0.20 and 0.54 g/L; NO₃⁻ between 1.44 and 3.44 g/L; KH₂PO₄ between 0.10 and 0.24 g/L ...