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- David García-Seisdedos; Bohdan Babiy; Milagros Lerma; María E. Casado; Javier Martínez-Botas; Miguel A. Lasunción; Óscar Pastor; Rebeca Busto
- Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158638
- Curcuma longa; animal models; ceramides; curcumin; enzyme inhibitors; exosomes; fumonisin B1; hydrophobicity; mice; neuroglia; polyphenols; rhizomes; secretion; serine C-palmitoyltransferase; sphingosine N-acyltransferase
- ... Curcumin, a hydrophobic polyphenol found in the rhizome of Curcuma longa, has been shown to reduce intracellular lipid accumulation in mouse models of lysosomal storage diseases such as Niemann-Pick type C. Exosomes are small extracellular vesicles secreted by cells in response to changes in intracellular ceramide composition. Curcumin can induce exosome/microvesicle release in cellular models of ...
- Hiroaki Takeda; Yoshihiro Izumi; Shohei Tamura; Tomonari Koike; Yui Koike; Masashi Shiomi; Takeshi Bamba
- Journal of proteome research 2020 v.19 no.3 pp. 1100-1108
- animal models; antioxidant activity; biosynthesis; blood serum; cardiovascular diseases; ceramides; cholesterol; fatty acids; humans; hypercholesterolemia; lipid composition; lipid metabolism; liver; lysophosphatidylcholine; mass spectrometry; phosphatidylethanolamines; pleiotropy; protein metabolism; proteome; rabbits; secretion; supercritical fluid chromatography; therapeutics; very low density lipoprotein
- ... Statins are widely used for the treatment of atherosclerotic cardiovascular diseases. They inhibit cholesterol biosynthesis in the liver and cause pleiotropic effects, including anti-inflammatory and antioxidant effects. To develop novel therapeutic drugs, the effect of blood-borne lipid molecules on the pleiotropic effects of statins must be elucidated. Myocardial infarction-prone Watanabe herita ...