Jump to Main Content
- Onyeagusi, Chibueze I.; Shao, Xinxin; Malcolmson, Steven J.
- Organic letters 2020 v.22 no.4 pp. 1681-1685
- regioselectivity, etc ; Lewis bases; alkylation; amines; catalysts; catalytic activity; chemical structure; diastereoselective synthesis; Show all 8 Subjects
- ... We describe a strategy for the enantio- and diastereoselective synthesis of homoallylic α-trifluoromethyl amines by the catalytic hydroalkylation of terminal dienes. Trifluoromethyl-substituted isatin-derived azadienolate nucleophiles undergo γ-selective alkylation with a Pd–DTBM-SEGPHOS catalyst, which additionally promotes regioselective addition to the diene and delivers products in up to 86% y ...
- PubMed Central: