PubAg

Main content area

You searched for: Author "Wang, Can" Remove constraint Author: "Wang, Can" Publication Year 2020 Remove constraint Publication Year: 2020
Start Over

Search

1  Search Results

1 entry found
Number of results to display per page

Search Results

1. Manganese induces autophagy dysregulation: The role of S-nitrosylation in regulating autophagy related proteins in vivo and in vitro

Author:
Wang, Can,   et al.   ; Ma, Zhuo; Liu, Chang; Yan, Dong-Ying; Tan, Xuan; Liu, Kuan; Jing, Meng-Jiao; Deng, Yu; Liu, Wei; Xu, Bin;     Show all 10 Authors
Source:
The Science of the total environment 2020 v.698
ISSN:
0048-9697
Subject:
autophagy; central nervous system; humans; manganese; mice; mitogen-activated protein kinase; neurons; neurotoxicity; neutralization; phosphorylation; proteins; signal transduction
Abstract:
... Exposure to excess levels of manganese (Mn) may lead to nitrosative stress and neurotoxic effects on the central nervous system (CNS). The dysfunction of autophagy correlates with Mn-induced nitrosative stress; however, the exact mechanism of Mn-mediated autophagy dysfunction is still unclear. Three S-nitrosylated target proteins, namely, JNK, Bcl-2, and IKKβ, were classified as the pivotal signal ...
DOI:
10.1016/j.scitotenv.2019.134294