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1. Promotion of CTL epitope presentation by a nanoparticle with environment-responsive stability and phagolysosomal escape capacity

Author:
Parent, Kristin N.,   et al.   ; Dong, Shuyun; Subramanian, Sundharraman; Chen, Mingnan;     Show all 4 Authors
Source:
Journal of controlled release 2020 v.328 pp. 653-664
ISSN:
0168-3659
Subject:
DNA-directed DNA polymerase; Human alphaherpesvirus 1; T-lymphocytes; cytotoxicity; dendritic cells; epitopes; immune response; nanoparticles; phagosomes; polypeptides; vaccines
Abstract:
... Vaccines that induce cytotoxic T lymphocyte (CTL)-mediated immune responses constitute an important class of medical tools to fend off diseases like infections and malignancy. Epitope peptides, as a format of CTL vaccines, are being tested preclinically and clinically. To elicit CTL responses, epitope vaccines go through an epitope presentation pathway in dendritic cells (DCs) that has multiple bo ...
DOI:
10.1016/j.jconrel.2020.09.033

2. Dietary intake and lipid levels in Norwegian and Spanish children with familial hypercholesterolemia

Author:
Torvik, Kristin,   et al.   ; Christensen, J.J.; Rodríguez-Borjabad, Cèlia; Narveud, Ingunn; Christensen, Jacob Juel; Ulven, Stine Marie; Malo, Ana Irene; Ibarretxe, Daiana; Girona, Josefa; Bogsrud, Martin Prøven; Retterstøl, Kjetil; Plana, Núria; Masana, Luis; Holven, Kristen Bjørklund;     Show all 14 Authors
Source:
Nutrition, metabolism, and cardiovascular diseases 2020
ISSN:
0939-4753
Subject:
Mediterranean diet; apolipoprotein B; cardiovascular diseases; children; cross-sectional studies; eggs; fatty fish; food groups; food intake; high density lipoprotein; hypercholesterolemia; legumes; lipid metabolism; low density lipoprotein cholesterol; margarine; meat; monounsaturated fatty acids; nutrient content; nuts; olive oil; phenotype; polyunsaturated fatty acids; rapeseed oil; whole grain foods; Norway; Spain
Abstract:
... Both the Nordic and Mediterranean diets claim to have a beneficial effect on lipid metabolism and cardiovascular prevention. The objective of this study was to compare diets consumed by children with FH at the time of diagnosis in Norway and Spain and to study their relationship with the lipid profile.In this cross-sectional study, we appraised the dietary intake in children (4–18 years old) with ...
DOI:
10.1016/j.numecd.2020.12.002

3. Top-down mass spectrometry of histone modifications in sorghum reveals potential epigenetic markers for drought acclimation

Author:
Engbrecht, Kristin,   et al.   ; Zhou, Mowei; Malhan, Neha; Ahkami, Amir H.; Myers, Gabriel; Dahlberg, Jeffery; Hollingsworth, Joy; Sievert, Julie A.; Hutmacher, Robert; Madera, Mary; Lemaux, Peggy G.; Hixson, Kim K.; Jansson, Christer; Paša-Tolić, Ljiljana;     Show all 14 Authors
Source:
Methods 2020 v.184 pp. 29-39
ISSN:
1046-2023
Subject:
Sorghum bicolor; acclimation; acetylation; carbon dioxide; chromatin; developmental stages; drought; epigenetics; genotype; histone code; histones; leaves; mass spectrometry
Abstract:
... Sorghum [Sorghum bicolor (L.) Moench] is an important cereal crop noted for its ability to survive water-limiting conditions. Herein, we present an analytical workflow to explore the changes in histone modifications through plant developmental stages and two drought stresses in two sorghum genotypes that differ in their response to drought. Top-down mass spectrometry (MS) is an ideal method to pro ...
DOI:
10.1016/j.ymeth.2019.10.007

4. A vast resource of allelic expression data spanning human tissues

Author:
Ardlie, Kristin G.,   et al.   ; Castel, Stephane E.; Aguet, François; Mohammadi, Pejman; Lappalainen, Tuuli;     Show all 5 Authors
Source:
Genome biology 2020 v.21 no.1 pp. 234
ISSN:
1474-760X
Subject:
alleles; haplotypes; humans; single nucleotide polymorphism; tissues
Abstract:
... Allele expression (AE) analysis robustly measures cis-regulatory effects. Here, we present and demonstrate the utility of a vast AE resource generated from the GTEx v8 release, containing 15,253 samples spanning 54 human tissues for a total of 431 million measurements of AE at the SNP level and 153 million measurements at the haplotype level. In addition, we develop an extension of our tool phASER ...
DOI:
10.1186/s13059-020-02122-z

