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- Wang, Can, et al. Show all 10 Authors
- The Science of the total environment 2020 v.698
- autophagy; central nervous system; humans; manganese; mice; mitogen-activated protein kinase; neurons; neurotoxicity; neutralization; phosphorylation; proteins; signal transduction
- ... Exposure to excess levels of manganese (Mn) may lead to nitrosative stress and neurotoxic effects on the central nervous system (CNS). The dysfunction of autophagy correlates with Mn-induced nitrosative stress; however, the exact mechanism of Mn-mediated autophagy dysfunction is still unclear. Three S-nitrosylated target proteins, namely, JNK, Bcl-2, and IKKβ, were classified as the pivotal signal ...