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1. Coronaviruses Induce Entry-Independent, Continuous Macropinocytosis

Author:
Freeman, Megan Culler; Peek, Christopher T.; Becker, Michelle M.; Smith, Everett Clinton; Denison, Mark R.
Source:
mBio 2014 v.5 no.4 pp. e01340-14
ISSN:
2150-7511
Subject:
Murine hepatitis virus,   etc   ; cell fusion; epidermal growth factor receptors; giant cells; humans; pathogenesis; pathogens; pseudopodia; surface proteins; viral load; virus replication; viruses; Middle East;     Show all 13 Subjects
Abstract:
... Macropinocytosis is exploited by many pathogens for entry into cells. Coronaviruses (CoVs) such as severe acute respiratory syndrome (SARS) CoV and Middle East respiratory syndrome CoV are important human pathogens; however, macropinocytosis during CoV infection has not been investigated. We demonstrate that the CoVs SARS CoV and murine hepatitis virus (MHV) induce macropinocytosis, which occurs l ...
DOI:
10.1128/mBio.01340-14
PubMed:
25096879
PubMed Central:
PMC4128357

2. Murine AKAP7 Has a 2′,5′-Phosphodiesterase Domain That Can Complement an Inactive Murine Coronavirus ns2 Gene

Author:
Gusho, Elona; Zhang, Rong; Jha, Babal K.; Thornbrough, Joshua M.; Dong, Beihua; Gaughan, Christina; Elliott, Ruth; Weiss, Susan R.; Silverman, Robert H.
Source:
mBio 2014 v.5 no.4 pp. e01312-14
ISSN:
2150-7511
Subject:
Murine hepatitis virus,   etc   ; RNA; adenosine monophosphate; antiviral properties; bone marrow; cAMP-dependent protein kinase; complementary DNA; cyclic AMP; cytoplasm; evolution; genes; hepatitis; host-pathogen relationships; humans; interferons; liver; macrophages; mice; mutants; pathogenesis; protein subunits; ribonucleases; viral proteins; virulence; virus replication; viruses;     Show all 26 Subjects
Abstract:
... Viral 2′,5′-phosphodiesterases (2′,5′-PDEs) help disparate RNA viruses evade the antiviral activity of interferon (IFN) by degrading 2′,5′-oligoadenylate (2-5A) activators of RNase L. A kinase anchoring proteins (AKAPs) bind the regulatory subunits of protein kinase A (PKA) to localize and organize cyclic AMP (cAMP) signaling during diverse physiological processes. Among more than 43 AKAP isoforms ...
DOI:
10.1128/mBio.01312-14
PubMed:
24987090
PubMed Central:
PMC4161237