5. Development of a gp60-subtyping method for Cryptosporidium felis

Author:
Elwin, Kristin,   et al.   ; Rojas-Lopez, Laura; Chalmers, Rachel M.; Enemark, Heidi L.; Beser, Jessica; Troell, Karin;     Show all 6 Authors
Source:
Parasites & vectors 2020 v.13 no.1 pp. 39
ISSN:
1756-3305
Subject:
Cryptosporidium; cats; cryptosporidiosis; epidemiological studies; genes; genetic variation; genotyping; glycoproteins; humans; nucleotide sequences; polymerase chain reaction; ribosomal RNA; sequence analysis
Abstract:
... BACKGROUND: Feline cryptosporidiosis is an increasing problem, especially in catteries. In humans, close contact with cats could be a potential source of infection although the risk of contracting cryptosporidiosis caused by Cryptosporidium felis is considered to be relatively low. Sequencing of the 60-kDa glycoprotein gene is a commonly used tool for investigation of the genetic diversity and tra ...
DOI:
10.1186/s13071-020-3906-9
PubMed:
31973771
PubMed Central:
PMC6979280

6. Distribution of allele frequencies for genes associated with physical activity and/or physical capacity in a homogenous Norwegian cohort- a cross-sectional study

Author:
Larsen, Inger Kristin,   et al.   ; Goleva-Fjellet, Sannija; Bjurholt, Anne Mari; Kure, Elin H.; Støren, Øyvind; Sæbø, Mona;     Show all 6 Authors
Source:
BMC genetics 2020 v.21 no.1 pp. 8
ISSN:
1471-2156
Subject:
alleles; cross-sectional studies; education; environmental factors; exercise; gene frequency; genotype; heritability; socioeconomic factors; sports
Abstract:
... BACKGROUND: There are large individual differences in physical activity (PA) behavior as well as trainability of physical capacity. Heritability studies have shown that genes may have as much impact on exercise participation behavior as environmental factors. Genes that favor both trainability and participation may increase the levels of PA. The present study aimed to assess the allele frequencies ...
DOI:
10.1186/s12863-020-0813-1
PubMed:
31973699
PubMed Central:
PMC6979285

7. Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx

Author:
Ardlie, Kristin G.,   et al.   ; Gay, Nicole R.; Gloudemans, Michael; Antonio, Margaret L.; Abell, Nathan S.; Balliu, Brunilda; Park, YoSon; Martin, Alicia R.; Musharoff, Shaila; Rao, Abhiram S.; Aguet, François; Barbeira, Alvaro N.; Bonazzola, Rodrigo; Hormozdiari, Farhad; Brown, Christopher D.; Im, Hae Kyung; Lappalainen, Tuuli; Wen, Xiaoquan; Montgomery, Stephen B.;     Show all 19 Authors
Source:
Genome biology 2020 v.21 no.1 pp. 233
ISSN:
1474-760X
Subject:
ancestry; gene expression; loci; population structure; tissues
Abstract:
... BACKGROUND: Population structure among study subjects may confound genetic association studies, and lack of proper correction can lead to spurious findings. The Genotype-Tissue Expression (GTEx) project largely contains individuals of European ancestry, but the v8 release also includes up to 15% of individuals of non-European ancestry. Assessing ancestry-based adjustments in GTEx improves portabil ...
DOI:
10.1186/s13059-020-02113-0

8. Predictors of disordered weight loss behaviors among same-sex and opposite-sex romantic partners

Author:
August, Kristin J.,   et al.   ; Markey, Charlotte H.; Gillen, Meghan M.; Dunaev, Jamie L.;     Show all 4 Authors
Source:
Eating behaviors 2020 v.39 pp. 101440
ISSN:
1471-0153
Subject:
adults; at-risk population; body dissatisfaction; eating disorders; eating habits; males; models; self-esteem; weight loss
Abstract:
... Although the majority of adults will attempt to lose weight at some point in their lives, most weight loss behaviors are ineffective and potentially harmful. Further, weight loss behaviors often closely resemble disordered eating, and include behaviors such as fasting and purging. The current study examined potential predictors of disordered approaches to weight loss in the context of same-sex and ...
DOI:
10.1016/j.eatbeh.2020.101440

