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- Vainshtein, Inna; Sun, Bo; Roskos, Lorin K.; Liang, Meina
- Journal of immunological methods 2020 v.477 pp. 112688
- false negative results, etc ; Pseudomonas; antibodies; clinical trials; drugs; exotoxins; immune response; leukemia; neutralization; patients; screening; Show all 11 Subjects
- ... Biologics are potentially immunogenic and can elicit immune response. Complex biologics, such as bispecific antibodies or multi-domain molecules can induce anti-drug antibodies (ADA) with specificity to different domains. Domain specific ADAs may differently affect drug efficacy and safety, and thus, characterization of ADA domain specificity has become a regulatory expectation for multi-domain bi ...