9. Simulating forest resilience: A review

Author:
Braziunas, Kristin H.,   et al.   ; Albrich, Katharina; Rammer, Werner; Turner, Monica G.; Ratajczak, Zak; Hansen, Winslow D.; Seidl, Rupert;     Show all 7 Authors
Source:
Global ecology and biogeography 2020 v.29 no.12 pp. 2082-2096
ISSN:
1466-822X
Subject:
analytical methods; biogeography; databases; empirical research; environmental factors; forest ecosystems; forests; global change; landscapes; literature; objectives; simulation models; soil; trees
Abstract:
... AIM: Simulation models are important tools for quantifying the resilience (i.e., persistence under changed environmental conditions) of forest ecosystems to global change. We synthesized the modelling literature on forest resilience, summarizing common models and applications in resilience research, and scrutinizing the implementation of important resilience mechanisms in these models. Models appl ...
DOI:
10.1111/geb.13197

10. sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression

Author:
Ardlie, Kristin G.,   et al.   ; He, Yuan; Chhetri, Surya B.; Arvanitis, Marios; Srinivasan, Kaushik; Aguet, François; Barbeira, Alvaro N.; Bonazzola, Rodrigo; Im, Hae Kyung; Brown, Christopher D.; Battle, Alexis;     Show all 11 Authors
Source:
Genome biology 2020 v.21 no.1 pp. 235
ISSN:
1474-760X
Subject:
etiology; gene expression regulation; genes; humans; models; quantitative trait loci; tissues; transcription factors
Abstract:
... Genetic regulation of gene expression, revealed by expression quantitative trait loci (eQTLs), exhibits complex patterns of tissue-specific effects. Characterization of these patterns may allow us to better understand mechanisms of gene regulation and disease etiology. We develop a constrained matrix factorization model, sn-spMF, to learn patterns of tissue-sharing and apply it to 49 human tissues ...
DOI:
10.1186/s13059-020-02129-6

11. The effects and interaction of soybean maturity gene alleles controlling flowering time, maturity, and adaptation in tropical environments

Author:
Bilyeu, Kristin,   et al.   ; Miranda, Carrie; Scaboo, Andrew; Cober, Elroy; Denwar, Nicholas;     Show all 5 Authors
Source:
BMC plant biology 2020 v.20 no.1 pp. 65
ISSN:
1471-2229
Subject:
alleles; breeding programs; crop yield; genotype; juveniles; latitude; mutants; phenology; phenotype; plant architecture; plant breeding; plant height; soybeans; temperate zones; East Asia; Ghana
Abstract:
... BACKGROUND: Soybean is native to the temperate zones of East Asia. Poor yields of soybean in West African countries may be partially attributed to inadequate adaptation of soybean to tropical environments. Adaptation will require knowledge of the effects of allelic combinations of major maturity genes (E1, E2, and E3) and stem architecture. The long juvenile trait (J) influences soybean flowering ...
DOI:
10.1186/s12870-020-2276-y
PubMed:
32033536
PubMed Central:
PMC7006184

12. What evidence exists for the impact of Baltic Sea ecosystems on human health and well-being? A systematic map protocol

Author:
Kuhn, Kristin,   et al.   ; Storie, Joanna; Suškevičs, Monika; Külvik, Mart; Lehtoranta, Virpi; Vikström, Suvi; Riikonen, Simo; Kuosa, Harri; Oinonen, Soile;     Show all 9 Authors
Source:
Environmental evidence 2020 v.9 no.1 pp. 5
ISSN:
2047-2382
Subject:
anthropogenic activities; databases; ecosystem services; environmental impact; environmental protection; geographical distribution; health policy; human health; interviews; marine ecosystems; marine environment; seafoods; stakeholders; toxic substances; Baltic Sea
Abstract:
... BACKGROUND: The Baltic Sea ecosystems supply many benefits to society, termed ecosystem services. These depend upon a healthy marine environment requiring marine and relevant land-based policies integrated with public health policies. Until recently marine environment protection policies have largely focussed on human impacts on the environment and have not taken into account impacts of ecosystems ...
DOI:
10.1186/s13750-020-00189-6

13. Combinatorial Glycomic Analyses to Direct CAZyme Discovery for the Tailored Degradation of Canola Meal Non-Starch Dietary Polysaccharides

Author:
Low, Kristin E.,   et al.   ; Xing, Xiaohui; Moote, Paul E.; Inglis, G. Douglas; Venketachalam, Sivasankari; Hahn, Michael G.; King, Marissa L.; Tétard-Jones, Catherine Y.; Jones, Darryl R.; Willats, William G. T.; Slominski, Bogdan A.; Abbott, D. Wade;     Show all 12 Authors
Source:
Microorganisms 2020 v.8 no.12
ISSN:
2076-2607
Subject:
Bacteroides; Enterococcus; bacteria; bacterial growth; byproducts; canola meal; canola oil; cell walls; chickens; degradation; digestion; enzyme-linked immunosorbent assay; enzymes; extraction; feeds; genome; glycomics; glycosidic linkages; herbivores; intestinal microorganisms; lignin; metabolizable energy; omnivores; polysaccharides; protein supplements
Abstract:
... Canola meal (CM), the protein-rich by-product of canola oil extraction, has shown promise as an alternative feedstuff and protein supplement in poultry diets, yet its use has been limited due to the abundance of plant cell wall fibre, specifically non-starch polysaccharides (NSP) and lignin. The addition of exogenous enzymes to promote the digestion of CM NSP in chickens has potential to increase ...
DOI:
10.3390/microorganisms8121888

14. Higher dietary micronutrients are required to maintain optimal performance of Atlantic salmon (Salmo salar) fed a high plant material diet during the full production cycle

Author:
Hamre, Kristin,   et al.   ; Vera, Luisa M.; Espe, Marit; Hemre, Gro-Ingunn; Skjærven, Kaja; Lock, Erik-Jan; Prabhu, Antony Jesu; Leeming, Daniel; Migaud, Herve; Tocher, Douglas R.; Taylor, John F.;     Show all 11 Authors
Source:
Aquaculture 2020 v.528 pp. 735551
ISSN:
0044-8486
Subject:
Salmo salar; ascorbic acid; biochemical pathways; cholesterol; dietary mineral supplements; dietary minerals; dietary recommendations; fish feeding; fish meal; fish oils; genes; harvesting; ingredients; metabolism; niacin; nutrients; parr; riboflavin; taurine; transcriptome; vitamin B12; vitamin-mineral supplements; zinc
Abstract:
... A full life cycle (parr to harvest) study of growth and performance was conducted in Atlantic salmon fed diets high in plant ingredients supplemented with graded levels of a nutrient premix (NP), containing selected amino acids, taurine, cholesterol, vitamins and minerals to re-evaluate current nutrient recommendations. Triplicate groups were fed one of three NP levels included at 1×, 2× and 4×, w ...
DOI:
10.1016/j.aquaculture.2020.735551

15. Being Well-Connected Pays in a Disturbed World: Enhanced Herbivory in Better-Linked Habitats

Author:
Jinks, Kristin I.,   et al.   ; Brown, Christopher J.; Schlacher, Thomas A.; Olds, Andrew D.; Engelhard, Sarah L.; Pearson, Ryan M.; Connolly, Rod M.;     Show all 7 Authors
Source:
Diversity 2020 v.12 no.11
ISSN:
1424-2818
Subject:
Clibanarius; algae; ecological function; ecosystems; habitats; herbivores; network theory; shape
Abstract:
... Seascapes are typically comprised of multiple components that are functionally linked by the movement of organisms and fluxes of matter. Changes to the number and spatial arrangement of these linkages affect biological connectivity that, in turn, can alter ecological functions. Herbivory is one such function, pivotal in controlling excessive algal growth when systems become disturbed. Here, we use ...
DOI:
10.3390/d12110424

16. New Oleoyl Hybrids of Natural Antioxidants: Synthesis and In Vitro Evaluation as Inducers of Apoptosis in Colorectal Cancer Cells

Author:
Hartmann, Kristin M.,   et al.   ; Carullo, Gabriele; Mazzotta, Sarah; Koch, Adrian; Friedrich, Oliver; Gilbert, Daniel F.; Vega-Holm, Margarita; Schneider-Stock, Regine; Aiello, Francesca;     Show all 9 Authors
Source:
Antioxidants 2020 v.9 no.11
ISSN:
2076-3921
Subject:
DNA damage; administrative management; antineoplastic agents; antioxidants; apoptosis; bioavailability; carboxylic ester hydrolases; catalysts; catechin; cell lines; colorectal neoplasms; cytotoxicity; foods; humans; hybrids; in vitro studies; lifestyle; neoplasm cells; oleic acid; polyphenols; population; positional isomers; quercetin; swine; synthesis
Abstract:
... Nowadays, the beneficial role of a healthy lifestyle, particularly emphasizing the quality of foods and cancer management, is accepted worldwide. Polyphenols and oleic acid play a key role in this context, but are still scarcely used as anti-cancer agents due to their bio-accessibility limits. Therefore, we aimed to synthesize a set of new oleoyl-hybrids of quercetin, morin, pinocembrin, and catec ...
DOI:
10.3390/antiox9111077

17. Evaluating the use of zein in structuring plant-based products

Author:
Mattice, Kristin D.,   et al.   ; Marangoni, Alejandro G.;     Show all 2 Author
Source:
Current research in food science 2020 v.3 pp. 59-66
ISSN:
2665-9271
Subject:
Cheddar cheese; Fourier transform infrared spectroscopy; animal proteins; breast meat; chicken meat; chickens; gluten; ingredients; muscle tissues; plant products; plant source protein; plant-based foods; polymers; rheological properties; temperature; zein
Abstract:
... The recent interest in plant-based foods has brought upon the need to develop novel structures using plant-based proteins. However, there is still room for improvement in the development of plant-based meat and cheese alternatives. The rheological properties of self-assembled zein networks were examined to evaluate potential in animal protein replacement. These plant-based protein networks were co ...
DOI:
10.1016/j.crfs.2020.03.004

18. MILK Symposium review: Microbiological quality and safety of milk from farm to milk collection centers in Rwanda

Author:
Nyman, Ann-Kristin,   et al.   ; Ndahetuye, Jean Baptiste; Artursson, Karin; Båge, Renée; Ingabire, Alice; Karege, Callixte; Djangwani, Juvenal; Ongol, Martin Patrick; Tukei, Michael; Persson, Ylva;     Show all 10 Authors
Source:
Journal of dairy science 2020 v.103 no.11 pp. 9730-9739
ISSN:
0022-0302
Subject:
Brucella; Escherichia coli; Salmonella; antibiotic residues; antibodies; bacteria; bacterial contamination; bulk milk; dairy cows; dairy farming; farms; feeds; microbiological quality; milk; milk contamination; milking; milking parlors; plate count; raw milk; somatic cell count; transportation; udders; washing; Rwanda
Abstract:
... The aim of this study was to generate knowledge on the most important milk quality and safety attributes, including somatic cell count (SCC), total bacterial count (TBC), Escherichia coli, Salmonella, and Brucella spp. antibodies and antibiotic residues in milk in the chain from farm to milk collection center (MCC) in Rwanda. In addition, we investigated farm and management factors associated with ...
DOI:
10.3168/jds.2020-18302

19. Surveying for Potential Diseases and Abiotic Disorders of Industrial Hemp (Cannabis sativa) Production

Author:
Hicks, Kristin,   et al.   ; Thiessen, Lindsey D.; Schappe, Tyler; Cochran, Sarah; Post, Angela R.;     Show all 5 Authors
Source:
Plant health progress 2020 v.21 no.4 pp. 321-332
ISSN:
1535-1025
Subject:
Botrytis cinerea; Cannabis sativa; Exserohilum; Fusarium graminearum; Fusarium oxysporum; Fusarium wilt; Helminthosporium; Pythium; agricultural extension; agriculture; clones; consultants; extension agents; flowers; greenhouses; growers; hemp; insects; leaf spot; public services and goods; rain; researchers; roots; sampling; surveys; taxonomy; North Carolina
Abstract:
... Industrial hemp (Cannabis sativa L.) has recently been reintroduced as an agricultural commodity in the United States, and, through state-led pilot programs, growers and researchers have been investigating production strategies. Diseases and disorders of industrial hemp in the United States are largely unknowns because record-keeping and taxonomy have improved dramatically in the last several deca ...
DOI:
10.1094/PHP-03-20-0017-RS

20. Applications in geomorphology

Author:
Morell, Kristin,   et al.   ; Keller, Edward; Adamaitis, Chandler; Alessio, Paul; Anderson, Sarah; Goto, Erica; Gray, Summer; Gurrola, Larry;     Show all 8 Authors
Source:
Geomorphology 2020 v.366 pp. 106729
ISSN:
0169-555X
Subject:
anthropology; earthquakes; ecosystem management; engineering; floods; land use; landscapes; landslides; planning; risk; topography; tsunamis
Abstract:
... Geomorphology is a pure science with the goal of understanding Earth surface processes and landscape evolution, and it is also an applied science with the goal of addressing the needs of society. With many new high-resolution methods of depicting topography and much improved numerical dating, geomorphologists are working on problems involving rates of surface processes, landscape evolution, and ap ...
DOI:
10.1016/j.geomorph.2019.04.001